Reviews - Circulation Research
... al54 found that protein phosphatase inhibitors, such as calyculin A, caused substantial inhibition of intracellular Na⫹– dependent Ca2⫹ influx into CHO cells expressing bovine cardiac NCX1. Because use of the PKC inhibitor and deletion of the central hydrophilic loop of NCX1 did not block such inhib ...
... al54 found that protein phosphatase inhibitors, such as calyculin A, caused substantial inhibition of intracellular Na⫹– dependent Ca2⫹ influx into CHO cells expressing bovine cardiac NCX1. Because use of the PKC inhibitor and deletion of the central hydrophilic loop of NCX1 did not block such inhib ...
Endocardial mapping of atrial fibrillation in the human right atrium
... limited efficacy and chronic antiarrhythmic therapy can be associated with increased mortality[8]. Catheter ablation strategies to restore and maintain sinus rhythm after atrial fibrillation have been developed following the success of surgical ablation procedures[9], but their Revision submitted 5 Ju ...
... limited efficacy and chronic antiarrhythmic therapy can be associated with increased mortality[8]. Catheter ablation strategies to restore and maintain sinus rhythm after atrial fibrillation have been developed following the success of surgical ablation procedures[9], but their Revision submitted 5 Ju ...
The DDDR closed loop stimulation for the prevention of the
... the pacemaker system not only initiates the rate modulating function automatically, but also compensates permanently for long-term drifts of the input signal. Several studies have shown that vasovagal syncope may be incompletely prevented by standard pacemaker therapy[5,6]. More sophisticated pacema ...
... the pacemaker system not only initiates the rate modulating function automatically, but also compensates permanently for long-term drifts of the input signal. Several studies have shown that vasovagal syncope may be incompletely prevented by standard pacemaker therapy[5,6]. More sophisticated pacema ...
Potent and Reversible Effects of ATI
... University of Oulu, Oulu, Finland (M.J.P.R.); and ARYx Therapeutics, Los Altos Hills, California (P.D., P.M.) Accepted for publication July 5, 2000 ...
... University of Oulu, Oulu, Finland (M.J.P.R.); and ARYx Therapeutics, Los Altos Hills, California (P.D., P.M.) Accepted for publication July 5, 2000 ...
Frequently Asked Questions About AEDs
... the heart. Built-in computers assess the patient's heart rhythm, judge whether defibrillation is needed, and then administer the shock. Audible and/or visual prompts guide the user through the process. 3. How does an AED work? A microprocessor inside the defibrillator interprets (analyzes) the victi ...
... the heart. Built-in computers assess the patient's heart rhythm, judge whether defibrillation is needed, and then administer the shock. Audible and/or visual prompts guide the user through the process. 3. How does an AED work? A microprocessor inside the defibrillator interprets (analyzes) the victi ...
Between Right and Left Coronary Artery in Man
... are caused by left anterior descending artery disease, whereas only the posterior segments of the inferobasal wall will show segmental abnormalities in case of right coronary artery disease in a right dominant coronary artery system."4 Two of the three anterior wall hemiaxes and the two posterior he ...
... are caused by left anterior descending artery disease, whereas only the posterior segments of the inferobasal wall will show segmental abnormalities in case of right coronary artery disease in a right dominant coronary artery system."4 Two of the three anterior wall hemiaxes and the two posterior he ...
thesis
... Early and successful myocardial reperfusion with the use of thrombolytic therapy or primary percutaneous coronary intervention (PCI) is still the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. Paradoxically, however, the return of blood flow ...
... Early and successful myocardial reperfusion with the use of thrombolytic therapy or primary percutaneous coronary intervention (PCI) is still the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. Paradoxically, however, the return of blood flow ...
Print - Circulation Research
... weight of heart. The total amount of histamine, adenosine, or inosine released during anaphylaxis was estimated by summation of the average content of the substance in the effluent within each collection interval. In the case of adenosine and inosine, basal release determined from preantigen levels ...
... weight of heart. The total amount of histamine, adenosine, or inosine released during anaphylaxis was estimated by summation of the average content of the substance in the effluent within each collection interval. In the case of adenosine and inosine, basal release determined from preantigen levels ...
Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte
... Key Words: myocardium 䡲 heart failure 䡲 diastole 䡲 titin ...
... Key Words: myocardium 䡲 heart failure 䡲 diastole 䡲 titin ...
Heart rate variability - European Society of Cardiology
... system and cardiovascular mortality, including sudden cardiac death[1–4]. Experimental evidence for an association between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activ ...
... system and cardiovascular mortality, including sudden cardiac death[1–4]. Experimental evidence for an association between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activ ...
Functional mitral regurgitation in patients with heart failure and
... Proximal isovelocity surface area Proximal isovelocity surface area (PISA) is the recommended quantitative approach as it can be used reliably in both central and eccentric jets. Quantitation of FMR is important in patients with moderate to severe mitral regurgitation (especially asymptomatic) for d ...
... Proximal isovelocity surface area Proximal isovelocity surface area (PISA) is the recommended quantitative approach as it can be used reliably in both central and eccentric jets. Quantitation of FMR is important in patients with moderate to severe mitral regurgitation (especially asymptomatic) for d ...
The role of altered fatty acid metabolism in cardiomyopathy and
... The heart in diabetes and obesity differs from the healthy heart. The diabetic heart has an increased and almost exclusive (90-100%) dependence on FAO to provide energy for its function (23). Furthermore, the diabetic heart is also thought to be metabolically inflexible to switch from FA to glucose ...
... The heart in diabetes and obesity differs from the healthy heart. The diabetic heart has an increased and almost exclusive (90-100%) dependence on FAO to provide energy for its function (23). Furthermore, the diabetic heart is also thought to be metabolically inflexible to switch from FA to glucose ...
Syncope: Overview and approach to management
... syncope is benign and self-limited but it can mimic a cardiac arrest and even be its precursor. Several causes for syncope, generally cardiac, are potentially fatal. When syncope is caused by hemodynamic collapse from critical aortic stenosis, ventricular tachycardia, AV block, dissecting aortic ane ...
... syncope is benign and self-limited but it can mimic a cardiac arrest and even be its precursor. Several causes for syncope, generally cardiac, are potentially fatal. When syncope is caused by hemodynamic collapse from critical aortic stenosis, ventricular tachycardia, AV block, dissecting aortic ane ...
A Study of Coronary Artery Predominance and Its Clinical Importance
... cases, in contrast to this in our present study it was a branch of dominant artery in 59.74% (46 hearts), in 37.66% (29 hearts) it arose from non dominant artery[figure: 2]. And in remaining 2.6% (2 hearts) SA nodal artery arose from both right coronary and left circumflex arteries[table no: 2]. Fro ...
... cases, in contrast to this in our present study it was a branch of dominant artery in 59.74% (46 hearts), in 37.66% (29 hearts) it arose from non dominant artery[figure: 2]. And in remaining 2.6% (2 hearts) SA nodal artery arose from both right coronary and left circumflex arteries[table no: 2]. Fro ...
A fordított frekvenciafüggés, mint a szív intrinzik tulajdonsága
... Based on our present knowledge, the action potential of myocardium is formed by several ionic currents. Congenital or acquired defects of these ionic currents cause electrical signal formation and/or conduction disturbances and arrhythmias, which deteriorate the pump function of the heart and finall ...
... Based on our present knowledge, the action potential of myocardium is formed by several ionic currents. Congenital or acquired defects of these ionic currents cause electrical signal formation and/or conduction disturbances and arrhythmias, which deteriorate the pump function of the heart and finall ...
New Insights into Mechanisms of Atrial Fibrillation
... There is more evidence showing that the pulmonary veins are capable of automaticity. Specialized cardiac cells associated with pacemaking, resembling pale (P) and Purkinje cells, have been observed in the pulmonary veins in rats, dogs and humans (Wit and Boyden 2007). These cells might be residua of ...
... There is more evidence showing that the pulmonary veins are capable of automaticity. Specialized cardiac cells associated with pacemaking, resembling pale (P) and Purkinje cells, have been observed in the pulmonary veins in rats, dogs and humans (Wit and Boyden 2007). These cells might be residua of ...
CURRICULUM VITAE John Alex Elefteriades, M.D. Date of Revision
... interventions for the failing left ventricle, including coronary artery bypass grafting, left ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale-New Haven Hospital, one of the nation's largest facilities for treatment of the dilated t ...
... interventions for the failing left ventricle, including coronary artery bypass grafting, left ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale-New Haven Hospital, one of the nation's largest facilities for treatment of the dilated t ...
Professor Denis Noble CBE FRS FMedSci FRCP (Hon)
... 1990. Butland Visiting Professor at the University of Auckland, New Zealand. 1990. Annual Review Lecture, Korean Physiological Society (delivered partly in Korean). 1991. Invited lecturer at the 150th anniversary celebrations of the Académie Royale de Médecine de Belgique, Brussels. (delivered in Fr ...
... 1990. Butland Visiting Professor at the University of Auckland, New Zealand. 1990. Annual Review Lecture, Korean Physiological Society (delivered partly in Korean). 1991. Invited lecturer at the 150th anniversary celebrations of the Académie Royale de Médecine de Belgique, Brussels. (delivered in Fr ...
ANTIARRHYTHMIC THERAPY FOR ATRIAL
... above the His bundle or involving components of the atrium or atrioventricular node falls under the supraventricular arrhythmia (SVA). Of these disturbances, atrial fibrillation is the most common sustained arrhythmia, with an incidence of between 0.15 and 1% in the general population, and a prepond ...
... above the His bundle or involving components of the atrium or atrioventricular node falls under the supraventricular arrhythmia (SVA). Of these disturbances, atrial fibrillation is the most common sustained arrhythmia, with an incidence of between 0.15 and 1% in the general population, and a prepond ...
In vitro functional study of Cardiomyocyte
... http://diseasebiophysics.seas.harvard.edu/research/mechanotransduction/ ...
... http://diseasebiophysics.seas.harvard.edu/research/mechanotransduction/ ...
Electrophysiology Products
... Catheter ablation procedures present the potential for significant x-ray exposure, which can result in acute radiation injury as well as increased risk for somatic and genetic effects, to both patients and laboratory staff due to the x-ray beam intensity and duration of the fluoroscopic imaging. Cat ...
... Catheter ablation procedures present the potential for significant x-ray exposure, which can result in acute radiation injury as well as increased risk for somatic and genetic effects, to both patients and laboratory staff due to the x-ray beam intensity and duration of the fluoroscopic imaging. Cat ...
Overexpression of microRNA-1 impairs cardiac
... rapidly evolving for the critical roles of microRNAs (miRNAs) in regulating cardiac development and function.1 – 3 MicroRNA-1 (miR-1) stands out as a most prominent one, not only because it is a musclespecific, cardiac-enriched miRNA, but also because it has diverse functions in the heart. The pione ...
... rapidly evolving for the critical roles of microRNAs (miRNAs) in regulating cardiac development and function.1 – 3 MicroRNA-1 (miR-1) stands out as a most prominent one, not only because it is a musclespecific, cardiac-enriched miRNA, but also because it has diverse functions in the heart. The pione ...
Employing vasopressin during cardiopulmonary resuscitation and
... epinephrine; during in-hospital CPR, comparable short-term survival was found in groups treated with either vasopressin or epinephrine. Currently, a large trial of out-of-hospital cardiac arrest patients being treated with vasopressin vs. epinephrine is ongoing in Germany, Austria and Switzerland. T ...
... epinephrine; during in-hospital CPR, comparable short-term survival was found in groups treated with either vasopressin or epinephrine. Currently, a large trial of out-of-hospital cardiac arrest patients being treated with vasopressin vs. epinephrine is ongoing in Germany, Austria and Switzerland. T ...
Intracardiac Echogenic Foci
... does not appear to be an association. The majority of these studies do not have proper control groups for comparison and also suffer from ascertainment bias (high risk patients referred to specialized centers constitute the study group; in such a group there will be a higher incidence of identificat ...
... does not appear to be an association. The majority of these studies do not have proper control groups for comparison and also suffer from ascertainment bias (high risk patients referred to specialized centers constitute the study group; in such a group there will be a higher incidence of identificat ...
PDF - Circulation
... first shock. Of note, the shape of the curve between percent success and the defibrillation threshold ratio depended on the particular electrodes used. This suggests that in addition to surface area of electrodes, the efficiency of a particular electrode system may also be important in determining t ...
... first shock. Of note, the shape of the curve between percent success and the defibrillation threshold ratio depended on the particular electrodes used. This suggests that in addition to surface area of electrodes, the efficiency of a particular electrode system may also be important in determining t ...
Arrhythmogenic right ventricular dysplasia
Arrhythmogenic right ventricular dysplasia (ARVD), also called arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is an inherited heart disease.ARVD is caused by genetic defects of the parts of heart muscle (also called myocardium or cardiac muscle) known as desmosomes, areas on the surface of heart muscle cells which link the cells together. The desmosomes are composed of several proteins, and many of those proteins can have harmful mutations.The disease is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.ARVD can be found in association with diffuse palmoplantar keratoderma, and woolly hair, in a autosomal recessive condition called Naxos disease, because this genetic abnormality can affect also the integrity of the superficial layers of the skin most exposed to pressure stress.ARVC/D is an important cause of ventricular arrhythmias in children and young adults. It is seen predominantly in males, and 30-50% of cases have a familial distribution.