Modern Methods in Drug Discovery
... in vitro (model system of single and multiple cells) and in vivo (testing on animals) on the lead candidate(s). During this stage filing for patent also occurs, whereby always a series of compounds is claimed in order to • not stick to one single substance • reserve similar potential substances • co ...
... in vitro (model system of single and multiple cells) and in vivo (testing on animals) on the lead candidate(s). During this stage filing for patent also occurs, whereby always a series of compounds is claimed in order to • not stick to one single substance • reserve similar potential substances • co ...
5-HT receptor - Pharmatutor
... 5-HT2 antagonists Ketanserin is a 5-HT2A/2C antagonist used for the treatment of hypertension. In addition to its serotonin antagonism, it has affinity for alpha-1 receptors, which may contribute to its antihypertensive effect. Clozapine is an atypical antipsychotic drug that acts as 5-HT2A/2C recep ...
... 5-HT2 antagonists Ketanserin is a 5-HT2A/2C antagonist used for the treatment of hypertension. In addition to its serotonin antagonism, it has affinity for alpha-1 receptors, which may contribute to its antihypertensive effect. Clozapine is an atypical antipsychotic drug that acts as 5-HT2A/2C recep ...
Robotripping - Muncie Neighborhoods
... and supermarkets. The dozens of overdoses in the last two years-including at least five deaths in which the abuse of over-the-counter medicines was a factor-reflect how medicines such as Robitussin and Coricidin are becoming more popular as recreational drugs for kids as young as 12. ...
... and supermarkets. The dozens of overdoses in the last two years-including at least five deaths in which the abuse of over-the-counter medicines was a factor-reflect how medicines such as Robitussin and Coricidin are becoming more popular as recreational drugs for kids as young as 12. ...
Dev. Date
... by two independent, non-selective carrier systems. One of three processes which are critical for renal clearance. Involves the reabsorption of water and drug molecules across the tubule membranes and back into the plasma. A non-steroidal anti-inflammatory drug which exists as a weak acid. To make mo ...
... by two independent, non-selective carrier systems. One of three processes which are critical for renal clearance. Involves the reabsorption of water and drug molecules across the tubule membranes and back into the plasma. A non-steroidal anti-inflammatory drug which exists as a weak acid. To make mo ...
Importance of Pharmacovigilance in Indian Pharmaceutical Industry
... regulatory agencies have the responsibility of having a well-established pharmacovigilance system to monitor adverse reactions of drugs. During the drug development phase and later during the life time of a marketed drug.7 Pharmacovigilance is fastest emerging as an important approach for the early ...
... regulatory agencies have the responsibility of having a well-established pharmacovigilance system to monitor adverse reactions of drugs. During the drug development phase and later during the life time of a marketed drug.7 Pharmacovigilance is fastest emerging as an important approach for the early ...
3 Perinatal Pharmacology
... the maternal plasma half-life of these drugs is very short, and less drug will ultimately reach the fetus. Conversely, some drugs have long-lived metabolites which can reach the fetus. For example, normeperidine, a metabolite of meperidine, is twice as toxic as the parent compound but only half as a ...
... the maternal plasma half-life of these drugs is very short, and less drug will ultimately reach the fetus. Conversely, some drugs have long-lived metabolites which can reach the fetus. For example, normeperidine, a metabolite of meperidine, is twice as toxic as the parent compound but only half as a ...
Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and
... comparable between cohorts Significant potential for treatment variation since multiple countries and many years involved Primary and secondary outcome measures were not clearly defined Standardization and training did not occur among various investigators involved Questionnaires and frequency of fo ...
... comparable between cohorts Significant potential for treatment variation since multiple countries and many years involved Primary and secondary outcome measures were not clearly defined Standardization and training did not occur among various investigators involved Questionnaires and frequency of fo ...
Basic concepts of pharmacokinetics
... Plasma Drug Concentration-Time Profile A direct relationship exists between the concentration of drug at the biophase (site of action) and the concentration of drug in plasma. Two categories of parameters can be ...
... Plasma Drug Concentration-Time Profile A direct relationship exists between the concentration of drug at the biophase (site of action) and the concentration of drug in plasma. Two categories of parameters can be ...
pps
... The available knowledge on the human genome and the present SNPs in it allow two approaches: 1. Finding new targets (either on the genome, the mRNA, or the protein level) 2. pharmacogenomic methods will lead to personalized medicine (which drug and at what dosage), esp. for long term application of ...
... The available knowledge on the human genome and the present SNPs in it allow two approaches: 1. Finding new targets (either on the genome, the mRNA, or the protein level) 2. pharmacogenomic methods will lead to personalized medicine (which drug and at what dosage), esp. for long term application of ...
pps
... The available knowledge on the human genome and the present SNPs in it allow two approaches: 1. Finding new targets (either on the genome, the mRNA, or the protein level) 2. pharmacogenomic methods will lead to personalized medicine (which drug and at what dosage), esp. for long term application of ...
... The available knowledge on the human genome and the present SNPs in it allow two approaches: 1. Finding new targets (either on the genome, the mRNA, or the protein level) 2. pharmacogenomic methods will lead to personalized medicine (which drug and at what dosage), esp. for long term application of ...
Determining safe antibiotics for drug hypersensitive patients with the
... rarely anaphylaxis. The reactions occur within minutes to hours generally on second exposure to the drug after the development of sensitisation during the initial exposure1. Medical history is the most important step in the evaluation of antibiotic hypersensitivity and in differential diagnosis of o ...
... rarely anaphylaxis. The reactions occur within minutes to hours generally on second exposure to the drug after the development of sensitisation during the initial exposure1. Medical history is the most important step in the evaluation of antibiotic hypersensitivity and in differential diagnosis of o ...
Alternatives to placebo-controlled trials in psychiatry
... consideration even if the results might provide a scientifically less convincing basis for establishing efficacy. On the other hand, there are other serious conditions, for example, recurrent brief depression, for which no treatment to date has been shown to be effective in placebo-controlled studie ...
... consideration even if the results might provide a scientifically less convincing basis for establishing efficacy. On the other hand, there are other serious conditions, for example, recurrent brief depression, for which no treatment to date has been shown to be effective in placebo-controlled studie ...
Randomized Placebo-Controlled Crossover Trial of Tadalafil in Raynaud’s Phenomenon Secondary to
... than SSc, surgical sympathectomy involving the upper limb performed within the previous 12 months, participation in another study with an investigational drug or device during the 30 days prior to study entry, or during the study, use of HIV protease inhibitors, ketoconazole or rifampin. Also, the s ...
... than SSc, surgical sympathectomy involving the upper limb performed within the previous 12 months, participation in another study with an investigational drug or device during the 30 days prior to study entry, or during the study, use of HIV protease inhibitors, ketoconazole or rifampin. Also, the s ...
New Drug Update 2015
... If after 2 weeks: HR is > 60 BPM increased to 7.5mg BID HR 50-60 BPM remain at 5mg BID HR < 50 BPM decrease to 2.5mg BID May start at 2.5 mg BID if concerned ...
... If after 2 weeks: HR is > 60 BPM increased to 7.5mg BID HR 50-60 BPM remain at 5mg BID HR < 50 BPM decrease to 2.5mg BID May start at 2.5 mg BID if concerned ...
Treatment of Restless Legs Syndrome in Adults
... The guideline authors addressed the following concerns for long-term use of certain prescription drugs (dopaminergic medications): • Augmentation • RLS symptoms can get worse over time from the prescription drug levodopa and from other dopaminergic medications in the following ways: - RLS symptoms ...
... The guideline authors addressed the following concerns for long-term use of certain prescription drugs (dopaminergic medications): • Augmentation • RLS symptoms can get worse over time from the prescription drug levodopa and from other dopaminergic medications in the following ways: - RLS symptoms ...
Guideline on Repeated Dose Toxicity Corr - EMA
... Bone marrow smear should be prepared from all animals, but only examined if treatment-related changes are suspected in tissues/organs or in peripheral blood. The smears will be examined by visual assessment for cellularity, distribution, and morphology and an assessment of the myeloid:erythroid rati ...
... Bone marrow smear should be prepared from all animals, but only examined if treatment-related changes are suspected in tissues/organs or in peripheral blood. The smears will be examined by visual assessment for cellularity, distribution, and morphology and an assessment of the myeloid:erythroid rati ...
The pharmacotherapy of smoking cessation
... The aim of NRT is to assist smoking cessation by providing a near-constant level of nicotine above that which is associated with withdrawal. No form of NRT can replicate the rapid nicotine delivery from a cigarette. The NRT formulations available in India include gum, patches and oral inhaler. Nico ...
... The aim of NRT is to assist smoking cessation by providing a near-constant level of nicotine above that which is associated with withdrawal. No form of NRT can replicate the rapid nicotine delivery from a cigarette. The NRT formulations available in India include gum, patches and oral inhaler. Nico ...
Sex differences in the vulnerability to drug abuse
... studies of acquisition of drug self-administration in drugnaı̈ve animals are important for investigating factors that affect vulnerability to initiation of drug use in humans [18]. Analyses of steady-state maintenance levels of drug intake are often conducted using animal models of drug abuse that e ...
... studies of acquisition of drug self-administration in drugnaı̈ve animals are important for investigating factors that affect vulnerability to initiation of drug use in humans [18]. Analyses of steady-state maintenance levels of drug intake are often conducted using animal models of drug abuse that e ...
Lower Side Effects of Milnacipran than Paroxetine in the Treatment
... Milnacipran is a dual-action antidepressant which inhibits both serotonin and norepinephrine reuptake. To our knowledge, it has limited affinity for most monoamine neurotransmitter receptors. With limited pharmacokinetic interaction with the cytochrome 450 system, milnacipran may have a low risk in ...
... Milnacipran is a dual-action antidepressant which inhibits both serotonin and norepinephrine reuptake. To our knowledge, it has limited affinity for most monoamine neurotransmitter receptors. With limited pharmacokinetic interaction with the cytochrome 450 system, milnacipran may have a low risk in ...
Alcohol Intake: A Review of Effects and
... its antagonist formation, the DKK1, causing disturbs on bone formation [24]. Alcohol intake causes significant commitment in quality of cortical bone demonstrated through the analysis of the cross-sectional geometry of femur in young rats [4]. In rats, Nishiguchi et al. [25] reported bone loss in di ...
... its antagonist formation, the DKK1, causing disturbs on bone formation [24]. Alcohol intake causes significant commitment in quality of cortical bone demonstrated through the analysis of the cross-sectional geometry of femur in young rats [4]. In rats, Nishiguchi et al. [25] reported bone loss in di ...
Tussionex Pennkinetic
... used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept i ...
... used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept i ...
Biomedical Interventional Protocol
... only one of several commercial agents included in the study. If needed, please provide background information on other agent(s) and/or treatments in this study that are not described in section 1.2 including rationale for including them in this study, their mechanism of action, information to suppor ...
... only one of several commercial agents included in the study. If needed, please provide background information on other agent(s) and/or treatments in this study that are not described in section 1.2 including rationale for including them in this study, their mechanism of action, information to suppor ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.