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FactSHEET DNCB What is DNCB?
FactSHEET DNCB What is DNCB?

... DNCB is thought to stimulate several parts of the cell-mediated immune system — specifically those parts that are weakened in HIV disease. DNCB seems to prompt the cellmediated immune system both to produce chemicals (called cytokines) that regulate the immune system and to increase specific immune ...
Human and Mouse Naïve/Memory T-Cell Panels
Human and Mouse Naïve/Memory T-Cell Panels

Chapter 19 Disorders Associated with the Immune System
Chapter 19 Disorders Associated with the Immune System

... the human immunodeficiency virus (HIV), which destroys helper T cells. AIDS is the final stage of a lengthy HIV infection. At this time the loss of an effective immune system leaves the victim susceptible to many opportunistic infections. HIV is a retrovirus and requires the enzyme reverse transcrip ...
Slide 1
Slide 1

... Adjuvant = substance that promotes immune response to an Ag T-independent Ags = Ags with large repetitive structures (e.g., bacteria, flagellin, ...
Anti-food polysaccharide antibody formation in Inflammatory
Anti-food polysaccharide antibody formation in Inflammatory

... people per 100K populations in UK, which burdens the NHS with £720 million per annum (British Society of Gastroenterology, 2009). It has been shown that IBD patients produce an abnormally high level of antibodies against yeast polysaccharide such as ß-glucans. These antibodies may be a factor trigge ...
Adaptive Immunity: Activation of naive T cells
Adaptive Immunity: Activation of naive T cells

... An adaptive immune response requires vigorous expansion of naïve T cells having the appropriate antigen specificity; this is known as “clonal selection”. This increases the number of lymphocytes that can provide a useful response. Naïve T cells must also differentiate into effector cells in order to ...
Major functions of the immune system
Major functions of the immune system

...  secondary – tonsils, adenoids, spleen, Peyer patches, appendix  lymphocytes  antibodies  macrophages Copyright © 2005 by Elsevier Inc. All rights reserved ...
Defence against infections Immunisation
Defence against infections Immunisation

... ii. ...
Antibodies. Cell cooperation in immune response
Antibodies. Cell cooperation in immune response

... lymphoid node. At the same time antigenes which have penetrated on mucous membranes of respiratory ways or intestines get in the lymphoid tissue of the mucose membranes and an antigene which directly will penetrate into blood, is located in a spleen. ...
"Immunity to Infection". In: Encyclopedia of Life Sciences (ELS)
"Immunity to Infection". In: Encyclopedia of Life Sciences (ELS)

... and the B cell is activated to secrete IgM. In turn, fragments of antigen are bound to MHC class II molecules (Figure 2) and transported to the cytoplasmic membrane. This enables recognition by T helper cells and is important for the production of immunglobulins with higher affinity and specificity tha ...
IMT- II PG - E
IMT- II PG - E

... 6. Which of the following uniquely distinguishes the T-cell receptor (TCR) from an antibody? a. The TCR can bind an antigen fragment only in a trimolecular complex with either the class I or class II surface proteins of the major histocompatibility complex b. The TCR can function as a cell surface a ...
Secondary Immunodeficiency I
Secondary Immunodeficiency I

FUNCTIONS OF THE BLOOD
FUNCTIONS OF THE BLOOD

... Recognition by phagocytes. • Binding to receptors- polysaccharides or similar bacterial cell wall substances [nonspecific]. • Electrical charge of the surface- positive charge in living tissue. No charge in dead tissues and negative out side of bacteria. • Opsonized material is said to be “tasty” t ...
Unit 14
Unit 14

... A. Your immune system allows your body to defend itself against most invaders. Your immune system includes lymph nodes which filter a fluid portion of your blood (called lymph) for invaders and special white blood cells which respond to any found invaders. ○ 1. An antigen is the term used to describ ...
Chapter 2 Antigen
Chapter 2 Antigen

... • Compared to a normal antigen-induced Tcell response where 0.001-0.0001% of the body’s T-cells are activated, SAgs are capable of activating up to 20% of the body’s T-cells. This causes a massive immune response that is not specific to any particular epitope on the SAg. ...
Chapter 27
Chapter 27

... • Another group of antigens found in most red blood cells is the Rh factor. • People can be either Rh-positive or Rh-negative. • This has significance when a mother and her fetus have opposite Rh groups. ...
Characterization of the mycobacterial lipids presented by
Characterization of the mycobacterial lipids presented by

... Mycobacteria, including Mycobacterium tuberculosis (Mtb) - a causative agent of tuberculosis, are characterized by exceptionally high content of lipids in their cell walls. Several mycobacterial lipid antigens have been found to be associated with group I CD1 molecules - non-polymorphic, MHC class I ...
Immune System
Immune System

... Immune System Animals have various means of defense against pathogens—agents that cause disease. Defense systems are based on the recognition of self (one’s own) and nonself (foreign) molecules. ...
Immunology Basics Biology Lecture PowerPoint
Immunology Basics Biology Lecture PowerPoint

... – Presence stimulates certain parts of the second line of immune defense, helping the body defend itself from invaders. – Normal flora of the intestines improve our overall health by producing several types of vitamins. ...
Chapter 2 Antigen
Chapter 2 Antigen

... • Compared to a normal antigen-induced Tcell response where 0.001-0.0001% of the body’s T-cells are activated, SAgs are capable of activating up to 20% of the body’s T-cells. This causes a massive immune response that is not specific to any particular epitope on the SAg. ...
Slide 1
Slide 1

... This increase was associated with longer telomere lengths, improved immune effector function, and ...
Biology of the B Lymphocyte
Biology of the B Lymphocyte

... T cells use an Ag recognition system (TCR) that interacts with a fragment of an Ag presented on the surface of a cell bound to MHC gene product Major histocompatibility complex (MHC) ...
Antibody
Antibody

... foreign materials, neutralizes and removes them • one basis of immunity is the recognition of a foreign material, the antigen, by a glycoprotein molecule in the body, the antibody. • antibodies that recognize “self” occur in the body, but they are removed and destroyed immediately after synthesis. • ...
Q1. Use the information in the passage and your
Q1. Use the information in the passage and your

... One type contains HIV in an inactivated form. A second type contains attenuated HIV which replicates in the body but does not kill host cells. A third type uses a different, non-pathogenic virus to carry genetic information from HIV into the person’s cells. This makes the person’s cells produce HIV ...
chapter 4 an introduction to cell structure and host
chapter 4 an introduction to cell structure and host

... • Microbial flora can protect us through microbial antagonism. – Many bacteria produce bacteriocins which are localized bacterial antibiotics. – Bacteriocins can kill invading organisms but do not affect the bacteria that produce them. Competition for space and other resources. ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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