FORMULATION AND EVALUATION OF CARBAMAZEPINE EXTENDED RELEASE TABLET BY Research Article
... 60-mesh sieve 10 times. Granules were prepared with PVP K-30 solution in Isopropyl alcohol which were dried at 40oC for 2hrs, and then sifted through sieve no 22, to get uniform sized granules ready for compression. Sifted Talc and Magnesium stearate were added to the prepared granules and mixed pro ...
... 60-mesh sieve 10 times. Granules were prepared with PVP K-30 solution in Isopropyl alcohol which were dried at 40oC for 2hrs, and then sifted through sieve no 22, to get uniform sized granules ready for compression. Sifted Talc and Magnesium stearate were added to the prepared granules and mixed pro ...
Prescription Stimulants (Canadian Drug Summary)
... While prescription stimulants are prescribed for therapeutic purposes, they have the potential to be misused because of their psychoactive properties. The risk for psychological and physical dependence (addiction) is increased through accessibility, multiple opportunities for diversion along the sup ...
... While prescription stimulants are prescribed for therapeutic purposes, they have the potential to be misused because of their psychoactive properties. The risk for psychological and physical dependence (addiction) is increased through accessibility, multiple opportunities for diversion along the sup ...
Sinning and sinned against: The stigmatisation of problem
... significantly greater for non idu groups. Matched by levels of brain activity ...
... significantly greater for non idu groups. Matched by levels of brain activity ...
| Barriers to new drug development in respiratory disease Peter J. Barnes
... The challenges of drug discovery Very high attrition rates during the process of drug discovery are making it more difficult and more expensive to bring new drugs, particularly new chemical entities, to market. For every approved new drug there are ∼10 000 chemicals with a marked loss of compounds a ...
... The challenges of drug discovery Very high attrition rates during the process of drug discovery are making it more difficult and more expensive to bring new drugs, particularly new chemical entities, to market. For every approved new drug there are ∼10 000 chemicals with a marked loss of compounds a ...
Tales of Bath Salts and Legal Marijuana: TheRapidExpansion
... usually found among smokers of “real” marijuana. Recently linked to over 352 nationwide emergency room incidents ...
... usually found among smokers of “real” marijuana. Recently linked to over 352 nationwide emergency room incidents ...
Polymorph Impact on the Bioavailability and Stability of Poorly
... particle size to nanodimensions [5,6]. Including or dispersing the poorly soluble drug in a carrier such as a cyclodextrin [7,8] or a polymer (solid dispersion) [9] are also common applied approaches. Modifications in the solid state, conversion from one polymorph to another [10], solvation/hydratio ...
... particle size to nanodimensions [5,6]. Including or dispersing the poorly soluble drug in a carrier such as a cyclodextrin [7,8] or a polymer (solid dispersion) [9] are also common applied approaches. Modifications in the solid state, conversion from one polymorph to another [10], solvation/hydratio ...
Drugs of Abuse 2 CEUs
... It is used in rave clubs to enhance the experience and give energy for all night dancing. It may be taken orally, sublingually, or snorted. Most physiologic harm comes from the stimulant properties of ecstasy. It can cause hyperthermia (sometimes fatal referred to as Saturday Night Fever), rhabdomyo ...
... It is used in rave clubs to enhance the experience and give energy for all night dancing. It may be taken orally, sublingually, or snorted. Most physiologic harm comes from the stimulant properties of ecstasy. It can cause hyperthermia (sometimes fatal referred to as Saturday Night Fever), rhabdomyo ...
Inhalation Anesthetic Agents
... Glycopyrrolate – Also known as Robinal. Glycopyrrolate is an anticholinergic. It is given preoperatively as an anti-muscarinic to reduce salivary, tracheobronchial and pharyngeal secretions. It also blocks cardiac vagal inhibitory reflexes during the induction of anesthesia and intubation. This drug ...
... Glycopyrrolate – Also known as Robinal. Glycopyrrolate is an anticholinergic. It is given preoperatively as an anti-muscarinic to reduce salivary, tracheobronchial and pharyngeal secretions. It also blocks cardiac vagal inhibitory reflexes during the induction of anesthesia and intubation. This drug ...
full text pdf
... Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administrat ...
... Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administrat ...
FORMULATION AND EVALUATION OF FLURBIPROFEN SOLID DISPERSION Research Article AHMED LAITH
... microsphere to control the drug release [23]. Adding Eudragit L100 in various ratios with ethyl cellulose will increase drug content and entrapment efficiency the same result was reported in other study [24], this may be attributed to low solubility of Eudragit L100 in low pH media. Eudragit L100 is ...
... microsphere to control the drug release [23]. Adding Eudragit L100 in various ratios with ethyl cellulose will increase drug content and entrapment efficiency the same result was reported in other study [24], this may be attributed to low solubility of Eudragit L100 in low pH media. Eudragit L100 is ...
Oral Fluoroquinolones
... Levofloxacin safety when used for longer than 14 days in pediatric patients has not been studied; use for > 14 days when bene fit outweighs risk ...
... Levofloxacin safety when used for longer than 14 days in pediatric patients has not been studied; use for > 14 days when bene fit outweighs risk ...
Fosamax Drug Could Become Next Merck Woe
... Merck and other bisphosphonate makers should change their labels to reflect the risk of ONJ as early as August 2004, 11 months before Merck changed the Fosamax label. Merck counters that it submitted a draft revised label for Fosamax to the agency in March 2005. An FDA spokeswoman says it isn't "at ...
... Merck and other bisphosphonate makers should change their labels to reflect the risk of ONJ as early as August 2004, 11 months before Merck changed the Fosamax label. Merck counters that it submitted a draft revised label for Fosamax to the agency in March 2005. An FDA spokeswoman says it isn't "at ...
view - Cure Alzheimer`s Fund
... and is currently in large phase III trials (Wyeth-Elan). However, this approach requires the production and IV injection of anti-amyloid antibodies, which makes it more expensive than oral medicines and more difficult to administer. When one considers the demographics of AD, it is not clear whether ...
... and is currently in large phase III trials (Wyeth-Elan). However, this approach requires the production and IV injection of anti-amyloid antibodies, which makes it more expensive than oral medicines and more difficult to administer. When one considers the demographics of AD, it is not clear whether ...
Microsponge Delivery System: An updated review, current status
... the microsponge‟s ranges from 5-300μm in diameter and a typical 25μm sphere can have up to 250000 pores and an internal pore structure equivalent to 10 feet in length, providing a total pore volume of about 1ml/g for extensive drug retention. The surface can be varied from 20 to 500 m2/g and pore vo ...
... the microsponge‟s ranges from 5-300μm in diameter and a typical 25μm sphere can have up to 250000 pores and an internal pore structure equivalent to 10 feet in length, providing a total pore volume of about 1ml/g for extensive drug retention. The surface can be varied from 20 to 500 m2/g and pore vo ...
FORMULATION AND EVALUATION OF GUM OLIBANUMBASED SUSTAINED RELEASE MATRIX TABLETS OF AMBROXOL HYDROCHLORIDE
... and cumulative percent drug release was calculated. The study was performed in triplicate. The commercial Ambroxol SR capsules were used as the reference formulation, and were also subjected to in vitro drug release studies. Calculation of similarity factor (f2) 15 Similarity factor ...
... and cumulative percent drug release was calculated. The study was performed in triplicate. The commercial Ambroxol SR capsules were used as the reference formulation, and were also subjected to in vitro drug release studies. Calculation of similarity factor (f2) 15 Similarity factor ...
Antiamoebic Drugs
... resulting in a reduction in intestinal flora – the ameba’s major food source. The trophozoites within the intestine are slowly carried toward the rectum, where they return to the cyst form and are excreted in feces. ...
... resulting in a reduction in intestinal flora – the ameba’s major food source. The trophozoites within the intestine are slowly carried toward the rectum, where they return to the cyst form and are excreted in feces. ...
University of Minnesota Medical Technology Evaluation and Market
... to determine the safety and effectiveness of the technology • Products subject to PMA review include artificial heart valves, coronary stents, novel diagnostic tests, bioartificial skin, and spinal implants. • It typically takes the agency over a year to complete a review of a PMA ...
... to determine the safety and effectiveness of the technology • Products subject to PMA review include artificial heart valves, coronary stents, novel diagnostic tests, bioartificial skin, and spinal implants. • It typically takes the agency over a year to complete a review of a PMA ...
PowerPoint - Garnet Valley
... becomes totally dependent on alcohol. He or she can usually not stop after one drink, and feels a constant need to drink. • Stage 3 – Late Stage of Alcoholism: when alcoholics lose their mental, emotional, and physical health. Their entire life revolves around drinking; they become isolated from soc ...
... becomes totally dependent on alcohol. He or she can usually not stop after one drink, and feels a constant need to drink. • Stage 3 – Late Stage of Alcoholism: when alcoholics lose their mental, emotional, and physical health. Their entire life revolves around drinking; they become isolated from soc ...
Mechanism of Action
... in intact microtubules with different affinities This action suppresses dynamic instability, • which increases the time that microtubules spend in a state of attenuated activity, neither growing nor shortening ...
... in intact microtubules with different affinities This action suppresses dynamic instability, • which increases the time that microtubules spend in a state of attenuated activity, neither growing nor shortening ...
Semantic integration of medication data into the EHOP Clinical Data
... several academic hospitals in France. The database contains both structured (e.g. labs results, DRG data) and non-structured patient data (e.g. clinical or imagery reports). The query workbench allows performing simple to complex queries with semantic expansion, negation or uncertainty detection and ...
... several academic hospitals in France. The database contains both structured (e.g. labs results, DRG data) and non-structured patient data (e.g. clinical or imagery reports). The query workbench allows performing simple to complex queries with semantic expansion, negation or uncertainty detection and ...
Medication Alternatives for the Elderly
... Potential for dependence, angina, hypertension and myocardial infarction ...
... Potential for dependence, angina, hypertension and myocardial infarction ...
Pages 12-15 - eCM journal
... approximately 75% of the microparticle mass while high surface area activated carbon comprises the remaining. The synergy between these two components creates a magnetically susceptible particle capable of carrying therapeutic quantities of a wide range of pharmaceutical agents which may be targeted ...
... approximately 75% of the microparticle mass while high surface area activated carbon comprises the remaining. The synergy between these two components creates a magnetically susceptible particle capable of carrying therapeutic quantities of a wide range of pharmaceutical agents which may be targeted ...
Migraines in a Minute (or less)
... Early use of medication for patients with episodic headache Limit use of all acute meds to 2 days/week ...
... Early use of medication for patients with episodic headache Limit use of all acute meds to 2 days/week ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.