Goblet Cells and Mucins: Role in Innate Defense
... stem cells and differentiation into specific cell lineages in the intestine involves a complex interplay of multiple developmental pathways including Wnt/β-catenin, bone morphogenic protein (BMP), and PI3-kinase/Akt signaling [20]. Basic helix-loop-helix (bHLH) gene Math1 is a mammalian homolog of t ...
... stem cells and differentiation into specific cell lineages in the intestine involves a complex interplay of multiple developmental pathways including Wnt/β-catenin, bone morphogenic protein (BMP), and PI3-kinase/Akt signaling [20]. Basic helix-loop-helix (bHLH) gene Math1 is a mammalian homolog of t ...
TOLL-like receptors linking innate and adaptive immune response
... Besides LPS, the murine TLR4/MD-2 complex recognises other distantly related substances, including the diterpene taxol, a widely used anticancer drug representing a LPS mimic for murine but not for human Mf. Taxol signalling depends on TLR4 (Kawasaki et al., 2000), and MD-2 appears to confer the abo ...
... Besides LPS, the murine TLR4/MD-2 complex recognises other distantly related substances, including the diterpene taxol, a widely used anticancer drug representing a LPS mimic for murine but not for human Mf. Taxol signalling depends on TLR4 (Kawasaki et al., 2000), and MD-2 appears to confer the abo ...
Canine Immune-Mediated Thrombocytopenia
... how complex and variable ITP is, the treatment of each patient is based on the individual presentation. Long term treatment involves the use of immunosuppressive medications and other medications based on clinical signs. Animals are often on medications for 6-8 months after the time of presentation. ...
... how complex and variable ITP is, the treatment of each patient is based on the individual presentation. Long term treatment involves the use of immunosuppressive medications and other medications based on clinical signs. Animals are often on medications for 6-8 months after the time of presentation. ...
sv-lncs
... The Artificial Immune System algorithm (AIRS) can be applied to classification problems, which is a very common real world data mining task. Most other artificial immune system research concerns unsupervised learning and clustering. The only other attempt to use immune systems for supervised learnin ...
... The Artificial Immune System algorithm (AIRS) can be applied to classification problems, which is a very common real world data mining task. Most other artificial immune system research concerns unsupervised learning and clustering. The only other attempt to use immune systems for supervised learnin ...
Mdm2 Promotes Systemic Lupus Erythematosus and
... injections caused severe lymphoproliferation.11–13 We therefore speculated that, beyond its autoantigen and autoadjuvant effects, endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitoge ...
... injections caused severe lymphoproliferation.11–13 We therefore speculated that, beyond its autoantigen and autoadjuvant effects, endogenous DNA might have also a mitogenic effect in SLE, similar to the mitogenic effect of bacterial DNA.14 Bacterial DNA was first described in 1995 as a B cell mitoge ...
Data and Results Graduate Physical and Life Sciences PhD Pharmacology
... Discovered in 2001, Trace Amine Associated Receptor 1 (TAAR1) is a direct target of amphetamine, methamphetamine and MDMA. It is expressed in the brain reward circuity and modulates dopamine transporter function and dopamine neuron firing rates. Newly-developed compounds that specifically target TAA ...
... Discovered in 2001, Trace Amine Associated Receptor 1 (TAAR1) is a direct target of amphetamine, methamphetamine and MDMA. It is expressed in the brain reward circuity and modulates dopamine transporter function and dopamine neuron firing rates. Newly-developed compounds that specifically target TAA ...
Intro to paper (draft)
... at the University of Alberta used nanoparticles as markers to track the interactions of a particular protein (CD45) known to have a role in triggering TCells. (10)It was found via this method that the protein was attached to the cell cytoskeleton, and the particular proteins it was attached to. Ther ...
... at the University of Alberta used nanoparticles as markers to track the interactions of a particular protein (CD45) known to have a role in triggering TCells. (10)It was found via this method that the protein was attached to the cell cytoskeleton, and the particular proteins it was attached to. Ther ...
Lesson Overview
... produced by microorganisms that didn’t normally cause disease. Previously healthy people began to suffer from Pneumocystis carinii pneumonia, Kaposi sarcoma (a rare form of skin cancer), and fungal infections of the mouth and throat. Since these diseases are normally prevented by a healthy immune re ...
... produced by microorganisms that didn’t normally cause disease. Previously healthy people began to suffer from Pneumocystis carinii pneumonia, Kaposi sarcoma (a rare form of skin cancer), and fungal infections of the mouth and throat. Since these diseases are normally prevented by a healthy immune re ...
Introduction to Virology
... Released from virus-infected cells, binds to receptors on nearby uninfected cells Stimulate transcription of genes encoding proteins with antiviral activities INF induced by one kind of virus can inhibit replication of different virus types Species- dependent ...
... Released from virus-infected cells, binds to receptors on nearby uninfected cells Stimulate transcription of genes encoding proteins with antiviral activities INF induced by one kind of virus can inhibit replication of different virus types Species- dependent ...
Trinity™ Multipotential Cellular Bone Matrix
... from which many tissues are formed, including bone, cartilage and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their rel ...
... from which many tissues are formed, including bone, cartilage and muscle as well as components of the circulatory, excretory, reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their rel ...
Optimal Control of Innate Immune Response
... However, innate immunity normally is not adequate for defeating microbes that burrow into cells, such as viruses, intracellular bacteria, and protozoa. The adaptive immune system provides the cellular (or strategic) response to intracellular microbial assault, producing protective cells that remembe ...
... However, innate immunity normally is not adequate for defeating microbes that burrow into cells, such as viruses, intracellular bacteria, and protozoa. The adaptive immune system provides the cellular (or strategic) response to intracellular microbial assault, producing protective cells that remembe ...
poster - Natural Killer Cell Symposium
... Natural killer (NK) cells are lymphocytes of the innate immune system that deliver a selective cytotoxic effect against target cells such as virally infected and tumor cells. NK cell function involves cytokine secretion and tissue remodeling. NK cellular cytotoxicity is delicately balanced by signal ...
... Natural killer (NK) cells are lymphocytes of the innate immune system that deliver a selective cytotoxic effect against target cells such as virally infected and tumor cells. NK cell function involves cytokine secretion and tissue remodeling. NK cellular cytotoxicity is delicately balanced by signal ...
Full Text PDF
... Interleukin-4 IL-4 affects the immune system in many ways. It can directly inhibit the Th1 cell response in a similar way to IL-10, IL-11 or antibodies against TNF. Unlike the mentioned factors which have suppressive properties, IL-4 can directly differentiate Th cells. It is responsible for transfo ...
... Interleukin-4 IL-4 affects the immune system in many ways. It can directly inhibit the Th1 cell response in a similar way to IL-10, IL-11 or antibodies against TNF. Unlike the mentioned factors which have suppressive properties, IL-4 can directly differentiate Th cells. It is responsible for transfo ...
OX40 ligand newly expressed on bronchiolar progenitors mediates
... This is a very interesting paper, suggesting that OX40L can be a receptor for influenza virus and aid infection of bronchial epithelial cells. In general the experiments are quite convincing but additional experiments are needed to solidify and enhance the conclusions. 1. In Figure 1a, the authors s ...
... This is a very interesting paper, suggesting that OX40L can be a receptor for influenza virus and aid infection of bronchial epithelial cells. In general the experiments are quite convincing but additional experiments are needed to solidify and enhance the conclusions. 1. In Figure 1a, the authors s ...
in Children with Autism.
... in late-onset autism Finegold S.M. et al., Clin Infect Dis, 2002 Sep 1;35(Suppl 1):S6-S16 Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with reg ...
... in late-onset autism Finegold S.M. et al., Clin Infect Dis, 2002 Sep 1;35(Suppl 1):S6-S16 Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with reg ...
Lymphatic System - American Academy
... 3. lymph nodes- small masses of tissue that remove pathogens and dead cells from lymph 4. lymph-fluid and particles absorbed by the lymph capillaries ...
... 3. lymph nodes- small masses of tissue that remove pathogens and dead cells from lymph 4. lymph-fluid and particles absorbed by the lymph capillaries ...
Aging of the hematopoietic system
... fail in aging HSCs. Increased autophagy is maintained in aged HSCs [52 ]. Genome-wide expression studies did not reveal major changes in genes essential for maintenance of quiescence in HSCs [8,27], and HSC cycling does not increase with age. Although genetic deletion of stem cell-specific protectiv ...
... fail in aging HSCs. Increased autophagy is maintained in aged HSCs [52 ]. Genome-wide expression studies did not reveal major changes in genes essential for maintenance of quiescence in HSCs [8,27], and HSC cycling does not increase with age. Although genetic deletion of stem cell-specific protectiv ...