Crabtree2
... and working backward biochemically from the regulatory regions of the IL-2 gene to the cell membrane. The other pathways such as Map kinase, Jnk, NFkB etc were defined by a candidate gene approach. Calcineurin was recognized to be critical for T cell activation when it was found to be the in vitro a ...
... and working backward biochemically from the regulatory regions of the IL-2 gene to the cell membrane. The other pathways such as Map kinase, Jnk, NFkB etc were defined by a candidate gene approach. Calcineurin was recognized to be critical for T cell activation when it was found to be the in vitro a ...
Cleavage of Anti-Apoptotic Bcl-2 Family Members after TCR
... maintain the integrity of the mitochondrial outer membrane by inhibiting proapoptotic Bax and Bak (18, 19). During apoptosis, Bcl-2 and Bcl-xL can be cleaved by caspases and lose their antiapoptotic functions (20–22). Bcl-2 and Bcl-xL with mutations of the cleavage sites are more efficient in inhibi ...
... maintain the integrity of the mitochondrial outer membrane by inhibiting proapoptotic Bax and Bak (18, 19). During apoptosis, Bcl-2 and Bcl-xL can be cleaved by caspases and lose their antiapoptotic functions (20–22). Bcl-2 and Bcl-xL with mutations of the cleavage sites are more efficient in inhibi ...
Antigen-non-specific regulation centered on CD25+Foxp3+
... often involved in negative feedback. If tolerance has been maintained by antigen-specific Tregs, subsequent antigen challenge may not lead to excessive responses. If excessive responses have been triggered by the dominance of Teff over Treg levels, there may be little chance to generate enough Treg ...
... often involved in negative feedback. If tolerance has been maintained by antigen-specific Tregs, subsequent antigen challenge may not lead to excessive responses. If excessive responses have been triggered by the dominance of Teff over Treg levels, there may be little chance to generate enough Treg ...
Document
... their differentiation into antibody-secreting plasma cells. The secreted antibody (Ab) binds to the antigen and facilitates its clearance from the body. The cell-mediated responses involve various subpopulations of T cells that recognize antigen presented on self-cells. Helper T cells respond to ant ...
... their differentiation into antibody-secreting plasma cells. The secreted antibody (Ab) binds to the antigen and facilitates its clearance from the body. The cell-mediated responses involve various subpopulations of T cells that recognize antigen presented on self-cells. Helper T cells respond to ant ...
PDF - Bentham Open
... This study reveals the therapeutic efficacy and mechanisms of action of the ginger species Halia Bara, or Zingiber officinale Roscoe var. rubrum (ZOR), on key immunopathogenic mechanisms relevant to psoriasis. It is known that psoriasis is a chronic autoimmune skin disease characterised by hyperplas ...
... This study reveals the therapeutic efficacy and mechanisms of action of the ginger species Halia Bara, or Zingiber officinale Roscoe var. rubrum (ZOR), on key immunopathogenic mechanisms relevant to psoriasis. It is known that psoriasis is a chronic autoimmune skin disease characterised by hyperplas ...
Mature Dendritic Cells Derived from Human Monocytes
... protocol, they were equally potent in inducing Ag-specific T cell proliferation and IFN-␥ production as well as in priming autologous naive T cells using tetanus toxoid as a model Ag. These findings indicate that FastDC are as effective as monocytederived DCs in stimulating primary, Ag-specific, Th ...
... protocol, they were equally potent in inducing Ag-specific T cell proliferation and IFN-␥ production as well as in priming autologous naive T cells using tetanus toxoid as a model Ag. These findings indicate that FastDC are as effective as monocytederived DCs in stimulating primary, Ag-specific, Th ...
Immunotherapy of Metastatic Renal Cell Cancer
... phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from an immunological viewpoint, the cancer cell is viewed as a potential target of antibodies, natural killer (NK) cells, or cytotoxic T lymphocytes (CTLs) b ...
... phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from an immunological viewpoint, the cancer cell is viewed as a potential target of antibodies, natural killer (NK) cells, or cytotoxic T lymphocytes (CTLs) b ...
Immunotoxicity derived from manipulating leukocytes with lipid
... nonspecific but must be activated in order to function [7,8]. Macrophages mediate crucial innate immune responses via the clearance mechanism: caspase-1-dependent processing and secretion of interleukin (IL)-1β and IL-18. The second arm of the immune system, the adaptive immune arm, is able to respon ...
... nonspecific but must be activated in order to function [7,8]. Macrophages mediate crucial innate immune responses via the clearance mechanism: caspase-1-dependent processing and secretion of interleukin (IL)-1β and IL-18. The second arm of the immune system, the adaptive immune arm, is able to respon ...
Aplastic anemia (AA) is a bone marrow failure disease, which mainly
... With the continuous improvement of allogeneic hematopoietic stem cell transplantation technology, HSCT has become the most effective for children with SAA[7-8]. The reconstruction of immune function in children requires a long time after transplantation, which means the recovery of various immune ef ...
... With the continuous improvement of allogeneic hematopoietic stem cell transplantation technology, HSCT has become the most effective for children with SAA[7-8]. The reconstruction of immune function in children requires a long time after transplantation, which means the recovery of various immune ef ...
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma
... regression or differentiation in low-stage or stage 4s neuroblastomas, even without therapeutic intervention.1 Neuroblastoma has the highest rate of spontaneous regression observed among human cancers.12 Based on the biological characteristics of neuroblastomas, various mechanisms including delayed ...
... regression or differentiation in low-stage or stage 4s neuroblastomas, even without therapeutic intervention.1 Neuroblastoma has the highest rate of spontaneous regression observed among human cancers.12 Based on the biological characteristics of neuroblastomas, various mechanisms including delayed ...
Overview of the Immune System
... operate independently of each other; they function as a highly interactive and cooperative system, producing a total response more effective than either could alone. ...
... operate independently of each other; they function as a highly interactive and cooperative system, producing a total response more effective than either could alone. ...
Rosacea: skin innate immunity gone awry? - PIEL
... Finally, the findings by Yamasaki et al. suggest that therapeutic agents targeting cathelicidin peptides or SCTE could be useful for the treatment of rosacea. Although a number of treatments exist, many of rosacea’s clinical features, especially the persistent erythema, are difficult to remedy. Inte ...
... Finally, the findings by Yamasaki et al. suggest that therapeutic agents targeting cathelicidin peptides or SCTE could be useful for the treatment of rosacea. Although a number of treatments exist, many of rosacea’s clinical features, especially the persistent erythema, are difficult to remedy. Inte ...
Improvement of adoptive T-cell therapy for Cancer
... Universitatis Upsaliensis. ISBN 978-91-554-9661-6. Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of Tcells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. Patient’s T-cells are isolated, acti ...
... Universitatis Upsaliensis. ISBN 978-91-554-9661-6. Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of Tcells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. Patient’s T-cells are isolated, acti ...
Antibodies from combinatorial libraries use functional receptor
... because most therapeutic antibodies are against selfantigens. Since the ability to circumvent tolerance is one of the key strengths of the combinatorial antibody libraries, it is perhaps worth explaining a little further for the general reader. In terms of theory and practice, immune tolerance is th ...
... because most therapeutic antibodies are against selfantigens. Since the ability to circumvent tolerance is one of the key strengths of the combinatorial antibody libraries, it is perhaps worth explaining a little further for the general reader. In terms of theory and practice, immune tolerance is th ...
Lung cancer-initiating cells: a novel target for cancer therapy
... Putative CICs have been identified in acute myeloid leukemia (AML) [7, 8], and solid tumors of the brain [9, 10] and breast [11], among others. More recently, lung CICs have been isolated from human cell lines and patient samples [12–19]. CICs are posited to share many of the properties of normal so ...
... Putative CICs have been identified in acute myeloid leukemia (AML) [7, 8], and solid tumors of the brain [9, 10] and breast [11], among others. More recently, lung CICs have been isolated from human cell lines and patient samples [12–19]. CICs are posited to share many of the properties of normal so ...
Basic Virology
... * Alpha interferon has been approved for use in patients with (Genital warts) and chronic active hepatitis caused by hepatitis C virus. * Gamma interferon reduces recurrent infections in patients with chronic ...
... * Alpha interferon has been approved for use in patients with (Genital warts) and chronic active hepatitis caused by hepatitis C virus. * Gamma interferon reduces recurrent infections in patients with chronic ...
Mechanism of action of Low Dose Naltrexone (LDN)
... P21 inhibitory pathways of cancer cell division R. N. Donahue, P. J. McLaughlin, I. S. Zagon. Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model. Experimental Biology and Medicine, ...
... P21 inhibitory pathways of cancer cell division R. N. Donahue, P. J. McLaughlin, I. S. Zagon. Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model. Experimental Biology and Medicine, ...
KS4 What is Blood
... Filtration and expulsion of urea Plasma carries the urea from the liver to the kidneys that filter the blood. Urea is removed from the plasma of the blood and passes down a tube to the bladder. ...
... Filtration and expulsion of urea Plasma carries the urea from the liver to the kidneys that filter the blood. Urea is removed from the plasma of the blood and passes down a tube to the bladder. ...
Involvement of Glycoreceptors in Galactoxylomannan-Induced T Cell Death
... by a variety of apoptotic stimuli such as genomic toxicity and cytokine withdrawal, and it is mainly controlled by Bcl-2 protein family members (18, 19). Conversely, the extrinsic pathway is activated by death receptors of the TNF receptor superfamily that, through the activation of caspase-8, lead ...
... by a variety of apoptotic stimuli such as genomic toxicity and cytokine withdrawal, and it is mainly controlled by Bcl-2 protein family members (18, 19). Conversely, the extrinsic pathway is activated by death receptors of the TNF receptor superfamily that, through the activation of caspase-8, lead ...
Heme-Onc Step3 Review
... B-cell lymphoma Translocation of protooncogene C-myc from Chromosome 8 to 14 Presentation: abdominal pain/fullness Retroperitoneal or pelvic lymphadenopathy Treatment: low risk – chemotherapy and high risk – autologous stem cell transplant ...
... B-cell lymphoma Translocation of protooncogene C-myc from Chromosome 8 to 14 Presentation: abdominal pain/fullness Retroperitoneal or pelvic lymphadenopathy Treatment: low risk – chemotherapy and high risk – autologous stem cell transplant ...
lecture 4
... • Allows you to turn a little capture into a visible color change that can be quantified using an absorbance plate reader ...
... • Allows you to turn a little capture into a visible color change that can be quantified using an absorbance plate reader ...