Not just the powerhouse of the cell: emerging
... termed the mitochondrial ‘proteome’) may provide valuable information in a variety of cardiac diseases. In this regard, Gucek and Murphy2 review the changes in the mitochondrial proteome which occur in a cardioprotective phenotype as a strategy for identifying novel mediators of cardioprotection. Th ...
... termed the mitochondrial ‘proteome’) may provide valuable information in a variety of cardiac diseases. In this regard, Gucek and Murphy2 review the changes in the mitochondrial proteome which occur in a cardioprotective phenotype as a strategy for identifying novel mediators of cardioprotection. Th ...
QT interval dispersion in obstructive sleep apnoea syndrome patients without hypertension
... current study, it was found that the number of evaluable leads was, on average, 10. Recovery time dispersion has been studied using both invasive and time-consuming methods, such as monophasic action potentials [24] or body surface mapping [25], respectively. QTcd is preferable to QTd when simultane ...
... current study, it was found that the number of evaluable leads was, on average, 10. Recovery time dispersion has been studied using both invasive and time-consuming methods, such as monophasic action potentials [24] or body surface mapping [25], respectively. QTcd is preferable to QTd when simultane ...
Use of Inotropic Agents in Treatment of Systolic Heart Failure
... the sensitivity of cardiomyocyte to intracellular calcium. Levosimendan increases the sensitivity of cardiomyocyte to intracellular calcium by binding to troponin C. Achieving an inotropic effect without increasing intracellular calcium levels can prevent an increased risk of cardiac arrhythmia with ...
... the sensitivity of cardiomyocyte to intracellular calcium. Levosimendan increases the sensitivity of cardiomyocyte to intracellular calcium by binding to troponin C. Achieving an inotropic effect without increasing intracellular calcium levels can prevent an increased risk of cardiac arrhythmia with ...
Influence of Body Height on Pulsatile Arterial Hemodynamic
... 0.23, p , 0.001). Scatterplots for the relation between body height and Dtp and body height and heart period are shown in Figure 2. Although these correlations are highly significant, linear regression analysis alone fails to consider the interrelation among the variables. Therefore, stepwise multip ...
... 0.23, p , 0.001). Scatterplots for the relation between body height and Dtp and body height and heart period are shown in Figure 2. Although these correlations are highly significant, linear regression analysis alone fails to consider the interrelation among the variables. Therefore, stepwise multip ...
Cardiomyopathy - The Heart Foundation
... Although rare, sometimes cardiomyopathy can cause sudden (over a few days), severe and life-threatening heart failure. If this happens, you will be put in hospital in intensive care and given treatment that may include using a heart and lung machine. A very small number of people will need a heart t ...
... Although rare, sometimes cardiomyopathy can cause sudden (over a few days), severe and life-threatening heart failure. If this happens, you will be put in hospital in intensive care and given treatment that may include using a heart and lung machine. A very small number of people will need a heart t ...
changes in left atrial size and cardiac rhythm in patients after mitral
... achieved by an additional curative procedure, such as direct surgery for atrial fibrillation, in patients who undergo opening of the left atrium during valvular surgery. Three different approaches are described in the literature: 1) isolation of the fibrillating atrium; 2) fragmentation, i.e., inter ...
... achieved by an additional curative procedure, such as direct surgery for atrial fibrillation, in patients who undergo opening of the left atrium during valvular surgery. Three different approaches are described in the literature: 1) isolation of the fibrillating atrium; 2) fragmentation, i.e., inter ...
Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010
... may be selected initially, the treatment strategy may change over time if the selected treatment strategy has been unsuccessful, as the arrhythmia progresses, or as the patient’s condition changes (Fig. 1).10 Thus, treatment strategies and their effectiveness, safety, and acceptability must be const ...
... may be selected initially, the treatment strategy may change over time if the selected treatment strategy has been unsuccessful, as the arrhythmia progresses, or as the patient’s condition changes (Fig. 1).10 Thus, treatment strategies and their effectiveness, safety, and acceptability must be const ...
Document
... inhibitors, drugs that decrease blood lipids, diuretics, antihypertensives, and platelet inhibitors. Potential adverse interactions of these drugs with anesthetics is an important preoperative consideration . All patients with known coronary artery disease, known peripheral vascular disease, or with ...
... inhibitors, drugs that decrease blood lipids, diuretics, antihypertensives, and platelet inhibitors. Potential adverse interactions of these drugs with anesthetics is an important preoperative consideration . All patients with known coronary artery disease, known peripheral vascular disease, or with ...
Echocardiography and Heart Failure: A Glimpse of the Right Heart
... A brief review of other imaging modalities will aid to understand the advantages (and disadvantages) of echocardiography in the evaluation of the right heart. Chest x-ray is often used as an initial step for patients with suspected right heart disease as it is widely available and relatively inexpen ...
... A brief review of other imaging modalities will aid to understand the advantages (and disadvantages) of echocardiography in the evaluation of the right heart. Chest x-ray is often used as an initial step for patients with suspected right heart disease as it is widely available and relatively inexpen ...
The Heart of the Matter: Cardiac Imaging of Sarcoidosis
... fibrogranulomatous infiltration/scar will demonstrate LGE • Typically subEPIcardial or mid‐ myocardial, may be subendocardial or transmural • RV septal fibrosis characteristic AV block due to Purkinje fiber involvement LGE is associated with 9x greater adverse cardiac event rate, and 11.5x hig ...
... fibrogranulomatous infiltration/scar will demonstrate LGE • Typically subEPIcardial or mid‐ myocardial, may be subendocardial or transmural • RV septal fibrosis characteristic AV block due to Purkinje fiber involvement LGE is associated with 9x greater adverse cardiac event rate, and 11.5x hig ...
Management of Atrial Fibrillation
... The AF may also be asymptomatic and as much as 25% of patients may have no symptoms.7 Such asymptomatic episodes, however, can still result in adverse atrial remodeling and increase the risk for thromboembolic stroke. There is increasing awareness that AF is not entirely a benign arrhythmia and is a ...
... The AF may also be asymptomatic and as much as 25% of patients may have no symptoms.7 Such asymptomatic episodes, however, can still result in adverse atrial remodeling and increase the risk for thromboembolic stroke. There is increasing awareness that AF is not entirely a benign arrhythmia and is a ...
Atrial Fibrillation in Acute Myocardial Infarction
... lipoprotein <1.04 mmol/l. High triglyceride level was defined as greater than 2.3 mmol/L. Anterior infarction was defined by the presence of ECG changes in leads I, aVL, V1-V6 on the standard 12 lead ECG. Inferior infarction was defined by changes in lead II, III, AVF, true posterior infarction defi ...
... lipoprotein <1.04 mmol/l. High triglyceride level was defined as greater than 2.3 mmol/L. Anterior infarction was defined by the presence of ECG changes in leads I, aVL, V1-V6 on the standard 12 lead ECG. Inferior infarction was defined by changes in lead II, III, AVF, true posterior infarction defi ...
LWW PPT Slide Template Master
... • Valves: open and close to maintain blood flow through the heart – Tricuspid valve – between right atrium and right ventricle – Mitral valve – between left atrium and left ventricle – Pulmonary valve – between the right ventricle and pulmonary artery ...
... • Valves: open and close to maintain blood flow through the heart – Tricuspid valve – between right atrium and right ventricle – Mitral valve – between left atrium and left ventricle – Pulmonary valve – between the right ventricle and pulmonary artery ...
Cardiology 2015 CME conference brochure
... Challenges and Dilemmas in Caring for the Patient with Single Ventricle Moderators: David Goldberg, M.D.; Kurt R. Schumacher, M.D., M.S. 4 p.m. Hybrid, Classic Norwood or Norwood RV to PA Conduit for the Neonate with HLHS: How Shall We Decide? Richard Ohye, M.D. 4:20 p.m. Interstage Mortal ...
... Challenges and Dilemmas in Caring for the Patient with Single Ventricle Moderators: David Goldberg, M.D.; Kurt R. Schumacher, M.D., M.S. 4 p.m. Hybrid, Classic Norwood or Norwood RV to PA Conduit for the Neonate with HLHS: How Shall We Decide? Richard Ohye, M.D. 4:20 p.m. Interstage Mortal ...
Differential Cardiovascular Regulatory Activities of the α1B
... these regulatory events have a correlation in mammalian tissues that natively express these receptors. High-density expression of non-native receptors into cells could promote promiscuous coupling to pathways that may not normally be involved in in vivo receptor function. Progress on the integrated ...
... these regulatory events have a correlation in mammalian tissues that natively express these receptors. High-density expression of non-native receptors into cells could promote promiscuous coupling to pathways that may not normally be involved in in vivo receptor function. Progress on the integrated ...
The effect of aerobic continuous training and detraining on left
... Regular exercise training induces cardiac physiological hypertrophy. The aim of this study was to determine the effect of aerobic continuous training and a detraining period on left ventricular structure and function in non-athlete healthy men. Ten untrained healthy male students (aged 18-22 years) ...
... Regular exercise training induces cardiac physiological hypertrophy. The aim of this study was to determine the effect of aerobic continuous training and a detraining period on left ventricular structure and function in non-athlete healthy men. Ten untrained healthy male students (aged 18-22 years) ...
Heart Murmurs in Pediatric Patients: When Do You Refer?
... abnormalities, and patent ductus arteriosus. An atrial septal defect is often confused with a functional murmur, but the conditions can usually be differentiated based on specific physical findings. Characteristics of pathologic murmurs include a sound level of grade 3 or louder, a diastoMc murmur o ...
... abnormalities, and patent ductus arteriosus. An atrial septal defect is often confused with a functional murmur, but the conditions can usually be differentiated based on specific physical findings. Characteristics of pathologic murmurs include a sound level of grade 3 or louder, a diastoMc murmur o ...
Structure and Function of the Developing Zebrafish Heart
... studies (Stainier et al., 1996; Weinstein and Fishman, 1996; Warren and Fishman, 1998). The cardiovascular system appears when needs for oxygen and nutrition cannot be met by diffusion alone, because of the volume or increased metabolic rate of an organism (Burggren and Pinder, 1991; Pelster and Bur ...
... studies (Stainier et al., 1996; Weinstein and Fishman, 1996; Warren and Fishman, 1998). The cardiovascular system appears when needs for oxygen and nutrition cannot be met by diffusion alone, because of the volume or increased metabolic rate of an organism (Burggren and Pinder, 1991; Pelster and Bur ...
Catheter Ablation of Ventricular Tachycardia without Structural Heart
... 1. All peaks of bipolar deflections exceeding ±0.05mV are identified and tagged white (0.05-0.15 mV) or purple (>0.15mV) 2. Intervals between 2 successive peaks of 0.05 to 0.15mV are determined 3. Number of intervals between 70 and 120ms during 2,5 sec recording period determined (referred as interv ...
... 1. All peaks of bipolar deflections exceeding ±0.05mV are identified and tagged white (0.05-0.15 mV) or purple (>0.15mV) 2. Intervals between 2 successive peaks of 0.05 to 0.15mV are determined 3. Number of intervals between 70 and 120ms during 2,5 sec recording period determined (referred as interv ...
Are Diabetic Patients at Increased Risk of Arrhythmias?
... sclerosis (macrovascular disease). Diabetes is also associated with microvascular disease and autonomic neuropathy, and these non-coronary atherosclerotic pathophysiological processes have the potential to increase the risk of sudden cardiac death. 29 The arrhythmological substrate in ischaemic hear ...
... sclerosis (macrovascular disease). Diabetes is also associated with microvascular disease and autonomic neuropathy, and these non-coronary atherosclerotic pathophysiological processes have the potential to increase the risk of sudden cardiac death. 29 The arrhythmological substrate in ischaemic hear ...
File
... – SA node joins the bundle of His – If the SA node fails or slows below the normal rate, AV junctional tissues initiate electrical activity and thus the role of secondary pacemaker Accessory pathway: an irregular muscle connection between atria and ventricles that bypasses the AV node ...
... – SA node joins the bundle of His – If the SA node fails or slows below the normal rate, AV junctional tissues initiate electrical activity and thus the role of secondary pacemaker Accessory pathway: an irregular muscle connection between atria and ventricles that bypasses the AV node ...
- Wiley Online Library
... and full repair in childhood. Those who enjoy film are referred to ‘Something the Lord Made’(2). The BT shunt was subsequently modified (mBTS) from an end-to-side direct vascular anastomosis to the current side-to-side tube graft maintaining subclavian artery continuity. It is most commonly performe ...
... and full repair in childhood. Those who enjoy film are referred to ‘Something the Lord Made’(2). The BT shunt was subsequently modified (mBTS) from an end-to-side direct vascular anastomosis to the current side-to-side tube graft maintaining subclavian artery continuity. It is most commonly performe ...
Percutaneous Ventricular Assist Device and Extracorporeal Membrane
... edges are very friable and the VSD enlarges during the first 10 days after acute myocardial infarction, the timing for the VSD closure can pose a major problem, and waiting for tissue maturation may not be possible. During the last decade there have been noticeable attempts to use left ventricular a ...
... edges are very friable and the VSD enlarges during the first 10 days after acute myocardial infarction, the timing for the VSD closure can pose a major problem, and waiting for tissue maturation may not be possible. During the last decade there have been noticeable attempts to use left ventricular a ...
Heart failure with preserved ejection fraction (HFPEF).
... and given the neutral result of many large trials on HFPEF, further studies are still necessary11,12. True cardiac hypertrophy has little in common with limited myocardial infarction, and in both conditions, the underlying mechanisms that drive LV remodeling are likely to be different and, actually, ...
... and given the neutral result of many large trials on HFPEF, further studies are still necessary11,12. True cardiac hypertrophy has little in common with limited myocardial infarction, and in both conditions, the underlying mechanisms that drive LV remodeling are likely to be different and, actually, ...
Beyond ejection fraction: an integrative approach for assessment of
... death (SCD), is currently the primary metric by which decisions regarding ICD placement are made. An LVEF ≤35% is the currently recommended treatment cut-off for ICD implantation for the primary prevention of SCD,1 primarily based on studies that utilized LVEF as the only common entry criterion and ...
... death (SCD), is currently the primary metric by which decisions regarding ICD placement are made. An LVEF ≤35% is the currently recommended treatment cut-off for ICD implantation for the primary prevention of SCD,1 primarily based on studies that utilized LVEF as the only common entry criterion and ...
Electrocardiography
Electrocardiography (ECG or EKG*) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on a patient's body. These electrodes detect the tiny electrical changes on the skin that arise from the heart muscle depolarizing during each heartbeat.In a conventional 12 lead ECG, ten electrodes are placed on the patient's limbs and on the surface of the chest. The overall magnitude of the heart's electrical potential is then measured from twelve different angles (""leads"") and is recorded over a period of time (usually 10 seconds). In this way, the overall magnitude and direction of the heart's electrical depolarization is captured at each moment throughout the cardiac cycle. The graph of voltage versus time produced by this noninvasive medical procedure is referred to as an electrocardiogram (abbreviated ECG or EKG).During each heartbeat, a healthy heart will have an orderly progression of depolarization that starts with pacemaker cells in the sinoatrial node, spreads out through the atrium, passes through the atrioventricular node down into the bundle of His and into the Purkinje fibers spreading down and to the left throughout the ventricles. This orderly pattern of depolarization gives rise to the characteristic ECG tracing. To the trained clinician, an ECG conveys a large amount of information about the structure of the heart and the function of its electrical conduction system. Among other things, an ECG can be used to measure the rate and rhythm of heartbeats, the size and position of the heart chambers, the presence of any damage to the heart's muscle cells or conduction system, the effects of cardiac drugs, and the function of implanted pacemakers.