Novel psychoactive substances of interest for psychiatry
... countries/territories (2), with some 5% of 19-24 years old European people having already experimented with them. The web plays a major role in shaping this unregulated market (3), with users being attracted by these substances due to both their intense psychoactive effects and likely lack of detect ...
... countries/territories (2), with some 5% of 19-24 years old European people having already experimented with them. The web plays a major role in shaping this unregulated market (3), with users being attracted by these substances due to both their intense psychoactive effects and likely lack of detect ...
You Should Continue Breastfeeding
... the radioactivity need be gone? After 12 hours, 75% of the technetium is gone, and the concentration in the milk very low. I think that waiting 2 half lives is enough, for a material such as technetium. But:: Not all technetium scans require stopping breastfeeding at all (HIDA scan, for example). It ...
... the radioactivity need be gone? After 12 hours, 75% of the technetium is gone, and the concentration in the milk very low. I think that waiting 2 half lives is enough, for a material such as technetium. But:: Not all technetium scans require stopping breastfeeding at all (HIDA scan, for example). It ...
Cocaine - drug info @ your library
... chemically synthesised. It is a stimulant drug (see definition on page 2), as well as a potent local anaesthetic. Coca leaves have been used for thousands of years in South America for religious, mystical, social and medicinal purposes. The active chemical was isolated in 1855, and purified and name ...
... chemically synthesised. It is a stimulant drug (see definition on page 2), as well as a potent local anaesthetic. Coca leaves have been used for thousands of years in South America for religious, mystical, social and medicinal purposes. The active chemical was isolated in 1855, and purified and name ...
GROSSET_TBETHICS
... place of isoniazid in the initial phase of treatment (Time to culture conversion, Safety/tolerability) • Investigators at Johns Hopkins are also developing a similar approach ...
... place of isoniazid in the initial phase of treatment (Time to culture conversion, Safety/tolerability) • Investigators at Johns Hopkins are also developing a similar approach ...
Lecture outline Mechanisms of AF Atrial Fibrillation Coarse - Pri-Med
... Rhythm control: Maintain sinus rhythm with antiarrhythmic drugs, DC cardioversion, ablation, surgery; Need drugs for rate control + anticoagulation (by risk score) Neither strategy shown to be superior; Both strategies can fail and patients may cross over ...
... Rhythm control: Maintain sinus rhythm with antiarrhythmic drugs, DC cardioversion, ablation, surgery; Need drugs for rate control + anticoagulation (by risk score) Neither strategy shown to be superior; Both strategies can fail and patients may cross over ...
Side effects
... Trazodone has structural similarities with TCAs but probably acts by antagonism of central ...
... Trazodone has structural similarities with TCAs but probably acts by antagonism of central ...
Synthetics -slide show AA MSPP
... Issue: Language -With the hundreds of new drugs (or are they “chemicals”) of abuse in use in various regions of this and other countries we will mostly be looking at these 2 categories of mind altering substances, as teens understand them: ...
... Issue: Language -With the hundreds of new drugs (or are they “chemicals”) of abuse in use in various regions of this and other countries we will mostly be looking at these 2 categories of mind altering substances, as teens understand them: ...
The Texas Tech University – HSC
... absorption occurs, making this route ideal for producing a local effect as in allergy testing. (A tuberculin syringe is generally used with 26g or 27g needle, 1/2" – 5/8" in length.) The Subcutaneous route allows for more rapid delivery of a drug compared to the oral route, and slower, sustained dru ...
... absorption occurs, making this route ideal for producing a local effect as in allergy testing. (A tuberculin syringe is generally used with 26g or 27g needle, 1/2" – 5/8" in length.) The Subcutaneous route allows for more rapid delivery of a drug compared to the oral route, and slower, sustained dru ...
Ecstasy - a quick guide to drugs and alcohol
... It is possible that using ecstasy when pregnant increases the risk of miscarriage. The use of amphetamine like substances such as ecstasy during Ecstasy tablet Image: U.S. Drug Enforcement Administration ...
... It is possible that using ecstasy when pregnant increases the risk of miscarriage. The use of amphetamine like substances such as ecstasy during Ecstasy tablet Image: U.S. Drug Enforcement Administration ...
P21 The role of ethanol containing lotions on ethylglucuronide in
... M. Yegles, S. Schneider, R. Wennig Laboratoire National de Sante - Toxicologie, Luxembourg Ethyl glucuronide (EtG) in hair, a non-volatile, direct metabolite of ethanol proved to be an interesting marker for the evaluation of social and chronic excessive alcohol consumption. Regarding the influence ...
... M. Yegles, S. Schneider, R. Wennig Laboratoire National de Sante - Toxicologie, Luxembourg Ethyl glucuronide (EtG) in hair, a non-volatile, direct metabolite of ethanol proved to be an interesting marker for the evaluation of social and chronic excessive alcohol consumption. Regarding the influence ...
DRUG CALCULATIONS
... this type of calculation it is usually easier to convert the number containing the decimal point into a larger figure, rather than the other way round. So, first multiply 0.05mg by 1000 to convert it to micrograms. 0.05mg = 50 micrograms. Now you can use this figure to calculate the number of tablet ...
... this type of calculation it is usually easier to convert the number containing the decimal point into a larger figure, rather than the other way round. So, first multiply 0.05mg by 1000 to convert it to micrograms. 0.05mg = 50 micrograms. Now you can use this figure to calculate the number of tablet ...
Adverse Drug Reactions
... • Mediated by IgG • It is manifested as serum sickness Type IV • Delayed hypersensitivity reaction • Mediated by T lymphocytes and macrophages • Examples include allergic contact dermatitis ...
... • Mediated by IgG • It is manifested as serum sickness Type IV • Delayed hypersensitivity reaction • Mediated by T lymphocytes and macrophages • Examples include allergic contact dermatitis ...
nhse_qa43_7_final - Specialist Pharmacy Service
... Tricycling and dose doubling of COCs as described above are unlicensed uses. The manufacturer of the chosen contraceptives will not accept liability if a problem should occur. It is important that the patient is aware that the combination of two COCs, along with a shortened pill free interval, is un ...
... Tricycling and dose doubling of COCs as described above are unlicensed uses. The manufacturer of the chosen contraceptives will not accept liability if a problem should occur. It is important that the patient is aware that the combination of two COCs, along with a shortened pill free interval, is un ...
Drugs for Tuberculosis and Mycobacterium avium complex disease
... Can’t use rifampin in people being treated with PIs or NNRTIs. May substitute Rifabutin, in one half the dose, unless patient is taking ...
... Can’t use rifampin in people being treated with PIs or NNRTIs. May substitute Rifabutin, in one half the dose, unless patient is taking ...
HEMATOLOGy & ONCOLOGy
... Every woman who gets breast cancer should have the best possible treatment for her individual disease, including the most up-to-date chemotherapy regimens. But even in this age of national cancer treatment guidelines, empowered patients, and comprehensive cancer centers, many women still don’t recei ...
... Every woman who gets breast cancer should have the best possible treatment for her individual disease, including the most up-to-date chemotherapy regimens. But even in this age of national cancer treatment guidelines, empowered patients, and comprehensive cancer centers, many women still don’t recei ...
Is There a Magic Bullet? - American Counseling Association
... that ultimately influences client’s medication compliance. Is there a Magic Bullet? The resounding answer is no. Addiction is considered a bio-psych-social phenomenon and PAAM only addresses one component of addiction— the biological component. PAAM is rarely sufficient treatment for drug addiction ...
... that ultimately influences client’s medication compliance. Is there a Magic Bullet? The resounding answer is no. Addiction is considered a bio-psych-social phenomenon and PAAM only addresses one component of addiction— the biological component. PAAM is rarely sufficient treatment for drug addiction ...
Pharmacology as a tool to dose individualize cancer therapy
... 1. What is the optimal starting (labeled) dose for the indicated population? 2. What is the optimal starting dose for the individual, as determined by that patient’s pretreatment characteristics? 3. What is the optimal dose for the individual, as based on pharmacologic response to the previous doses ...
... 1. What is the optimal starting (labeled) dose for the indicated population? 2. What is the optimal starting dose for the individual, as determined by that patient’s pretreatment characteristics? 3. What is the optimal dose for the individual, as based on pharmacologic response to the previous doses ...
Formulation and evaluation of Pseudoephedrine hydrochloride and
... Formulation of granules is the key factor in the production of tablet dosage from involving extended release of drug from matrix type particle. Physical parameters such as area, hardness, surface characteristics and size can significantly affect the rate of dissolution of drugs contained in a comple ...
... Formulation of granules is the key factor in the production of tablet dosage from involving extended release of drug from matrix type particle. Physical parameters such as area, hardness, surface characteristics and size can significantly affect the rate of dissolution of drugs contained in a comple ...
ISMP Medication Safety Alert - Institute For Safe Medication Practices
... entering the order because it had either been entered into a non-PN template without dose limits or entered using an adult template. A free-text label that listed the sodium content as 14.7 mEq was placed over the compounder label, ...
... entering the order because it had either been entered into a non-PN template without dose limits or entered using an adult template. A free-text label that listed the sodium content as 14.7 mEq was placed over the compounder label, ...
Comparison of Tibial Intraosseous, Sternal Intraosseous
... ministered via tibial IO, sternal IO, and IV routes in a porcine model of cardiac arrest during cardiopulmonary resuscitation (CPR). The research questions that guided the study were as follows: 1. Are there statistically significant differences in the Cmax of epinephrine in the heart when the drug ...
... ministered via tibial IO, sternal IO, and IV routes in a porcine model of cardiac arrest during cardiopulmonary resuscitation (CPR). The research questions that guided the study were as follows: 1. Are there statistically significant differences in the Cmax of epinephrine in the heart when the drug ...
Evaluation for Zero-order Controlled Release Preparations of
... systems which are developed to obtain a stronger therapeutic eŠect from agents that have already been marketed as well as for use with novel compounds. Oral controlled-release preparations are a representative type of drug delivery system. Advanced pharmaceutical technology is necessary for controll ...
... systems which are developed to obtain a stronger therapeutic eŠect from agents that have already been marketed as well as for use with novel compounds. Oral controlled-release preparations are a representative type of drug delivery system. Advanced pharmaceutical technology is necessary for controll ...
Drug_Misuse_LES_Pharmacy_2011_12
... The patient exhibits unacceptable behaviour (based on the pharmacist’s professional judgement), which may result in a ban The patient presents in an intoxicated state and treatment is withheld The pharmacist is concerned at the observed deterioration in the health of a patient The pharmacist ...
... The patient exhibits unacceptable behaviour (based on the pharmacist’s professional judgement), which may result in a ban The patient presents in an intoxicated state and treatment is withheld The pharmacist is concerned at the observed deterioration in the health of a patient The pharmacist ...
Manuscript "Fast-track drug approval in inflammatory bowel diseases"
... oncology drugs that have a targeted approach ie the BRAF therapies or treatments for advanced melanoma have to IBD drug development. Are there similar targeted IBD therapies being developed? Thank you for this great point. To our knowledge, there are no similar targeted IBD therapies as of yet. What ...
... oncology drugs that have a targeted approach ie the BRAF therapies or treatments for advanced melanoma have to IBD drug development. Are there similar targeted IBD therapies being developed? Thank you for this great point. To our knowledge, there are no similar targeted IBD therapies as of yet. What ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.