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Dead cell-associated antigens
Dead cell-associated antigens

... Even without SCS macrophages, B cells are eventually activated by VSVderived antigens, although less efficiently ...
Unit 2 Exam Biochem, Cell Bio, Metabolism
Unit 2 Exam Biochem, Cell Bio, Metabolism

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... Foreign versus Self • Immune system protects organisms from foreign invaders • Protection from harmful organisms (pathogens) is based upon the ability to identify foreign molecules as “nonself” • Foreign may be bacteria, viruses, fungi, tumor, or transplanted cells • Molecules recognized by the imm ...
‘Research at the Interface’ 2014 Annual Symposium, Friday 9th May 2014
‘Research at the Interface’ 2014 Annual Symposium, Friday 9th May 2014

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An introduction to the immune system: how vaccines work

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... Various protein and carbohydrate molecules exposed on the surface of the membrane:  act as markers – these indicate to cells of the immune system whether a cell is norm or abnormal (see MHC proteins).  serve as receptors that interact with substance in the cell’s environment and initiate specific ...
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Bax - Hypromatrix

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... Whole genome expression profiling and analysis Global gene expression in tumor specimens from anti-PD-1 responders (R, n=4) and nonresponders (NR, n=7) was measured by DASL (cDNA-mediated Annealing, Selection, extension, and Ligation) assays arrayed on the Illumina Human HT-12 WG-DASL V4.0 R2 expre ...
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... territory. Pheromones can be species specific or colony specific. II. Transmission of hormone signals  Hormones are long-distance signals that are released by endocrine cells and travel to the target cells in animals through the blood stream.  Hormones are used to alter existing cell functions, re ...
Missing genetic link found in a challenging immune disease
Missing genetic link found in a challenging immune disease

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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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