Cathinone derivatives: A review of their chemistry, pharmacology
... widespread phenomenon later in the decade.[17] Mephedrone (4methylmethcathinone) became commonplace via these outlets in 2007 and 2008. It seems that mephedrone originally became available in Israel, but its production ceased in 2008 when the Israeli government banned it. This was followed by an unp ...
... widespread phenomenon later in the decade.[17] Mephedrone (4methylmethcathinone) became commonplace via these outlets in 2007 and 2008. It seems that mephedrone originally became available in Israel, but its production ceased in 2008 when the Israeli government banned it. This was followed by an unp ...
Mephedrone
... transporter under any of the treatment conditions used. Furthermore, mephedrone did not cause microglial activation in striatum nor did it increase glial fibrillary acidic protein levels. These results strongly suggest that mephedrone does not cause neurotoxicity to dopamine nerve endings of the str ...
... transporter under any of the treatment conditions used. Furthermore, mephedrone did not cause microglial activation in striatum nor did it increase glial fibrillary acidic protein levels. These results strongly suggest that mephedrone does not cause neurotoxicity to dopamine nerve endings of the str ...
Europol–EMCDDA Joint Report on a new psychoactive substance: 4
... of the imported mephedrone is not known. One Member State, Austria, reported a case involving an ‘Internet online shop’ where legal substances, including mephedrone, were sold sourced from China and the Netherlands for EUR 3 000–7 000 per kilogram. Afterwards, these were sold in powder form to buyer ...
... of the imported mephedrone is not known. One Member State, Austria, reported a case involving an ‘Internet online shop’ where legal substances, including mephedrone, were sold sourced from China and the Netherlands for EUR 3 000–7 000 per kilogram. Afterwards, these were sold in powder form to buyer ...
Multiple-Drug Toxicity Caused by the Coadministration of 4
... vary from 10% to more than 80% based on geographical location (1). Cyanosis, drowsiness, stupor, hypotension, and bradycardia are signs of heroin toxicity. Death from heroin toxicity is caused by respiratory depression and failure (4). Any other central nervous system depressant that is coadminister ...
... vary from 10% to more than 80% based on geographical location (1). Cyanosis, drowsiness, stupor, hypotension, and bradycardia are signs of heroin toxicity. Death from heroin toxicity is caused by respiratory depression and failure (4). Any other central nervous system depressant that is coadminister ...
Mephedrone: use, subjective effects and health risks
... Around 30% of our participants experienced three or more DSM‐IV dependence criteria. The predominant symptoms were increased tolerance (the study did not ask about within session development of tolerance), impaired control, continuing to take mephedrone despite physical and ps ...
... Around 30% of our participants experienced three or more DSM‐IV dependence criteria. The predominant symptoms were increased tolerance (the study did not ask about within session development of tolerance), impaired control, continuing to take mephedrone despite physical and ps ...
Head Shop Compound abuse amongst attendees of The Drug
... is not metabolized as completely as Methylone and is present in the urine in sufficient amounts to detect it. It is not known how long any of these compounds remain detectable in urine after a typical ingestion. Samples were analysed for Head Shop compounds by LC/MS (Liquid Chromatography/Mass Spect ...
... is not metabolized as completely as Methylone and is present in the urine in sufficient amounts to detect it. It is not known how long any of these compounds remain detectable in urine after a typical ingestion. Samples were analysed for Head Shop compounds by LC/MS (Liquid Chromatography/Mass Spect ...
Bath Salts and Spice
... EMCDDA (2009). Action on new drugs briefing paper: Understanding the ‘spice’ phenomenon. A report from an ...
... EMCDDA (2009). Action on new drugs briefing paper: Understanding the ‘spice’ phenomenon. A report from an ...
mephedrone fact sheet
... stimulants similar to amphetamine compounds, but they can also have ecstasy-like effects. Cathinone itself is a naturally occurring stimulant found in the khat plant. Cathinone derivatives are currently being sold online and in headshops (a shop specialising in drug paraphernalia) as ‘legal highs’. ...
... stimulants similar to amphetamine compounds, but they can also have ecstasy-like effects. Cathinone itself is a naturally occurring stimulant found in the khat plant. Cathinone derivatives are currently being sold online and in headshops (a shop specialising in drug paraphernalia) as ‘legal highs’. ...
Mephedrone
Mephedrone, also known as 4-methylmethcathinone (4-MMC) or 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone, M-CAT, White Magic and meow meow. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort or inject, producing similar effects to MDMA, amphetamines and cocaine.In addition to its stimulant effects, mephedrone produces side effects, of which teeth grinding is the most common. The metabolism of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage. Despite similarities to known neurotoxins such as methamphetamine and cathinone derivatives, mephedrone does not appear to produce neurotoxic effects in the dopamine system of mice.Mephedrone was first synthesised in 1929, but did not become widely known until it was rediscovered in 2003. By 2007, mephedrone was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010, it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. Mephedrone was first made illegal in Israel in 2008, followed by Sweden later that year. In 2010, it was made illegal in many European countries and in December 2010, the EU ruled it illegal. In Australia, New Zealand and the USA, it is considered an analog of other illegal drugs and can be controlled by laws similar to the Federal Analog Act. In September 2011, the USA temporarily classified mephedrone as illegal, in effect from October 2011.