Bleeding tendency
... usually follows an acute viral infection. Childhood ITP is caused by an antibody (IgG or IgM) that binds to the platelet membrane. The condition results in Fc receptor-mediated splenic destruction of antibodycoated platelets. Rarely, ITP may be the presenting symptom of an autoimmune disease, such a ...
... usually follows an acute viral infection. Childhood ITP is caused by an antibody (IgG or IgM) that binds to the platelet membrane. The condition results in Fc receptor-mediated splenic destruction of antibodycoated platelets. Rarely, ITP may be the presenting symptom of an autoimmune disease, such a ...
Assessment of perioperative bleeding risk
... Rapid performance of investigations & compatibility tests Rapid issue of blood products Haematological advice/consultation Documentation ...
... Rapid performance of investigations & compatibility tests Rapid issue of blood products Haematological advice/consultation Documentation ...
Blood coagulation
... Definition: is the process wherein a fibrin clot, the product of coagulation, is broken down (clot retraction). Its main enzyme plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases or by the kidney and liver ...
... Definition: is the process wherein a fibrin clot, the product of coagulation, is broken down (clot retraction). Its main enzyme plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases or by the kidney and liver ...
Neonatal Coagulation Disorders
... -Exchange transfusion -Heparin-induced thrombocytopenia -Polycythemia/Hyperviscosity B. Impaired platelet function is rare in the newborn except for: •Decreased platelet adhesivenesss associated with indomethacin therapy •Von Willebrand’s Disease 2. Coagulation Protein Disorders A. Congenital factor ...
... -Exchange transfusion -Heparin-induced thrombocytopenia -Polycythemia/Hyperviscosity B. Impaired platelet function is rare in the newborn except for: •Decreased platelet adhesivenesss associated with indomethacin therapy •Von Willebrand’s Disease 2. Coagulation Protein Disorders A. Congenital factor ...
antihemophilic factor - DavisPlus
... Lab Test Considerations: Monitor plasma factor VIII levels. To prevent spontaneous bleeding, at least 5% of the normal factor VIII level must be present. Obtain baseline and periodic results of CBC, platelet count, direct Coombs’ test, urinalysis, partial thromboplastin time (PTT), thromboplastin ge ...
... Lab Test Considerations: Monitor plasma factor VIII levels. To prevent spontaneous bleeding, at least 5% of the normal factor VIII level must be present. Obtain baseline and periodic results of CBC, platelet count, direct Coombs’ test, urinalysis, partial thromboplastin time (PTT), thromboplastin ge ...
Poster
... Mice carrying the Gln387Pro substitution showed a significantly reduced ability of thrombomodulin to activate Protein C but did not show acute thrombosis (4). But when the mutation was examined in the context of pregnancy it was found to be associated with placental abnormality and pregnancy loss (5 ...
... Mice carrying the Gln387Pro substitution showed a significantly reduced ability of thrombomodulin to activate Protein C but did not show acute thrombosis (4). But when the mutation was examined in the context of pregnancy it was found to be associated with placental abnormality and pregnancy loss (5 ...
Tetanus Immune Globulin
... as HIV and hepatitis. Each blood donation is also tested for the presence of blood-borne viruses prior to being used to make TIg. A number of chemical and physical steps are included when preparing TIg to inactivate and remove viruses and bacteria that can cause disease. The final preparation of TIg ...
... as HIV and hepatitis. Each blood donation is also tested for the presence of blood-borne viruses prior to being used to make TIg. A number of chemical and physical steps are included when preparing TIg to inactivate and remove viruses and bacteria that can cause disease. The final preparation of TIg ...
Cytomegalovirus: time for a requiem?
... Lack of regulation of the complement system is associated with thrombosis. In this issue of Blood, Ståhl and colleagues report that deficiency of factor H in patients with atypical hemolytic uremic syndrome activates platelets and generates platelet microparticles. everal membrane and plasma protein ...
... Lack of regulation of the complement system is associated with thrombosis. In this issue of Blood, Ståhl and colleagues report that deficiency of factor H in patients with atypical hemolytic uremic syndrome activates platelets and generates platelet microparticles. everal membrane and plasma protein ...
Hemostasis and Blood Coagulation
... They become sticky so that they adhere to collagen in the tissues and to a protein called von willebrand factor that leaks into the traumatized tissue from the plasma They secrete large quantities of ADP; and their enzymes form thromboxane A2 The ADP and thromboxane in turn act on nearby plate ...
... They become sticky so that they adhere to collagen in the tissues and to a protein called von willebrand factor that leaks into the traumatized tissue from the plasma They secrete large quantities of ADP; and their enzymes form thromboxane A2 The ADP and thromboxane in turn act on nearby plate ...
Hyperhomocysteinemia Brochure - University of Iowa Health Care
... Deep vein thrombosis: A blood clot that forms in the deep veins of the extremities. DNA: The substance from which the genetic code is made. Factor V: One of the blood clotting proteins. Factor V Leiden: A form of inherited thrombophilia caused by a mutation in the gene for the blood clotting protein ...
... Deep vein thrombosis: A blood clot that forms in the deep veins of the extremities. DNA: The substance from which the genetic code is made. Factor V: One of the blood clotting proteins. Factor V Leiden: A form of inherited thrombophilia caused by a mutation in the gene for the blood clotting protein ...
Dental students-hemodynamics
... (4) In tissues that were previously congested because of sluggish venous outflow. (5) When flow is re-established to a site of previous arterial occlusion. ...
... (4) In tissues that were previously congested because of sluggish venous outflow. (5) When flow is re-established to a site of previous arterial occlusion. ...
BLOOD PRODUCT FACT SHEET Antihemophilic Factor / von
... The following information, i.e. guideline/educational material/policy or procedure, has been developed for use only within BC Children's Hospital (BC Children's) and BC Women's Hospital and Health Centre (BC Women's). Agencies other than BC Children's or BC Women's should use this information as a g ...
... The following information, i.e. guideline/educational material/policy or procedure, has been developed for use only within BC Children's Hospital (BC Children's) and BC Women's Hospital and Health Centre (BC Women's). Agencies other than BC Children's or BC Women's should use this information as a g ...
Hemodynamic disorders
... 2- Abnormal aortic and arterial dilations, called aneurysms (stasis). 3- Acute myocardial infarction results in focally noncontractile myocardium; can lead to aneurysm formation. 4- Hyperviscosity syndromes (such as polycythemia;) increase resistance to flow and cause small vessel stasis. 5- Deforme ...
... 2- Abnormal aortic and arterial dilations, called aneurysms (stasis). 3- Acute myocardial infarction results in focally noncontractile myocardium; can lead to aneurysm formation. 4- Hyperviscosity syndromes (such as polycythemia;) increase resistance to flow and cause small vessel stasis. 5- Deforme ...
Anticoagulant Presentation
... are more susceptible – Anemia or pulmonary disease – Even partial obstruction of a small vessel may lead to infarction, whereas under normal circumstances it would be without effect ...
... are more susceptible – Anemia or pulmonary disease – Even partial obstruction of a small vessel may lead to infarction, whereas under normal circumstances it would be without effect ...
THE PHYSIOLOGY OF BLOOD
... •hemophilia A for factor VIII deficiency •hemophilia B for factor IX deficiency. •hemophilia C for factor XI deficiency In some cases of von Willebrand disease, either a deficient level or a mutant version of the factor eliminates its protective effect on factor 8. SYMPTOMS •Easy Bruising •Frequent ...
... •hemophilia A for factor VIII deficiency •hemophilia B for factor IX deficiency. •hemophilia C for factor XI deficiency In some cases of von Willebrand disease, either a deficient level or a mutant version of the factor eliminates its protective effect on factor 8. SYMPTOMS •Easy Bruising •Frequent ...
NURSING CARE OF THE CHILD WITH A HEMATOLOGIC …
... • Iron Deficiency Anemia – Most common anemia caused by improper iron intake » Giving cow’s milk instead of baby formula is main culprit during the first year » Adolescent girls are at risk because of menstruation » Causes poor growth, poor test scores later – Treatment » Ferrous Sulfate for two mon ...
... • Iron Deficiency Anemia – Most common anemia caused by improper iron intake » Giving cow’s milk instead of baby formula is main culprit during the first year » Adolescent girls are at risk because of menstruation » Causes poor growth, poor test scores later – Treatment » Ferrous Sulfate for two mon ...
Thrombophilia
Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). Such abnormalities can be identified in 50% of people who have an episode of thrombosis (such as deep vein thrombosis in the leg) that was not provoked by other causes. A significant proportion of the population has a detectable abnormality, but most of these only develop thrombosis in the presence of an additional risk factor.There is no specific treatment for most thrombophilias, but recurrent episodes of thrombosis may be an indication for long-term preventative anticoagulation. The first major form of thrombophilia, antithrombin deficiency, was identified in 1965, while the most common abnormalities (including factor V Leiden) were described in the 1990s.