Text S1.
... appendix in Versteegh et al, 2005). Pathogens grow exponentially, presentation of antigen to the immune system is proportional to the numbers of pathogens present. In response the immune system produces antibodies with a rate proportional to the amount of circulating antigen. The rate of inactivatio ...
... appendix in Versteegh et al, 2005). Pathogens grow exponentially, presentation of antigen to the immune system is proportional to the numbers of pathogens present. In response the immune system produces antibodies with a rate proportional to the amount of circulating antigen. The rate of inactivatio ...
Presentation
... CONCEPT: Self-antigen is always present but foreign antigens are generally not present at sites of development (due to timing and/or routes of antigen trafficking); therefore developing lymphocytes that see antigen are typically seeing self-antigen Immature B cell + self-antigen: •B cells can contin ...
... CONCEPT: Self-antigen is always present but foreign antigens are generally not present at sites of development (due to timing and/or routes of antigen trafficking); therefore developing lymphocytes that see antigen are typically seeing self-antigen Immature B cell + self-antigen: •B cells can contin ...
Autoimmune diseases
... are the cause of a systemic autoimmune disease called IPEX (an acronym for immune dysregulation, polyendocrinopathy, enteropathy, X-linked). In mice knockout of the gene encoding IL-2 or the IL-2 receptor α or β chain also results in severe multi-organ autoimmunity, because IL-2 is essential for the ...
... are the cause of a systemic autoimmune disease called IPEX (an acronym for immune dysregulation, polyendocrinopathy, enteropathy, X-linked). In mice knockout of the gene encoding IL-2 or the IL-2 receptor α or β chain also results in severe multi-organ autoimmunity, because IL-2 is essential for the ...
Hematopathology
... acute infection • IgA: dimer, present in secretions (saliva, breast milk, tears), protects mucosal surfaces • IgE: monomer, allergic and anti-parasite responses • IgD: monomer, small amount in plasma, triggers initial B-cell activation ...
... acute infection • IgA: dimer, present in secretions (saliva, breast milk, tears), protects mucosal surfaces • IgE: monomer, allergic and anti-parasite responses • IgD: monomer, small amount in plasma, triggers initial B-cell activation ...
Defense Lecture Study ppt File
... 2. Receptor-mediated endocytosis of crosslinked antigen-receptor complexes occurs 3. Stimulated B cell grows to form a clone of identical cells bearing the same antigenspecific receptors (T cells are usually required to help B cells ...
... 2. Receptor-mediated endocytosis of crosslinked antigen-receptor complexes occurs 3. Stimulated B cell grows to form a clone of identical cells bearing the same antigenspecific receptors (T cells are usually required to help B cells ...
Research To Practice
... proceedings from the live CME event and may include the use of trade names and other raw, unedited content. Select slides from the original presentation are omitted where Research To Practice was unable to obtain permission from the publication source and/or author. Links to view the actual referenc ...
... proceedings from the live CME event and may include the use of trade names and other raw, unedited content. Select slides from the original presentation are omitted where Research To Practice was unable to obtain permission from the publication source and/or author. Links to view the actual referenc ...
1. dia
... 2006 - Patients was successfully treated with metastatic melanoma using killer T cells genetically retargeted to attack the cancer cells 2006 - Succesfull gene-based th. for the treatment of HIV: lentiviral vector for delivery of an antisense gene againts ...
... 2006 - Patients was successfully treated with metastatic melanoma using killer T cells genetically retargeted to attack the cancer cells 2006 - Succesfull gene-based th. for the treatment of HIV: lentiviral vector for delivery of an antisense gene againts ...
Document
... – Small molecules act as haptens and complex with skin proteins to be taken up by APCs and presented to Th1 cells to get sensitization. – During secondary exposure Th1 memory cells become activated to cause DTH. ...
... – Small molecules act as haptens and complex with skin proteins to be taken up by APCs and presented to Th1 cells to get sensitization. – During secondary exposure Th1 memory cells become activated to cause DTH. ...
Immunology and Cancer
... Antibody and complement Lymphokines and other cytokines Cell-Mediated Immunity: Cytotoxic T-Cells Natural Killer Cells (NK Cells) Activated Killer Cells Activated macrophages Lymphokine-activated Lymphocytes Granulocytes Combined Humoral and Cell-mediated: Antibody-dependent Cell-mediated Cytotoxici ...
... Antibody and complement Lymphokines and other cytokines Cell-Mediated Immunity: Cytotoxic T-Cells Natural Killer Cells (NK Cells) Activated Killer Cells Activated macrophages Lymphokine-activated Lymphocytes Granulocytes Combined Humoral and Cell-mediated: Antibody-dependent Cell-mediated Cytotoxici ...
RECOMBINANT T-CELL RECEPTOR LIGAND (RTL)
... be a central component in the pathogenesis of autoimmune diseases. CD4+ T-cells are activated when they are presented with small fragments of antigens by major histocompatibility complex (MHC) class II molecules, that are expressed on the surface of antigen-presenting cells (APCs). The APC interacti ...
... be a central component in the pathogenesis of autoimmune diseases. CD4+ T-cells are activated when they are presented with small fragments of antigens by major histocompatibility complex (MHC) class II molecules, that are expressed on the surface of antigen-presenting cells (APCs). The APC interacti ...
IL-1 family - Stanford Translational Medicine
... ras-Erk MAPK cascade and further upregulates the expression of C/EBPβ. Lastly, phosphatidyl-inositol (PI)3-kinase has been described as a signal transducer of IL-6 triggering the activation of Akt and subsequently promoting survival in many cell types. • In addition to membrane-bound IL-6R, a solubl ...
... ras-Erk MAPK cascade and further upregulates the expression of C/EBPβ. Lastly, phosphatidyl-inositol (PI)3-kinase has been described as a signal transducer of IL-6 triggering the activation of Akt and subsequently promoting survival in many cell types. • In addition to membrane-bound IL-6R, a solubl ...
Lymphatic System
... Lymphocytes- are the main warriors of the immune system and they arise in the red bone marrow. T cells and B cells protect against antigen. Activated T cells manage immune response & some attack & and destroy infected cells. B cells- protect the body by producing plasma cells which are daughter cell ...
... Lymphocytes- are the main warriors of the immune system and they arise in the red bone marrow. T cells and B cells protect against antigen. Activated T cells manage immune response & some attack & and destroy infected cells. B cells- protect the body by producing plasma cells which are daughter cell ...
Lecture Notes
... with surface constituents of other cells and this interaction triggers the killer activity of the NK cells. However, they also express another set of receptors whose interactions induce inhibitory signals that prevent target cell killing, and these inhibitory signals are normally dominant over the a ...
... with surface constituents of other cells and this interaction triggers the killer activity of the NK cells. However, they also express another set of receptors whose interactions induce inhibitory signals that prevent target cell killing, and these inhibitory signals are normally dominant over the a ...
Thyroid Autoimmune Diseases:
... -The hallmark of the diagnosis of this disease is the presence of circulating Autoantibodies: 1-Anti-thyroglobulin antibodies. 2-Anti-thyroid peroxidase antibodies. -These antibodies show a sensitivity of 90% and detected ...
... -The hallmark of the diagnosis of this disease is the presence of circulating Autoantibodies: 1-Anti-thyroglobulin antibodies. 2-Anti-thyroid peroxidase antibodies. -These antibodies show a sensitivity of 90% and detected ...
Exam 4 review questions
... The liver’s production of insulinlike growth factors in response to growth hormone, which ...
... The liver’s production of insulinlike growth factors in response to growth hormone, which ...
What is plasmapheresis?
... disease, primarily affects the lungs and kidneys, leading to rapid renal failure. The hallmark of this disorder is the presence of anti-glomerular basement membrane (anti-GBM) antibodies. This antibody is directed toward the α3 chain of type IV collagen, which is found in the basement membrane of re ...
... disease, primarily affects the lungs and kidneys, leading to rapid renal failure. The hallmark of this disorder is the presence of anti-glomerular basement membrane (anti-GBM) antibodies. This antibody is directed toward the α3 chain of type IV collagen, which is found in the basement membrane of re ...
Marginal zone B cells
... 1. For cytotoxic CD8 T-cells, ligation of the TCR by MHC I/peptide + co-stimulation results in release of granzymes and perforin and/or FasL, leading to apoptosis of the target cells. 2. Viruses evade host defense, in part, by down-regulating MHC Class I. Uninfected dendritic cells circumvent this b ...
... 1. For cytotoxic CD8 T-cells, ligation of the TCR by MHC I/peptide + co-stimulation results in release of granzymes and perforin and/or FasL, leading to apoptosis of the target cells. 2. Viruses evade host defense, in part, by down-regulating MHC Class I. Uninfected dendritic cells circumvent this b ...
Human / Rhesus / Canine TGF
... involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis fa ...
... involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis fa ...
Natural Killer Cells
... Fever = abnormally high body temperature Pyrogens = chemicals secreted by white blood cells and macrophages that cause a rise in body temperature. When a fever is good: Bacteria require iron and zinc. During a fever the liver hoards these minerals. Fever also increases the metabolic rate which deli ...
... Fever = abnormally high body temperature Pyrogens = chemicals secreted by white blood cells and macrophages that cause a rise in body temperature. When a fever is good: Bacteria require iron and zinc. During a fever the liver hoards these minerals. Fever also increases the metabolic rate which deli ...
