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学生课件二
学生课件二

... Inject recombined receptor cell to patient body , so express the exogenous gene in patient Direct gene therapy Inject the exogenous gene to the patient body directly, and make it transcript and express . ...
Principal component analysis and correlative adaptometry used in
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... The immune system is very important in overcoming the influence of harmful factors by human organism. This is one of the three integrative systems of the organism, which provides maintenance of homeostasis together with the nervous and endocrine systems [1]. The immune system is a unique natural prot ...
Chapter 21 The Lymphatic System
Chapter 21 The Lymphatic System

... and diseased host cells Involves 4 classes of T cells Cytotoxic (killer) T cells: carry out attack Helper T cells: help promote T cell and B cell action and nonspecific defense mechanisms Suppressor T cells: limit cell mediated attack Memory T cells: provide immunity from future exposure to antigen ...
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Activated B Cell

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Innate Immune System

... is a potent initiator of inflammation. C5b goes on to complex with other complement proteins to form the membrane attack complex MAC (C5b6789n) which inserts into the cell membrane and lyses infected cells. 7. What are phagocytes and what are their functions? What groups of bacteria can avoid their ...
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... It is widely known that the subset of T cells that are CD4+CD25+ regulate the activity of other T cells. The ability of these Regulatory T cells (Treg) to suppress an immune response via educating the effector T cells (Teff) is a trait that has potential utility to treat various autoimmune diseases ...
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... b) B cells c) killer T cells d) macrophages e) antigen presenting cells 40. T cell maturation occurs in what area of the lymphatic system? a) spleen b) liver c) thymus d) lymph nodes e) all of the above 41. An antigen is: a) part of a T cell that reconizes foreign tissue b) part of a B cell that rec ...
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... Lymphocytes are a type of agranular WBC found in the body. They are of two types namely B lymphocytes and T lymphocytes. 4. Explain the role of B lymphocytes. They proliferate on coming in contact with an antigen. Most of them differentiate into antibody producing plasma cells which is called primar ...
late onset
late onset

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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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