Disease Genomics Part 2 - Medical Sciences Division
... • Excellent functional genomics resources – The comparison between a human phenotype and a mouse phenotype is often very readily interpretable. – Other useful organisms include the fly, the worm and even yeast • Useful as they have well-curated data for many genes ...
... • Excellent functional genomics resources – The comparison between a human phenotype and a mouse phenotype is often very readily interpretable. – Other useful organisms include the fly, the worm and even yeast • Useful as they have well-curated data for many genes ...
Development of the Custom AtMtDEFL Array and Robust Data
... genes. The array also contains probe sets with invariant levels of expression (hereafter called invariant genes) to aid microarray data normalization. Probe sets were interspersed on the custom array, although chip hybridization and microarray data analysis were performed for only one plant species ...
... genes. The array also contains probe sets with invariant levels of expression (hereafter called invariant genes) to aid microarray data normalization. Probe sets were interspersed on the custom array, although chip hybridization and microarray data analysis were performed for only one plant species ...
Chapter 6
... ten obliterating the desirable color, taste, or size. Grafting, on the other hand, is a type of cloning: the fruit-bearing part of the new tree will be genetically identical to the original branch, and its fruit will have all the desired qualities. And while apple rootstocks are generally apple vari ...
... ten obliterating the desirable color, taste, or size. Grafting, on the other hand, is a type of cloning: the fruit-bearing part of the new tree will be genetically identical to the original branch, and its fruit will have all the desired qualities. And while apple rootstocks are generally apple vari ...
Diapositive 1
... Michel et al. New Phytol. 2010 PMID: 20618908 Michel et al. New Phytol. 2010 PMID: 20618907 ...
... Michel et al. New Phytol. 2010 PMID: 20618908 Michel et al. New Phytol. 2010 PMID: 20618907 ...
Introduction to the GCG Wisconsin Package
... DataServe: Automatically updates nucleic acid on a daily basis via FTP. DataExtended: the most compete set of nucleic acid and protein data. The timing of the release is coordinated with the major ...
... DataServe: Automatically updates nucleic acid on a daily basis via FTP. DataExtended: the most compete set of nucleic acid and protein data. The timing of the release is coordinated with the major ...
Introduction to the GCG Wisconsin Package
... DataServe: Automatically updates nucleic acid on a daily basis via FTP. DataExtended: the most compete set of nucleic acid and protein data. The timing of the release is coordinated with the major ...
... DataServe: Automatically updates nucleic acid on a daily basis via FTP. DataExtended: the most compete set of nucleic acid and protein data. The timing of the release is coordinated with the major ...
MB207Jan2010
... - ionizing radiation because it removes electrons from biological molecules. - generating highly reactive intermediates that cause various types of DNA damage. ...
... - ionizing radiation because it removes electrons from biological molecules. - generating highly reactive intermediates that cause various types of DNA damage. ...
COAS_B1_Ch08 Nucleic acids
... There are also polynucleotides which contain the sugar ribose rather than deoxyribose. They are therefore called ribonucleic acids, or RNA for short. Figure 8.9 shows the structure of RNA. RNA is generally single stranded, while DNA is generally double stranded. Another difference between them is th ...
... There are also polynucleotides which contain the sugar ribose rather than deoxyribose. They are therefore called ribonucleic acids, or RNA for short. Figure 8.9 shows the structure of RNA. RNA is generally single stranded, while DNA is generally double stranded. Another difference between them is th ...
Near Neutrality, Rate Heterogeneity, and Linkage Govern
... comparison, consistent with variation in mutation rates across the genome. Neutrality indices (dN/dS) are significantly greater than unity among G. morhua genomes and between sister species, which suggests that polymorphisms within species are slightly deleterious, as expected under the nearly neutr ...
... comparison, consistent with variation in mutation rates across the genome. Neutrality indices (dN/dS) are significantly greater than unity among G. morhua genomes and between sister species, which suggests that polymorphisms within species are slightly deleterious, as expected under the nearly neutr ...
Chapter 8 DNA Fingerprinting and Forensic Analysis
... – The gene encoding this protein has lots of sequence variability across the human population. – Since this gene is not present in other life forms, it reduces the interference that could otherwise be contributed by bacteria, fungi, dog, or cat DNA picked up in the sample at crime scene. ...
... – The gene encoding this protein has lots of sequence variability across the human population. – Since this gene is not present in other life forms, it reduces the interference that could otherwise be contributed by bacteria, fungi, dog, or cat DNA picked up in the sample at crime scene. ...
Widespread and nonrandom distribution of DNA
... palindromic structure15 (Supplementary Fig. 1 online). This result was not simply due to the high degree of MYC amplification, because digestion with EcoRI before formation of snap-back DNA and digestion with S1 eliminated the signal probably because the EcoRI fragment does not contain the center of ...
... palindromic structure15 (Supplementary Fig. 1 online). This result was not simply due to the high degree of MYC amplification, because digestion with EcoRI before formation of snap-back DNA and digestion with S1 eliminated the signal probably because the EcoRI fragment does not contain the center of ...
ATP16 Genes and Neighboring ORFs Are Duplicated on
... chromosome IV in S. cerevisiae (Jacq et al., 1997; Giraud & Velours, 1994). The ATP16 (YDL004w) gene was disrupted with the yeast HIS3 gene (plasmid pYEF-16/4) by the homologous recombination methods as described previously (Takeda et al., 1995; Takeda et al., 1999; Takeda et al., 2010; Takeda et al ...
... chromosome IV in S. cerevisiae (Jacq et al., 1997; Giraud & Velours, 1994). The ATP16 (YDL004w) gene was disrupted with the yeast HIS3 gene (plasmid pYEF-16/4) by the homologous recombination methods as described previously (Takeda et al., 1995; Takeda et al., 1999; Takeda et al., 2010; Takeda et al ...
Validated preCRMs
... The RP scores and different classes of predicted GATA-1 binding sites were combined to identify distinctive groups of predicted cis-regulatory modules (preCRMs) for experimental tests (Fig. 2A). Within the eight target loci, we tested 44 noncoding DNA segments with a positive RP score and at least o ...
... The RP scores and different classes of predicted GATA-1 binding sites were combined to identify distinctive groups of predicted cis-regulatory modules (preCRMs) for experimental tests (Fig. 2A). Within the eight target loci, we tested 44 noncoding DNA segments with a positive RP score and at least o ...
Initiation of recombination suppression and PAR formation during
... increase in G+C content within PAR through GC-biased gene conversion (gBGC) [12, 13]. Previous studies suggest that the rapid progression of Y gene decay occurred shortly after the initiation of the sex chromosome differentiation in eutherian [4, 14, 15]. Therefore, the eutherian sex chromosomes mi ...
... increase in G+C content within PAR through GC-biased gene conversion (gBGC) [12, 13]. Previous studies suggest that the rapid progression of Y gene decay occurred shortly after the initiation of the sex chromosome differentiation in eutherian [4, 14, 15]. Therefore, the eutherian sex chromosomes mi ...
Woods Hole – Zebrafish Genetics and Development Bioinformatics
... Note: This document “wh_informatics_practical.doc” and supporting materials can be downloaded at the MBL ZF course website. Setting the stage: These tasks each pertain to the mutation that we (virtually) mapped in lab. The curved body axis and U-shaped somites observed in these mutants are hallmarks ...
... Note: This document “wh_informatics_practical.doc” and supporting materials can be downloaded at the MBL ZF course website. Setting the stage: These tasks each pertain to the mutation that we (virtually) mapped in lab. The curved body axis and U-shaped somites observed in these mutants are hallmarks ...
Inquiry into Life, Eleventh Edition
... – The genetic map • Exact number of genes is unknown at this time • Researchers only need to know a short sequence of bases in a gene, and a computer searches the genome for a match ...
... – The genetic map • Exact number of genes is unknown at this time • Researchers only need to know a short sequence of bases in a gene, and a computer searches the genome for a match ...
Mitochondrial DNA disease - Human Molecular Genetics
... spindle transfer is performed at an earlier stage and the karyoplast is smaller than with pronuclear transfer, with the potential for less carryover of mtDNA. However, recent studies in human embryos show equivalent levels of carryover (unpublished data), providing further evidence that the risks of ...
... spindle transfer is performed at an earlier stage and the karyoplast is smaller than with pronuclear transfer, with the potential for less carryover of mtDNA. However, recent studies in human embryos show equivalent levels of carryover (unpublished data), providing further evidence that the risks of ...
Mutations in a gene encoding a novel protein tyrosine
... Fig. 4). A single cDNA (266552) representing transcript B shared identity with transcript A, except for the omission of a 1,770-bp segment due to splicing (Figs 3, 4). The common origin of transcripts A and B suggests they are alternative forms of the same gene, the products of which would be predic ...
... Fig. 4). A single cDNA (266552) representing transcript B shared identity with transcript A, except for the omission of a 1,770-bp segment due to splicing (Figs 3, 4). The common origin of transcripts A and B suggests they are alternative forms of the same gene, the products of which would be predic ...
Chapter06_Outline
... Genome Size • The genetic complement of a cell or virus constitutes its genome. • In eukaryotes, this term is commonly used to refer to one complete haploid set of chromosomes, such as that found in a sperm or egg. • The C-value is the DNA content of the haploid genome ...
... Genome Size • The genetic complement of a cell or virus constitutes its genome. • In eukaryotes, this term is commonly used to refer to one complete haploid set of chromosomes, such as that found in a sperm or egg. • The C-value is the DNA content of the haploid genome ...
Factors modifying the yield of radiation
... breaks and exchanges induced immediately and after different times following irradiation of human lymphocytes. By combining PCC with FISH it was possible to study the process of exchange aberration formation with time. Some of the human chromosomes such as #1, #19 are rich in actively transcribing g ...
... breaks and exchanges induced immediately and after different times following irradiation of human lymphocytes. By combining PCC with FISH it was possible to study the process of exchange aberration formation with time. Some of the human chromosomes such as #1, #19 are rich in actively transcribing g ...
Section 4
... – During translation, amino acids are assembled from information encoded in mRNA. – As the mRNA codons move through the ribosome, tRNAs add specific amino acids to the growing polypeptide chain. – The process continues until a stop codon is reached and the newly made protein is released. ...
... – During translation, amino acids are assembled from information encoded in mRNA. – As the mRNA codons move through the ribosome, tRNAs add specific amino acids to the growing polypeptide chain. – The process continues until a stop codon is reached and the newly made protein is released. ...
Hutchinson Gilford Progeria Syndrome: A
... of HGPS [1-4]. In fact, a mouse model where the activity of mouse orthologue of Zmpste24 is impaired is currently used as model of HGPS and actually this mouse model recapitulates many aspects of human HGPS [5]. Within the nucleus, lamins can directly and indirectly bind to chromatin. Lamin-associat ...
... of HGPS [1-4]. In fact, a mouse model where the activity of mouse orthologue of Zmpste24 is impaired is currently used as model of HGPS and actually this mouse model recapitulates many aspects of human HGPS [5]. Within the nucleus, lamins can directly and indirectly bind to chromatin. Lamin-associat ...
Human genome
The human genome is the complete set of nucleic acid sequence for humans (Homo sapiens), encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells (the egg and sperm gamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNA base pairs, while diploid genomes (found in somatic cells) have twice the DNA content. While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4%) and bonobos. Humans share 50% of their DNA with bananas.The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution.Although the sequence of the human genome has been (almost) completely determined by DNA sequencing, it is not yet fully understood. Most (though probably not all) genes have been identified by a combination of high throughput experimental and bioinformatics approaches, yet much work still needs to be done to further elucidate the biological functions of their protein and RNA products. Recent results suggest that most of the vast quantities of noncoding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture, and signals controlling epigenetic inheritance.There are an estimated 20,000-25,000 human protein-coding genes. The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further. Protein-coding sequences account for only a very small fraction of the genome (approximately 1.5%), and the rest is associated with non-coding RNA molecules, regulatory DNA sequences, LINEs, SINEs, introns, and sequences for which as yet no function has been elucidated.