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What are genomes and how are they studied
What are genomes and how are they studied

...  Transfer of 1-200kb blocks of genomic sequence  Segmental duplications can occur on homologous chromosomes (intrachromosomal) or non homologous chromosomes (interchromosomal)  Not always tandemly arranged  Relatively recent Interchromosomal segments Intrachromosomal  duplicated among non homol ...
BIME, ERIC, REP, RIME, and Other Short Bacterial Repeated
BIME, ERIC, REP, RIME, and Other Short Bacterial Repeated

Plant Nuclear Genome Size Variation
Plant Nuclear Genome Size Variation

... Most are likely paleopolyploids Aneuploid variation – gain or less of one or more chromosomes ...
When algebra meets biology (PDF File 90.1 KB)
When algebra meets biology (PDF File 90.1 KB)

... how different species are related; what sequence of changes to the molecular fundamentals of life have led to the diverse landscape of organisms that we can currently observe? To understand the relatedness of forms of life at a molecular level, one must understand the mechanisms by which evolution o ...
No Slide Title
No Slide Title

... • Targeted Search (Candidate genes) – Examine a specific and small set of candidate variations based on what we know about the biology of the disease. – Can use both families with multiple affected individuals and families with only one affected individual. – Problem: There are 50,000 genes and we k ...
Chapter 13
Chapter 13

... 19. Discuss the use of nutritional mutants (auxotrophs) in the study of bacterial conjugation 20. Describe parasexual mating (conjugation) between F+ and F- bacteria including role of pilus 21. Explain the F factor, what it encodes, and the mechanism of transfer from F+ to F-. 22. Examine the utilit ...
Slide 1
Slide 1

... • The number of unique mRNA molecules is much larger than the number of genes. • A large fraction of the mRNA molecules is degraded by the NMD pathway. – NMD provides a means to regulate gene-expression at the post-transcriptional level ...
A4.3.1HowDoChromosomesCarryInformation
A4.3.1HowDoChromosomesCarryInformation

... 6. Where are centromeres located on chromosomes? Make a sketch of a chromosome and indicate where its centromere is located. 7. Where are telomeres located on chromosomes? Make a sketch of a chromosome and indicate where its telomeres are located. 8. From the variation window, select one of the chro ...
genes
genes

Document
Document

... Rapid ID of yeasts by gene sequences • Domains 1 and 2 (D1/D2) of LSU rDNA •Easy to PCR (universal primers), sequence, align… •Short (400-650 bp) but variable enough to distinguish most of yeast species •Universally available database for all known yeast species Kurtzman and Robnett (1998) - ascomyc ...
Proteomics of the chloroplast to chromoplast transition
Proteomics of the chloroplast to chromoplast transition

Lecture_13_2005
Lecture_13_2005

... • Only 271 of 4106 genes are essential for growth • Many genes are involved in a few metabolic functions (DNA, RNA, protein, cell wall) • 70% of essential genes have homologs in ...
Microbial Minimalism: Genome Reduction in Bacterial Pathogens
Microbial Minimalism: Genome Reduction in Bacterial Pathogens

... the opportunity to reconstruct the process of genome reduction. Such an attempt to reconstruct the pattern of gene deletions during the evolution of Buchnera suggested that, in addition to gradual erosion of some individual genes through small deletions, some deletions were large and spanned dozens ...
Construction of a Fibrobacter succinogenes Genomic Map and
Construction of a Fibrobacter succinogenes Genomic Map and

ppt
ppt

... - parallel efforts in key model organisms: bacteria, yeast, ...
Heredity and Behavior
Heredity and Behavior

... Natural Selection posits that heritable characteristics that provide a survival or reproductive advantage are more likely than alternative characteristics to be passed on to subsequent generations and thus come to be ‘selected’ over time. ◦ Populations NOT individuals and a gradual ...
Defining Genes in the Era of Genomics
Defining Genes in the Era of Genomics

... What about products from alternatively spliced genes? In the human genome, more than half the genes have spliced isoforms, and this is likely an underestimate since not all variants have been identified (14,15). Gene products from alternatively spliced messages have functionally unique and distinct ...
投影片 1
投影片 1

... Spot overlap ...
Iterative literature searching
Iterative literature searching

... Gene Ontology  Expression data basics ...
No Slide Title
No Slide Title

... Overview of Course Syllabus ...
The Biology of Autism
The Biology of Autism

... • Large number of chromosome abnormalities associated with autism, familial clustering of autism is well above the normal population prevalence, twinbased studies • Hereditability around 90% (Schizophrenia and major depression around 4050% • Not simple genetic transmission Autisms rather than autism ...
Identification of Coding Sequences
Identification of Coding Sequences

... A hidden Markov model explicitly models the probabilities for the transition from one part of a gene to another. In this model, used by the GENSCAN algorithm, each circle or diamond represents a functional unit in the gene. For example Eint is the initial exon and Eterm is the last. The arrows repre ...
Next Generation Sequencing-Broadening the Horizon For Genetic
Next Generation Sequencing-Broadening the Horizon For Genetic

Final Exam Review Sheet
Final Exam Review Sheet

...  Name 5 foreign genes that have been introduced and expressed in plants for the purpose of genetically engineering superior varieties of crop plants? Identify the foreign gene and the corresponding trait that it confers to the transgenic plant.  Describe how transgenic animals are commonly produce ...
Document
Document

... YAC transgenesis • transgenic mice produced by microinjection of the pronucleus of the fertilized egg or transfection of ES cells with YACs ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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