Doctoral thesis from the Department of Immunology,
... lysosomes; avoid exposure to the bactericidal mechanisms within lysosomes; prevent degradation and hence processing and presentation of mycobacterial antigens to the immune system [20]. Another mechanism by which mycobacteria could interfere with phagolysosomal fusion is by retention of an important ...
... lysosomes; avoid exposure to the bactericidal mechanisms within lysosomes; prevent degradation and hence processing and presentation of mycobacterial antigens to the immune system [20]. Another mechanism by which mycobacteria could interfere with phagolysosomal fusion is by retention of an important ...
Pattern recognition receptors: sentinels in innate - e
... domains. IRAK-4 is essential for activation of TLR-mediated signaling and once activated, IRAK-4 subsequently activates IRAK-1 and/or IRAK-2 by phosphorylation, which is followed by recruitment of TNF receptor-associated factor 6 (TRAF6) [71–74] . TRAF6 is a ubiquitin E3 ligase and in conjunction wi ...
... domains. IRAK-4 is essential for activation of TLR-mediated signaling and once activated, IRAK-4 subsequently activates IRAK-1 and/or IRAK-2 by phosphorylation, which is followed by recruitment of TNF receptor-associated factor 6 (TRAF6) [71–74] . TRAF6 is a ubiquitin E3 ligase and in conjunction wi ...
Sperm-based contraceptive vaccine for wild rabbit
... A further fertility trial with the laboratory rabbit confirmed the efficacy of the vaccine with overall a ~ 3 fold reduction in fertility rate compared with controls. Prolonged immunisation of laboratory rabbits (n=6) over 18 months caused no ill effects or gross pathological changes to major organs ...
... A further fertility trial with the laboratory rabbit confirmed the efficacy of the vaccine with overall a ~ 3 fold reduction in fertility rate compared with controls. Prolonged immunisation of laboratory rabbits (n=6) over 18 months caused no ill effects or gross pathological changes to major organs ...
crosstalk between epithelial cells and macrophages - DORAS
... with anti-inflammatory and immunosuppressive effects of TNF-α. Our in vivo study on DSS-induced colitis in mice also demonstrated regulation of TNFR2 in the later stage of colitis, correlating with disease resolution. Furthermore, we provide evidence that TNFR2 is also involved in the resolution of ...
... with anti-inflammatory and immunosuppressive effects of TNF-α. Our in vivo study on DSS-induced colitis in mice also demonstrated regulation of TNFR2 in the later stage of colitis, correlating with disease resolution. Furthermore, we provide evidence that TNFR2 is also involved in the resolution of ...
Psychoneuroimmunology: Psychological Influences
... injections (Schedlowski, Falk, et al., 1993) and likely reflect transient alterations in lymphocyte migration from lymphoid organs and peripheral blood mediated through receptors on lymphocytes or through sympathetic nervous system (SNS) innervation of lymphoid organs like the spleen (Ackerman, Bell ...
... injections (Schedlowski, Falk, et al., 1993) and likely reflect transient alterations in lymphocyte migration from lymphoid organs and peripheral blood mediated through receptors on lymphocytes or through sympathetic nervous system (SNS) innervation of lymphoid organs like the spleen (Ackerman, Bell ...
Baker AAAS talk.pptx
... Aaron B. Baker, Ph.D. Department of Biomedical Engineering University of Texas at Aus3n ...
... Aaron B. Baker, Ph.D. Department of Biomedical Engineering University of Texas at Aus3n ...
Detection of fg/mL Levels of GM
... system. Infection and inflammation cause macrophages, mast cells, and lymphocytes to secrete GM-CSF, which stimulates differentiation of myeloid progenitor cells into immune cells. Chemotherapy patients are sometimes given recombinant GM-CSF (molgramostim or sargramostim) to increase production of w ...
... system. Infection and inflammation cause macrophages, mast cells, and lymphocytes to secrete GM-CSF, which stimulates differentiation of myeloid progenitor cells into immune cells. Chemotherapy patients are sometimes given recombinant GM-CSF (molgramostim or sargramostim) to increase production of w ...
Understanding Endorphins
... perception of pain to flood the system and cause panic, distress, or confusion. These neurotransmitters are polypeptides, meaning that they consist of very short chains of amino acids. Two different enkephalins have been identified: met-enkephalin and leu-enkephalin. An enkephalin is a pentapeptide ...
... perception of pain to flood the system and cause panic, distress, or confusion. These neurotransmitters are polypeptides, meaning that they consist of very short chains of amino acids. Two different enkephalins have been identified: met-enkephalin and leu-enkephalin. An enkephalin is a pentapeptide ...
REVIEWS
... antibodies and drugs are more effective against fungal infections than when either therapy is used alone15,20,23. Consequently, antibody-based therapies could easily be incorporated into existing treatment protocols; however, demonstrating the advantages of combination therapy in rigorous clinical t ...
... antibodies and drugs are more effective against fungal infections than when either therapy is used alone15,20,23. Consequently, antibody-based therapies could easily be incorporated into existing treatment protocols; however, demonstrating the advantages of combination therapy in rigorous clinical t ...
Phagocytosis, a cellular immune response in insects
... active antimicrobial and proinflammatory phenotype. This change is known as activation of phagocytic cells. The signals delivered to the cell by the various receptors determine the final activation stage of the leukocyte. At later times, these activated leukocytes can process and present antigens to ...
... active antimicrobial and proinflammatory phenotype. This change is known as activation of phagocytic cells. The signals delivered to the cell by the various receptors determine the final activation stage of the leukocyte. At later times, these activated leukocytes can process and present antigens to ...
FACTORS INFLUENCING PROSTATE CANCER Review Article SANDEEP SINGH
... The cause for prostate cancer remains unknown but age and family history have some vital role in its genesis. Diagnosis of this cancer in men less than 40 years is extremely difficult but the possibility for detection rises effectively after middle age. Inflammation also may play a role in the forma ...
... The cause for prostate cancer remains unknown but age and family history have some vital role in its genesis. Diagnosis of this cancer in men less than 40 years is extremely difficult but the possibility for detection rises effectively after middle age. Inflammation also may play a role in the forma ...
How do red blood cells know when to die?
... high PS and low CD47 expression are comparable to apoptotic host cells, while those expressing very low levels of CD47 can be likened to foreign cells. Bearing these analogies in mind, we hypothesize the existence of two alternative pathways of RBC phagocytosis that entail different macrophage react ...
... high PS and low CD47 expression are comparable to apoptotic host cells, while those expressing very low levels of CD47 can be likened to foreign cells. Bearing these analogies in mind, we hypothesize the existence of two alternative pathways of RBC phagocytosis that entail different macrophage react ...
Colonization Resistance to Pathogens Cooperate with Immunity To
... (25). Similarly, antibiotic treatment of mice induces substantial changes in the gut metabolome, resulting in an increase in specific carbon sources that support the germination and growth of C. difficile (12). Taken together, these observations indicate that commensal bacteria are best equipped to ...
... (25). Similarly, antibiotic treatment of mice induces substantial changes in the gut metabolome, resulting in an increase in specific carbon sources that support the germination and growth of C. difficile (12). Taken together, these observations indicate that commensal bacteria are best equipped to ...
Section1: The immune system and CD4 count - HIV i-Base
... Most people develop immune cells that specifically try to fight the virus. These are called HIV-specific CD4 cells (or T4 cells). However, these cells get worn out and disappear in most people within 6 months after infection. HIV then continues infecting other CD4 cells. Without HIV treatment (ART), ...
... Most people develop immune cells that specifically try to fight the virus. These are called HIV-specific CD4 cells (or T4 cells). However, these cells get worn out and disappear in most people within 6 months after infection. HIV then continues infecting other CD4 cells. Without HIV treatment (ART), ...
clinical features of leprosy
... EPITHELOID CELLS, PLENTY OF LYMPHOCYTES NARROW CLEAR ZONE BACILLI ARE FEW & ARE FOUND IN NERVES ...
... EPITHELOID CELLS, PLENTY OF LYMPHOCYTES NARROW CLEAR ZONE BACILLI ARE FEW & ARE FOUND IN NERVES ...
Ibrutinib inhibition of Bruton protein
... SH3, SH2, and finally a protein kinase domain. Dysregulation of B cell receptor signaling occurs in several B cell neoplasms including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. Ibrutinib is FDA-approved as first-line or second line treatment for these disea ...
... SH3, SH2, and finally a protein kinase domain. Dysregulation of B cell receptor signaling occurs in several B cell neoplasms including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. Ibrutinib is FDA-approved as first-line or second line treatment for these disea ...
Tài liệu PDF
... The cells of protists are among the most elaborate of all cells. Most protists are microscopic and unicellular, but some true multicellular forms exist. A few protists live as colonies that behave in some ways as a group of free-living cells and in other ways as a multicellular organism. Still other ...
... The cells of protists are among the most elaborate of all cells. Most protists are microscopic and unicellular, but some true multicellular forms exist. A few protists live as colonies that behave in some ways as a group of free-living cells and in other ways as a multicellular organism. Still other ...
- Journal of Clinical Investigation
... influences, these immune responses can lose their typically exquisite specificity for one or a small, finite number of foreign peptides, instead acquiring more generalized reactivity to other antigens, which may include self-peptides (e.g., epitope spread). In other cases, the extrinsic antigens sha ...
... influences, these immune responses can lose their typically exquisite specificity for one or a small, finite number of foreign peptides, instead acquiring more generalized reactivity to other antigens, which may include self-peptides (e.g., epitope spread). In other cases, the extrinsic antigens sha ...
Mucosal IL-17 immunity in disease 12112012
... T cells are CD4 lymphocytes participating in cell-mediated immunity, and play a critical role in immune-mediated diseases. T cells divide further into subclasses such as Th1, Th2, and Th17 that participate in mucosal immunity responses caused by extracellular pathogens and also play a role in autoim ...
... T cells are CD4 lymphocytes participating in cell-mediated immunity, and play a critical role in immune-mediated diseases. T cells divide further into subclasses such as Th1, Th2, and Th17 that participate in mucosal immunity responses caused by extracellular pathogens and also play a role in autoim ...