Clinical Pharmacokinetics 2012 - Accueil
... and acenocoumarol.[17] VKORC1 haplotype group A/A, as described by Rieder et al.,[18] is present in 37% of EuropeanAmerican subjects and is associated with lower levels of VKORC1 messenger RNA expression and a need for lower warfarin maintenance doses, compared with the A/B or B/B haplotype groups. ...
... and acenocoumarol.[17] VKORC1 haplotype group A/A, as described by Rieder et al.,[18] is present in 37% of EuropeanAmerican subjects and is associated with lower levels of VKORC1 messenger RNA expression and a need for lower warfarin maintenance doses, compared with the A/B or B/B haplotype groups. ...
The Protective Role of Extract of Allium cepa Linn. (Liliaceae) (Red
... Serious concerns have been raised about uncontrolled use of artemisinin derivatives because at the moment they are the last resort in the combat against multi-drug resistant P. falciparum malaria [4] although it is associated with severe side effects at high doses and under prolonged usage. The effe ...
... Serious concerns have been raised about uncontrolled use of artemisinin derivatives because at the moment they are the last resort in the combat against multi-drug resistant P. falciparum malaria [4] although it is associated with severe side effects at high doses and under prolonged usage. The effe ...
Pharmacology Study Guide - Wright State University`s College of
... We recognize the attached grid is very lengthy, but have included some of the key components as identified below. Most medications addressed are either high usage or high risk. Please note that auto-corrections will change generic names to starting with caps. In the grid, we have tried to list gener ...
... We recognize the attached grid is very lengthy, but have included some of the key components as identified below. Most medications addressed are either high usage or high risk. Please note that auto-corrections will change generic names to starting with caps. In the grid, we have tried to list gener ...
Chelation in Metal Intoxication
... polyamino-polycarboxylic acid and since 1950s has been one of the mainstays for the treatment of childhood lead poisoning [12]. The drug has been claimed beneficial in vascular disease since 1955. It is believed that chelation therapy may alter plaque morphology and volume, or improve endothelial fu ...
... polyamino-polycarboxylic acid and since 1950s has been one of the mainstays for the treatment of childhood lead poisoning [12]. The drug has been claimed beneficial in vascular disease since 1955. It is believed that chelation therapy may alter plaque morphology and volume, or improve endothelial fu ...
AROMASIN® (exemestane tablets) Doctor Discussion Guide
... Do not take AROMASIN if you are allergic to AROMASIN or to anything in it. The active ingredient is exemestane. Do not take AROMASIN if you are pregnant or if you might become pregnant as it may cause birth defects or miscarriage. If you become pregnant while taking AROMASIN, talk to your doctor imm ...
... Do not take AROMASIN if you are allergic to AROMASIN or to anything in it. The active ingredient is exemestane. Do not take AROMASIN if you are pregnant or if you might become pregnant as it may cause birth defects or miscarriage. If you become pregnant while taking AROMASIN, talk to your doctor imm ...
Assessment of the Influence of Histaminergic Actions on Cocaine
... the locomotor stimulant effects of cocaine. In addition, a second generation of compounds was synthesized that had reduced muscarinic affinity (Agoston et al., 1997). These compounds also possessed a reduced cocaine-like spectrum of behavioral effects (Katz et al., 2004), suggesting that the antimus ...
... the locomotor stimulant effects of cocaine. In addition, a second generation of compounds was synthesized that had reduced muscarinic affinity (Agoston et al., 1997). These compounds also possessed a reduced cocaine-like spectrum of behavioral effects (Katz et al., 2004), suggesting that the antimus ...
Product Monograph Template - Standard
... The safety and efficacy of AERIUS DUAL ACTION 12 HOUR has not been established in patients with impaired hepatic function, and there are insufficient data to give adequate dose recommendations. The combination product is not recommended for use in patients with impaired hepatic function (See ACTION ...
... The safety and efficacy of AERIUS DUAL ACTION 12 HOUR has not been established in patients with impaired hepatic function, and there are insufficient data to give adequate dose recommendations. The combination product is not recommended for use in patients with impaired hepatic function (See ACTION ...
here - Zoetis
... approximately 30 hours. This can be employed to control the time of farrowing in sows and gilts in ...
... approximately 30 hours. This can be employed to control the time of farrowing in sows and gilts in ...
- Boehringer Ingelheim (Canada)
... The safety of ATROVENT pressurized inhalation solution in pregnancy has not been established. Nonclinical studies with ipratropium bromide have shown no embryotoxic or teratogenic effects following inhalation or intranasal application at doses considerably higher than those recommended in man. Becau ...
... The safety of ATROVENT pressurized inhalation solution in pregnancy has not been established. Nonclinical studies with ipratropium bromide have shown no embryotoxic or teratogenic effects following inhalation or intranasal application at doses considerably higher than those recommended in man. Becau ...
Relationship between the Serotonergic Activity and Reinforcing
... (Macaca mulatta), Lile et al. (2003) reported robust selfadministration of a cocaine analog, HD-60, with at least 80-fold selectivity for the SERT relative to the DAT. This same compound was not a positive reinforcer in rats in the study of Roberts et al. (1999) (called WF-60). Thus, it is possible ...
... (Macaca mulatta), Lile et al. (2003) reported robust selfadministration of a cocaine analog, HD-60, with at least 80-fold selectivity for the SERT relative to the DAT. This same compound was not a positive reinforcer in rats in the study of Roberts et al. (1999) (called WF-60). Thus, it is possible ...
Exposure and Response after a Single Dose
... 9 mg, is eliminated, leaving 81 mg remaining at 2 hrs, and so on. Although this method illustrates the application of k in determining the time course of drug elimination, and hence drug remaining in the body, it is rather laborious and has some error associated with it. A simpler and more accurate ...
... 9 mg, is eliminated, leaving 81 mg remaining at 2 hrs, and so on. Although this method illustrates the application of k in determining the time course of drug elimination, and hence drug remaining in the body, it is rather laborious and has some error associated with it. A simpler and more accurate ...
Pharmacogenetic Testing Prior to Initiation of Warfarin
... CYP2C9*2, *3, and VKCORC1 (-)1639 G>A variants. CYP2C9 DNA analysis is performed by allele-specific PCR followed by electrophoresis to detect the *2 and *3 alleles. VKORC1 DNA analysis is performed by PCR followed by restriction enzyme digestion to detect (-)1639 G>A. Individuals with one or more of ...
... CYP2C9*2, *3, and VKCORC1 (-)1639 G>A variants. CYP2C9 DNA analysis is performed by allele-specific PCR followed by electrophoresis to detect the *2 and *3 alleles. VKORC1 DNA analysis is performed by PCR followed by restriction enzyme digestion to detect (-)1639 G>A. Individuals with one or more of ...
Diuretics - JUdoctors
... reabsorption of salts and water from kidney tubules ( increase water and salt excretion) These agents are ion transport inhibitors that decrease the reabsorption of Na+ at different sites in the nephron, thus increasing the volume of the urine and often change its pH as well as the ionic composition ...
... reabsorption of salts and water from kidney tubules ( increase water and salt excretion) These agents are ion transport inhibitors that decrease the reabsorption of Na+ at different sites in the nephron, thus increasing the volume of the urine and often change its pH as well as the ionic composition ...
Telfast 180mg
... rhinitis patients given fexofenadine hydrochloride up to 240 mg twice daily for 2 weeks when compared to placebo. Also, no significant change in QTc intervals was observed in healthy subjects given fexofenadine hydrochloride up to 60 mg twice daily for 6 months, 400 mg twice daily for 6.5 days and 2 ...
... rhinitis patients given fexofenadine hydrochloride up to 240 mg twice daily for 2 weeks when compared to placebo. Also, no significant change in QTc intervals was observed in healthy subjects given fexofenadine hydrochloride up to 60 mg twice daily for 6 months, 400 mg twice daily for 6.5 days and 2 ...
PPT - ACoP7
... Simulation of QTc Prolongation: The final popPK and QTc models were used to simulate likely QTc interval prolongation as a function of FQ1 dose, day, infusion duration, and subject covariates. For each such combination, a distribution of Cmax values was computed. For each Cmax value, the final QTc m ...
... Simulation of QTc Prolongation: The final popPK and QTc models were used to simulate likely QTc interval prolongation as a function of FQ1 dose, day, infusion duration, and subject covariates. For each such combination, a distribution of Cmax values was computed. For each Cmax value, the final QTc m ...
committee for veterinary medicinal products
... children and infants clearly shows the safe use of paromomycin in young population. All results show clearly that paromomycin can be used during lactation without adverse effects on mothers and infants. The lack of adverse effects on reproductive function in males is documented by the clinical use o ...
... children and infants clearly shows the safe use of paromomycin in young population. All results show clearly that paromomycin can be used during lactation without adverse effects on mothers and infants. The lack of adverse effects on reproductive function in males is documented by the clinical use o ...
Nepafenac - Therapeutic Goods Administration
... indications and dose regimen in the EU are the same as those proposed in this submission. There are minor differences in both the indications and duration of post operative use in the USA and Canada. The sponsor has stated that based on the duration of action of amfenac being >24 h, a once a day pro ...
... indications and dose regimen in the EU are the same as those proposed in this submission. There are minor differences in both the indications and duration of post operative use in the USA and Canada. The sponsor has stated that based on the duration of action of amfenac being >24 h, a once a day pro ...
Analgesia dose prescribing and estimated glomerular filtration rate
... pathology. Therefore, the complete avoidance of NSAIDs or aspirin among CKD patients may impact on quality of life by excluding a major group of drug treatment for pain symptoms. NSAIDs have been associated with gastrointestinal and vascular complications;7 therefore, where contraindicated, paraceta ...
... pathology. Therefore, the complete avoidance of NSAIDs or aspirin among CKD patients may impact on quality of life by excluding a major group of drug treatment for pain symptoms. NSAIDs have been associated with gastrointestinal and vascular complications;7 therefore, where contraindicated, paraceta ...
Role for Reactive Oxygen Species in Methamphetamine Modulation
... This research has been funded by the National Institutes of Drug Abuse and Alcoholism and Alcohol Abuse. Without their support, none of our hypotheses could have amounted to anything. Additionally, BYU Graduate Studies has provided considerable support through the Graduate Studies Fellowship and the ...
... This research has been funded by the National Institutes of Drug Abuse and Alcoholism and Alcohol Abuse. Without their support, none of our hypotheses could have amounted to anything. Additionally, BYU Graduate Studies has provided considerable support through the Graduate Studies Fellowship and the ...
Effects of psilocybin on hippocampal neurogenesis and extinction of
... p = 0.34]. Notably, there was a significant effect of Trial [F(1,90) = 105.85, p < 0.0001], indicating that mice spent significantly more time freezing after the CS–US pairings during the context test compared to habituation baseline. These data show that all mice learned to fear the context in whi ...
... p = 0.34]. Notably, there was a significant effect of Trial [F(1,90) = 105.85, p < 0.0001], indicating that mice spent significantly more time freezing after the CS–US pairings during the context test compared to habituation baseline. These data show that all mice learned to fear the context in whi ...
PRODUCT MONOGRAPH Frisium® (clobazam) Tablets, 10 MG
... Anterograde amnesia: Anterograde amnesia is known to occur even if benzodiazepines are used in the normal dose range, but especially at higher dose levels. Amnesia effects may be associated with inappropriate behaviour. Use in patients with depression or psychosis: FRISIUM is not recommended for use ...
... Anterograde amnesia: Anterograde amnesia is known to occur even if benzodiazepines are used in the normal dose range, but especially at higher dose levels. Amnesia effects may be associated with inappropriate behaviour. Use in patients with depression or psychosis: FRISIUM is not recommended for use ...
Xl Annual Scientific Meeting, Argentine Society of Experimental
... In mammalians, the ATP-binding cassette (ABC) superfamily was first described as responsible for the multidrug resistance phenotype. Nowadays, these biological pumps have been identified as having a major impact on the pharmacological behavior of most drugs in use. ABC transporters are present in al ...
... In mammalians, the ATP-binding cassette (ABC) superfamily was first described as responsible for the multidrug resistance phenotype. Nowadays, these biological pumps have been identified as having a major impact on the pharmacological behavior of most drugs in use. ABC transporters are present in al ...
Fentanyl Buccal Lozenges (Actiq®)
... fentanyl citrate formulations, these products are not interchangeable on a mcg per mcg basis and should not be substituted on a mcg for mcg basis as enhanced or attenuated pharmacologic effects could occur. Patients receiving fentanyl oral transmucosal lozenges for breakthrough pain are prescribed a ...
... fentanyl citrate formulations, these products are not interchangeable on a mcg per mcg basis and should not be substituted on a mcg for mcg basis as enhanced or attenuated pharmacologic effects could occur. Patients receiving fentanyl oral transmucosal lozenges for breakthrough pain are prescribed a ...
ภาพนิ่ง 1
... IMPROVE-IT: Examining outcomes in subjects with acute coronary syndrome: Vytorin (ezetimibe/simvastatin) vs simvastatin (Study P04103). Available at: http://www.clinicaltrials.gov/ct/show/NCT00202878. Accessed November 2006. ...
... IMPROVE-IT: Examining outcomes in subjects with acute coronary syndrome: Vytorin (ezetimibe/simvastatin) vs simvastatin (Study P04103). Available at: http://www.clinicaltrials.gov/ct/show/NCT00202878. Accessed November 2006. ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.