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ALS - WordPress.com
ALS - WordPress.com

... • Use engineered nanoparticles to deliver and self-assemble siRNA • Implant neural precursor cells (NPCs) and glial restricted precursors (GRPs) into the CNS of patients with ALS • Modulate microtubule polymer (MT) dynamics by inducing microtubule modulating agents ...
Glandotropy, Ergotropy, and Trophotropy
Glandotropy, Ergotropy, and Trophotropy

Restless legs syndrome (RLS): Diagnosis
Restless legs syndrome (RLS): Diagnosis

... D1 receptors modify the pain conduction only in L-DOPA-primed animals, not in the L-DOPA-naive animals. In the physiological condition, D1 receptors may slightly facilitate the conduction of pain sensation and this effect can be suppressed by an activation of D2 receptors After a withdrawal of LDOPA ...
Mechanisms of Hormone Action: Steroid Receptors
Mechanisms of Hormone Action: Steroid Receptors

... Rapid effects of steroids may involve changes in ion channels and membrane permeability, such as influencing membrane potentials in CNS neurons. In human sperm, a membrane-bound progesterone “receptor” has been described, which may mediate the effects of P on sperm maturation. progesterone ...
Mechanisms of Hormone Action: Peptide Hormones
Mechanisms of Hormone Action: Peptide Hormones

... •Wess (1997) G protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G protein activation. FASEB J 11:346. •Van der Gerr et al (1994) Receptor protein tyrosine kinases and their signal transduction pathways. ...
Mood Disorders and Schizophrenia
Mood Disorders and Schizophrenia

... About 1.3% of people will suffer from schizophrenia at some point in their lives More common in developed countries Equal occurrence for men and women Onset is usually in the 20’s ...
schiz drugs
schiz drugs

... which connect the prefrontal cortex with subcorticol areas, including the striatum, caudate, putmen and hippocampus.  The prefrontal cortical and limbic (hippocampus) link may represent the key vulnerability for development of schizophrenia, which has long been considered to be a disorder of cognit ...
Mood Disorders and Schizophrenia
Mood Disorders and Schizophrenia

... – About 1.3% of people will suffer from schizophrenia at some point in their lives – More common in developed countries – Equal occurrence for men and women – Onset is usually in the 20’s Genetics – Concordance rate is 50% – However, genes are not the only influence – A gene has not been located for ...
Access Slides - Science Signaling
Access Slides - Science Signaling

... Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. ...
1

5-HT2C receptor

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located at the X chromosome. As males have one copy of the gene and in females one of the two copies of the gene is repressed, polymorphisms at this receptor can affect the two sexes to differing extent.
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