TНЕМЕ: "PATHOLOGY OF HYPOTHALAMO
... of human organism. Regulation of all vital functions of an organism carried out by the nervous and endocrine systems. The action of the last will be realized due to a secretion and transporting of specific humoral factors of distance action - hormones. Violation of hormones formation or transporting ...
... of human organism. Regulation of all vital functions of an organism carried out by the nervous and endocrine systems. The action of the last will be realized due to a secretion and transporting of specific humoral factors of distance action - hormones. Violation of hormones formation or transporting ...
- Future Medicine
... continuous cART on morbidity and mortality [48] . SMART was one of the first studies to identify a relationship between viral replication, immune activation and non-AIDS events, and several substudies of SMART have identified multiple biomarkers that are associated with non-AIDS events [49–53] and m ...
... continuous cART on morbidity and mortality [48] . SMART was one of the first studies to identify a relationship between viral replication, immune activation and non-AIDS events, and several substudies of SMART have identified multiple biomarkers that are associated with non-AIDS events [49–53] and m ...
inflamation and infections of the female reproductive system
... covers the vaginal portion of the cervix is replaced by ...
... covers the vaginal portion of the cervix is replaced by ...
Persistence of Mycoplasmal Infections and Various Clinical Conditions
... immune systems, and they may use these activities to evade host immune responses. For example, some mycoplasmas can inhibit or stimulate the proliferation of normal lymphocyte subsets, induce B-cell differentiation and trigger the secretion of cytokines, including interleukin-1 (IL-1), IL-2, IL-4, I ...
... immune systems, and they may use these activities to evade host immune responses. For example, some mycoplasmas can inhibit or stimulate the proliferation of normal lymphocyte subsets, induce B-cell differentiation and trigger the secretion of cytokines, including interleukin-1 (IL-1), IL-2, IL-4, I ...
Immunocompetence of Schwann Cells
... our knowledge of the underlying disease mechanisms.80 In the more frequent demyelinating CMT forms, a genetic defect results in progressive destruction of myelin sheaths and secondary axonal loss.117 One may easily conceive that such genetically determined defects of myelination can trigger a second ...
... our knowledge of the underlying disease mechanisms.80 In the more frequent demyelinating CMT forms, a genetic defect results in progressive destruction of myelin sheaths and secondary axonal loss.117 One may easily conceive that such genetically determined defects of myelination can trigger a second ...
It`s not just a yeast infection - St. Louis Nurses in Advanced Practice
... • VVA-in peri-menopausal/postmenopausal, 50% of them experience, c/o dyspareunia, may be the cause of decreased libido (be careful), dryness with wiping, states feel like sandpaper, can have an outline of light/ incontinence pad in vulvar regions • VVA- ph is usually more alkaline around 7 and above ...
... • VVA-in peri-menopausal/postmenopausal, 50% of them experience, c/o dyspareunia, may be the cause of decreased libido (be careful), dryness with wiping, states feel like sandpaper, can have an outline of light/ incontinence pad in vulvar regions • VVA- ph is usually more alkaline around 7 and above ...
2008 - Deutsche Gesellschaft für Hygiene und Mikrobiologie
... of DC with E. coli induced TNF- , IL-12 and IL-6 secretion and expression of activation-markers, increased T-cell activation and led to Th1 polarization. Stimulation with B. vulgatus only led to secretion of IL-6 and DC were driven to a semi-mature state with low expression of activation-markers, di ...
... of DC with E. coli induced TNF- , IL-12 and IL-6 secretion and expression of activation-markers, increased T-cell activation and led to Th1 polarization. Stimulation with B. vulgatus only led to secretion of IL-6 and DC were driven to a semi-mature state with low expression of activation-markers, di ...
African Journal of Rheumatology - University of Nairobi Personal
... Systemic Sclerosis (SSc) is a connective tissue disease with multifactorial aetiology and autoimmune pathogenesis. SSc is characterized by structural and functional alterations of microcirculation, with important clinical implications, such as Raynaud Phenomenon (RP) and digital ulcers1,2. For these ...
... Systemic Sclerosis (SSc) is a connective tissue disease with multifactorial aetiology and autoimmune pathogenesis. SSc is characterized by structural and functional alterations of microcirculation, with important clinical implications, such as Raynaud Phenomenon (RP) and digital ulcers1,2. For these ...
More Common Than You Think: Common Variable Immune Deficiency
... diagnosis of exclusion with the following criteria: (1) age ≥4 years, (2) profound hypogammaglobulinemia, (3) failure to generate antibodies after exposure to two or more protein antigens, and (4) exclusion of other causes of hypogammaglobulinemia. The average period between onset of symptoms and di ...
... diagnosis of exclusion with the following criteria: (1) age ≥4 years, (2) profound hypogammaglobulinemia, (3) failure to generate antibodies after exposure to two or more protein antigens, and (4) exclusion of other causes of hypogammaglobulinemia. The average period between onset of symptoms and di ...
The Suppression of Immune System Disorders by Passive
... necessary to maintain the cell type. The group of cells that compete for the same set of factors is referred to as the niche. The niche may be shared by many sub-populations of cells such as antigen specific memory cells from previous infections. Studying the homeostatic mechanisms tells us the long ...
... necessary to maintain the cell type. The group of cells that compete for the same set of factors is referred to as the niche. The niche may be shared by many sub-populations of cells such as antigen specific memory cells from previous infections. Studying the homeostatic mechanisms tells us the long ...
Megaloblastic anaemia an Iron deficiency
... Severe lack of IF due to gastric atrophy Incidence 25/100,000/year aged over 40years 10 female: 7 male 20% have positive family history Association with autoimmune disease (30% with Crohn’s disease) 90% parietal cell antibody positive (~20% in normal population) 60% IF antibody positive ...
... Severe lack of IF due to gastric atrophy Incidence 25/100,000/year aged over 40years 10 female: 7 male 20% have positive family history Association with autoimmune disease (30% with Crohn’s disease) 90% parietal cell antibody positive (~20% in normal population) 60% IF antibody positive ...
Asthma as a chronic disease of the innate and adaptive immune
... a practical perspective, the Th2 hypothesis has led to a focused and sometimes dogmatic approach to diagnosis and therapy of asthma. A few of these therapeutic approaches, such as leukotriene receptor antagonists and anti-IgE antibodies, have achieved limited acceptance (37, 38). Others, for example ...
... a practical perspective, the Th2 hypothesis has led to a focused and sometimes dogmatic approach to diagnosis and therapy of asthma. A few of these therapeutic approaches, such as leukotriene receptor antagonists and anti-IgE antibodies, have achieved limited acceptance (37, 38). Others, for example ...
Manifestation of ulcerative lichen planus and
... ratio ranged approximately from 1 to 3 and greater, being consistent with inflammation of periradicular tissues. The final differentiation of B lymphocytes to plasma cells was also detected, whilst natural killer (NK) cells were found in only 10 cases (22%). Moreover, antigen presenting cells and T ...
... ratio ranged approximately from 1 to 3 and greater, being consistent with inflammation of periradicular tissues. The final differentiation of B lymphocytes to plasma cells was also detected, whilst natural killer (NK) cells were found in only 10 cases (22%). Moreover, antigen presenting cells and T ...
Identification of the yaa lupus as a IIr
... antigens [9]. Thus, it appears that the Yaa locus bears gene(s) that influence antigenicity of RNA-containing antigens. Since Yaa was known to be associated with a marginal zone defect and generalized B-cell hyper-reactivity [10], Pisitkun and colleagues reasoned that, by deleting Bruton’s tyrosine ...
... antigens [9]. Thus, it appears that the Yaa locus bears gene(s) that influence antigenicity of RNA-containing antigens. Since Yaa was known to be associated with a marginal zone defect and generalized B-cell hyper-reactivity [10], Pisitkun and colleagues reasoned that, by deleting Bruton’s tyrosine ...
Angioimmunoblastic T-cell lymphoma
... Pathologically, AITL shows distinctive features with (1) a diffuse polymorphous infiltrate containing a variable – often minor – content of medium-sized neoplastic T cells with an abundant clear cytoplasm, admixed with a variable proportion of small lymphocytes, histiocytes or epithelioid cells, imm ...
... Pathologically, AITL shows distinctive features with (1) a diffuse polymorphous infiltrate containing a variable – often minor – content of medium-sized neoplastic T cells with an abundant clear cytoplasm, admixed with a variable proportion of small lymphocytes, histiocytes or epithelioid cells, imm ...
Lia van der Hoek Hidde Ploegh Theme
... “For instance in oncology, for fighting tumours. Once you can connect antibodies, they become far more effective.” Wagner: “That goes in fact for everything related to the immune system.” In order to let patients benefit from this development, a lot more work has to be done. AIMM now starts investig ...
... “For instance in oncology, for fighting tumours. Once you can connect antibodies, they become far more effective.” Wagner: “That goes in fact for everything related to the immune system.” In order to let patients benefit from this development, a lot more work has to be done. AIMM now starts investig ...
HIV-1 Persistence in Macrophage Reservoirs during Antiretroviral
... be found in macrophages from patients on extended cART therapy [21,22]. During late-stage disease, when CD4+ T cell counts drop to undetectable levels, HIV-1-infected macrophages continue to proliferate and are found at high levels in different tissue types [23]. Circulating monocytes (macrophage pr ...
... be found in macrophages from patients on extended cART therapy [21,22]. During late-stage disease, when CD4+ T cell counts drop to undetectable levels, HIV-1-infected macrophages continue to proliferate and are found at high levels in different tissue types [23]. Circulating monocytes (macrophage pr ...
Tecentriq and the Cancer Immunity Cycle
... response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. (1.1) • Metastatic non-small cell lung cancer who have disease progression during or following platinum-containing chemothera ...
... response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. (1.1) • Metastatic non-small cell lung cancer who have disease progression during or following platinum-containing chemothera ...
Analysis of a wild mouse promoter variant reveals a novel role
... Genetic variants of the inhibitory Fc receptor FcRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse ...
... Genetic variants of the inhibitory Fc receptor FcRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse ...
GAD AS AN IMMUNOMODULATOR IN TYPE 1 DIABETES Stina Axelsson
... months, a subgroup analysis showed that the treatment had an effect on preservation of residual insulin secretion, but the effect was not seen until after 30 months. Taken together, these results suggest that GAD-alum treatment might exert its effect through induction of an early Th2 skewed immune r ...
... months, a subgroup analysis showed that the treatment had an effect on preservation of residual insulin secretion, but the effect was not seen until after 30 months. Taken together, these results suggest that GAD-alum treatment might exert its effect through induction of an early Th2 skewed immune r ...
Passive vs active & vaccines
... gaining antibodies without the immune system having to produce them. The thick, yellowish milk (colostrum) that is produced for the first few days after birth is particularly rich in antibodies. ...
... gaining antibodies without the immune system having to produce them. The thick, yellowish milk (colostrum) that is produced for the first few days after birth is particularly rich in antibodies. ...
GERD and Coughing, What PIDD Patients Need to Know
... due to sinopulmonary problems. And, depending on the individual, GERD can be caused by a varying amount of reflux. Esophageal damage is more common when the reflux is very acidic and occurs frequently, and when there is slow clearing of acid by the esophagus. What Are the Symptoms of GERD? The most ...
... due to sinopulmonary problems. And, depending on the individual, GERD can be caused by a varying amount of reflux. Esophageal damage is more common when the reflux is very acidic and occurs frequently, and when there is slow clearing of acid by the esophagus. What Are the Symptoms of GERD? The most ...
Inflammation in the visceral adipose tissue of obese subjects
... • Obesity is characterized by a chronic low-grade inflammatory state which is reflected by chronic increases in circulating concentrations of inflammatory markers. • The inflammatory state of adipose tissue, with the contribution of adipose macrophages and T cells, is believed to contribute to thi ...
... • Obesity is characterized by a chronic low-grade inflammatory state which is reflected by chronic increases in circulating concentrations of inflammatory markers. • The inflammatory state of adipose tissue, with the contribution of adipose macrophages and T cells, is believed to contribute to thi ...
T-Cell Abnormalities in Common Variable Immunodeficiency
... CVID patients have reduced naive CD4+ T-cell and recent thymic emigrant (RTE) cell counts. In a study by Oraei et al [35], CVID patients had fewer naive and RTE CD4+ T cells than healthy controls. Interestingly, this reduction was more apparent in male than in female patients [35]. The reduction ...
... CVID patients have reduced naive CD4+ T-cell and recent thymic emigrant (RTE) cell counts. In a study by Oraei et al [35], CVID patients had fewer naive and RTE CD4+ T cells than healthy controls. Interestingly, this reduction was more apparent in male than in female patients [35]. The reduction ...
Immune response of the small intestinal mucosa in children with
... expressed at lower levels in CD patients compared to controls. In addition, IELs expressing RAG1 were less abundant in CD patients compared to controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Seco ...
... expressed at lower levels in CD patients compared to controls. In addition, IELs expressing RAG1 were less abundant in CD patients compared to controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Seco ...