Open Information Day 2011
... response rates and decrease the duration of treatment but will likely have further side effects and additional costs ...
... response rates and decrease the duration of treatment but will likely have further side effects and additional costs ...
Autoimmune Hemolytic Anemia in Dogs
... With primary AIHA, the dog's immune system is not working properly and it incorrectly makes antibodies that target its own red blood cells. In dogs, it is estimated that about three-quarters of cases of AIHA are primary. With secondary AIHA, the surface of the red blood cells becomes altered by an u ...
... With primary AIHA, the dog's immune system is not working properly and it incorrectly makes antibodies that target its own red blood cells. In dogs, it is estimated that about three-quarters of cases of AIHA are primary. With secondary AIHA, the surface of the red blood cells becomes altered by an u ...
Document
... The presentation of Class I MHC/ peptide by a target cell to a CD8+ Tc cell results in the proliferation and subsequent differentiation of a Tc into a killer/effector cell. The Tc can then participate in ...
... The presentation of Class I MHC/ peptide by a target cell to a CD8+ Tc cell results in the proliferation and subsequent differentiation of a Tc into a killer/effector cell. The Tc can then participate in ...
Abeloff`s Clinical Oncology Update
... efficacy data were first reported in abstract form in 2012 for patients with melanoma, the study protocol had been amended to add additional cohorts of melanoma patients. Data from the first 135 patients enrolled in KEYNOTE-001 were published in 2013, with a centrally confirmed Response Evaluation C ...
... efficacy data were first reported in abstract form in 2012 for patients with melanoma, the study protocol had been amended to add additional cohorts of melanoma patients. Data from the first 135 patients enrolled in KEYNOTE-001 were published in 2013, with a centrally confirmed Response Evaluation C ...
MD Anderson Cancer Center
... on the biology of T cells—the attack dogs of the immune system—laid the foundation for the development of the drug. Ipilimumab works by blocking a molecule that normally keeps T cells on a short leash. The drug can silence melanoma for years in 22% of patients, Allison says. Immunotherapy is now a v ...
... on the biology of T cells—the attack dogs of the immune system—laid the foundation for the development of the drug. Ipilimumab works by blocking a molecule that normally keeps T cells on a short leash. The drug can silence melanoma for years in 22% of patients, Allison says. Immunotherapy is now a v ...
Cytopenias developing after solid organ transplantation
... Leukopenia by marrow suppression Sirolimus Anemia esp in renal transplant (iron hemostasis, direct anti proliferative effect, IL 10 activation) Azathioprine Anemia/pancytopenia Alemtuzumab: reports of PRCA and immune hemolysis Pure red-cell aplasia : MMF, tacrolimus, azothioprine and A ...
... Leukopenia by marrow suppression Sirolimus Anemia esp in renal transplant (iron hemostasis, direct anti proliferative effect, IL 10 activation) Azathioprine Anemia/pancytopenia Alemtuzumab: reports of PRCA and immune hemolysis Pure red-cell aplasia : MMF, tacrolimus, azothioprine and A ...
Slides - View the full AIDS 2016 programme
... • Revaccination with PPSV23 at least five years • PCV13 can be given at any CD4 cell count, but it may be preferable to defer PPSV23 administration until the CD4 cell count ≥200 • PPSV23 only for >65 years or additional co-morbidities (other than HIV) ...
... • Revaccination with PPSV23 at least five years • PCV13 can be given at any CD4 cell count, but it may be preferable to defer PPSV23 administration until the CD4 cell count ≥200 • PPSV23 only for >65 years or additional co-morbidities (other than HIV) ...
Lecture 2
... such as Staphylococcus , Burkholderia cepacia , Nocardia , Mycobacteria, Serratia , Klebsiella , Pseudomonas species, and fungi, especially Aspergillus species and Candida . • Recurrent bacterial and fungal infections result in lymphadenitis, abscesses, and granuloma formation, with most patients pr ...
... such as Staphylococcus , Burkholderia cepacia , Nocardia , Mycobacteria, Serratia , Klebsiella , Pseudomonas species, and fungi, especially Aspergillus species and Candida . • Recurrent bacterial and fungal infections result in lymphadenitis, abscesses, and granuloma formation, with most patients pr ...
Key Questions for Understanding the Blood
... of leukemia? When bone marrow becomes cancerous and huge numbers of WBC’s are “turned out” rapidly, the body becomes sensitive to bacteria and viruses because the WBC’s are incapable of normal activities. ...
... of leukemia? When bone marrow becomes cancerous and huge numbers of WBC’s are “turned out” rapidly, the body becomes sensitive to bacteria and viruses because the WBC’s are incapable of normal activities. ...
Regulation of the immune response by programmed cell death
... mice with the human fibroblast cell line FS-7, and then screened an expression library for the anti-human IFN receptor. He accidentally found an mAb that had a cytopathic activity against human FL cells. The antigen recognized by the antibody was designated as the Fas antigen (FS-7-associated surfac ...
... mice with the human fibroblast cell line FS-7, and then screened an expression library for the anti-human IFN receptor. He accidentally found an mAb that had a cytopathic activity against human FL cells. The antigen recognized by the antibody was designated as the Fas antigen (FS-7-associated surfac ...
Immune System: Cytokines
... central role in the immune system, cytokines are involved in a variety of immunological, inflammatory, and infectious diseases. However, not all their functions are limited to the immune system, as they are also involved in several developmental processes during embryogenesis. When the immune system ...
... central role in the immune system, cytokines are involved in a variety of immunological, inflammatory, and infectious diseases. However, not all their functions are limited to the immune system, as they are also involved in several developmental processes during embryogenesis. When the immune system ...
corporate overview
... Verastem’s strategy, future plans and prospects, including statements regarding the development and activity of Verastem’s investigational product candidates, including duvelisib and defactinib, and Verastem’s PI3K and FAK programs generally, the structure of our planned and pending clinical trials ...
... Verastem’s strategy, future plans and prospects, including statements regarding the development and activity of Verastem’s investigational product candidates, including duvelisib and defactinib, and Verastem’s PI3K and FAK programs generally, the structure of our planned and pending clinical trials ...
Lymphatic System
... Cytokines Signaling molecules produced by lymphocytes, monocytes, or other cells Both interferon and interleukins have been used as immunotherapeutic drugs Enhance the ability of the individual’s T cells (and B cells) to fight cancer ...
... Cytokines Signaling molecules produced by lymphocytes, monocytes, or other cells Both interferon and interleukins have been used as immunotherapeutic drugs Enhance the ability of the individual’s T cells (and B cells) to fight cancer ...
Photosynthesis
... Cytokines Signaling molecules produced by lymphocytes, monocytes, or other cells Both interferon and interleukins have been used as immunotherapeutic drugs Enhance the ability of the individual’s T cells (and B cells) to fight cancer ...
... Cytokines Signaling molecules produced by lymphocytes, monocytes, or other cells Both interferon and interleukins have been used as immunotherapeutic drugs Enhance the ability of the individual’s T cells (and B cells) to fight cancer ...
A Mathematical Model for within-host Toxoplasma gondii Invasion
... immunocompetent patients, the infection enters a latent phase, during which tissue cysts may form in the brain and muscle. Recent studies show that latent Toxoplasmosis may have significant effects on human behavior and may lead to neuropsychiatric disorders, e.g. schizophrenia. In addition, infecti ...
... immunocompetent patients, the infection enters a latent phase, during which tissue cysts may form in the brain and muscle. Recent studies show that latent Toxoplasmosis may have significant effects on human behavior and may lead to neuropsychiatric disorders, e.g. schizophrenia. In addition, infecti ...
Elements of Adaptive Immunity
... • B Lymphocytes (B Cells) and Antibodies – Specificity and antibody structure – Antibodies are immunoglobulins similar to BCRs – Antibodies: secreted form, no transmembrane domain – BCR: membrane-bound form, with transmembrane domain – Secreted by activated B cells called plasma cells – Have identic ...
... • B Lymphocytes (B Cells) and Antibodies – Specificity and antibody structure – Antibodies are immunoglobulins similar to BCRs – Antibodies: secreted form, no transmembrane domain – BCR: membrane-bound form, with transmembrane domain – Secreted by activated B cells called plasma cells – Have identic ...
The intestinal immune system
... Most studies of isolated GALT cells have been performed using Peyer's patch cells. Whether these reflect the function of all organised GALT is unknown. The dome of Peyer's patches is covered by a unique epithelium comprising cuboidal epithelial cells which express class II MHC antigens, very few gob ...
... Most studies of isolated GALT cells have been performed using Peyer's patch cells. Whether these reflect the function of all organised GALT is unknown. The dome of Peyer's patches is covered by a unique epithelium comprising cuboidal epithelial cells which express class II MHC antigens, very few gob ...
PLoS Pathog
... In the process of evolution, the mucosal immune system has generated two layers of antiinflammatory defence: (1) immune exclusion performed by secretory IgA (and secretory IgM) antibodies to modulate or inhibit surface colonisation of microorganisms and dampen penetration of potentially dangerous an ...
... In the process of evolution, the mucosal immune system has generated two layers of antiinflammatory defence: (1) immune exclusion performed by secretory IgA (and secretory IgM) antibodies to modulate or inhibit surface colonisation of microorganisms and dampen penetration of potentially dangerous an ...
Allergic sensitization: host-immune factors R E V I E W Open Access
... epithelial layer. Allergic inflammatory diseases are accompanied by increased permeability of the epithelium, which is more susceptible to environmental triggers. Allergens and co-factors from the environment interact with innate immune receptors, such as Toll-like and protease-activated receptors o ...
... epithelial layer. Allergic inflammatory diseases are accompanied by increased permeability of the epithelium, which is more susceptible to environmental triggers. Allergens and co-factors from the environment interact with innate immune receptors, such as Toll-like and protease-activated receptors o ...
Network Immunology - University of British Columbia
... The symmetrical network theory is introduced in Chapter 10. This chapter describes how much of the important phenomenology can be understood in terms of this most complete version of network theory. The central role of mathematical modelling in finding a self-consistent theory is also made clear in ...
... The symmetrical network theory is introduced in Chapter 10. This chapter describes how much of the important phenomenology can be understood in terms of this most complete version of network theory. The central role of mathematical modelling in finding a self-consistent theory is also made clear in ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.