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Page 1 of 200 - Gamma Delta Conference 2016
... ability to target HMGR or FPPS in the Mev pathway. We have previously shown that ZA-treated dendritic cells (DC) produce and release high amounts of soluble IPP and are strong Vγ9Vδ2 T-cell activators. However, the mechanisms regulating IPP release in DC and other cells are still unknown. Here we de ...
... ability to target HMGR or FPPS in the Mev pathway. We have previously shown that ZA-treated dendritic cells (DC) produce and release high amounts of soluble IPP and are strong Vγ9Vδ2 T-cell activators. However, the mechanisms regulating IPP release in DC and other cells are still unknown. Here we de ...
Th1/Th2 Balance - Alternative Medicine Review
... Background to the Hypothesis Of all the body’s organ systems, the immune system may be the most challenging to coordinate. The system is a disparate, far-flung collection of individual immune cells, immune cell aggregates, immune tissues, and immune organs.7 This mode of structural organization rend ...
... Background to the Hypothesis Of all the body’s organ systems, the immune system may be the most challenging to coordinate. The system is a disparate, far-flung collection of individual immune cells, immune cell aggregates, immune tissues, and immune organs.7 This mode of structural organization rend ...
UNIVERSIDAD DE MURCIA FACULTAD DE VETERINARIA In vivo
... The general aim of this thesis will be the evaluation of the swine immune response against PRRSV infection in the swine target cells and organs, paying special atention to the PRRSV ability to modulate the IIR and in consequence the AIR. First. Considering the central importance of MØ for PRRS patho ...
... The general aim of this thesis will be the evaluation of the swine immune response against PRRSV infection in the swine target cells and organs, paying special atention to the PRRSV ability to modulate the IIR and in consequence the AIR. First. Considering the central importance of MØ for PRRS patho ...
Texas Tech University Health Science Center School of Medicine
... A. A method of detecting antibody which solely relies on its reaction with particulate antigen and involves no other indicating system B. A method of detecting antibody which relies solely on its reaction with soluble antigen and invovles no other indicating system C. A method of detecting combinati ...
... A. A method of detecting antibody which solely relies on its reaction with particulate antigen and involves no other indicating system B. A method of detecting antibody which relies solely on its reaction with soluble antigen and invovles no other indicating system C. A method of detecting combinati ...
The role of different monocyte subsets and macrophages in asthma
... monocytes were shown to infiltrate lung tissues and give rise to monocyte-derived pulmonary dendritic cells and macrophages [27]. Notably, capability of monocytes to transmigrate through endothelium remains predominantly a feature of CD16-positive monocytes and seems to be related to increased expre ...
... monocytes were shown to infiltrate lung tissues and give rise to monocyte-derived pulmonary dendritic cells and macrophages [27]. Notably, capability of monocytes to transmigrate through endothelium remains predominantly a feature of CD16-positive monocytes and seems to be related to increased expre ...
Crosstalk between cancer and immune cells: role of
... cancers. Furthermore, many tumour-produced factors, such as IL-10, IL-6 and VEGF, which are crucial for both tumour growth and immunosuppression, activate STAT3 to create an efficient ‘feedforward’ mechanism to ensure increased STAT3 activity both in tumour cells and in tumour-associated immune cell ...
... cancers. Furthermore, many tumour-produced factors, such as IL-10, IL-6 and VEGF, which are crucial for both tumour growth and immunosuppression, activate STAT3 to create an efficient ‘feedforward’ mechanism to ensure increased STAT3 activity both in tumour cells and in tumour-associated immune cell ...
Establishment of immunohistochemical double staining
... different classes such as IgM, IgG, IgA, IgD and IgE. When the B-‐cells are activated they proliferate and produce antibodies (immunoglobulins) that will bind the antigen targets and neutralize them or le ...
... different classes such as IgM, IgG, IgA, IgD and IgE. When the B-‐cells are activated they proliferate and produce antibodies (immunoglobulins) that will bind the antigen targets and neutralize them or le ...
The use of antibodies in the treatment of infectious diseases
... in the treatment and prophylaxis of infectious diseases, because these molecules play a critical role in directing the effector mechanisms of the immune system against the pathogens they recognise. However, the widespread application of this therapy has been hampered by allergic reactions, productio ...
... in the treatment and prophylaxis of infectious diseases, because these molecules play a critical role in directing the effector mechanisms of the immune system against the pathogens they recognise. However, the widespread application of this therapy has been hampered by allergic reactions, productio ...
Genetic analysis of innate immunity in resistance to
... characterization of the effects of various cellular and gene deficiencies on susceptibility. As a result, mouse models have been used with great success to elucidate the involvement of various cell populations in the defense against systemic infection. Effector cells In an attempt to characterize th ...
... characterization of the effects of various cellular and gene deficiencies on susceptibility. As a result, mouse models have been used with great success to elucidate the involvement of various cell populations in the defense against systemic infection. Effector cells In an attempt to characterize th ...
Treg and CTLA-4: Two intertwining pathways to
... Despite the selection processes applied to T cells during their development in the thymus, T cells with the capacity to recognize self-proteins nevertheless arise and populate the periphery. These T cells have the potential to cause autoimmune diseases, but generally do not because powerful peripher ...
... Despite the selection processes applied to T cells during their development in the thymus, T cells with the capacity to recognize self-proteins nevertheless arise and populate the periphery. These T cells have the potential to cause autoimmune diseases, but generally do not because powerful peripher ...
Strategies of the protozoan parasite Entamoeba histolytica to evade
... could take place in E. histolytica as it also consumes arginine during its growth in TYI-S-33 media (Zuo and Coombs 1995). Arginase, a key enzyme in the catabolism of arginine, catalizes the conversion of L-arginine to Lornithine and urea. This activity was detected in a crude lysate of E. histolyti ...
... could take place in E. histolytica as it also consumes arginine during its growth in TYI-S-33 media (Zuo and Coombs 1995). Arginase, a key enzyme in the catabolism of arginine, catalizes the conversion of L-arginine to Lornithine and urea. This activity was detected in a crude lysate of E. histolyti ...
Distinct and Separable Roles of the Complement System in Factor H
... platelet and not other blood cells, such as the erythrocyte, despite their continuous exposure to plasma proteins (5). By analogy to erythrocyte CR1, we considered it possible that platelets are endowed with Cfh upon exit from the bone marrow. To investigate this, we cultured megakaryocytes from nor ...
... platelet and not other blood cells, such as the erythrocyte, despite their continuous exposure to plasma proteins (5). By analogy to erythrocyte CR1, we considered it possible that platelets are endowed with Cfh upon exit from the bone marrow. To investigate this, we cultured megakaryocytes from nor ...
Pathogenesis of the Helicobacter Induced Mucosal Disease: A
... Epidemiological studies have shown that 80% of gastric cancer patients are H. pylori positive. The outcome of the infection with this bacterium depends on bacterial factors, diet, genetic background of the host, and coinfection with other microorganisms. The most important cofactor in H. pylori indu ...
... Epidemiological studies have shown that 80% of gastric cancer patients are H. pylori positive. The outcome of the infection with this bacterium depends on bacterial factors, diet, genetic background of the host, and coinfection with other microorganisms. The most important cofactor in H. pylori indu ...
Antiphospholipid Antibodies: Their Origin and Development
... And finally, there have been reports of patients with monoclonal gammopathy with a monoclonal aPL. Interestingly, no such patient has been described with the clinical picture of APS. Until now there has been no scientifically proven explanation why some patients develop pathogenic aPL and subsequent ...
... And finally, there have been reports of patients with monoclonal gammopathy with a monoclonal aPL. Interestingly, no such patient has been described with the clinical picture of APS. Until now there has been no scientifically proven explanation why some patients develop pathogenic aPL and subsequent ...
Skeletal System
... they are attacked by the inflammatory response, by macrophages and finally, by lymphocytes of the immune system Lymphocytes are white blood cells and that each lymphocyte recognizes and attacks its own type of foreign molecule, called an antigen ...
... they are attacked by the inflammatory response, by macrophages and finally, by lymphocytes of the immune system Lymphocytes are white blood cells and that each lymphocyte recognizes and attacks its own type of foreign molecule, called an antigen ...
ICH E10
... studies are predictive of human immunotoxicity in a rather straightforward manner. That is, specific assays to determine immunotoxicity are probably not valuable in drug risk assessment since the target tissues are usually rapidly dividing cell types, such as bone marrow-derived immune system progen ...
... studies are predictive of human immunotoxicity in a rather straightforward manner. That is, specific assays to determine immunotoxicity are probably not valuable in drug risk assessment since the target tissues are usually rapidly dividing cell types, such as bone marrow-derived immune system progen ...
A - Personal.psu.edu
... the scientific community due to its ramifications on human health. The disease caused by B. pertussis, whooping cough, is an acute, severe coughing illness that can progress to become spasmodic. Extreme cases may lead to regurgitation, convulsions, collapse, coma, and death (3). A closely related me ...
... the scientific community due to its ramifications on human health. The disease caused by B. pertussis, whooping cough, is an acute, severe coughing illness that can progress to become spasmodic. Extreme cases may lead to regurgitation, convulsions, collapse, coma, and death (3). A closely related me ...
Anti-inflammatory properties of peptides derived Ornithodoros savignyi
... Ticks only rely on an innate immune defence for protection against microbes and therefore produce a variety of AMPs, like defensins. Tick defensins could potentially function as templates for the development of multifunctional peptides. Previous research has shown that a synthetic peptide, Os, deriv ...
... Ticks only rely on an innate immune defence for protection against microbes and therefore produce a variety of AMPs, like defensins. Tick defensins could potentially function as templates for the development of multifunctional peptides. Previous research has shown that a synthetic peptide, Os, deriv ...
C YTOKINES AND IMMUNE BALANCE IN PREECLAMPSIA
... The adaptive immunity reacts slower than the innate immunity, but has more long-lived and highly evolved antigen-specific protective responses, such as antibody production and cell-mediated immunity, reviewed by Tosi (2005). The cells included in adaptive immunity are B- and T-lymphocytes, and these ...
... The adaptive immunity reacts slower than the innate immunity, but has more long-lived and highly evolved antigen-specific protective responses, such as antibody production and cell-mediated immunity, reviewed by Tosi (2005). The cells included in adaptive immunity are B- and T-lymphocytes, and these ...
Peripheral blood mononuclear cells from severe
... that contributes to inducing IFN-␥ in an immunosuppressive environment.21 Other cytokines were analysed in order to understand the mechanisms that lead to asthma development. In the context of our treatment protocols, we evaluated peripheral ...
... that contributes to inducing IFN-␥ in an immunosuppressive environment.21 Other cytokines were analysed in order to understand the mechanisms that lead to asthma development. In the context of our treatment protocols, we evaluated peripheral ...
Modulating impact of human chorionic gonadotropin hormone on the maturation
... and CD4, as well as the forkhead family transcription factor FOXP3, a key control gene in their development and function. In addition, Tregs express the GITR gene, the CTLA-4, and TGF- on their cell surface. They secrete TGF- and IL-10, both thought to contribute to their suppressor activity. More ...
... and CD4, as well as the forkhead family transcription factor FOXP3, a key control gene in their development and function. In addition, Tregs express the GITR gene, the CTLA-4, and TGF- on their cell surface. They secrete TGF- and IL-10, both thought to contribute to their suppressor activity. More ...
Cnidarian-Microbe Interactions and the Origin of Innate Immunity in
... each animal produces genetically identical progeny, facilitating the establishment and maintenance of large populations of animals that can be housed in refrigerator-sized incubators. Hydra lacks any exoskeleton and is nearly transparent, greatly simplifying in vivo tracing of cell behavior and char ...
... each animal produces genetically identical progeny, facilitating the establishment and maintenance of large populations of animals that can be housed in refrigerator-sized incubators. Hydra lacks any exoskeleton and is nearly transparent, greatly simplifying in vivo tracing of cell behavior and char ...
Parasite Resistance and the Adaptive Significance of Sleep
... We use white blood cells as a proxy for immune system investment as they are central to all immune responses and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25 ...
... We use white blood cells as a proxy for immune system investment as they are central to all immune responses and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25 ...
Parasite resistance and the adaptive significance of sleep The
... We use white blood cells as a proxy for immune system investment as they are central to all immune responses and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25 ...
... We use white blood cells as a proxy for immune system investment as they are central to all immune responses and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25 ...
Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome
... remodeling and mRNA stabilization. PLoS Pathog 4(2): e31. doi:10.1371/journal.ppat.0040031 ...
... remodeling and mRNA stabilization. PLoS Pathog 4(2): e31. doi:10.1371/journal.ppat.0040031 ...
Immune system
![](https://en.wikipedia.org/wiki/Special:FilePath/Neutrophil_with_anthrax_copy.jpg?width=300)
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.