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... designed to interrogate the whole genome at a resolution much higher than is possible using traditional karyotyping or fluorescence in situ hybridization (FISH) methodologies. Our High Density SNP array contains a total of 2.6 million markers distributed throughout the genome for the detection of bo ...
... designed to interrogate the whole genome at a resolution much higher than is possible using traditional karyotyping or fluorescence in situ hybridization (FISH) methodologies. Our High Density SNP array contains a total of 2.6 million markers distributed throughout the genome for the detection of bo ...
S1 Appendix.
... We extract the information of a given genomic feature from the full-genome sequence (.fa or equivalent) and annotation (.gff3 or equivalent) files. First, GRS extracts the name and length of each chromosome from the sequence file. It creates a list for the header (starting with “>”) and sequence, ea ...
... We extract the information of a given genomic feature from the full-genome sequence (.fa or equivalent) and annotation (.gff3 or equivalent) files. First, GRS extracts the name and length of each chromosome from the sequence file. It creates a list for the header (starting with “>”) and sequence, ea ...
On the optimization of classes for the assignment of unidentified
... problem are unsupervised, for example, for transcriptome data6,30–34 (see Ref. 35 for a related counterexample). This is unfortunate because these methods measure only what changes; however, for functional assignment we are interested not in what changes but in which changes matter. One subclassific ...
... problem are unsupervised, for example, for transcriptome data6,30–34 (see Ref. 35 for a related counterexample). This is unfortunate because these methods measure only what changes; however, for functional assignment we are interested not in what changes but in which changes matter. One subclassific ...
Using comparative genomic hybridization to
... such as GC content, also contribute to variation in hybridization ratio, as does technical variation. Conclusions: Here we demonstrate that aCGH can accurately be used as a proxy to estimate genome-wide divergence, thus providing an efficient way to evaluate how evolutionary processes and genomic ar ...
... such as GC content, also contribute to variation in hybridization ratio, as does technical variation. Conclusions: Here we demonstrate that aCGH can accurately be used as a proxy to estimate genome-wide divergence, thus providing an efficient way to evaluate how evolutionary processes and genomic ar ...
slides
... Abundance: high frequency on the genome Posi@on: throughout the genome – coding region, intron region, promoter site Ease of genotyping (high-‐throughput genotyping) Less mutable than other forms of polymorphi ...
... Abundance: high frequency on the genome Posi@on: throughout the genome – coding region, intron region, promoter site Ease of genotyping (high-‐throughput genotyping) Less mutable than other forms of polymorphi ...
A1993LB48800002
... naming of new genes and nomenclature of chromosomal loci. DNA 8:1-13, 1989. (Cited 550 times.) 3. Nebert D W, Nelson D R, Coon M J, Estabrook R W, Feyereisen R, Fujii-Kuriyama Y, Gonzalez F J, Guengerich F P, Gunsalus I C, Johnson E F, Loper J C, Sato R, Waterman M R & Waxman D J. The P450 superfami ...
... naming of new genes and nomenclature of chromosomal loci. DNA 8:1-13, 1989. (Cited 550 times.) 3. Nebert D W, Nelson D R, Coon M J, Estabrook R W, Feyereisen R, Fujii-Kuriyama Y, Gonzalez F J, Guengerich F P, Gunsalus I C, Johnson E F, Loper J C, Sato R, Waterman M R & Waxman D J. The P450 superfami ...
No Slide Title
... importance of quantitative genetics • The machinery of classical quantitative genetics is easily modified (indeed, it is actually preadapted) to account for massive advances in genomics and other fields of biotechonology • Useful and powerful tools have been developed to address specific issues in t ...
... importance of quantitative genetics • The machinery of classical quantitative genetics is easily modified (indeed, it is actually preadapted) to account for massive advances in genomics and other fields of biotechonology • Useful and powerful tools have been developed to address specific issues in t ...
beyond Mendel - the molecular basis of inheritance
... • Mitotic nondisjunction: occurs at metaphase. If early in embryonic development, can be passed onto a large number of cells • Aneuploidy - an abnormal number of chromosomes (trisomic or monosomic); for example, Down syndrome is trisomy of chromosome 21 • Polyploidy - a chromosome number that is mor ...
... • Mitotic nondisjunction: occurs at metaphase. If early in embryonic development, can be passed onto a large number of cells • Aneuploidy - an abnormal number of chromosomes (trisomic or monosomic); for example, Down syndrome is trisomy of chromosome 21 • Polyploidy - a chromosome number that is mor ...
Supplementary Methods - Clinical Cancer Research
... (amplitude). This renders large systematic differences in the amplitude of copy number change (SNP6 higher, 450K lower) between the cohorts. The amplitude of copy number change is one important variable in the CAAI calculation. Global gene expression analysis Total RNA was obtained from the same tum ...
... (amplitude). This renders large systematic differences in the amplitude of copy number change (SNP6 higher, 450K lower) between the cohorts. The amplitude of copy number change is one important variable in the CAAI calculation. Global gene expression analysis Total RNA was obtained from the same tum ...
Genes Reading Group, Minutes 4. (Dec 4)
... Norm of Reactions (NOR) of outcomes across conditions attached to it) ...
... Norm of Reactions (NOR) of outcomes across conditions attached to it) ...
The surface-located YopN protein is involved in calcium signal
... The low-calcium response (Icr) is strongly conserved among the pathogenic Yersinia species ar»d is observed when the pathogen is grown at 37°C in Ca^ *-depleted medium. This response is characterized by a general metabolic downshift and by a specific induction of virulence-plasmid-encoded yop genes. ...
... The low-calcium response (Icr) is strongly conserved among the pathogenic Yersinia species ar»d is observed when the pathogen is grown at 37°C in Ca^ *-depleted medium. This response is characterized by a general metabolic downshift and by a specific induction of virulence-plasmid-encoded yop genes. ...
DNA Sequence Capture and Enrichment by Microarray Followed by
... standard, Sanger sequencing, in the application of targeted resequencing. We selected the NF1 gene as the clinical target in this pilot study. Neurofibromatosis type 1, a common tumor-predisposing disorder that occurs in 1 of 3000 births, is caused by autosomal dominant mutations in a single gene, N ...
... standard, Sanger sequencing, in the application of targeted resequencing. We selected the NF1 gene as the clinical target in this pilot study. Neurofibromatosis type 1, a common tumor-predisposing disorder that occurs in 1 of 3000 births, is caused by autosomal dominant mutations in a single gene, N ...
Data Flowchart
... If additional written informed consent is given, the clinical geneticist or research nurse checks the ‘Consent for view in Ensembl’ box and a coloured bar becomes visible in Ensembl showing the location and nature of the genomic variant to which are attached the phenotype terms (eg. short stature, c ...
... If additional written informed consent is given, the clinical geneticist or research nurse checks the ‘Consent for view in Ensembl’ box and a coloured bar becomes visible in Ensembl showing the location and nature of the genomic variant to which are attached the phenotype terms (eg. short stature, c ...
Japanese barleys offer frost-tolerance hope
... have been identified with moderate genetic frost-tolerance. This genetic resistance could form the basis of future breeding programs for genetic frost resistance in other cereal varieties. ...
... have been identified with moderate genetic frost-tolerance. This genetic resistance could form the basis of future breeding programs for genetic frost resistance in other cereal varieties. ...
Chapter 10: Genetics of Viruses
... infect bacteria. The genomes of bacteriophages are much smaller than those of bacteria. In many cases, the genome consists of less than 100 genes. While not living, viruses are important to biologists due to their ability to infect cells and cause disease. Thus, there is an interest in mapping viral ...
... infect bacteria. The genomes of bacteriophages are much smaller than those of bacteria. In many cases, the genome consists of less than 100 genes. While not living, viruses are important to biologists due to their ability to infect cells and cause disease. Thus, there is an interest in mapping viral ...
Mechanisms Underlying the Evolution and Maintenance of
... (Zhang, Dyer, and Rosenberg 2000) are good examples of multigene families that experience rapid gene turnover due to birth-and-death evolution. In these cases, rapid gene turnover has led to the creation of species-specific gene clusters as a result of frequent gene duplication and loss. Consequentl ...
... (Zhang, Dyer, and Rosenberg 2000) are good examples of multigene families that experience rapid gene turnover due to birth-and-death evolution. In these cases, rapid gene turnover has led to the creation of species-specific gene clusters as a result of frequent gene duplication and loss. Consequentl ...
Putting it all together: Finding the cystic fibrosis gene
... sticky mucus that clogs the lungs and leads to life-threatening lung infections. These thick secretions also obstruct the pancreas, preventing digestive enzymes from reaching the intestines to help break down and absorb food. The mucus also can block the bile duct in the liver, eventually causing pe ...
... sticky mucus that clogs the lungs and leads to life-threatening lung infections. These thick secretions also obstruct the pancreas, preventing digestive enzymes from reaching the intestines to help break down and absorb food. The mucus also can block the bile duct in the liver, eventually causing pe ...
Mathematical modeling reveals additional links between
... Duke University, Durham, NC, United States ...
... Duke University, Durham, NC, United States ...
COAS_B1_Ch14 Evolution
... by pathogens; or they may abiotic factors – that is, caused by non-living components of the environment, such as water supply or nutrient levels in the soil. For example, the increasing number of rabbits eats an increasing amount of vegetation, until food is in short supply. The larger population ma ...
... by pathogens; or they may abiotic factors – that is, caused by non-living components of the environment, such as water supply or nutrient levels in the soil. For example, the increasing number of rabbits eats an increasing amount of vegetation, until food is in short supply. The larger population ma ...
Proposal Submission Form
... IBC Registration Form This form must be completed for any work involving the following: recombinant DNA 1, pathogens (infectious agents) or select agents 2. This form must be submitted along with Description of Research form7 and the Viral Vector Information Form9 (if needed). Documents must be subm ...
... IBC Registration Form This form must be completed for any work involving the following: recombinant DNA 1, pathogens (infectious agents) or select agents 2. This form must be submitted along with Description of Research form7 and the Viral Vector Information Form9 (if needed). Documents must be subm ...