AlgPred: prediction of allergenic proteins and mapping of
... severe reactions such as acute and fatal anaphylactic shock can also occur. It affects a large population with very high prevalence particularly of skin sensitization (4,5). Most allergic responses occur on mucous membrane surface in response to allergens that enter the body by either inhalations or ...
... severe reactions such as acute and fatal anaphylactic shock can also occur. It affects a large population with very high prevalence particularly of skin sensitization (4,5). Most allergic responses occur on mucous membrane surface in response to allergens that enter the body by either inhalations or ...
Oncology - Taconic Biosciences
... T, B & NK CELL DEFICIENT MOUSE • Useful for transplanting allogeneic or xenogeneic stem cells, which are often rejected by NK cells. • May be used in combination with parent Rag2 knockout model for defining the role of NK cells in host resistance to tumors and infectious agents. ...
... T, B & NK CELL DEFICIENT MOUSE • Useful for transplanting allogeneic or xenogeneic stem cells, which are often rejected by NK cells. • May be used in combination with parent Rag2 knockout model for defining the role of NK cells in host resistance to tumors and infectious agents. ...
Lymphatic system ppt 1 - Liberty Union High School District
... Lymphatic Cells • macrophages – very large, avidly phagocytic cells of the connective tissue – develop from monocytes – phagocytize tissue debris, dead neutrophils, bacteria, and other foreign matter – process foreign matter and display antigenic fragments to certain T cells alerting the immune sys ...
... Lymphatic Cells • macrophages – very large, avidly phagocytic cells of the connective tissue – develop from monocytes – phagocytize tissue debris, dead neutrophils, bacteria, and other foreign matter – process foreign matter and display antigenic fragments to certain T cells alerting the immune sys ...
Exploiting Amoeboid and Non-Vertebrate Animal Model Systems to Study the
... non-vertebrate model hosts. Consequently, many researchers have turned to non-vertebrates as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases. An important advantage of many non-vertebrate hosts is that they are small enough to fit ...
... non-vertebrate model hosts. Consequently, many researchers have turned to non-vertebrates as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases. An important advantage of many non-vertebrate hosts is that they are small enough to fit ...
The role of lymph node sinus macrophages in host defense
... observed that these phagocytic amoeboid cells accumulated around a rose thorn introduced into the larvae and covered it completely. This process, known today as inflammation, was triggered not only by physical damage but also by microbial stimuli, leading to the concept that macrophages participate ...
... observed that these phagocytic amoeboid cells accumulated around a rose thorn introduced into the larvae and covered it completely. This process, known today as inflammation, was triggered not only by physical damage but also by microbial stimuli, leading to the concept that macrophages participate ...
Intrinsically Disordered Domains of the B Cell Receptor
... membrane [1]. MPs are also important for drug research, accounting for over 50% of all human drug targets [2]. In particular G protein-coupled receptors have intensively been targeted for therapeutic purposes. Even if nearly 30% of the proteome is comprised of MPs, only 1% of all deposited structure ...
... membrane [1]. MPs are also important for drug research, accounting for over 50% of all human drug targets [2]. In particular G protein-coupled receptors have intensively been targeted for therapeutic purposes. Even if nearly 30% of the proteome is comprised of MPs, only 1% of all deposited structure ...
Impact of treatment with methimazole on the Bcl
... cell survival is of vital importance in tissues with high cell turnover, such as the lymphoid system. Activation and proliferation of lymphocytes due to antigen stimulation leading to the increase in their number should be efficiently controlled. Just after ending the immunological response, the inc ...
... cell survival is of vital importance in tissues with high cell turnover, such as the lymphoid system. Activation and proliferation of lymphocytes due to antigen stimulation leading to the increase in their number should be efficiently controlled. Just after ending the immunological response, the inc ...
Title Natural killer cells become tolerogenic after
... suppressed CD4+ T cell proliferation and activation. Moreover, AC-treated NK cells displayed cytotoxicity against autologous activated CD4+ T cells by upregulating NKp46. We then identified that this lysis occurs in part through NKp46-Vimentin pathway, since activated CD4+ T cells expressed vimentin ...
... suppressed CD4+ T cell proliferation and activation. Moreover, AC-treated NK cells displayed cytotoxicity against autologous activated CD4+ T cells by upregulating NKp46. We then identified that this lysis occurs in part through NKp46-Vimentin pathway, since activated CD4+ T cells expressed vimentin ...
thesis
... the family member bad to investigate at the protein level. It binds to bcl-XL with a much higher affinity than bax or bak (26), and hence is a good candidate to block bcl-XL’s protective effects in DP T-cells. I also moved to investigation of bcl-XL at the protein level to address the possibility th ...
... the family member bad to investigate at the protein level. It binds to bcl-XL with a much higher affinity than bax or bak (26), and hence is a good candidate to block bcl-XL’s protective effects in DP T-cells. I also moved to investigation of bcl-XL at the protein level to address the possibility th ...
Diabetes Mellitus
... Prevention of T1DM: How Can We Approach This? There are no specific genetic markers Most patients with new-onset T1DM have no family history Detection of Islet-Cell antibodies (ICA’s) are not 100% specific…. & these are usually only checked in first degree relatives of persons with diabetes ...
... Prevention of T1DM: How Can We Approach This? There are no specific genetic markers Most patients with new-onset T1DM have no family history Detection of Islet-Cell antibodies (ICA’s) are not 100% specific…. & these are usually only checked in first degree relatives of persons with diabetes ...
Nerve growth factor: role in growth, differentiation
... models [47–49]. Although tumors have their own “cell shelter mechanisms” (immune escape, resistance to apoptosis and cell survival), a host-mediated immune response against tumors can occur and consequently two different models have been proposed. The “immunosurveillance model” suggests that tumor c ...
... models [47–49]. Although tumors have their own “cell shelter mechanisms” (immune escape, resistance to apoptosis and cell survival), a host-mediated immune response against tumors can occur and consequently two different models have been proposed. The “immunosurveillance model” suggests that tumor c ...
Cell Biophysics II - Univerzita Pavla Jozefa Šafárika v Košiciach
... During the Middle Ages, the ancient Greek and Indian medical traditions were further developed by Muslim physicians. Al-Razi (865-925 AD) was a versatile Persian physician, philosopher, and scholar who made fundamental and enduring contributions to the fields of medicine, chemistry and philosoph ...
... During the Middle Ages, the ancient Greek and Indian medical traditions were further developed by Muslim physicians. Al-Razi (865-925 AD) was a versatile Persian physician, philosopher, and scholar who made fundamental and enduring contributions to the fields of medicine, chemistry and philosoph ...
gastrointestinal (GI) tract
... microbial and nonmicrobial. Immune inductive sites are comprised of Peyer’s patches (pps) and mesenteric lymph nodes (mlns). Peyer’s patches have the anatomic appearance of secondary lymphoid organs, with clearly defined T- and B-cell–dependent areas. A single layer of epithelial cells separates the ...
... microbial and nonmicrobial. Immune inductive sites are comprised of Peyer’s patches (pps) and mesenteric lymph nodes (mlns). Peyer’s patches have the anatomic appearance of secondary lymphoid organs, with clearly defined T- and B-cell–dependent areas. A single layer of epithelial cells separates the ...
biographical sketch - Murdough Family Center for Psoriasis
... UV induction of immunosuppression and antigenic tolerance. J Exp Med 187(7):1133-1138, 1998. Szabo SK, Hammerberg C, Yoshida Y, Bata-Csorgo Z, Cooper KD: Identification and quantitation of interferon-producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets. J Invest Dermato ...
... UV induction of immunosuppression and antigenic tolerance. J Exp Med 187(7):1133-1138, 1998. Szabo SK, Hammerberg C, Yoshida Y, Bata-Csorgo Z, Cooper KD: Identification and quantitation of interferon-producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets. J Invest Dermato ...
Establishment of immunohistochemical double staining
... apparently most active within the tumour itself. The cancer specific cells appear to target the CD8+ cytotoxic T-‐ cells. 6 The PD1 has a cytoplasmic immunoreceptor tyrosine-‐ based inhibitory motif wh ...
... apparently most active within the tumour itself. The cancer specific cells appear to target the CD8+ cytotoxic T-‐ cells. 6 The PD1 has a cytoplasmic immunoreceptor tyrosine-‐ based inhibitory motif wh ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... infection of H. pylori may be one of the cause’s gastric cancer (Nunes, 1998). Infection by the H.r pylori has been identified as a major cause of peptic ulcer disorder (gastric and duodenal ulcers), gastritis chronic and gastric carcinoma even gastric lymphoma. This is unique, because Helicobacter ...
... infection of H. pylori may be one of the cause’s gastric cancer (Nunes, 1998). Infection by the H.r pylori has been identified as a major cause of peptic ulcer disorder (gastric and duodenal ulcers), gastritis chronic and gastric carcinoma even gastric lymphoma. This is unique, because Helicobacter ...
Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
... ABSTRACT: T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept ...
Caspase-8 regulates the expression of pro- and anti
... Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory stimuli is therefore of importance. Toll-like receptors (TLR)s are innate imm ...
... Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory stimuli is therefore of importance. Toll-like receptors (TLR)s are innate imm ...
Dual role for B-1a cells in immunity to influenza virus infection
... [email protected] Abbreviations used: AFC, antibody-forming cell; BAL, bronchoalveolar lavage; BCR, B cell receptor; BLF, BAL fluid; GC, germinal center; HI, hemagglutination inhibition; MedLN, mediastinal LN; PerC, peritoneal cavity wash out cell; PLN, peripheral LN. ...
... [email protected] Abbreviations used: AFC, antibody-forming cell; BAL, bronchoalveolar lavage; BCR, B cell receptor; BLF, BAL fluid; GC, germinal center; HI, hemagglutination inhibition; MedLN, mediastinal LN; PerC, peritoneal cavity wash out cell; PLN, peripheral LN. ...
Understanding MGUS and Smoldering Multiple Myeloma
... Is there more than one type of MGUS? Under normal circumstances, these antibodies attach to specific invader antigens and, together with other immune system cells, they disable and destroy the antigen and/or associated infectious agent or cell. Antibodies that arise from plasma cells in a normal imm ...
... Is there more than one type of MGUS? Under normal circumstances, these antibodies attach to specific invader antigens and, together with other immune system cells, they disable and destroy the antigen and/or associated infectious agent or cell. Antibodies that arise from plasma cells in a normal imm ...
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins
... If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protective‟ HLA-B allele (B*57, B*52, B*27 or B*14+Cw0802) as defined in the Intern ...
... If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protective‟ HLA-B allele (B*57, B*52, B*27 or B*14+Cw0802) as defined in the Intern ...
T Cell Memory in the Context of Persistent Herpes Viral Infections
... but also other organs such as the skin and the brain, and persist in the absence of antigen stimulation for several months, or even years [22–27]. These so called tissue-resident memory T cells (TRM) have little or absent homeostatic turnover and their persistence has been shown to be intimately dep ...
... but also other organs such as the skin and the brain, and persist in the absence of antigen stimulation for several months, or even years [22–27]. These so called tissue-resident memory T cells (TRM) have little or absent homeostatic turnover and their persistence has been shown to be intimately dep ...
投影片 1 - Imapac
... very good safety profile but these vaccine-candidates are usually poor immunogens. They require appropriate adjuvant to be efficacious. Is it possible to have solution for this dilemma? ...
... very good safety profile but these vaccine-candidates are usually poor immunogens. They require appropriate adjuvant to be efficacious. Is it possible to have solution for this dilemma? ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.