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Document
Document

... Also several short peptides that play an unknown role in antibacterial action – Defensins – like scorpion venom taxins – Cecropins and attacins (disrupt cell membrane) – Drosomycin (antifungal) – similar to plant substances – Rapid evolution of some these proteins indicates an ongoing evolutionary a ...
Immunity - MrsCoffinBio
Immunity - MrsCoffinBio

... antibodies pass from mother to baby across placenta or in mother’s milk  critical role of breastfeeding in infant health ...
The Lymphatic System and Body Defenses
The Lymphatic System and Body Defenses

Microbiology – Chapter 15
Microbiology – Chapter 15

... 5. Antibodies tend to react with specific parts of an antigen – called and antigenic determinant or epitope. Size and shape; lock-key just like in enzyme substrate interactions. 6. Small molecules that are too small to cause an immune response are called haptens. Penicillin is an example. By itself, ...
Post streptococcal glomerulonephritis (PSGN)
Post streptococcal glomerulonephritis (PSGN)

... SpeB, a bacterial serine protease enzyme, and NAPIr, a secreted bacterial protein known as “nephritis-associated plasmin receptor”. It is thought that these proteins when present in the kidney precipitate enzymatic damage to the basement membrane and endothelial cell integrity, thus allowing plasma ...
Chapter 15
Chapter 15

... 4 types of T cells  1.  T helper cells (CD4 or T H ) assist other T and B  cells; conductor of immune response  2.  Cytotoxic T cells (CD8 or T C )  destroy foreign  or abnormal cells by secreting perforins that lyse  cells  Video  3.  Delayed hypersensitivity cells (T D ) responsible  ...
Yannick Morias Human African trypanosomias (HAT), also
Yannick Morias Human African trypanosomias (HAT), also

... of -infection. Production of inflammatory compounds, such as TNF, NO and IFN-γ, by myeloid cells and T cells is indispensable to control this first parasite peak and leads to resistance to the -infection. However, when prolonged such immune response results into tissue damage, -especially in the liv ...
ANTIBODY
ANTIBODY

... Half life – 6 – 8 days. Ig A occurs in two forms – Serum Ig A & Secretory Ig A. Serum Ig A is a monomeric 7S molecule.(MW: 160,000), While Ig A in the mucosal surfaces & secretions (Secretory Ig A, MW: 400,000) is a dimer. It is formed by two monomer units joined together by a glycoprotein – J chain ...
Chapter 15: Nonspecific Immunity
Chapter 15: Nonspecific Immunity

PowerPoint to accompany
PowerPoint to accompany

... They have an important role in limiting viral infection in the early phase (before specific immunity is available) ...
Cancers (tumours) are not inherited, nor are they
Cancers (tumours) are not inherited, nor are they

AQA Immunity Booklet Answers
AQA Immunity Booklet Answers

... When an antigen is recognised by a type of white blood cell known as a lymphocyte, the resulting process is known as immunity, the ability of our body to protect itself from a disease that we have already experienced. There are two interlinked types of immunity; Cell mediated immunity and humoural i ...
Name Student ID Oct 29,2015 Choose the BEST alternative. What
Name Student ID Oct 29,2015 Choose the BEST alternative. What

... a. They secrete perforins that create pores in the membrane of target cells b. They secrete cytokines that stimulate growth and activation of B cells. c. They inhibit the immune response. d. They initiate delayed responses to antigens. e. They contribute to the initiation of classical complement pat ...
Specific Immune Response (Chapter 17)  Response in highly specific
Specific Immune Response (Chapter 17) Response in highly specific

... Systemic (anaphylactic shock) with lower blood pressure/fatal within minutes: treat with epinephrine to constrict blood pressure and raise BP Type II Cytotoxic Reactions: activate C΄ and lyse cell Transfusion reactions, HDN (hemolytic disease of newborn), Drug induced (thrombocytopenia purpura) Type ...
Project name: Release of Neutrophil Extracellular Traps (NETs) in
Project name: Release of Neutrophil Extracellular Traps (NETs) in

... NETs may act serving as effective antimicrobial defenses, but also as putative sources of molecules that induce inflammation and may promote tissue damage. Deficient NET formation predisposes humans to severe infection, while uncontrolled NET formation contributes to inflammation, vascular injury an ...
TOPIC: Immunity AIM: How does the immune system protect the
TOPIC: Immunity AIM: How does the immune system protect the

Immune System
Immune System

... IgA: produced by cells in mucous membranes; prevent attachment of viruses/bacteria to epithelial surfaces; also found in saliva, tears, and perspiration IgD: do not activate complement and cannot cross placenta; found on surfaces of B cells; probably help differentiation of B cells into plasma and m ...
5.5_antibodies
5.5_antibodies

Prestigious BMC Cancer journal publishes encouraging
Prestigious BMC Cancer journal publishes encouraging

CD4 and HIV
CD4 and HIV

... Life Cycle of HIV Major Target Cells for HIV Cell surface receptors for HIV CD4 CD4- gp120 Interactions Theories of Immune System cell Loss in HIV infection • Challenges Ahead ...
Th17 Cells
Th17 Cells

... Th2 cells were heavily involved in responses against extracellular pathogens and parasites. Uncontrolled Th1 responses were implicated in autoimmunity and aberrant Th2 responses were associated with allergy and asthma development. However, this model did not explain the observation that a deficiency ...
Week 1
Week 1

antigen presentation clonal selection induction of antibody synthesis
antigen presentation clonal selection induction of antibody synthesis

... the pathogen by a macrophage or dendritic cells. A fragment binds to the MHCII receptor which migrates to the cell surface. The MHCII-peptide complex is recognized by a specific T cell receptor (of which there are many). Binding is facilitated by the surface protein CD4 ( the HIV receptor). The macr ...
T lymphocytes of the normal human cornea
T lymphocytes of the normal human cornea

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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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