Control of neutrophil inflammation at mucosal surfaces by secreted
... by the apical junction complex, which consists of proteins from adjacent cells interacting to form the tight junctions and adherens junctions [reviewed in (16)]. Crossing this barrier is necessary for neutrophils to defend against extracellular pathogens in the lumen, and also plays an important rol ...
... by the apical junction complex, which consists of proteins from adjacent cells interacting to form the tight junctions and adherens junctions [reviewed in (16)]. Crossing this barrier is necessary for neutrophils to defend against extracellular pathogens in the lumen, and also plays an important rol ...
a case of hashimoto`s thyroiditis with autoimmune haemolytic anaemia
... activation of T cells or B cells or both, resulting in a spectrum of diseases that can target specific organs or affect the body systemically.[8]The initiation of autoimmune events in Hashimoto's thyroiditis may be caused by a molecular mimicry mechanism, abnormal antigen-specific induction of T cel ...
... activation of T cells or B cells or both, resulting in a spectrum of diseases that can target specific organs or affect the body systemically.[8]The initiation of autoimmune events in Hashimoto's thyroiditis may be caused by a molecular mimicry mechanism, abnormal antigen-specific induction of T cel ...
Programme
... diseases, but for a number of important infectious diseases (e.g. HIV/AIDS, cytomegalovirus, dengue, hepatitis C, respiratory syncytial virus infections and infections by Staphylococcus aureus) vaccines are still lacking. For other infectious diseases (e.g. for influenza, tuberculosis, malaria, mump ...
... diseases, but for a number of important infectious diseases (e.g. HIV/AIDS, cytomegalovirus, dengue, hepatitis C, respiratory syncytial virus infections and infections by Staphylococcus aureus) vaccines are still lacking. For other infectious diseases (e.g. for influenza, tuberculosis, malaria, mump ...
Recombinant core proteins of Japanese encephalitis virus as
... and pro-inflammatory mediators released by activated microglia induce neuronal death in JE [2]. The mechanisms of JE viral replication have been extensively studied; nevertheless, little is known about the molecular mechanisms by which viral components modulate host innate immune responses. The geno ...
... and pro-inflammatory mediators released by activated microglia induce neuronal death in JE [2]. The mechanisms of JE viral replication have been extensively studied; nevertheless, little is known about the molecular mechanisms by which viral components modulate host innate immune responses. The geno ...
IC31 and IC30, novel types of vaccine adjuvant based on peptide
... The potent function of polycationic peptides as cellular delivery systems has been recognized for several years. For example, a complex with a transfering polycation was able to transport bacterial DNA into cells [3]. Polycationic compounds have also been used previously to transport proteins, such ...
... The potent function of polycationic peptides as cellular delivery systems has been recognized for several years. For example, a complex with a transfering polycation was able to transport bacterial DNA into cells [3]. Polycationic compounds have also been used previously to transport proteins, such ...
Peroxisome proliferator–activated receptor (PPAR){alpha
... mice have shown that this propensity to develop Th1 immunity also helps females clear certain viruses (i.e., Theilers murine encephalomyelitis and herpes simplex virus-1) more effectively (14–16). Whether gender differences also exist in the development of Th17 immunity is not known. Although the m ...
... mice have shown that this propensity to develop Th1 immunity also helps females clear certain viruses (i.e., Theilers murine encephalomyelitis and herpes simplex virus-1) more effectively (14–16). Whether gender differences also exist in the development of Th17 immunity is not known. Although the m ...
Papillary Renal Cell Carcinoma Presenting with Hemoptysis
... • Tumors often express proteins that can be recognized as foreign by the immune system – Mutated proteins, developmental/tissue restricted proteins, etc. ...
... • Tumors often express proteins that can be recognized as foreign by the immune system – Mutated proteins, developmental/tissue restricted proteins, etc. ...
INSTITUT PASTEUR, DI, E. COEFFIER 1
... diseases affecting both humans and domestic animals. Most of these diseases are caused by arthropod-borne viruses (arboviruses) which are transmitted from insects to hosts following blood meals. Most of these arboviruses are increasing their geographical area following the extension of their insect ...
... diseases affecting both humans and domestic animals. Most of these diseases are caused by arthropod-borne viruses (arboviruses) which are transmitted from insects to hosts following blood meals. Most of these arboviruses are increasing their geographical area following the extension of their insect ...
Immune disorders
... Type IV Hypersensitivity Transplant rejection MHC molecules antigens are involved Tissue typing looks for a match of Ag’s between the donor and the recipient. Immunosuppression is needed in most transplant situations cyclosporin • suppresses T-cells but does not kill them • has no effect on B- ...
... Type IV Hypersensitivity Transplant rejection MHC molecules antigens are involved Tissue typing looks for a match of Ag’s between the donor and the recipient. Immunosuppression is needed in most transplant situations cyclosporin • suppresses T-cells but does not kill them • has no effect on B- ...
Macrophages in Kidney Injury and Repair
... cognate receptors in this switch are required. It would also be interesting to study the role of the cross talk between the influxed monocytes and local cells in determining the phenotypic switch (102-104). ...
... cognate receptors in this switch are required. It would also be interesting to study the role of the cross talk between the influxed monocytes and local cells in determining the phenotypic switch (102-104). ...
Aksje-Norge - Biotec Pharmacon ASA
... Inoculation of mice with human neuroblastoma cancer cells, leading to development of tumors Treatment with the mAb 3F8 in active and control group SBG in addition to mAb (3F8) in the active group Primary end point: Tumor size (% increase) ...
... Inoculation of mice with human neuroblastoma cancer cells, leading to development of tumors Treatment with the mAb 3F8 in active and control group SBG in addition to mAb (3F8) in the active group Primary end point: Tumor size (% increase) ...
roles in innate immune receptors: host - pathogen
... The CLRs consist of around one thousand members although all of them are not involved in recognition of PAMPs. These receptors typically recognize carbohydrates that are rich in mannose, fucose and glycan. The downstream result of binding to CLRs is often classified as activation of adaptive Th17 or ...
... The CLRs consist of around one thousand members although all of them are not involved in recognition of PAMPs. These receptors typically recognize carbohydrates that are rich in mannose, fucose and glycan. The downstream result of binding to CLRs is often classified as activation of adaptive Th17 or ...
biology bio315116
... ENERGY INPUT / OUTPUT Energy is used by all cells to carry out “work”. All activities of organisms are the result of their metabolism. Energy is used to build new molecules and break up old molecules and as a result all activities of cells use chemical energy. • Capture release and transfer of energ ...
... ENERGY INPUT / OUTPUT Energy is used by all cells to carry out “work”. All activities of organisms are the result of their metabolism. Energy is used to build new molecules and break up old molecules and as a result all activities of cells use chemical energy. • Capture release and transfer of energ ...
Document
... responsible for promoting the uptake of antigen into antigenpresenting cells (APCs). A direct effect on cytokine levels in vivo has been observed. Recent studies have confirmed the ability of MF59 to have a direct effect on immune cells, triggering the release of chemokines and other factors respons ...
... responsible for promoting the uptake of antigen into antigenpresenting cells (APCs). A direct effect on cytokine levels in vivo has been observed. Recent studies have confirmed the ability of MF59 to have a direct effect on immune cells, triggering the release of chemokines and other factors respons ...
PDF - The Journal of Experimental Medicine
... allele had been selectively lost. This was not part of a widespread series of such genetic changes, but instead was focused on these genes, suggesting a strong selective pressure to lose signaling from the interferon-γ receptor (Zaretsky et al., 2016). In addition to the loss of the adaptive immune ...
... allele had been selectively lost. This was not part of a widespread series of such genetic changes, but instead was focused on these genes, suggesting a strong selective pressure to lose signaling from the interferon-γ receptor (Zaretsky et al., 2016). In addition to the loss of the adaptive immune ...
Altered frequency and migration capacity of CD4
... that the brightest 2% of the CD25+ population contains most of the Tregs [19], the CD25+ brightest subset was studied further. Notably, the absolute numbers of Tregsbright were significantly decreased in patients with SLE (18.1 2.4 cells/l, P < 0.0001) and patients with RA (43.9 5.4 cells/l, P ...
... that the brightest 2% of the CD25+ population contains most of the Tregs [19], the CD25+ brightest subset was studied further. Notably, the absolute numbers of Tregsbright were significantly decreased in patients with SLE (18.1 2.4 cells/l, P < 0.0001) and patients with RA (43.9 5.4 cells/l, P ...
Platelets: killers of parasites or patients?
... the aim of searching for potential infectious agents in children who later developed ALL. No clear association between infections with DNA viruses in utero and development of ALL was found.10 In this study, ALL as a diagnostic group was analyzed. The authors state that they did not analyze ALL subgr ...
... the aim of searching for potential infectious agents in children who later developed ALL. No clear association between infections with DNA viruses in utero and development of ALL was found.10 In this study, ALL as a diagnostic group was analyzed. The authors state that they did not analyze ALL subgr ...
Canine Herpesvirus-1: A New Pathogenic Role for an Old Virus
... dogs also spark a response in the immune system’s ability to function. Today, there’s a shift from malnutrition to over nutrition, which will also cause stress to the immune system. So then the question, why would it be necessary to enhance a dog through supplements that is already healthy? Lifestag ...
... dogs also spark a response in the immune system’s ability to function. Today, there’s a shift from malnutrition to over nutrition, which will also cause stress to the immune system. So then the question, why would it be necessary to enhance a dog through supplements that is already healthy? Lifestag ...
Proliferation T Cell + Nonredundantly Stimulates CD8
... to stimulate CD8⫹ T cell proliferation, we first investigated whether immunization with a T cell-dependent Ag, GaMD, or inoculation with the nematode parasite N. brasiliensis would have this effect. Mice were immunized with GaMD or inoculated with N. brasiliensis because these stimuli induce strong ...
... to stimulate CD8⫹ T cell proliferation, we first investigated whether immunization with a T cell-dependent Ag, GaMD, or inoculation with the nematode parasite N. brasiliensis would have this effect. Mice were immunized with GaMD or inoculated with N. brasiliensis because these stimuli induce strong ...
