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Rapid tranquillisation - The British Journal of Psychiatry
Rapid tranquillisation - The British Journal of Psychiatry

... serious, including cardiorespiratory probproblems, with cardiac arrests in 2% and cardiovascular complications in 3%. Although not reported in this study, dystonic reactions are not uncommon in patients administered an intramuscular antipsychotic. These reactions can be severe, and extremely unpleas ...
Double-blind, Randomized, Placebo-Controlled Trial of Varenicline
Double-blind, Randomized, Placebo-Controlled Trial of Varenicline

... appear to benefit as much, OR had the problematic side effect of weakness (1 patient, most severely affected) FA: very early patients often developed that “weakness”: due to spasiticity? While varenicline gets a bad reputation for depression in smokers, it improved depression in this population ...
OTC Drugs Monograph - Thai Self Medication Industry Association
OTC Drugs Monograph - Thai Self Medication Industry Association

... • Take medicines three times a day with an interval of at least 4 hours between doses, avoid taking medicines on an empty stomach.  Other rules are described in the monograph. ...
ANTIGLAUCOMA MEDICATIONS
ANTIGLAUCOMA MEDICATIONS

... • rises during the next few days and plateaus at a maintenance level ...
- Institute for Theoretical Biology - Humboldt
- Institute for Theoretical Biology - Humboldt

... (but excepting alcohol) are plant neurotoxins or, in the case of several synthetic drugs, their close chemical analogs.1 These drugs acquire their psychoactive effects by interfering with neuronal signaling in the central nervous system (CNS), for example by binding to neurotransmitter receptors, or ...
IBS
IBS

... months he has had progressively worsening cramping pains, bloating and diarrhea (3 times/day). with loose stools. However, stools never contained blood. He has tried over-the-counter antidiarrheal medications but diarrhea often recurs. He is on no medication regularly and has no significant medical ...
What is depression? - Pharmaceutical Society of Australia
What is depression? - Pharmaceutical Society of Australia

... Presenter notes: There is increasing evidence that the risk of developing dementia can be reduced by engaging in intellectual and social activities. Treatment of underlying depression in older adults with cognitive impairment can also improve cognitive function. Intellectual and social activities: ...
[acute trust logo] - Coastal West Sussex Formulary
[acute trust logo] - Coastal West Sussex Formulary

... There have been reports of sudden death in children and adolescents who were taking atomoxetine at usual doses with existing structural cardiac abnormalities. Although some serious structural cardiac abnormalities alone carry an increased risk of sudden death, atomoxetine should only be used with ca ...
What is health-economic evaluation?
What is health-economic evaluation?

... According to the SPC [1], the safety of aflibercept in combination with FOLFIRI has been evaluated in a phase III study titled VELOUR [2] in 1,216 patients who have previously been treated for metastatic colorectal cancer. Of these, 611 patients were treated with aflibercept 4 mg/kg every two weeks ...
DRUGS THAT AFFECT CARDIOVASCULAR FUNCTIONS
DRUGS THAT AFFECT CARDIOVASCULAR FUNCTIONS

... manner and deny acetylcholine and other cholinergic drugs receptor sites in a competitive manner. • This effect is reversed when concentration of acetylcholine and other cholinergic drugs is increased. ...
ADHD MEDICATIONS EBOOK
ADHD MEDICATIONS EBOOK

... the brain cannot produce enough of the neurotransmitter dopamine, which is responsible for movement control, pleasure, motivation, and information processing. According to brain scans, the frontal lobe region is underactive because there is not enough dopamine to fuel it. As a result, the functions ...
drugs that affect cardiovascular system
drugs that affect cardiovascular system

... manner and deny acetylcholine and other cholinergic drugs receptor sites in a competitive manner. • This effect is reversed when concentration of acetylcholine and other cholinergic drugs is increased. ...
Antipsychotics
Antipsychotics

... used mainly in the treatment of schizophrenia, they are also used in the treatment of other psychoses associated with depression and manic-depressive illness, and psychosis associated with Alzheimer’s disease. These conditions are life-long and disabling. ...
Summary of Main DRUID Results - Druid
Summary of Main DRUID Results - Druid

... DRUID activities were implemented in seven scientific Work packages. A description of the problem situation of driving under the influence of psychoactive substance (DUI/DUID) was generated in WP1 and WP2 based on experimental and epidemiological studies, whereas the remaining five Work packages foc ...
2008 - SUNY Upstate Medical University
2008 - SUNY Upstate Medical University

... contact time and decontamination are the mainstay of minimizing toxicity. After contact exposure to external skin and eyes, patients should be copiously irrigated with the closest available irrigation solution, most commonly water or normal saline. In select circumstances, where the corrosive agent ...
dfdfdfdfd - Streetwise Reports
dfdfdfdfd - Streetwise Reports

... Certain statements contained in this presentation or in other documents of Relmada Therapeutics (the “Company”), along with certain statements that may be made by management of the Company orally in presenting this material, may contain “forwardlooking statements.” These statements can be identified ...
Nasal Drug Delivery in EMS
Nasal Drug Delivery in EMS

... seizures: My spin  IN benzos are very effective for seizure therapy both in children and in adults.  If a seizing patient needs to be treated and does not have an IV established, then administration of IN midazolam should be done without delay.  Ideal setting will be home treatment by family and ...
Review of ADHD Pharmacotherapies: Advantages, Disadvantages, and Clinical Pearls
Review of ADHD Pharmacotherapies: Advantages, Disadvantages, and Clinical Pearls

Introduction of new drugs and drug regimens for the management of
Introduction of new drugs and drug regimens for the management of

... MDR TB is not based on randomised clinical trial evidence but rather on expert opinion. For the treatment of even more resistant TB including XDR TB, the best data available is retrospective cohort data. While there is on-going clinical research into a shorter regimen with the current registered dru ...
Antiallergic agents
Antiallergic agents

... whole-body allergic reactions that occur within minutes of exposure, progresses rapidly and can lead to anaphylactic shock and death. ...
QA50_8_Hypersalivationgeneral
QA50_8_Hypersalivationgeneral

... swallowing difficulties (e.g. head and neck cancers) who may have problems with drooling or choking owing to the normal production of saliva. Hyoscine hydrobromide can also be given by non-topical routes but there is less evidence to support this. Glycopyrronium (see separate Q&A 52 for more detaile ...
`False-positive` and `false-negative` test results in clinical urine drug
`False-positive` and `false-negative` test results in clinical urine drug

... has a narrow window of detection in the urine (typically <12 h), but it is a specific marker for heroin administration. On the other hand, nonpharmaceutical heroin is prepared from opium and contains codeine and 6-acetylcodeine (6-AC) as manufacturing impurities [5,6] . 6-AC is rapidly metabolized i ...
FDA Warning Letter to Charles McKay, M.D. 2009-10-23
FDA Warning Letter to Charles McKay, M.D. 2009-10-23

... visits (at 1, 3, 6, 9, and 12 months from randomization) and then every 4 months for the duration of the trial, as specified in the protocol flow chart, to assess study medication compliance and accountability, concomitant therapy or intervention, and conduct of efficacy and safety-related assessmen ...
FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF
FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF

Opioids
Opioids

... • In contrast, nonsteroidal anti-inflammatory analgesic drugs have no significant effect on the emotional aspects of pain. Euphoria • intravenous drug users experience a pleasant floating sensation with lessened anxiety and distress (DA release in nucleus accumbance). • However, dysphoria, an unplea ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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