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ark LP 38 FPSS 1 1993 Abstract
ark LP 38 FPSS 1 1993 Abstract

... Immune response of common carp (Cyprinus carpio L.) to cortisol simulated stress / Samson Soon Min Ngen. ...
Antibody-Secreting Cells Human B Cell Differentiation to
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Rituximab: An Autoimmune Disease Therapy
Rituximab: An Autoimmune Disease Therapy

Protein Synthesis II
Protein Synthesis II

... via  rRNA  secondary   structure   –  Note  sharp  bend  of  mRNA   at  E  site  –  more  later   ...
2011 - Waddensymposium
2011 - Waddensymposium

... tumors and allows them to escape elimination by cytotoxic T-lymphocytes. Recently, we identified a novel category of tumor antigens that are selectively presented by such tumor variants and named them TEIPP (T cell epitopes associated with peptide processing)*. TEIPP antigens are derived from housek ...
Enhanced anti-tumor immune responses and delay of tumor development in human
Enhanced anti-tumor immune responses and delay of tumor development in human

... Introduction: Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. We have previously shown that Hp91, a peptide derived from the B box domain in high-mobility group box protein 1 (HMGB1), acts as a potent immune adjuvan ...
slides - Smith Lab
slides - Smith Lab

... • The MAC pore size is 70-100Å • Allows ions and small molecules to diffuse out • Disrupts osmotic stability and lyses bacteria, virus, or cells that are infected or damaged ...
PPT - Larry Smarr - California Institute for Telecommunications and
PPT - Larry Smarr - California Institute for Telecommunications and

... The human body is host to 100 trillion microorganisms, ten times the number of cells in the human body and these microbes contain 100 times the number of DNA genes that our human DNA does. The microbial component of this "superorganism" is comprised of hundreds of species spread over many taxonomic ...
ANTIGEN PRESENTATION and the MHC
ANTIGEN PRESENTATION and the MHC

... Production of antibody to most antigens requires not just B cells but also T cells. B cells take up antigen, then B cells process antigen and display processed peptides on MHC class II molecules. This process activates the B cell to make B7. T cells recognize MHC presented antigen and B7 co-stimulat ...
“MDR-Pseudomonas: Another Horse of the Apocalypse”
“MDR-Pseudomonas: Another Horse of the Apocalypse”

... • Notorious for resistance to antibiotics • Naturally resistant to many antibiotics due to permabiliity barrier Gram-negative outer membrane • Biofilm form makes the cells impervious to therapeutic concentrations antibiotics • Lives with actinomycetes and molds – acquired resistance to naturally occ ...
Part 1: Mechanisms and Management of Food Allergies
Part 1: Mechanisms and Management of Food Allergies

... T cell lymphocytes detect foreign proteins (antigens) in any form T cells then trigger a series of immunological reactions, mediated by cytokines ...
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3.As a basic biological science:microorganisms are the best model

... Bacteria are small, single-celled, microorganisms that belong to a group called prokaryotes . Bacteria are ubiquitous. They are a highly successful and diverse group of organisms that can obtain energy and carbon from a wide range of sources and therefore can colonize every niche on our planet from ...
Autoimmune Disorders in Pregnancy
Autoimmune Disorders in Pregnancy

... Release cytokines Memory attribute • Will remember the foreign antigenic material so that can respond even more vigorously to subsequent exposure ...
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Myeloma VL and VH Gene Sequences Reveal a
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... of myeloma clones. In fact, there have now been reports of a total of more than 50 sequences of VH genes used by tumor cells from patients’ BM biopsies, and these have revealed common features.3-5 One conclusion is that usage of VH genes from the available repertoire appears to reflect no striking b ...
Chapter 5 Protein Function
Chapter 5 Protein Function

... The Immune System and Immunoglobulins • The proteins at the center of the Humoral IS are the immunoglobulins (Ig) or the antibodies • These proteins bind bacteria, viruses or large molecules identified as “non-self” and target them for destruction • These proteins are produces by the B Lymphocytes ...
Parasite Immunology 2015 pre print - T-Stor
Parasite Immunology 2015 pre print - T-Stor

... 114 recognition receptors (PRRs) such as C-type lectin receptors (CLRs) and toll-like receptors 115 (TLRs). CLRs and TLRs are expressed by many cell types, including the cells of mucosal 116 surfaces and tissue immune cells such macrophages and dendritic cells, the major antigen 117 presenting cells ...
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... • Blocking of activated T and B cell proliferation and antibody formation ...
13-14 antigen specific B cell response
13-14 antigen specific B cell response

... Hematopoiesis results in a B-cell repertoire of around 107-9 distinct binding specificities daily in the bone marrow, directed by the mechanism of V(D)J recombination. This mechanism occurs independently of antigens and results in the generation of clonally defined variable region in both ...
Chapter 12 Lymphatic System and Body Defenses
Chapter 12 Lymphatic System and Body Defenses

... Cytokines are secreted by macrophages and are important in the immune response. Immunoglobulins (antibodies) are produced by B cells or plasma cells. ...
Primary lymphoma of the central nervous system
Primary lymphoma of the central nervous system

... divergent interpretations may be explained by (1) different platforms used for GEP, (2) different algorithms applied, (3) different methods to eliminate the background signature of the CNS, (4) the low number of cases suitable for GEP, and (5) a sample-induced bias (open resection vs stereotactic bi ...
Tumour antigens recognized by T lymphocytes
Tumour antigens recognized by T lymphocytes

Using Diet to Manage Immune and Autoimmune Diseases Sarah
Using Diet to Manage Immune and Autoimmune Diseases Sarah

... Absorption and activity of B vitamins Muscle contraction Connective tissue formation Production of insulin and testosterone Component of vitamin D receptor ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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