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21_Lecture_Presentation_PC
21_Lecture_Presentation_PC

... Concept 21.5: Duplication, rearrangement, and mutation of DNA contribute to genome evolution • The basis of change at the genomic level is mutation, which underlies much of genome evolution • The earliest forms of life likely had a minimal number of genes, including only those necessary for surviva ...
Read the first chapter
Read the first chapter

Genes that are located on the same
Genes that are located on the same

... genes. Alleles for these genes tend to segregate together during meiosis, unless they are separated by crossing-over. Crossing-over occurs when two homologous chromosomes exchange genetic material during meiosis I. **The closer together two genes are on a chromosome, the less likely their alleles wi ...
Project Description
Project Description

... Among the heterotrophic bacteria found in culture-dependent and –independent studies of aquatic habitats, the two most abundant groups of bacteria are often the Proteobacteria and the Bacteroidetes. Considering their natural abundance, the Bacteroidetes are relatively understudied, especially in com ...
Promoter sequence analysis
Promoter sequence analysis

...  Signal search analysis has played an instrumental role in the characterization of eukaryotic promoter elements  The method has originally been developed for the analysis of eukaryotic promoters but has a much broader application potential (e.g. Shine-Dalgarno signal analysis)  Rapidly growing co ...
Can ecology help genomics: the genome as ecosystem?
Can ecology help genomics: the genome as ecosystem?

... ecologists have made considerable progress in understanding the complex web of interactions that constitute an ecosystem. The field of genomics runs on a path parallel to ecology. Like ecology, genomicists seek to understand how each gene in the genome interacts with every other gene and how each gen ...
158-15(10-7-00) Human, Mouse, Rat . . . What`s Next?: Scientists
158-15(10-7-00) Human, Mouse, Rat . . . What`s Next?: Scientists

... King and Wilson’s initial estimate has held up well as geneticists have used more recently developed methods to directly compare the DNA sequences of a few chimp and human genes. These limited studies have consistently shown that the two genomes differ by 1 to 1.5 percent. What does that number mean ...
Toward forward genetic screens in malaria-causing
Toward forward genetic screens in malaria-causing

Amsterdam 2004 - Theoretical Biology & Bioinformatics
Amsterdam 2004 - Theoretical Biology & Bioinformatics

... multidomain proteins are split into single-domain segments and steps 1–4 are repeated with these sequences, which results in the assignment of individual domains to COGs in accordance with their distinct evolutionary affinities. • 6. Examination of large COGs that include multiple members from all o ...
PDF - 225KB - Centre for Science
PDF - 225KB - Centre for Science

Slide 1
Slide 1

... Sample sizes determine variant frequencies and effect size (Power) ...
Additional file 7
Additional file 7

... exist somewhere else in the genome and domain gain can occur relatively soon after the changes in the genome got the domain into the gene’s proximity. We investigated whether there were instances where a homologue of the gene that had gained a domain, and that was in the same TreeFam family, had a g ...
Understanding Genetics
Understanding Genetics

Answers to End-of-Chapter Questions – Brooker et al ARIS site
Answers to End-of-Chapter Questions – Brooker et al ARIS site

... pattern consistent with Mendel’s law of independent assortment. 2. What were the expected results of Bateson and Punnett’s cross? Answer: The expected results were a phenotypic ratio of 9:3:3:1. The researchers expected 9/16 of the offspring would have purple flowers and long pollen, 3/16 of the off ...
Practical Assignment - H3ABioNet training course material
Practical Assignment - H3ABioNet training course material

... e. What is the accession number for the genomic sequence for the GenBank entry for the gene? f. Is there a RefSeq entry for the LDLR gene? If so, provide the accession number of the sequence from which the RefSeq was derived. g. What disease is associated with mutations in the LDLR gene? Provide the ...
Document
Document

... Few of these replicated (small sample size, different methodologies) ...
Exploring the new world of the genome with DNA microarrays.
Exploring the new world of the genome with DNA microarrays.

... two samples are first labelled using different fluorescent dyes (say, a red dye and a green dye). They are then mixed and hybridized with the arrayed DNA spots. Use of differentially labelled mixtures avoids most of the complications of hybridization kinetics; we always measure the ratio. After hybr ...
Ferroplasma acidarmanus
Ferroplasma acidarmanus

... You may determine whether the gene is in a conserved cluster, whether it is conserved only in Archaea or does it appear in Bacteria as well? Is it conserved only in organisms that live at an extreme temperatures or pH? Are there any conserved functional domains within the protein? Adding the name of ...
From Atoms to Traits
From Atoms to Traits

... has also been made public. A side-by-side comparison of the three sequences offers several interesting revelations. First, each individual’s genome differs from the reference sequence by roughly 3.3 million single base-pair changes, which corresponds to variation in one of every 1,000 bases on avera ...
Newsletter Spring 2012 TRANSFAC® / ExPlain
Newsletter Spring 2012 TRANSFAC® / ExPlain

... ChIP-ChIP and ChIP-seq data sets published in the literature, or provided through the ENCODE project, provide a wealth of information about transcription factors and the genes that they regulate. Over the years we have integrated many of these data sets into TRANSFAC, processing and organizing the d ...
GENE EXPRESSION ANALYSIS
GENE EXPRESSION ANALYSIS

... The genomes of salmonids have undergone two rounds of whole genome duplication (WGD) relative to their last common ancestor with humans. Around 15% and 50% respectively of the duplicated genes (paralogues) from these WGD events have been retained in extant species. The regulatory regions of gene par ...
Scheme of work for Chapter 10, Genetics II
Scheme of work for Chapter 10, Genetics II

... autosomes and sex chromosomes ...
Cryptography and Linguistics of Macromolecules Cryptography and
Cryptography and Linguistics of Macromolecules Cryptography and

... In general terms, an MSA process results in a set of aligned sequences, usally with a calculation of the relative similarity among them, and a model of the alignment, usually with some score of its reliability. This model conveys the recu rrencies found in the set of sequences, and can be expressed ...
GenoWatch: a disease gene mining browser for association study
GenoWatch: a disease gene mining browser for association study

... Received January 28, 2008; Revised March 29, 2008; Accepted April 9, 2008 ...
Homology and developmental genes.
Homology and developmental genes.

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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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