- VCA Canada
... free wall and interventricular septal thickening secondary to pressure overload, dilation of the main pulmonary artery and paradoxic motion of the interventricular septum) may also be seen. Once PAH is diagnosed, further evaluation to determine the underlying etiology for development of this complic ...
... free wall and interventricular septal thickening secondary to pressure overload, dilation of the main pulmonary artery and paradoxic motion of the interventricular septum) may also be seen. Once PAH is diagnosed, further evaluation to determine the underlying etiology for development of this complic ...
oculocutaneous albinism and analysis of tyrosinase gene in
... Matsunaga, J., Dakeishi, M., Shimizu, H. and Tomita, Y.: R278TER and P431L mutations of the tyrosinase gene exist with tyrosinase-negative oculocutaneous albinism. J. Dermato!. Sci., 13, 134-139 (1996). Matsunaga, J., Tomita, Y. and Tagami, H.: Detection of point mutations in human tyrosinase gene b ...
... Matsunaga, J., Dakeishi, M., Shimizu, H. and Tomita, Y.: R278TER and P431L mutations of the tyrosinase gene exist with tyrosinase-negative oculocutaneous albinism. J. Dermato!. Sci., 13, 134-139 (1996). Matsunaga, J., Tomita, Y. and Tagami, H.: Detection of point mutations in human tyrosinase gene b ...
DEVELOPMENT OF AN ORAL SUBMUCOUS FIBROSIS-SPECIFIC HAPLOTYPIC SIGNATURE – Reveiw Article
... the often studied hospital-based ones. Further, TGF-1 -a pleiotropic cytokine, among other functions including immuno-suppression, is associated with an increase in TIMP genes (TIMP-1 and TIMP-2) as well as a Plasminogen activator inhibitor I. Hence, polymorphism-associated changes in this growth f ...
... the often studied hospital-based ones. Further, TGF-1 -a pleiotropic cytokine, among other functions including immuno-suppression, is associated with an increase in TIMP genes (TIMP-1 and TIMP-2) as well as a Plasminogen activator inhibitor I. Hence, polymorphism-associated changes in this growth f ...
Biomarkers in clinical medicine
... and activating mutation in Ras oncogene and loss of function mutations in APC and p53 tumour suppressor genes for colon cancer) (12). Subtypes of these cancers and most other common diseases are less deterministic; even apparently simple Mendelian disorders may prove to have widely variable clinical ...
... and activating mutation in Ras oncogene and loss of function mutations in APC and p53 tumour suppressor genes for colon cancer) (12). Subtypes of these cancers and most other common diseases are less deterministic; even apparently simple Mendelian disorders may prove to have widely variable clinical ...
based methods in the environment and hospital patients
... Methicillin-resistant Staphylococcus aureus (MRSA) was first discovered in the UK in 1961. It is a major pathogen associated with nosocomial disease both in the community and in hospitals. The number of MRSA infections is increasing with >1,600 deaths reported in 2006 in the UK alone. ...
... Methicillin-resistant Staphylococcus aureus (MRSA) was first discovered in the UK in 1961. It is a major pathogen associated with nosocomial disease both in the community and in hospitals. The number of MRSA infections is increasing with >1,600 deaths reported in 2006 in the UK alone. ...
Evaluating the Efficacy of Mucoactive Aerosol Therapy
... combination therapy at half the concentration of each drug significantly decreased in vitro cystic fibrosis sputum cohesivity, indicating an additive effect of the two drugs. Similar effects were observed when dornase alfa was used in conjunction with either hypertonic saline14 or gelsolin.12,13 The ...
... combination therapy at half the concentration of each drug significantly decreased in vitro cystic fibrosis sputum cohesivity, indicating an additive effect of the two drugs. Similar effects were observed when dornase alfa was used in conjunction with either hypertonic saline14 or gelsolin.12,13 The ...
A genome-wide scan in affected sibling pairs with
... indeed a condition for which genetic factors play a role it is likely that the patients’ mothers also had reduced reproductive fitness. Women or couples carrying genetic variants that most severely affect reproductive fitness would therefore be expected to produce a limited number of children (one chi ...
... indeed a condition for which genetic factors play a role it is likely that the patients’ mothers also had reduced reproductive fitness. Women or couples carrying genetic variants that most severely affect reproductive fitness would therefore be expected to produce a limited number of children (one chi ...
Hypokalaemic periodic paralysis
... (paralysis). The muscle weakness may be confined to a small group of muscles e.g. the forearm and hand muscles alone resulting in weakness of grip. Alternatively, the muscle weakness may be more generalised e.g. the muscles of the arms and legs. When the weakness is generalised the patient may be co ...
... (paralysis). The muscle weakness may be confined to a small group of muscles e.g. the forearm and hand muscles alone resulting in weakness of grip. Alternatively, the muscle weakness may be more generalised e.g. the muscles of the arms and legs. When the weakness is generalised the patient may be co ...
Genetic Defect FAQs - Red Angus Association of America
... their progeny? No. Confirmed carriers will be listed on the RAAA website. In addition, their registration certificate (printed and web versions) will identify them as a genetic defect carrier with the [*D] notation after their registration number. Furthermore, the specific genetic defect will be lis ...
... their progeny? No. Confirmed carriers will be listed on the RAAA website. In addition, their registration certificate (printed and web versions) will identify them as a genetic defect carrier with the [*D] notation after their registration number. Furthermore, the specific genetic defect will be lis ...
gene xpert mtb/rif-a novel diagnostic tool for rapid and specific
... Clinical sputum samples (or decontaminated sputum pellets) are treated with a sodium hydroxide and isopropanol-containing sample reagent (SR). The SR is added to the sample (currently recommended at a 3:1 ratio for sputum pellets and a 2:1 ratio for unprocessed sputum samples) and incubated at room ...
... Clinical sputum samples (or decontaminated sputum pellets) are treated with a sodium hydroxide and isopropanol-containing sample reagent (SR). The SR is added to the sample (currently recommended at a 3:1 ratio for sputum pellets and a 2:1 ratio for unprocessed sputum samples) and incubated at room ...
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... any associated heterologous gene. As long as the D., [1987] Molecular Biology. Jones and Bartlett Publish allolactose concentration in the cell is above 104M, ers, Inc, Portola Valley, CA; Beckwith, supra). It was calculated that greater than 20% of the lactose acted 35 the tac promoter provides hig ...
... any associated heterologous gene. As long as the D., [1987] Molecular Biology. Jones and Bartlett Publish allolactose concentration in the cell is above 104M, ers, Inc, Portola Valley, CA; Beckwith, supra). It was calculated that greater than 20% of the lactose acted 35 the tac promoter provides hig ...
Autologous Hematopoietic Stem Cell Transplantation for Patients
... treatment options should be considered. Every newly diagnosed patient with MM, even those older than age 70 years, should be considered a candidate for an AHSCT. Eligibility criteria vary by institution. Referral to a transplantation center, most often based on proximity and insurance contracting, s ...
... treatment options should be considered. Every newly diagnosed patient with MM, even those older than age 70 years, should be considered a candidate for an AHSCT. Eligibility criteria vary by institution. Referral to a transplantation center, most often based on proximity and insurance contracting, s ...
Isolation of the b-tubulin Gene From Yeast and Demonstration of its Essential Function in vivo.
... these transformants indicate that pRBl21 indeed has both its ends within the TUB2 gene (Table 1). First, some of the Ura+ transformants were benomyl-resistant, unlike the parent diploid, suggesting inactivation of the BEN’ allele. Second, some of the Ura+, benomyl-sensitive transformants showed good ...
... these transformants indicate that pRBl21 indeed has both its ends within the TUB2 gene (Table 1). First, some of the Ura+ transformants were benomyl-resistant, unlike the parent diploid, suggesting inactivation of the BEN’ allele. Second, some of the Ura+, benomyl-sensitive transformants showed good ...
Retrovirus Integration Database (RID): a public database for
... The NCI Retrovirus Integration Database is a MySql-based relational database created for storing and retrieving comprehensive information about retroviral integration sites, primarily, but not exclusively, HIV-1. The database is accessible to the public for submission or extraction of data originati ...
... The NCI Retrovirus Integration Database is a MySql-based relational database created for storing and retrieving comprehensive information about retroviral integration sites, primarily, but not exclusively, HIV-1. The database is accessible to the public for submission or extraction of data originati ...
Research
... stimulation device that has been shown to facilitate lymphoedema management, venous velocity and blood flow. Three case studies were undertaken with people with leg ulcers of primarily venous aetiology who were using no compression therapy or low compression therapy to assess adherence to the BodyFl ...
... stimulation device that has been shown to facilitate lymphoedema management, venous velocity and blood flow. Three case studies were undertaken with people with leg ulcers of primarily venous aetiology who were using no compression therapy or low compression therapy to assess adherence to the BodyFl ...
Evaluation and treatment of hirsutism in premenopausal women
... It is restricted to use in women for whom alternative drug therapy is ineffective, contra-indicated or considered inappropriate and may offer advantages over existing therapy for some women as it avoids the risks associated with systemic therapies. However, it is listed as “not preferred” in the Lot ...
... It is restricted to use in women for whom alternative drug therapy is ineffective, contra-indicated or considered inappropriate and may offer advantages over existing therapy for some women as it avoids the risks associated with systemic therapies. However, it is listed as “not preferred” in the Lot ...
HbF inducers
... ● Some studies have been carried out using valproic acid, a compound related to short fatty acid derivatives, reported increased HbF levels ...
... ● Some studies have been carried out using valproic acid, a compound related to short fatty acid derivatives, reported increased HbF levels ...
Table S3. Transcription factor binding sites identified in haplotypes
... The search was performed using the insect directory of the TRANSFAC® 6.0 database [99,100,101,102,103] with the help of the programs PATCHTM public 1.0 (limited to perfect matches of at least 5 bases) and MATCHTM public 1.0 [104] (using 70% as a minimum overall similarity and 100% as core similarity ...
... The search was performed using the insect directory of the TRANSFAC® 6.0 database [99,100,101,102,103] with the help of the programs PATCHTM public 1.0 (limited to perfect matches of at least 5 bases) and MATCHTM public 1.0 [104] (using 70% as a minimum overall similarity and 100% as core similarity ...
ERS-ATS COPD Guidelines
... Combining long-acting inhaled β-agonists and ipratropium leads to fewer exacerbations than either drug alone. ...
... Combining long-acting inhaled β-agonists and ipratropium leads to fewer exacerbations than either drug alone. ...
In children with moderate dehydration, oral rehydration reduced ED
... promote ORT,5 recent survey data suggest that many paediatricians in the developed world are not adopting this approach.6 One reason is the perception that ORT is more time consuming than IVT.7 In addition, uncertainty may exist about the appropriateness of ORT among the range of children presenting ...
... promote ORT,5 recent survey data suggest that many paediatricians in the developed world are not adopting this approach.6 One reason is the perception that ORT is more time consuming than IVT.7 In addition, uncertainty may exist about the appropriateness of ORT among the range of children presenting ...
Genetics - Fresno State
... which has its own gene • Therefore, Beadle and Tatum’s hypothesis is now restated as the one gene–one polypeptide hypothesis • Note that it is common to refer to gene products as proteins rather than polypeptides • A gene can be defined as a region of DNA that can be expressed to produce a final fun ...
... which has its own gene • Therefore, Beadle and Tatum’s hypothesis is now restated as the one gene–one polypeptide hypothesis • Note that it is common to refer to gene products as proteins rather than polypeptides • A gene can be defined as a region of DNA that can be expressed to produce a final fun ...
AP Biology Unit 4: Genetics - Chapter 14
... Inheritance patterns are often more complex than predicted by simple Mendelian genetics. • Pleiotropy – If one gene results in more than one phenotypic character, that one gene is called pleiotrophic. Most genes have multiple phenotypic effects, a property called pleiotropy • For example, pleiotropi ...
... Inheritance patterns are often more complex than predicted by simple Mendelian genetics. • Pleiotropy – If one gene results in more than one phenotypic character, that one gene is called pleiotrophic. Most genes have multiple phenotypic effects, a property called pleiotropy • For example, pleiotropi ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.