PROSTIN VR Concentrate For Solution
... Alprostadil (prostaglandin Et) is one of a family of naturally occurring acidic lipids with various pharmacologic effects. Vasodilation, inhibition of platelet aggregation, and stimulation of intestinal and uterine smooth muscle are among the most notable of these effects. Intravenous doses of 1 to ...
... Alprostadil (prostaglandin Et) is one of a family of naturally occurring acidic lipids with various pharmacologic effects. Vasodilation, inhibition of platelet aggregation, and stimulation of intestinal and uterine smooth muscle are among the most notable of these effects. Intravenous doses of 1 to ...
PRODUCT MONOGRAPH PrBICILLIN® L-A (penicillin G benzathine
... Clostridium difficile-associated disease (CDAD) has been reported with use of many antibacterial agents, including Bicillin® L-A (penicillin g benzathine). CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea ...
... Clostridium difficile-associated disease (CDAD) has been reported with use of many antibacterial agents, including Bicillin® L-A (penicillin g benzathine). CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea ...
LIQUID MEMBRANE PHENOMENON IN THE BIOLOGICAL ACTION OF VENLAFAXINE Research Article
... different pharmacological categories have revealed that liquid membranes likely to be generated by the drugs either by themselves or in association with membrane lipids at their respective sites of action may modify access of relevant permeants to these sites[1-3]. This modification in the access of ...
... different pharmacological categories have revealed that liquid membranes likely to be generated by the drugs either by themselves or in association with membrane lipids at their respective sites of action may modify access of relevant permeants to these sites[1-3]. This modification in the access of ...
Comparative veterinary H. Hutchinson
... (CYP) binding affinity/inhibition and prediction of CYP induction). Table 2 shows a representative software tool for each of these categories, however, many other tools are available [51]. In silico tools have a number of potential advantages and provide complementary techniques to in vitro methods. ...
... (CYP) binding affinity/inhibition and prediction of CYP induction). Table 2 shows a representative software tool for each of these categories, however, many other tools are available [51]. In silico tools have a number of potential advantages and provide complementary techniques to in vitro methods. ...
AusPAR: Retigabine - Therapeutic Goods Administration
... proposed tighter control on particle size, based on the API used in pivotal clinical batches. A D10 limit was proposed and the D50 range was tightened. The new limits (D10 No Less Than [NLT] 13 µm, D50 45-80 µm, D90 NMT 265 µm) are adequately justified based on clinical trial results. ...
... proposed tighter control on particle size, based on the API used in pivotal clinical batches. A D10 limit was proposed and the D50 range was tightened. The new limits (D10 No Less Than [NLT] 13 µm, D50 45-80 µm, D90 NMT 265 µm) are adequately justified based on clinical trial results. ...
Rodent Anesthetics and Analgesics
... Isoflurane is the first choice of anesthetic used for animal restraint or surgical procedures in laboratory animal species. Isoflurane is delivered via a nose‐cone and inhaled in rodents or provided through an intra-tracheal tube. The concentration of drug can be administered to effect by adjusting ...
... Isoflurane is the first choice of anesthetic used for animal restraint or surgical procedures in laboratory animal species. Isoflurane is delivered via a nose‐cone and inhaled in rodents or provided through an intra-tracheal tube. The concentration of drug can be administered to effect by adjusting ...
NOVEMBER 2016 PBAC OUTCOMES – 1ST TIME DECISIONS NOT
... Forspiro® 500/50 will be available to Australian patients for the treatment of Asthma and COPD. The PBAC did not recommend the listing of ibrutinib on the PBS for the treatment of mantle cell lymphoma on the basis of high and uncertain costeffectiveness at the requested price. The PBAC considered th ...
... Forspiro® 500/50 will be available to Australian patients for the treatment of Asthma and COPD. The PBAC did not recommend the listing of ibrutinib on the PBS for the treatment of mantle cell lymphoma on the basis of high and uncertain costeffectiveness at the requested price. The PBAC considered th ...
digibind - GSK Australia
... Digoxin immune Fab (Ovine) has been used on only a limited scale in man and its safety has therefore not yet been completely defined. Standard therapy for digitalis intoxication includes withdrawal of the drug and correction of factors that may contribute to toxicity, such as electrolyte disturbance ...
... Digoxin immune Fab (Ovine) has been used on only a limited scale in man and its safety has therefore not yet been completely defined. Standard therapy for digitalis intoxication includes withdrawal of the drug and correction of factors that may contribute to toxicity, such as electrolyte disturbance ...
Infection, Genetics and Evolution
... HIV-1 drug resistance resulting from antiretroviral therapy far exceeds that from pre-exposure prophylaxis ...
... HIV-1 drug resistance resulting from antiretroviral therapy far exceeds that from pre-exposure prophylaxis ...
SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF
... Fig. 5: Effect of concentration of coupling reagents on the reaction product of 10 µg. mL-1 MDC in methods A, B, and C Effect of solvent The choice of diluent for the reaction mixture was also studied. Water, methanol, ethanol, acetone, and isopropanol were tested as diluting solvents. Water was the ...
... Fig. 5: Effect of concentration of coupling reagents on the reaction product of 10 µg. mL-1 MDC in methods A, B, and C Effect of solvent The choice of diluent for the reaction mixture was also studied. Water, methanol, ethanol, acetone, and isopropanol were tested as diluting solvents. Water was the ...
Generic Industry
... • Gives the right to stop others from making offering putting on the market or using the product or process using/importing a product obtained by a process which is patented ...
... • Gives the right to stop others from making offering putting on the market or using the product or process using/importing a product obtained by a process which is patented ...
PREPARATION AND UTILITY OF SUB-MICRON LACTOSE, A
... improve both the dosing consistency and the drug respirability from the device(1). In MDIs, the requirements for dosing consistency and respirability are still paramount, however the use of bulking agents in the latter systems has never been exploited to any great extent, presumably due to the formu ...
... improve both the dosing consistency and the drug respirability from the device(1). In MDIs, the requirements for dosing consistency and respirability are still paramount, however the use of bulking agents in the latter systems has never been exploited to any great extent, presumably due to the formu ...
Using METHOCEL Cellulose Ethers for Controlled
... among the most widely used means of providing controlled release in solid oral dosage forms. METHOCEL hydroxypropyl methylcellulose as the controlledrelease agent in hydrophilic matrix systems offers a wide range of properties, consistently high quality, and broad regulatory approval. In addition, M ...
... among the most widely used means of providing controlled release in solid oral dosage forms. METHOCEL hydroxypropyl methylcellulose as the controlledrelease agent in hydrophilic matrix systems offers a wide range of properties, consistently high quality, and broad regulatory approval. In addition, M ...
Pulmonary Drug Absorption
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
BIOAVAILABILITY OF ORAL PROPOFOL IN HUMANS Victor
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A
... More recently, the use of novel, pH titratable cationic lipids with distinct physicochemical properties that regulate particle formation, cellular uptake, fusogenicity, and endosomal release of NA drugs have been described. The chemical and biological properties of pH-titratable cationic lipids are ...
... More recently, the use of novel, pH titratable cationic lipids with distinct physicochemical properties that regulate particle formation, cellular uptake, fusogenicity, and endosomal release of NA drugs have been described. The chemical and biological properties of pH-titratable cationic lipids are ...
Moxy® drug-coated balloon: a novel device for the treatment of
... DCB are based on current evidence but also in the personal experience of the main operators involved in the different clinical studies. In order to minimise the transit time and hence the loss of paclitaxel, systematic predilation is recommended. This also minimises potential disruption of the drug ...
... DCB are based on current evidence but also in the personal experience of the main operators involved in the different clinical studies. In order to minimise the transit time and hence the loss of paclitaxel, systematic predilation is recommended. This also minimises potential disruption of the drug ...
GLYTRIN SPRAY
... trinitrate is quite short (because of its short half-life) additional measures are usually not required. Administer oxygen and artificial ventilation if necessary. In cases of severe overdose apply the general guidelines for treating overdose and/or shock therapy. For pronounced hypotension, volume ...
... trinitrate is quite short (because of its short half-life) additional measures are usually not required. Administer oxygen and artificial ventilation if necessary. In cases of severe overdose apply the general guidelines for treating overdose and/or shock therapy. For pronounced hypotension, volume ...
NOTHAPODYTES NIMMONIANA STEM Research Article
... available. Ayurveda is one of the most ancient systems of life, health and cure. Ayurveda is a highly evolved and codified system of life and health science based on its own unique and original concepts and fundamental principles1. The traditional medicinal methods, especially the use of medicinal p ...
... available. Ayurveda is one of the most ancient systems of life, health and cure. Ayurveda is a highly evolved and codified system of life and health science based on its own unique and original concepts and fundamental principles1. The traditional medicinal methods, especially the use of medicinal p ...
Low doses of esmolol and phenylephrine act as
... control group and received only the conventional anesthetic drugs and 20 ml/kg of lactated Ringer’s over 30 mins. The others were also given an infusion of 50 μg/kg/min of esmolol (beta1-receptor blocker) or 0.01 μg/kg/min of phenylephrine (alpha1-adrenergic agonist) over 3 hours. The distribution a ...
... control group and received only the conventional anesthetic drugs and 20 ml/kg of lactated Ringer’s over 30 mins. The others were also given an infusion of 50 μg/kg/min of esmolol (beta1-receptor blocker) or 0.01 μg/kg/min of phenylephrine (alpha1-adrenergic agonist) over 3 hours. The distribution a ...
THERMOSENSITIVE MICROGELS OF POLY
... medium. The reaction is initiated using the appropriate initiator, usually: ammonium persulfate (APS), potassium persulfate (KPS) and sodium persulfate (NPS). As the initiator is sometimes also used azo-bis-isobutyronitrile (AIBN). Each of the initiator molecules, resulting in activation, may become ...
... medium. The reaction is initiated using the appropriate initiator, usually: ammonium persulfate (APS), potassium persulfate (KPS) and sodium persulfate (NPS). As the initiator is sometimes also used azo-bis-isobutyronitrile (AIBN). Each of the initiator molecules, resulting in activation, may become ...
FOI 204-1314 document 1 - Therapeutic Goods Administration (TGA)
... Mania!Hypomania - During premarketing testing, hypomania or mania occurred in approximately 0.4% of ZOLDFT treated patients. Activation of mania/hypomania has also been reported in a small proportion of patients with major affective disorder treated with other antidepressant and antiobsessional drug ...
... Mania!Hypomania - During premarketing testing, hypomania or mania occurred in approximately 0.4% of ZOLDFT treated patients. Activation of mania/hypomania has also been reported in a small proportion of patients with major affective disorder treated with other antidepressant and antiobsessional drug ...
Vasostrict - Par Sterile Products
... women. It is not known whether vasopressin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Animal reproduction studies have not been conducted with vasopressin [see Clinical Pharmacology (12.3)]. Clinical Considerations: Because of increased clearance ...
... women. It is not known whether vasopressin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Animal reproduction studies have not been conducted with vasopressin [see Clinical Pharmacology (12.3)]. Clinical Considerations: Because of increased clearance ...
Decozol, Oral gel
... envisaged, the anticoagulant effect should be carefully monitored and titrated. (see Interactions) It is advisable to monitor miconazole and phenytoin levels, if they are used concomitantly. In patients using certain oral hypoglycaemic such as sulfonylureas, an enhanced therapeutic effect leading to ...
... envisaged, the anticoagulant effect should be carefully monitored and titrated. (see Interactions) It is advisable to monitor miconazole and phenytoin levels, if they are used concomitantly. In patients using certain oral hypoglycaemic such as sulfonylureas, an enhanced therapeutic effect leading to ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.