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Tinea capitis guidelines 2014 - British Association of Dermatologists
Tinea capitis guidelines 2014 - British Association of Dermatologists

... Favus A chronic, inflammatory tinea capitis typically seen in T. schoenleinii infection, this variant is most commonly encountered in the Middle East and North Africa. Favus is characterized by yellow, crusted, cup-shaped lesions (‘scutula’) composed of hyphae and keratin debris, which develop aroun ...
PDF
PDF

... There are various theories on the development of endometriosis, but there is no clear proof of one or the other etiology (cause in the formation of this illness). The juxtaposition of various factors in a patient is also possible. The implantation Theory – the Sampson's Theory. This theory is based ...
Clinical Practice Guideline - Lymphoma
Clinical Practice Guideline - Lymphoma

... CD45/CD3/CD20/CD30/CD15/ PAX5/MUM1 and should be selected on a case by case basis at the discretion of the hematopathologist. EBV studies by in situ hybridization (EBER) may be considered if difficulty exists diagnostically, as most cases of the mixed-cellularity subtype of classical Hodgkin lymphom ...
Randa Elfadil Ibrahim abdalla
Randa Elfadil Ibrahim abdalla

... research for the financial support. To all those who encouraged me, I owe and gladly acknowledge a considerable debt. Finally, I would like to acknowledge and thank The National Ribat University. Abstract Introduction: Asthma is an inflammatory disease that results from interactions between multiple ...
Phenotype Curation Tool and Ontologies at dictyBase
Phenotype Curation Tool and Ontologies at dictyBase

... • Developed in collaboration with NCBO • Similar in functionality to Phenote • Web-based tool that can be accessed from any computer ...
L-carnitine
L-carnitine

... modestly improve exercise tolerance and decrease electrocardiographic signs of ischemia during exercise testing in a limited number of angina patients. One randomized, placebocontrolled study in 200 patients with exercise-induced stable angina found that supplementing conventional medical therapy w ...
Genetics of the shaded American Shorthair
Genetics of the shaded American Shorthair

... zone, pigmented lips, a brick red or pink nose, colored paw pads, and frequently colored hair the back of the feet. Genetically, however, the unpatterned cats carry either classic or mackerel or both traits "masked" by the unpatterned tabby pattern. The agouti gene (A_) is a dominant gene that allow ...
Genetics of the shaded American Shorthair
Genetics of the shaded American Shorthair

... and chinchilla patterns are grouped together as shaded cats in this paper, since the difference between the shaded and chinchilla cats varies only in one pattern attribute, the width of the white undercoat. Evidence of a pattern or barring on the legs, neck, and tail or, worse, on the body is effec ...
Phylogenetic analysis of three complete gap
Phylogenetic analysis of three complete gap

... transfer of small molecules (<1 kDa) between neighboring cells [1]. Cell –cell communication via gap junctions is critical for normal cellular function and homeostasis as evidenced by the wide variety of connexin mutations that lead to human disease [2]. A single connexin protein folds into four con ...
YOUR INTERSTIM® THERAPY
YOUR INTERSTIM® THERAPY

... • It is a very good idea to bring this guide along to all of your health care provider appointments and share this information with doctors, dentists, MRI operators, and other health care professionals who may not be familiar with the InterStim Therapy system. Appendix B, Information for your doctor ...
Rationale for Comprehensive Nonsurgical Periodontal Therapy
Rationale for Comprehensive Nonsurgical Periodontal Therapy

... pocket. Periodontitis can present as a chronic and slowly progressing disease (most common form) or as an aggressive disease causing loss of bone over a relatively short period of time. Periodontitis of advanced severity can result in tooth mobility, occasional pain and discomfort (generally associa ...
What is Haemoglobin E/ Delta-beta thalassaemia
What is Haemoglobin E/ Delta-beta thalassaemia

... How are delta-beta thalassaemia and haemoglobin E inherited? They are inherited through genes. Every human characteristic, such as eye colour, or height, or type of haemoglobin is controlled by genes that we inherit from our parents. A child inherits two genes for every characteristic, one from eac ...
Whose Genetic Information Is It Anyway?
Whose Genetic Information Is It Anyway?

RIIN TAMM In-depth analysis of factors affecting variability in
RIIN TAMM In-depth analysis of factors affecting variability in

... Since the first working human genome draft was published in 2001, there has been rapid development of high-throughput sequencing technologies. The resultant mass of genomic datasets contains information about inter-individual genome variance of great interest for personalized medicine, which has bec ...
Original article MOLECULAR CHARACTERISATION OF LUMPY
Original article MOLECULAR CHARACTERISATION OF LUMPY

... 1979). Sheep pox and goat pox are endemic in Iraq (Zangana & Abdullah, 2013). The first natural outbreaks of LSD occurred in Iraq in 2013 (Al-Salihi & Hassan, 2015). In this study, molecular detection and phylogenic analysis of Capripoxvirus were performed in Sulaimani province in Kurdistan region o ...
Aalborg Universitet Detection, identification and quantification of microorganisms in selected infections
Aalborg Universitet Detection, identification and quantification of microorganisms in selected infections

... In suspected prosthetic joint infections it was found that although culture-dependent and molecular methods might give concordant results in some cases, the presence of biofilms on prosthesis surfaces might be the reason for cases where molecular methods could identify additional microorganisms. The ...
Case Study Findings Report
Case Study Findings Report

... Up until the early 2000s, the standard for adjuvant treatment of post-menopausal women with early stage, hormone receptor-positive (HR+) breast cancer was the prescription of a drug named tamoxifen. A selective estrogen receptor modulator, tamoxifen works by binding to the estrogen receptor thus kee ...
Characterization of the Phosphoenolpyruvate Carboxykinase Gene
Characterization of the Phosphoenolpyruvate Carboxykinase Gene

... O06084), Chlorobium limicola (SWISS-PROT Q08262) and Treponema pallidum SWISS-PROT O83159), however, these four genes were identified during sequencing projects only by sequence similarity and can therefore not be considered as being functionally analyzed. The present study describes for the first t ...
Session xx: - I-TECH TB Prevention Toolkit
Session xx: - I-TECH TB Prevention Toolkit

... Patient Education and Counselling • Patient education should take place prior to IPT initiation, but should also continue throughout the course of IPT use ...
Kinds of gene rearrangement
Kinds of gene rearrangement

... The hypotheses A successful hypothesis is normally based on zlerae causae (ascertained facts), while unsuccessful hypotheses are often marked by containing one or more jictae causae (imagined statements). The first hypothesis as to crossing over seems to have been that of JANSSENS (1909), who predic ...
Pleiotropic effects of the mouse lethal yellow (Ay) mutation
Pleiotropic effects of the mouse lethal yellow (Ay) mutation

... yellow pigment, phaeomelanin (Bultman et al., 1992; Miller et al., 1993). For most agouti genotypes, agouti RNA is expressed only in the skin during the time of phaeomelanin synthesis. However, Ay is associated with the ubiquitous expression of a chimeric RNA that fuses a novel 5′ end, ‘exon 1Ay’, t ...
LYMPHOMA Effective Date: April 2013
LYMPHOMA Effective Date: April 2013

... accurately subclassify many cases of DLBCL when compared to gene expression profiling.11 Therefore, routine use of immunohistochemical stains for the express purpose of subtyping ABC versus GC is not recommended. Relevant stains may be performed if considered of diagnostic importance by the reportin ...
Early Release
Early Release

... "unmask" disease at new sites not previously known to be infected by the pathogen. They also might represent a response to a previously unrecognized additional pathogen. The majority of patients who manifest IRIS do so within the first 4--8 weeks after starting ART, and have had high viral loads and ...
The purpose of this summary is exclusively educational, to provide
The purpose of this summary is exclusively educational, to provide

... specific IgE (sIgE) against the vaccine or its components; (iii) patients with negative vaccine skin tests will usually tolerate the vaccine; (iv) patients with positive vaccine skin tests may tolerate the vaccine, in these cases the vaccine should be gradually administered; (v) it is prudent to obs ...
Genetic analysis of non-syndromic craniosynostosis
Genetic analysis of non-syndromic craniosynostosis

... without consideration of the less common but much better characterized craniosynostosis syndromes. Approximately 15% of all craniosynostosis cases present with associated anomalies involving mainly the face and the limbs and are considered to be syndromic (2). More than 180 syndromes manifest cranio ...
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Gene therapy



Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.
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