STUDIES OF MUCOSAL IMMUNE REGULATION ANNE LAHDENPERÄ
... Background: Celiac disease (CD) and type 1 diabetes (T1D) are two chronic autoimmune diseases with increasing incidence worldwide. A combination of genetic, environmental and immunological factors is considered to be involved in development of the diseases, even though the exact disease mechanisms s ...
... Background: Celiac disease (CD) and type 1 diabetes (T1D) are two chronic autoimmune diseases with increasing incidence worldwide. A combination of genetic, environmental and immunological factors is considered to be involved in development of the diseases, even though the exact disease mechanisms s ...
Title of Presentation
... So Far, Seems Like This is the Real Deal • However, I have a lot of concerns… – Does CCSVI occur more often in MS than in normal age/sex matched controls? – How can this be reliably diagnosed today? – If you successfully repair the stenosis (es), does the patient get better? • If so, for how long? ...
... So Far, Seems Like This is the Real Deal • However, I have a lot of concerns… – Does CCSVI occur more often in MS than in normal age/sex matched controls? – How can this be reliably diagnosed today? – If you successfully repair the stenosis (es), does the patient get better? • If so, for how long? ...
Murine gammaherpesvirus-68 productively infects immature
... The maturation state of DCs affects their susceptibility to productive cHV-68 infection To investigate the susceptibility of DCs of different maturation states to cHV-68 infection, we first isolated and cultured DCs from C57BL/6 bone marrow. After 8 days of culture, the ex vivo-expanded DCs were lef ...
... The maturation state of DCs affects their susceptibility to productive cHV-68 infection To investigate the susceptibility of DCs of different maturation states to cHV-68 infection, we first isolated and cultured DCs from C57BL/6 bone marrow. After 8 days of culture, the ex vivo-expanded DCs were lef ...
Kuby`s Immunology
... animal and a bone marrow chimera animal? What is the importance of a bone marrow chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
... animal and a bone marrow chimera animal? What is the importance of a bone marrow chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
The functional network of ion channels in T lymphocytes
... 15 years passed by from the first detection of CRAC current to the identification of molecules that underlie it. Fig. 3A illustrates Kv1.3 and CRAC current in a Jurkat T cell. Although physiologically the CRAC channel is triggered in lymphocytes and mast cells by IP3-induced depletion of the ER Ca2+ ...
... 15 years passed by from the first detection of CRAC current to the identification of molecules that underlie it. Fig. 3A illustrates Kv1.3 and CRAC current in a Jurkat T cell. Although physiologically the CRAC channel is triggered in lymphocytes and mast cells by IP3-induced depletion of the ER Ca2+ ...
BIOGRAPHICAL SKETCH Santambrogio, Laura
... Principal Investigator: Laura Santambrogio Agency: Italian Multiple Sclerosis Society Period: 01/01/1996 – 01/01/1999 “Role of Exosomes in HIV release from multivesicular bodies in CNS microglial cells” Principal Investigator: Laura Santambrogio Agency: NIH (CFAR Pilot Project) Period: 08/01/2004-12 ...
... Principal Investigator: Laura Santambrogio Agency: Italian Multiple Sclerosis Society Period: 01/01/1996 – 01/01/1999 “Role of Exosomes in HIV release from multivesicular bodies in CNS microglial cells” Principal Investigator: Laura Santambrogio Agency: NIH (CFAR Pilot Project) Period: 08/01/2004-12 ...
Canine Vaccines:
... Neutralizing Antibody Titers of 9 Dogs (5-6 years old) Previously Vaccinated with Commercial Rabies Vaccines at 0.5, 1.5, 2.5 and 5.5 (6 year olds) Years (T. Tims et al., Vaccine 18:2804-2807 [2000] ) ...
... Neutralizing Antibody Titers of 9 Dogs (5-6 years old) Previously Vaccinated with Commercial Rabies Vaccines at 0.5, 1.5, 2.5 and 5.5 (6 year olds) Years (T. Tims et al., Vaccine 18:2804-2807 [2000] ) ...
An Innate Immune System for the Protection of
... basophiles, etc.), which recognizes, attacks, engulfs, and finally kills antigens. The innate, or native, response is a non antigen-specific barrier of the immune system, meant to fight against any infection without the need of previous immunization. Its response consists in actions of two different ...
... basophiles, etc.), which recognizes, attacks, engulfs, and finally kills antigens. The innate, or native, response is a non antigen-specific barrier of the immune system, meant to fight against any infection without the need of previous immunization. Its response consists in actions of two different ...
Absence of cellular responses to a putative autoantigen in
... filarial intensity. Clear columns represent proliferative reautoreactive T cells are sequestered in ocular tissues sponses to Ov39 in subjects infected with Onchocerca volvulus and cannot be detected in assays using peripheral without chorioretinopathy, and shaded columns denote reblood. This seems ...
... filarial intensity. Clear columns represent proliferative reautoreactive T cells are sequestered in ocular tissues sponses to Ov39 in subjects infected with Onchocerca volvulus and cannot be detected in assays using peripheral without chorioretinopathy, and shaded columns denote reblood. This seems ...
Systems biology in vaccine design
... is a biological preparation that improves immunity to a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antige ...
... is a biological preparation that improves immunity to a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antige ...
Effects of Ionizing Radiation — UNSCEAR 2006 Report, Volume II
... 2. Peripheral lymphoid tissues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. Remarks concerning organs and tissues of the immune system . . . . . . . . . ...
... 2. Peripheral lymphoid tissues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. Remarks concerning organs and tissues of the immune system . . . . . . . . . ...
Chapter 13
... network has been likened to a circus tent, in which I-J is the centre-pole, and the anti-MHC class II clones are the canvas. The centre-pole is stabilized by the presence of the canvas and vice versa. This model solves some of the main parts of the I-J puzzle, as I described in references 65 and 66 ...
... network has been likened to a circus tent, in which I-J is the centre-pole, and the anti-MHC class II clones are the canvas. The centre-pole is stabilized by the presence of the canvas and vice versa. This model solves some of the main parts of the I-J puzzle, as I described in references 65 and 66 ...
T/F HIV-1 Bx11 - International AIDS Society
... was induced following HIV-1and infection and was significantly increased by CD4 T-cells The increased immune sensing pDC maturation during pDC/lymphocyte cross talk efficient innate immune responses and may be of able to control viral infection might IFN-αpromote induction was not inhibited followi ...
... was induced following HIV-1and infection and was significantly increased by CD4 T-cells The increased immune sensing pDC maturation during pDC/lymphocyte cross talk efficient innate immune responses and may be of able to control viral infection might IFN-αpromote induction was not inhibited followi ...
Modulating impact of human chorionic gonadotropin hormone on the maturation
... surge, which corresponds to Days 19 –21 of the menstrual cycle. hCG is a heterodimeric placental glycoprotein and is excessively expressed during pregnancy, besides the hormones estrogene and progesterone. The ␣-subunit is identical to that of other glycoprotein hormones, such as thyroid-stimulating ...
... surge, which corresponds to Days 19 –21 of the menstrual cycle. hCG is a heterodimeric placental glycoprotein and is excessively expressed during pregnancy, besides the hormones estrogene and progesterone. The ␣-subunit is identical to that of other glycoprotein hormones, such as thyroid-stimulating ...
A Review Part-1 (Experimental Studies)
... 7 and day 14 respectively. IgE release assay was then performed with the serum of mice collected on day 7, 14 and 21. Cetrizine (10 mg/kg), a widely used anti allergic drug was used as positive control. It was observed that serum IgE levels rose significantly 26 and 39 fold at 14 and 21 day, respect ...
... 7 and day 14 respectively. IgE release assay was then performed with the serum of mice collected on day 7, 14 and 21. Cetrizine (10 mg/kg), a widely used anti allergic drug was used as positive control. It was observed that serum IgE levels rose significantly 26 and 39 fold at 14 and 21 day, respect ...
Bovine herpesvirus glycoprotein D: a review of its structural
... after injection of native or deglycosylated forms of gD in rabbits and measurement of the delayed-type hypersensitivity (DTH) response where a stronger DTH reaction in deglycosylated gD-vaccinated rabbits was observed. In contrast, the total antibody response to gD after carbohydrate removal was low ...
... after injection of native or deglycosylated forms of gD in rabbits and measurement of the delayed-type hypersensitivity (DTH) response where a stronger DTH reaction in deglycosylated gD-vaccinated rabbits was observed. In contrast, the total antibody response to gD after carbohydrate removal was low ...
Killed but metabolically active microbes: a new vaccine paradigm for
... given on 3 consecutive days induced 3.8% OVAspecific CD8+ T cells. In contrast, vaccination Figure 3 S-59/UVA Lm ∆actA∆uvrAB-OVA elicit functional CD8+ T cells in vaccinated mice and protect with S-59/UVA Lm ∆act-OVA or heat-killed against a subsequent viral challenge. (a) OVA-specific CD8+ T-cell r ...
... given on 3 consecutive days induced 3.8% OVAspecific CD8+ T cells. In contrast, vaccination Figure 3 S-59/UVA Lm ∆actA∆uvrAB-OVA elicit functional CD8+ T cells in vaccinated mice and protect with S-59/UVA Lm ∆act-OVA or heat-killed against a subsequent viral challenge. (a) OVA-specific CD8+ T-cell r ...
Initiation and Regulation of Type 2 Immunity and Inflammation at
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
... gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediated immunity, antigen presentation by CD11c+ cells is insufficient to generate protective type 2 immune ...
Full-Text PDF
... The intestinal microbiota provides energy and nutrients to the host through the breakdown of nondigestible products in the large intestine [41]. Additionally, intestinal bacteria play an important metabolic role through synthesising vitamins K and B12, folic acid [41] and short-chain fatty acids (SC ...
... The intestinal microbiota provides energy and nutrients to the host through the breakdown of nondigestible products in the large intestine [41]. Additionally, intestinal bacteria play an important metabolic role through synthesising vitamins K and B12, folic acid [41] and short-chain fatty acids (SC ...
chapter 5 complement
... causes cholera) by immune sera, and found that the ability of an immune serum to lyse its targets was lost upon heating (e.g., at 56° C for 30 min). This ability to cause lysis was also lost after simple storage of the serum for a few days at room temperature. Bordet showed that such heating did not ...
... causes cholera) by immune sera, and found that the ability of an immune serum to lyse its targets was lost upon heating (e.g., at 56° C for 30 min). This ability to cause lysis was also lost after simple storage of the serum for a few days at room temperature. Bordet showed that such heating did not ...