Peripartum Cardiomyopathy
... - fatal in up to 50% of patients - survivors -> exercise impairment and may require heart transplant - ?myocarditis from virus or autoimmune mediated - ?immune reaction to fetal cells -> migration to myocardium -> provocation of an immune response DEFINITION = echo evidence of idiopathic cardiomyopa ...
... - fatal in up to 50% of patients - survivors -> exercise impairment and may require heart transplant - ?myocarditis from virus or autoimmune mediated - ?immune reaction to fetal cells -> migration to myocardium -> provocation of an immune response DEFINITION = echo evidence of idiopathic cardiomyopa ...
Notes on Some Immunosuppressive Agents and Their Use in
... of the main metabolite of azathioprine, 6-mercaptopurine, has also been shown to cause liver damage, as for instance, when used in leukemic patients [4]. Although cyclophosphamide, given in very high doses, has been found to cause liver damage in rodents, patients have been treated with the drug for ...
... of the main metabolite of azathioprine, 6-mercaptopurine, has also been shown to cause liver damage, as for instance, when used in leukemic patients [4]. Although cyclophosphamide, given in very high doses, has been found to cause liver damage in rodents, patients have been treated with the drug for ...
azathioprine - British Association of Dermatologists
... This leaflet has been written to help you understand more about azathioprine. It tells you what it is, how it works, how it is used to treat skin conditions, and where you can find out more information about it. What is azathioprine and how does it work? Azathioprine has been available for more than ...
... This leaflet has been written to help you understand more about azathioprine. It tells you what it is, how it works, how it is used to treat skin conditions, and where you can find out more information about it. What is azathioprine and how does it work? Azathioprine has been available for more than ...
Febuxostat - ACI Limited
... serum uric acid (SUA) less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment. Us ...
... serum uric acid (SUA) less than 6 mg per dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment. Us ...
Slide 1
... Erythematosus at Dr. Soetomo General Hospital Surabaya Background : Systemic Lupus Erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with diverse clinical and laboratory manifestations and variable course and prognosis. Organ damage may be involved singly or in any combi ...
... Erythematosus at Dr. Soetomo General Hospital Surabaya Background : Systemic Lupus Erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with diverse clinical and laboratory manifestations and variable course and prognosis. Organ damage may be involved singly or in any combi ...
Azathioprine - Wolverhampton Formulary
... TMPT levels should be checked prior to starting therapy Discuss the benefits and side effects of treatment with the patient. Dose stabilisation: initial dosage adjustment until stable. Thereafter, during maintenance treatment, advice to the GP on any further dose adjustments required. 5. Ask the GP ...
... TMPT levels should be checked prior to starting therapy Discuss the benefits and side effects of treatment with the patient. Dose stabilisation: initial dosage adjustment until stable. Thereafter, during maintenance treatment, advice to the GP on any further dose adjustments required. 5. Ask the GP ...
Adverse Events Associated With Common Therapy Regimens for
... induce and maintain remission of the symptoms of CD eliminate long-term corticosteroid use ...
... induce and maintain remission of the symptoms of CD eliminate long-term corticosteroid use ...
Drugs and Myasthenia Gravis
... that particular drug, the lack of a suitable substitute and the gravity of the situation requiring the use of the drug. None of these medications are absolutely contraindicated in patients with MG. However,when possible substitutes should be used. If there are no acceptable substitutes, the patient ...
... that particular drug, the lack of a suitable substitute and the gravity of the situation requiring the use of the drug. None of these medications are absolutely contraindicated in patients with MG. However,when possible substitutes should be used. If there are no acceptable substitutes, the patient ...
Inflammatory Bowel Disease
... - occur at 2-3 weeks; cease on withdrawal Hepatotoxicity; pancreatitis (<5%) Leucopenia (3%) – myelotoxicity - determined by TPMT activity - weekly FBC x 8 weeks - 3 monthly thereafter - warn patients re: sore throat/fever ...
... - occur at 2-3 weeks; cease on withdrawal Hepatotoxicity; pancreatitis (<5%) Leucopenia (3%) – myelotoxicity - determined by TPMT activity - weekly FBC x 8 weeks - 3 monthly thereafter - warn patients re: sore throat/fever ...
azathioprine / 6 mercaptopurine - British Society of Gastroenterology
... There are very few case reports of an association between cervical cancer and IBD patients taking azathioprine, although there is more evidence available for patients with rheumatoid arthritis or systemic lupus erythematosus. There are occasional reports of IBD patients on immunosuppressive therapy ...
... There are very few case reports of an association between cervical cancer and IBD patients taking azathioprine, although there is more evidence available for patients with rheumatoid arthritis or systemic lupus erythematosus. There are occasional reports of IBD patients on immunosuppressive therapy ...
Azathioprine
... doctor if you notice the following while taking this medication: fever, rash, easy bruising or bleeding, or signs of an infection. Be sure to talk with your doctor before receiving any vaccines or undergoing any surgeries while taking this medication. If you are pregnant or are considering having a ...
... doctor if you notice the following while taking this medication: fever, rash, easy bruising or bleeding, or signs of an infection. Be sure to talk with your doctor before receiving any vaccines or undergoing any surgeries while taking this medication. If you are pregnant or are considering having a ...
Azathioprine
Azathioprine (INN, /ˌæzəˈθaɪɵpriːn/, abbreviated AZA) is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues. Synthesized originally as a cancer drug and a prodrug for mercaptopurine in 1957, it has been widely used as an immunosuppressant for more than 50 years.Azathioprine acts as a prodrug for mercaptopurine, inhibiting an enzyme required for the synthesis of DNA. Thus, it most strongly affects proliferating cells, such as the T cells and B cells of the immune system.The main adverse effect of azathioprine is bone marrow suppression, which can be life-threatening, especially in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. It is also listed by the International Agency for Research on Cancer as a group 1 carcinogen (carcinogenic to humans).Azathioprine is produced by a number of manufacturers under different brand names (Azasan by Salix in the U.S., Imuran by GlaxoSmithKline in Canada, the U.S., Australia, Ireland and the United Kingdom, Azamun in Finland, and Imurel in Scandinavia and France, among others). It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.