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Immunology Review
Immunology Review

... Greatest quantity is found attached to immunocompetent, unstimulated B lymphocytes. ...
Butyrate and Mucosal Inflammation: New Scientific
Butyrate and Mucosal Inflammation: New Scientific

... Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are bacterial metabolites generated via the fermentation of dietary fibers. Luminal SCFAs are recognized as a preferred energy substrate for the colonic epithelium. As early as the 1980s, SCFAs were observed to offer therape ...
Positive and negative regulation of Natural Killer cells: Therapeutic
Positive and negative regulation of Natural Killer cells: Therapeutic

... the primary advantages of murine studies-versus-higher vertebrates is that they are relatively easy to maintain and significantly lower in cost and provide rapid readouts for many disease states, including cancer. The ability to work with the highly characterized mouse genome and genetically identic ...
Immunology at a Glance. 10th Edition. At a Glance Brochure
Immunology at a Glance. 10th Edition. At a Glance Brochure

... 8 Phagocytic cells and the reticuloendothelial system 24 9 Phagocytosis 26 Adaptive immunity (i) The molecular basis 10 Evolution of recognition molecules: the immunoglobulin superfamily 28 11 The major histocompatibility complex 30 12 The T–cell receptor 32 13 Antibody diversifi cation and synthes ...
Boundless Study Slides
Boundless Study Slides

... • cytotoxic T cell a subgroup of lymphocytes (white blood cells) that are capable of inducing death to infected somatic or tumor cells; part of cell-mediated immunity • effector cell a plasma B cell or cytotoxic T cell, which are the main types of cells responsible for the humoral and cellular immun ...
Plasmacytoid dendritic cells and dermatological - HAL
Plasmacytoid dendritic cells and dermatological - HAL

Th17 responses to Mycobacterium tuberculosis are compromised in
Th17 responses to Mycobacterium tuberculosis are compromised in

... infected TLR2-/- animals, 54 days post-infection. In line with the histological analysis, at late ...
FAQ About HSCT (Hematopoietic Stem Cell Therapy) in MS Q. What
FAQ About HSCT (Hematopoietic Stem Cell Therapy) in MS Q. What

... who may be eligible to participate. At least one other trial is in planning stages, but no details are available yet. Outside of clinical trials, there are a few centers where autologous HSCT procedures are typically offered for treating MS. They include Fred Hutchinson Cancer Center in Seattle and ...
Natural killer cell cytotoxicity: how do they pull the trigger?
Natural killer cell cytotoxicity: how do they pull the trigger?

... induces the polarization of secretory lysosomes to the lytic synapse, but not their exocytosis.20 Conversely, binding of the NK receptor CD16 to IgG on opsonized target cells induces exocytosis, but not secretory lysosome polarization.20 Actin polymerization and cytoskeletal reorganization at the ly ...
Data Reveals Plant-Made Flu Vaccine Demonstrates Ability to Elicit
Data Reveals Plant-Made Flu Vaccine Demonstrates Ability to Elicit

... Nicotina enthamiana, a close relative of the tobacco plant. Data appeared in the recent issue of Clinical Immunology, entitled “Influenza virus-like particle vaccines made in Nicotiana enthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens”. The full ...
Antiviral activity of Engystol® and Gripp-Heel®: an in
Antiviral activity of Engystol® and Gripp-Heel®: an in

... GH: 28.6% at 1:5 dilution). Antiviral activity of GrippHeel® against RSV was found only after 2 h pre-incubation (26.1%); also for Para 3, the best inhibitory effect was determined after 2 h (29.2%). Through our evaluation of the prophylactic activity, we observed that the pre-incubation time influe ...
Treatment options for precancerous lesions of the cervix
Treatment options for precancerous lesions of the cervix

... cancer death reside in sub Saharan Africa – SSA have less than 5% of cancer treatment resources ...
2015 Immunology Whitebook - Dalhousie Medical School
2015 Immunology Whitebook - Dalhousie Medical School

The Immune System: Defenders of our Health
The Immune System: Defenders of our Health

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue
TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue

... that there is a continuous and lifelong turnover of perivascular brain macrophages replenished by bone marrow– derived cells. Furthermore, it has been demonstrated that bone marrow cells are recruited to sites of axonal degeneration [4,5] or to beta-amyloid depositions in Alzheimer disease animal mo ...
Understanding Lupus and Auto-Immune Diseases
Understanding Lupus and Auto-Immune Diseases

... Innate immune system: component of the immune system that consists of a set of genetically encoded responses to pathogens and does not change or adapt during the lifetime of the organism. Lupus Erythematosus: an auto-immune chronic inflammatory disease that can affect various parts of the body, espe ...
Regulatory T cells - TARA
Regulatory T cells - TARA

... cells isolated from ovalbumin specific TCR transgenic mice in the presence of IL-10 resulted in the expansion of a population of Tr cells that produced high levels of IL-10 and were capable of suppressing Th1 responses and Th1 mediated autoimmune diseases and called these cells Tr1 cells27. More rec ...
- Nottingham ePrints
- Nottingham ePrints

... Tregs are reduced substantially by cyclophosphamide (C). Low metronomic doses down-regulate the expression of FOXP3 and glucocorticoid-induced TNF receptorrelated proteins and selectively abolish Tregs, without detrimental effects on T effector cells [29,30]. In breast cancer there is evidence of in ...
CD4 T cells promote tissue inflammation via CD40 signaling without
CD4 T cells promote tissue inflammation via CD40 signaling without

... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
Inflammatory Bowel Disease Effector Function in a Murine Model of
Inflammatory Bowel Disease Effector Function in a Murine Model of

... shown to be MyD88 dependent (25). Recently, IL-4 receptor associated kinase, the most proximal downstream signaling molecule after MyD88, has been shown to be essential in eliciting CD4⫹ T cell activation (26). Finally, TLRs modulate Treg proliferation and their ability to suppress T cell activation ...
Immunometabolism governs dendritic cell and macrophage function
Immunometabolism governs dendritic cell and macrophage function

Immunometabolism governs dendritic cell and macrophage function
Immunometabolism governs dendritic cell and macrophage function

SEF_paper3_allergies
SEF_paper3_allergies

... After extensive research Mills realized that the people who were developing a meat allergy were widespread in the southeast, Mid-Atlantic, and Northeast regions of the United States, places where there were also a lot of people with rocky mountain spotted fever caused by a lone star tick. The aller ...
Full Text in English  - Health Science Journals: Indonesia
Full Text in English - Health Science Journals: Indonesia

... 95% of patients carry both HLA alleles, indicating CD is unlikely to develop in person with absent of these HLA alleles.5 In addition, other genetic factors such as abnormality in chromosome 5, 6, 11 and 19 have been investigated.1,5,8 However, direct relation is not clearly defined yet. There are c ...
Analysis of immune deviation elicited by antigens injected
Analysis of immune deviation elicited by antigens injected

... chamber (AC) has been described in detail in the literature.1"7 The main characteristics of anterior chamber-associated immune deviation (ACAID) are impaired delayed-type hypersensitivity (DTH), T cells that suppress DTH, and the inability to produce complement-fixing antibodies.1 Antigenspecific im ...
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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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