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Robert A. Weinberg the biology of
Robert A. Weinberg the biology of

... A linear path of clonal succession oversimplifies the reality of cancer: intra-tumor heterogeneity ...
this PDF file
this PDF file

... School and Harvard School of Engineering ...
CHAPTER 24 The Immune System
CHAPTER 24 The Immune System

... – “Self” is signaled by major histocompatibility complex (MHC), a group of proteins unique to the individual that is present on the surface of cells ...
Chapter 21
Chapter 21

... the development of a single unique cell-surface receptor protein (receptor). a. Each cell can bind to 1 and only 1 kind of antigen. b. Acquired before it meets a foreign antigen. c. Body has millions of immunocompetent cells which will never meet its antigen, and never be involved in immune response ...
Immune System
Immune System

... Complex) molecules  Abnormal cells –like those with viruses – make MHCs which bind to viral proteins  Those antigens are presented on the surface of the ...
Humoral Immunity Antibodies.
Humoral Immunity Antibodies.

... • Antibody dependant cell mediated cytotoxicity: Antibodies attached to target cell cause destruction by non specific immune system cells. ...
External regulation of immune response
External regulation of immune response

Secondary Immune Response
Secondary Immune Response

... Process of clonal selection explain why/how adaptive immune response act against any antigen. •Lymphocyte developed –with antigen receptor. •Then speciallized into B-cell receptor and T-cell receptor. •The receptor can react with specific epitopes of an antigen. •Each of receptor is different /iden ...
skin and immune system
skin and immune system

... •AIDS is an autoimmune disease that results from infection with HIV – Normally healthy patients die from microorganisms that don’t normally cause disease, from extremely rare forms of cancers and pneumonia and from pathogens that healthy people can normally fight off •HIV – a retrovirus – it carries ...
Biology 2201
Biology 2201

... immune response act against any antigen. •Lymphocyte developed –with antigen receptor. •Then speciallized into B-cell receptor and T-cell receptor. •The receptor can react with specific epitopes of an antigen. •Each of receptor is different /identical. •Therefore cell has only one antigen specificit ...
(Innate) Immunity Lecture
(Innate) Immunity Lecture

DISEASE - IMMUNE SYSTEM
DISEASE - IMMUNE SYSTEM

...  You were given a vaccination for polio so your body built up antibodies to the polio antigen  Active immunity is long lasting. It develops in two ways:  (i) when a person had the disease  (ii) by vaccination of a weakened or milder form of the ...
Introduction to Blood
Introduction to Blood

... (MTOC), as well as the secretory apparatus, including the Golgi (GA). The GA-derived lytic granules (stained in red in the photomicrograph) are specifically directed onto the target cell. ...
Chapter 13
Chapter 13

... Immunity: Cells That Plan for the ...
Folie 1
Folie 1

... Methods: A 67 yrs. old male was treated with cART ca. 3 months after HIV exposure and 1 month after seroconversion for a total of 5,5 yrs.; cART was stopped in May 2004 and the patient remained BLOD(< 20 c/ml) and shows normal T cell counts and distribution without ART since 9 years. We performed co ...
6mb
6mb

... It must detect self versus non-self It must differentiate different forms of non-self Antigen (Ag)- the molecule or structure against which the immune response is directed The immune response only sees bio-organic molecules The antigenic universe is incredibly diverse This diversity must be overcome ...
Immune System
Immune System

... allow them to only recognize & target a specific Ag; this process is known as “antigen recognition”  Versatility – millions of different lymphocyte populations, each with specific Ag recognizing receptors; allows for “anticipation” of potential Ag’s ...
lecture08_C
lecture08_C

... • How are antibodies made? – B cells • Lymphocytes that make antibodies • Have B cell receptors on surface • 100 million different types of B cells, each with different surface receptors • B cell receptors are so diverse they can recognize every organic molecule ...
Pathogens and the immune system
Pathogens and the immune system

... • Which components of your kit are most like antibodies? • Arrange the components of the kit to demonstrate how these antibodies “bridge” a pathogen and the tool to kill it? ...
Chp.7 Immune Lec
Chp.7 Immune Lec

10 Hypersensitivity.
10 Hypersensitivity.

... Antigen-IgE complexes form on a small scale, and not enough mediator is released to produce a major reaction. This permits the administration of a drug or foreign protein to a hypersensitive person, but hypersensitivity is restored days or weeks later. involves the long-term weekly administration of ...
Concept check 31 - Plain Local Schools
Concept check 31 - Plain Local Schools

... B cells defend against bacteria and viruses by secreting antibiotics (humoral). T cells directly attack infected cells (cell-mediated immunity) 3. Explain why a second exposure to chicken pox does not usually result in illness. Memory B and T cells rapidly produce large number of plasma cells and cy ...
Animal Organ Systems
Animal Organ Systems

... Animal Organ Systems • Anatomy and Physiology ...
328 Comparative evolutionary analysis of IL6 in lagomorphs F
328 Comparative evolutionary analysis of IL6 in lagomorphs F

... single individual, but successfully pass between individuals becoming a contagious cancer derived from a single neoplastic cell. Devil Facial Tumour Disease (DFTD) is one such contagious cancer that has emerged in the Tasmanian devil, a carnivorous marsupial endemic to the island of Tasmania. Despit ...
Topic 6.3 Defence against infectious disease
Topic 6.3 Defence against infectious disease

... Involves production of antibodies against foreign antigens. Antibodies are produced by a subset of lymphocytes called B cells. B cells that are stimulated will actively secrete antibodies and are called plasma cells. Antibodies are found in extracellular fluids (blood plasma, lymph, mucus, etc.) and ...
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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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