Psychogenic nonepileptic seizures
... these studies and the fact that only video-EEGproven cases were counted, these figures are likely to be an underestimate. Taking account of these uncertainties, the prevalence has been estimated as 2–33/100 000 [11]. Whatever their population prevalence, psychogenic nonepileptic seizures are commonl ...
... these studies and the fact that only video-EEGproven cases were counted, these figures are likely to be an underestimate. Taking account of these uncertainties, the prevalence has been estimated as 2–33/100 000 [11]. Whatever their population prevalence, psychogenic nonepileptic seizures are commonl ...
The differential diagnosis of epilepsy: A critical review
... centers, it may be more common in general neurology practices. The first reason that syncope is misdiagnosed as seizures is the erroneous belief that seizures can cause a flaccid motionless episode of loss of consciousness (LOC) for seconds to minutes. In reality, no seizure type does this. Generalize ...
... centers, it may be more common in general neurology practices. The first reason that syncope is misdiagnosed as seizures is the erroneous belief that seizures can cause a flaccid motionless episode of loss of consciousness (LOC) for seconds to minutes. In reality, no seizure type does this. Generalize ...
The Strange Case of the Missing Myelin
... from Jean Marie Charcot, in his famous clinical sessions at the Hospital de la Salpêtrière (1872-1873). He distinguished it from amiotrophic lateral sclerosis, whose only similarity lies in the name. Charcot insisted that patients with multiple sclerosis have an “intention” tremor when they are abou ...
... from Jean Marie Charcot, in his famous clinical sessions at the Hospital de la Salpêtrière (1872-1873). He distinguished it from amiotrophic lateral sclerosis, whose only similarity lies in the name. Charcot insisted that patients with multiple sclerosis have an “intention” tremor when they are abou ...
Age-Related Uptake of Heavy Metals in Human Spinal Interneurons
... central nervous system in diseases such as ALS/MND, but judging if a patient died with, or from, a toxicant is a challenge. The toxicant could have entered the nervous system years before the disease become clinically apparent and could no longer be detectable at the time of post mortem examination. ...
... central nervous system in diseases such as ALS/MND, but judging if a patient died with, or from, a toxicant is a challenge. The toxicant could have entered the nervous system years before the disease become clinically apparent and could no longer be detectable at the time of post mortem examination. ...
Epilepsy Day Oct 2016 - Christos Lambrakis, M.D.
... Very common with many etiologies Sudden and unpredictable ...
... Very common with many etiologies Sudden and unpredictable ...
Anatomy and Pathology of the Cerebellar Peduncle
... The cerebellum is connected to the brainstem by three cerebellar peduncles: 1) the inferior cerebellar peduncle (restiform body and juxtrarestiform body) 2) the middle cerebellar peduncle (brachium pontis), and 3) the superior cerebellar peduncle (brachium conjunctivum). The middle cerebellar pedunc ...
... The cerebellum is connected to the brainstem by three cerebellar peduncles: 1) the inferior cerebellar peduncle (restiform body and juxtrarestiform body) 2) the middle cerebellar peduncle (brachium pontis), and 3) the superior cerebellar peduncle (brachium conjunctivum). The middle cerebellar pedunc ...
PSEUDOSEIZURES (PSYCHOGENIC NON
... morphology may be single or multiple or mixed. The classical convulsive type, atonic variety, complete loss of awareness, complicated behavior, confusion, like complex partial seizures are common. Bizarre twitching movements which are usually described as “Arc de cercle”, ophisthotonic postures. Rar ...
... morphology may be single or multiple or mixed. The classical convulsive type, atonic variety, complete loss of awareness, complicated behavior, confusion, like complex partial seizures are common. Bizarre twitching movements which are usually described as “Arc de cercle”, ophisthotonic postures. Rar ...
Reith RM, McKenna J, Wu H, Hashmi SS, Cho SH, Dash PK, Gambello MJ. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiology of Disease. 2013 Mar;51:93-103.
... to the autistic-phenotype. Since TSC is the prototypical mTORopathy, and about 25%–60% of children with TSC have ASD (Gillberg et al., 1994; Hunt and Dennis, 1987; Hunt and Shepherd, 1993; Smalley et al., 1992), an understanding of this association might uncover general principles applicable to idio ...
... to the autistic-phenotype. Since TSC is the prototypical mTORopathy, and about 25%–60% of children with TSC have ASD (Gillberg et al., 1994; Hunt and Dennis, 1987; Hunt and Shepherd, 1993; Smalley et al., 1992), an understanding of this association might uncover general principles applicable to idio ...
OCT and MS
... domain (SD-)OCT with the Spectralis 3.5 mm circle scan protocol with locked reference images and eye tracking mode. Patients with an attack of optic neuritis within 12 months prior to the onset of the study were excluded. Principal Findings: Although the disease was highly active over the observatio ...
... domain (SD-)OCT with the Spectralis 3.5 mm circle scan protocol with locked reference images and eye tracking mode. Patients with an attack of optic neuritis within 12 months prior to the onset of the study were excluded. Principal Findings: Although the disease was highly active over the observatio ...
the clinical role of evoked potentials
... VEPs provide a sensitive indication of abnormal conduction in the visual pathway. Increases in retino-striate conduction time caused by processes such as demyelination can be detected by measuring the latency of this cortical response. Abnormalities in the amplitude and waveform of the VEPs may also ...
... VEPs provide a sensitive indication of abnormal conduction in the visual pathway. Increases in retino-striate conduction time caused by processes such as demyelination can be detected by measuring the latency of this cortical response. Abnormalities in the amplitude and waveform of the VEPs may also ...
A Fresh Look at the Potential Mechanisms of
... among MS patients should be treated with an individual and integrated approach (16). Currently there are no definitive treatment for MS disease and medications only reduce relapse rate, prolong remission, limit the onset of new MS lesions, and postpone the development of longterm disability (17). No ...
... among MS patients should be treated with an individual and integrated approach (16). Currently there are no definitive treatment for MS disease and medications only reduce relapse rate, prolong remission, limit the onset of new MS lesions, and postpone the development of longterm disability (17). No ...
The Pathology of Multiple Sclerosis and Its Variants
... etiology remains controversial, although recent evidence suggests that it actually involves at least four different pathologic variants (1). Numerous clinical demyelinating disorders may be part of the MS spectrum or may represent different diseases with similar clinical and pathologic features. For ...
... etiology remains controversial, although recent evidence suggests that it actually involves at least four different pathologic variants (1). Numerous clinical demyelinating disorders may be part of the MS spectrum or may represent different diseases with similar clinical and pathologic features. For ...
Formation, Maturation, and Disorders of Brain Neocortex
... postulated for the subplate: production of neurotransmitters that interact with migrating neurons, waiting zone for corticopetal axons, formation of "pioneer" axons at early stages of neocorticogenesis, and participation in the gyration of the cerebral surface (19, 20). By the time of birth, the sub ...
... postulated for the subplate: production of neurotransmitters that interact with migrating neurons, waiting zone for corticopetal axons, formation of "pioneer" axons at early stages of neocorticogenesis, and participation in the gyration of the cerebral surface (19, 20). By the time of birth, the sub ...
Mietzsch U, McKenna J 3rd, Reith RM, Way SW, Gambello MJ. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013 Nov. 521(16):3817-31.
... Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with an incidence of 1 in 6,000 live births (Gomez, 1999; Crino et al., 2006). The tumors or cysts associated with TSC most commonly affect the brain, kidney, skin, heart, and lung. Greater than 95% of patients have some degree of an ...
... Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with an incidence of 1 in 6,000 live births (Gomez, 1999; Crino et al., 2006). The tumors or cysts associated with TSC most commonly affect the brain, kidney, skin, heart, and lung. Greater than 95% of patients have some degree of an ...
Way SW, McKenna J 3rd, Mietzsch U, Reith RM, Wu HC, Gambello MJ. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Human Molecular Genetics. 2009 Apr 1; 18(7):1252-65.
... Tuberous sclerosis complex (TSC) is an autosomal dominant, tumor predisposition disorder characterized by significant neurodevelopmental brain lesions, such as tubers and subependymal nodules. The neuropathology of TSC is often associated with seizures and intellectual disability. To learn about the ...
... Tuberous sclerosis complex (TSC) is an autosomal dominant, tumor predisposition disorder characterized by significant neurodevelopmental brain lesions, such as tubers and subependymal nodules. The neuropathology of TSC is often associated with seizures and intellectual disability. To learn about the ...
Read More - LiveWiseMS
... 8983 subjects (average age = 53 years) who were members of the North American Research Committee on Multiple Sclerosis Registry, over a third reported at least one physical comorbidity (Marrie et al., 2008). The most commonly reported comorbidities of patients with MS were similar to those seen in t ...
... 8983 subjects (average age = 53 years) who were members of the North American Research Committee on Multiple Sclerosis Registry, over a third reported at least one physical comorbidity (Marrie et al., 2008). The most commonly reported comorbidities of patients with MS were similar to those seen in t ...
D. What Causes Multiple Sclerosis?
... (CNS) that is generally considered to be autoimmune in nature. White matter tracts are affected, including those of the cerebral hemispheres, infratentorium, and spinal cord. MS lesions, known as plaques, may form in CNS white matter in any location; thus, clinical presentations may be diverse. Cont ...
... (CNS) that is generally considered to be autoimmune in nature. White matter tracts are affected, including those of the cerebral hemispheres, infratentorium, and spinal cord. MS lesions, known as plaques, may form in CNS white matter in any location; thus, clinical presentations may be diverse. Cont ...
ALS, MS AND MD - ALS Society of Canada
... the spinal cord and those that travel to the voluntary muscles, so there are symptoms of both central and peripheral involvement, with weakness and wasting in arms, legs, and mouth/throat ...
... the spinal cord and those that travel to the voluntary muscles, so there are symptoms of both central and peripheral involvement, with weakness and wasting in arms, legs, and mouth/throat ...
Clinical trials in relapsing-remitting multiple sclerosis (a new
... The reason for such a gender difference remains still unknown. The natural cause of MS is characterized by variability of pattern, relapse rate and progression indices. In many patients there is a tendency to improve even without treatment. These facts create a dramatic impact on the interpretation ...
... The reason for such a gender difference remains still unknown. The natural cause of MS is characterized by variability of pattern, relapse rate and progression indices. In many patients there is a tendency to improve even without treatment. These facts create a dramatic impact on the interpretation ...
Drug that boosts nerve signals offers hope for multiple
... And the benefits of remyelinating drugs are expected to manifest over years, not months. At the neurology meeting, Biogen will report on a trial of anti-LINGO-1 in 82 patients with optic neuritis, a loss of vision common among people with multiple sclerosis. The trial found that the antibody was no ...
... And the benefits of remyelinating drugs are expected to manifest over years, not months. At the neurology meeting, Biogen will report on a trial of anti-LINGO-1 in 82 patients with optic neuritis, a loss of vision common among people with multiple sclerosis. The trial found that the antibody was no ...
PT Management in Others Neurological conditions
... MS (Multiple sclerosis) • Relapse-remitting MS (RRMS): Here you have an attack, go into complete or partial remission, then have the symptoms return. • Primary-progressive MS (PPMS): Here you continually decline and have no remissions. There may be a temporary relief in symptoms. • A few patients h ...
... MS (Multiple sclerosis) • Relapse-remitting MS (RRMS): Here you have an attack, go into complete or partial remission, then have the symptoms return. • Primary-progressive MS (PPMS): Here you continually decline and have no remissions. There may be a temporary relief in symptoms. • A few patients h ...
Stereological estimates of neuronal loss in the primary motor cortex
... cell loss in limb specific areas of the MS primary motor cortex (PMC). No limb specific neuronal cell counts had been reported to date in human brain. Objective To estimate the absolute number of neurons in the PMC associated with limb function in pwPMS and a reference case. Methods The left hemisph ...
... cell loss in limb specific areas of the MS primary motor cortex (PMC). No limb specific neuronal cell counts had been reported to date in human brain. Objective To estimate the absolute number of neurons in the PMC associated with limb function in pwPMS and a reference case. Methods The left hemisph ...
Tuberous sclerosis
Tuberous sclerosis or tuberous sclerosis complex (TSC) is a rare multi-system genetic disease that causes benign tumors to grow in the brain and on other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, intellectual disability, developmental delay, behavioral problems, skin abnormalities, lung and kidney disease. TSC is caused by a mutation of either of two genes, TSC1 and TSC2, which code for the proteins hamartin and tuberin respectively. These proteins act as tumor growth suppressors, agents that regulate cell proliferation and differentiation.The name, composed of the Latin tuber (swelling) and the Greek skleros (hard), refers to the pathological finding of thick, firm and pale gyri, called ""tubers,"" in the brains of patients postmortem. These tubers were first described by Désiré-Magloire Bourneville in 1880; the cortical manifestations may sometimes still be known by the eponym Bourneville's disease.