Lymphocyte Subpopulations in Lymph Nodes and Peripheral Blood: A Comparison between
... of natural killer (NK) cells. An increased T cell activity has been associated with plaque instability and risk of acute cardiac events. Lymphocyte analyses in blood are widely used to evaluate the immune status. However, peripheral blood contains only a minor proportion of lymphocytes. In this stud ...
... of natural killer (NK) cells. An increased T cell activity has been associated with plaque instability and risk of acute cardiac events. Lymphocyte analyses in blood are widely used to evaluate the immune status. However, peripheral blood contains only a minor proportion of lymphocytes. In this stud ...
Paraneoplastic Syndromes
... ●Treatment for both paraneoplastic and non-tumor Lambert-Eaton begins with 3,4diaminopyridine (3,4-DAP). ●3,4-DAP treats muscle weakness in Lambert-Eaton patients by inhibiting presynaptic voltagegated potassium channels. This serves to prolong presynaptic membrane depolarization and allows the unbl ...
... ●Treatment for both paraneoplastic and non-tumor Lambert-Eaton begins with 3,4diaminopyridine (3,4-DAP). ●3,4-DAP treats muscle weakness in Lambert-Eaton patients by inhibiting presynaptic voltagegated potassium channels. This serves to prolong presynaptic membrane depolarization and allows the unbl ...
Infect Immun. 2011 Feb;79(2):688-94. Epub 2010 Nov 22.
... one unknown DNA sensor exists, as targeted deletion of DAI does not abrogate the IFN response to transfected DNA in most cell types (7, 16, 36). This sensor was recently proposed to be IFN-inducible protein 16 (IFI16), a member of the PYHIN family of DNA binding proteins (34). In addition to recogni ...
... one unknown DNA sensor exists, as targeted deletion of DAI does not abrogate the IFN response to transfected DNA in most cell types (7, 16, 36). This sensor was recently proposed to be IFN-inducible protein 16 (IFI16), a member of the PYHIN family of DNA binding proteins (34). In addition to recogni ...
Sex differences in carotenoid status and immune performance in
... Sex differences in immunity are common throughout the animal kingdom, with males typically showing reduced immune capacity compared with females due to the immunosuppressive action of androgens like testosterone. However, in animals (e.g. birds, fishes) in which immunostimulatory carotenoid pigments ...
... Sex differences in immunity are common throughout the animal kingdom, with males typically showing reduced immune capacity compared with females due to the immunosuppressive action of androgens like testosterone. However, in animals (e.g. birds, fishes) in which immunostimulatory carotenoid pigments ...
Lung inflammatory responses
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
An Identification Guide for Avian Blood Components
... When studying avian blood, a common method of judging overall health is to count leukocytes by comparing the number of lymphocytes to the number of heterophils in a given area of the sample. Some methods include counting the number of eosinophils as well, and some may make a more inclusive count of ...
... When studying avian blood, a common method of judging overall health is to count leukocytes by comparing the number of lymphocytes to the number of heterophils in a given area of the sample. Some methods include counting the number of eosinophils as well, and some may make a more inclusive count of ...
Plasmacytoid predendritic cells initiate psoriasis through interferon
... onset of the lesions is commonly followed by chronic relapses of the disease triggered by infections, mechanical stress, and drugs (5). Although it is still unclear how these environmental factors drive the pathogenic T cell cascade, it has been suggested that innate immune pathways may provide the ...
... onset of the lesions is commonly followed by chronic relapses of the disease triggered by infections, mechanical stress, and drugs (5). Although it is still unclear how these environmental factors drive the pathogenic T cell cascade, it has been suggested that innate immune pathways may provide the ...
Raulet, D.H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3:781-790.
... cells1,2. NKG2A, NKG2C and NKG2E complementary DNAs were isolated in the same screen. The corresponding receptors were all type-2 transmembrane receptors with sequence similarities to C-type lectins. Although originally given a common name, subsequent analysis showed that NKG2D should be considered ...
... cells1,2. NKG2A, NKG2C and NKG2E complementary DNAs were isolated in the same screen. The corresponding receptors were all type-2 transmembrane receptors with sequence similarities to C-type lectins. Although originally given a common name, subsequent analysis showed that NKG2D should be considered ...
Characterization of the novel antibacterial peptide Leucrocin from
... In addition to their action towards microbes, some antimicrobial peptides can function as regulatory molecules in the host. For example, in vitro studies suggest that defensins attract phagocytes and lymphocytes to sites of infection, inhibit the release of cortisol from adrenal cells, induce the pr ...
... In addition to their action towards microbes, some antimicrobial peptides can function as regulatory molecules in the host. For example, in vitro studies suggest that defensins attract phagocytes and lymphocytes to sites of infection, inhibit the release of cortisol from adrenal cells, induce the pr ...
- Journal of Clinical Investigation
... can broadly be defined as fibrosis — accumulation of extracellular matrix (ECM) and loss of cellular homeostasis — are seen in normal physiological responses. Importantly, the cellular and molecular mechanisms that participate in physiological responses are also much the same as those identified in ...
... can broadly be defined as fibrosis — accumulation of extracellular matrix (ECM) and loss of cellular homeostasis — are seen in normal physiological responses. Importantly, the cellular and molecular mechanisms that participate in physiological responses are also much the same as those identified in ...
Drosophila melanogasteras a model for human intestinal infection
... maturing to eventually reach complete maturation close to the opening of the crypts. There is a continuous turnover of TA cells, which are either shed or become apoptotic upon maturation (Crosnier et al., 2006; Scoville et al., 2008). The Drosophila posterior midgut has a very simple lineage, with o ...
... maturing to eventually reach complete maturation close to the opening of the crypts. There is a continuous turnover of TA cells, which are either shed or become apoptotic upon maturation (Crosnier et al., 2006; Scoville et al., 2008). The Drosophila posterior midgut has a very simple lineage, with o ...
Nerve growth factor levels and localisation in human asthmatic bronchi
... (range 61.0–102.9) of the predicted normal values, and their geometric mean provocation dose causing a 20% fall in FEV1 (PD20) was 255.7 mg (table 1). Control subjects (three males and four females, aged 21–38 yrs, median age 25 yrs) were all healthy nonatopic, nonallergic volunteers. The nonasthmat ...
... (range 61.0–102.9) of the predicted normal values, and their geometric mean provocation dose causing a 20% fall in FEV1 (PD20) was 255.7 mg (table 1). Control subjects (three males and four females, aged 21–38 yrs, median age 25 yrs) were all healthy nonatopic, nonallergic volunteers. The nonasthmat ...
The avian lung-associated immune system: a review
... which are covered by a distinct layer of epithelial cells harbouring considerable numbers of lymphocytes [22], the lymphoepithelium or follicle-associated epithelium (FAE) [7, 20, 21]. The FAE is made up of ciliated and non-ciliated cells, the relative numbers of which differ significantly at differ ...
... which are covered by a distinct layer of epithelial cells harbouring considerable numbers of lymphocytes [22], the lymphoepithelium or follicle-associated epithelium (FAE) [7, 20, 21]. The FAE is made up of ciliated and non-ciliated cells, the relative numbers of which differ significantly at differ ...
Lung inflammatory responses
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
The immune response to yellow fever vaccination in aged individuals
... and man, complicate the direct translation of these results to humans (Davis, 2008; Vallejo, 2011). The response of the human aged immune system to a challenge has been investigated so far mostly after secondary immunizations, such as influenza, tetanus or Varicella-zoster ...
... and man, complicate the direct translation of these results to humans (Davis, 2008; Vallejo, 2011). The response of the human aged immune system to a challenge has been investigated so far mostly after secondary immunizations, such as influenza, tetanus or Varicella-zoster ...
jait0302_08 - Journal of Advances in Information Technology
... satisfiability of an instance. In the worst case, the computation time required for the execution of such methods, increases exponentially with the size of the instance to solve. The method of Davis and Putnam (DP) [27] is one of the first methods dedicated to solving SAT problem. The DP method is b ...
... satisfiability of an instance. In the worst case, the computation time required for the execution of such methods, increases exponentially with the size of the instance to solve. The method of Davis and Putnam (DP) [27] is one of the first methods dedicated to solving SAT problem. The DP method is b ...
... The cause of sarcoidosis has been sought for almost 100 yrs. Historically, a relationship with tuberculosis akin to the two forms of leprosy (multibacillary lepromatous disease and paucibacillary tuberculoid disease) has been suspected, but never substantiated. The issue has been given new life by t ...
T-cell intrinsic expression of MyD88 is required for sustained
... GP33–41 peptide in vitro (Fig. 1b). A markedly reduced response was also observed for NP396–404-specific CD8+ T cells and GP61–80-specific CD4+ T cells (Fig. 1b). The impaired T-cell response in MyD882/2 mice was evident by 6 days p.i. and became even more pronounced with time, eventually resulting ...
... GP33–41 peptide in vitro (Fig. 1b). A markedly reduced response was also observed for NP396–404-specific CD8+ T cells and GP61–80-specific CD4+ T cells (Fig. 1b). The impaired T-cell response in MyD882/2 mice was evident by 6 days p.i. and became even more pronounced with time, eventually resulting ...
Human Invariant Natural Killer T cells possess
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
A Study of the Ebola Virus Glycoprotein
... including cell rounding and detachment in those cells expressing GP. This phenomenon is referred to as GPmediated cytopathology and is the focus of the work described herein. We have undertaken studies to identify the mucin domain, a highly glycosylated domain within GP, as sufficient to cause this ...
... including cell rounding and detachment in those cells expressing GP. This phenomenon is referred to as GPmediated cytopathology and is the focus of the work described herein. We have undertaken studies to identify the mucin domain, a highly glycosylated domain within GP, as sufficient to cause this ...
Wiskott-Aldrich syndrome protein–mediated actin dynamics control
... IFN–inducible genes in WAS patients Dysregulated production of type-I IFN by pDCs represents a crucial step in the pathogenesis of autoimmune diseases such as SLE, Sjogren syndrome, and psoriasis. Some typical features of these diseases, such as skin lesions, arthritis, renal diseases, and cutaneous ...
... IFN–inducible genes in WAS patients Dysregulated production of type-I IFN by pDCs represents a crucial step in the pathogenesis of autoimmune diseases such as SLE, Sjogren syndrome, and psoriasis. Some typical features of these diseases, such as skin lesions, arthritis, renal diseases, and cutaneous ...
Building a Meta-predictor for MHC Class II Binding Peptides
... approach are presented. The Bayesian framework has the flexibility to incorporate any predictor that makes prediction from a computed score correlated with the binding affinity of MHC class II peptides. Here, in order to illustrate the steps of the Bayesian framework, three individual predictors, i. ...
... approach are presented. The Bayesian framework has the flexibility to incorporate any predictor that makes prediction from a computed score correlated with the binding affinity of MHC class II peptides. Here, in order to illustrate the steps of the Bayesian framework, three individual predictors, i. ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.