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WHITE BLOOD CELLS (WBCs) Leukocytes
WHITE BLOOD CELLS (WBCs) Leukocytes

Opexa Therapeutics, Inc. (Form: 8-K, Received: 10
Opexa Therapeutics, Inc. (Form: 8-K, Received: 10

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... o The inflammatory response is the body’s response to tissue damage. As soon as pathogen enters your body, damaged tissue releases chemical signal. Blood vessels expand. What is a consequence of this? Plasma carries macrophages that engulf and destroy pathogens during phagocytosis If infection persi ...
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... the CTLs appear. When the CTLs are maximally effective there may be little net selection because the virus load has been depressed to a low level. In chronic HIV infection, the CTLs may be suboptimal giving rise to many escape mutants because of high virus turnover. ...
Bio 263/F94/T3 V2 - Millersville University
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... 21. Integrins bind to a specific three amino acid sequence (designated RGD) in a number of proteins. A dish is coated with a protein containing the RGD sequence. Some cultured cells with integrins embedded in their membranes were added to the culture dish along with tripeptides with the RGD sequence ...
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... © 2010 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners. These products may be covered by one or more Limited Use Label Licenses (see Invitrogen catalog or www.invitrogen.com). By use of t ...
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... containment and early control of HIV or SIV replication [10,14-16]. In primary infections, a potent anti-HIV or SIV specific CTL response is detected at a time when a humoral response is weak or nonexistent, suggesting that CD8+ effector cells are key controllers of early viremia [15,16]. Neverthele ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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