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Immunology - Acquired Specific Immune System
Immunology - Acquired Specific Immune System

... Part of the cellular immune response (aka cell-mediated immune response) because these cells act directly against various antigens – Endogenous invaders (intracellular pathogens inside the body’s cells) ...
DCVax-Prostate
DCVax-Prostate

... Information and opinions presented in this report have been obtained or derived from sources believed to be reliable, but NWBT makes no representation as to their accuracy or completeness. NWBT accepts no liability for loss arising from the use of the material presented in this report, except that t ...
Cytokines
Cytokines

... • Each cytokine binds to its unique receptor. • Binding affinities are very strong, with dissociation constants in the range of 10-10 to 10-12 (Abs are in the range of 10-7 to 10-10). • The receptor may be composed of multiple subunits with one specific subunit and one or more common subunits (also ...
Chapter Two Line Title Here and Chapter Title Here and Here
Chapter Two Line Title Here and Chapter Title Here and Here

...  Helper T cells have the CD4 glycoprotein. They help to regulate the activity of B cells and cytotoxic T cells during an immune response. There are two main subpopulations: Th1 cells assist cytotoxic T cells and innate macrophages, and Th2 cells function in conjunction with B cells.  Regulatory T ...
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... – Secondary function: provide a removal/clearance function • Immune complexes (IC) bind to C3b, which is then trafficked on CR1 of RBCs (and other cells) to the liver and spleen for removal by macrophages… ...
Effect of eliminating intermittent white blood cells
Effect of eliminating intermittent white blood cells

... of B cell and a member of the CR2 complex. It can regulate the activation and proliferation of B cell, and participate in the signal transmission of B cell. The abnormality of T cell subgroup may play an important role in inducing the disease.[5,6] The decreased number and dysfunction of T supply ce ...
3.051J/20.340J Lecture 8: Cell-Surface Interactions: Host
3.051J/20.340J Lecture 8: Cell-Surface Interactions: Host

... ¾ susceptible devices require use of anti-coagulation drugs (heparin) ⇒ bleeding risk ...
Paul Kubes, University of Calgary Role of the Adapter Molecule
Paul Kubes, University of Calgary Role of the Adapter Molecule

... inflammation would be reduced. Astoundingly, elimination of these proteins severely worsens IBD. For this reason, these receptors in the gut are suggested to be important in letting our immune system tolerate bacteria in the intestines. We have recently found a way to inhibit all 13 TLRs. We found t ...
Biol260exam2summer2012
Biol260exam2summer2012

... c. Macrophages and NK cells d. Macrophages, neutrophils and plasma cells e. Macrophages and plasma cells 2. Which type of leukocyte is the first to be recruited to a site of bacterial infection? a. Cytotoxic T cell b. Plasma cell c. Naïve B cell d. Neutrophil e. Dendritic cell 3. Which of the follow ...
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Preliminary Program click here! - GEBIN

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WHO clinical staging of HIV disease in adults and adolescents (2/4)
WHO clinical staging of HIV disease in adults and adolescents (2/4)

... • Reduction in the CD4 cell number and the effects on their function reduces the capacity of the body to fight infectious diseases. • Individuals with HIV infection are therefore increasingly susceptible to many infections especially at later stages of HIV infection ...
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... and fuel encapsidated DNA synthesis. ...
The Innate Immune System
The Innate Immune System

... C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines. These activities could influence t ...
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Supplementary Figure Legends (doc 38K)

... infection and further restimulated at 37 ℃ for 4 h with ionomycin and PMA, and Brefeldin A within the last 2 h of restimulation. Restimulated cells were further stained with anti-CD4, anti-CD3 and anti-TCRβ antibodies for surface staining and anti-IL-17A, anti-IL-17F intracellularly. Data represent ...
The Immune System and Immunisation
The Immune System and Immunisation

... foreign antigen in order to develop normally • Maternally acquired immunity is temporary and does not protect against all infections. • The infant immune system has the capacity to cope with a vast array of antigens ...
Lymphatic and Immune System
Lymphatic and Immune System

... bacteria or viruses  then they burst • Interferons= proteins produced by a virus infected cell, warning other non infected cells in the area. Also produce substance that interfere with viral replication ...
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Chapter 27: Communicable Diseases

... 3. ________ is ________ cell growth. a. ___________ destroy this type of cell, however, sometimes the ____ ______ gets out of the ______ of the immune system. b. Cancer ____ invade nearby _______. c. Cancer ____ enter into the ___________ or __________ systems allowing it to _______ to _____ parts o ...
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... A story Inspection, palpation, percussion, auscultation – the unalterable, ever-applicable tetrad. Whatever part of the patient you examine, whatever disease you suspect, the four actions must be done in that order. You look first, then feel; when you have felt, you may tap, but not before – and las ...
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B Cells

... 4-Anaphylaxis: if mediators were released in more than one system the reaction is known as anaphylaxis. In addition to the foregoing, the GIT can also be affected with symptoms of nausea, abdominal cramping, and diarrhea. Systemic vasodilatation and vasopermeability can result in significant hypote ...
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... the ingestion of any solid matter ( including microorganisms) by a cell Phagocytes: white blood cells or derivatives of white blood cells A. Formed elements of the Blood – cells or cell fragments 1. plasma – fluid portion of the blood 2. erythrocytes – red blood cells 3. leukocytes – white blood cel ...
this PDF file - Smart Science Technology
this PDF file - Smart Science Technology

... and specific immunosuppressive methodologies to help protecting transplanted organ or tissue from acute and chronic immune rejection, and minimizing the side effects accompanied with conventional immunosuppressant drugs [10]. From these backgrounds, we hypothesized that immune protection of ESCs- or ...
bacterial Pathogenesis
bacterial Pathogenesis

... ii. Endotoxin (LPS) from gram-negatives only ►damage is caused by host through macrophages producing cytokines (TNF-α, IL-1, IL-6) iii. Exotoxins (proteins) ►several have A-B motif - A=active portion, B=binding portion ►lytic (lyse host cells - creating pores or lipase activity) ►cytotoxic (kill cel ...
Module 023806: Advanced topics in Immunology
Module 023806: Advanced topics in Immunology

... SLE in these mice can be modulated by the administration of anti-oestrogen drugs. Androgens such as testosterone are also implicated since female NOD are more susceptible to diabetes than males, and castration increases the risk of disease in male mice. Testosterone may be protective against MS, dia ...
Chapter 24: The Immune System 24.1 Innate defenses against
Chapter 24: The Immune System 24.1 Innate defenses against

... – Is slower than the secondary immune response 24.8 Antibodies are the weapons of humoral immunity • Antibody molecules – Are secreted by plasma (effector) B cells • An antibody molecule – Has antigen-binding sites specific to the antigenic determinants that elicited its secretion 24.9 Antibodies ma ...
Taking Immunotherapy to the Next Level
Taking Immunotherapy to the Next Level

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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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