The Mitochondria as a Minimal Chassis:
... whole synthetic organisms. • Microbial engineering: A minimalistic cell could be more prone to accept new metabolic pathways than a more complex organism. ...
... whole synthetic organisms. • Microbial engineering: A minimalistic cell could be more prone to accept new metabolic pathways than a more complex organism. ...
Documentation for Candidate Gene Prioritization
... This script performs all of the counting, testing, and scoring steps. It uses R (it was written under R version 2.3.1 and is fully compatible with R version 2.4.0). It requires the files ‘GOannotation.txt’, ‘expcounts.txt’, and ‘correl.txt’. The script reads in the file ‘correl.txt’, which contains ...
... This script performs all of the counting, testing, and scoring steps. It uses R (it was written under R version 2.3.1 and is fully compatible with R version 2.4.0). It requires the files ‘GOannotation.txt’, ‘expcounts.txt’, and ‘correl.txt’. The script reads in the file ‘correl.txt’, which contains ...
Automatic detection of conserved gene clusters in
... case, two unrelated clusters may be merged in the same group, which makes it difficult to obtain a multiple alignment of gene orders. On the other hand, complete linkage identifies only small groups of uniform gene cluster organizations, which is not suitable for detecting variations among species. ...
... case, two unrelated clusters may be merged in the same group, which makes it difficult to obtain a multiple alignment of gene orders. On the other hand, complete linkage identifies only small groups of uniform gene cluster organizations, which is not suitable for detecting variations among species. ...
TAN Huarong
... Recombinant strains were constructed by increasing an extra copy of sanU and sanV in Streptomyces ansochromogenes, by which the nikkomycin production was about 2 fold higher than that of wild-type strain. The sanJ gene was inactivated by the insertion of kanamycin resistance gene and the resulting ...
... Recombinant strains were constructed by increasing an extra copy of sanU and sanV in Streptomyces ansochromogenes, by which the nikkomycin production was about 2 fold higher than that of wild-type strain. The sanJ gene was inactivated by the insertion of kanamycin resistance gene and the resulting ...
D P DEFINING SUCCESS IN MULTIPLE SCLEROSIS: TREATMENT FAILURES AND NONRESPONDERS
... highly variable; this makes it challenging to predict its course for individual patients. The underlying mechanisms that lead to MS progression remain uncertain, which makes the timing of treatment initiation a significant challenge. Initially, an unidentified factor triggers immune system inflammat ...
... highly variable; this makes it challenging to predict its course for individual patients. The underlying mechanisms that lead to MS progression remain uncertain, which makes the timing of treatment initiation a significant challenge. Initially, an unidentified factor triggers immune system inflammat ...
Document
... • Pathogenicity of viruses is disrupted by disabling ability to replicate in target cells • Accomplished by deletion of genes providing necessary replication functions from the viral genome • Introduction of these genes along with the defective vector into cells results in synthesis of vector genome ...
... • Pathogenicity of viruses is disrupted by disabling ability to replicate in target cells • Accomplished by deletion of genes providing necessary replication functions from the viral genome • Introduction of these genes along with the defective vector into cells results in synthesis of vector genome ...
Genetic evaluation with major genes and polygenic
... use pedigree, genotype and phenotype information when some individuals are not genotyped. We propose to consider gene content at the major gene as a second trait correlated to the quantitative trait, in a gene content multipletrait best linear unbiased prediction (GCMTBLUP) method. Results: The gen ...
... use pedigree, genotype and phenotype information when some individuals are not genotyped. We propose to consider gene content at the major gene as a second trait correlated to the quantitative trait, in a gene content multipletrait best linear unbiased prediction (GCMTBLUP) method. Results: The gen ...
Case Report Section
... Manabe et al., 2010). Four children have been reported, aged 3-14 years old, of which three had ALL and the oldest had AML (Harada et al., 1997). ...
... Manabe et al., 2010). Four children have been reported, aged 3-14 years old, of which three had ALL and the oldest had AML (Harada et al., 1997). ...
Alpha Thalassemia - Lab Test Directory
... • HBA1 and HBA2 large gene deletions account for up to 90% of α thalassemia o The -α3.7 and -α4.2 deletions result in the deletion of a single gene o The -(α)20.5, --SEA, --MED, --FIL, and --THAI deletions result in the deletion of the HBA1 and HBA2 genes from the same chromosome • Point mutations a ...
... • HBA1 and HBA2 large gene deletions account for up to 90% of α thalassemia o The -α3.7 and -α4.2 deletions result in the deletion of a single gene o The -(α)20.5, --SEA, --MED, --FIL, and --THAI deletions result in the deletion of the HBA1 and HBA2 genes from the same chromosome • Point mutations a ...
Gene Section HMGA2 (high mobility group AT-hook 2) in Oncology and Haematology
... Heterogenous disease that arises in precursor B or T cells. Cytogenetics One case with a t(9;12)(p22;q14), frequent deletions at 12q14.3. Hybrid/Mutated Gene t(9;12): FISH analysis indicated a breakpoint in the 5' region of the gene, RT-PCR showed overexpression of HMGA2 lacking the carboxyterminal ...
... Heterogenous disease that arises in precursor B or T cells. Cytogenetics One case with a t(9;12)(p22;q14), frequent deletions at 12q14.3. Hybrid/Mutated Gene t(9;12): FISH analysis indicated a breakpoint in the 5' region of the gene, RT-PCR showed overexpression of HMGA2 lacking the carboxyterminal ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... CMT 1 - the genes involved in myelin sheath production are faulty. The myelin sheath gradually wastes away. Approximately one third of all CMT cases are of this type. CMT 2 - approximately 17% of all CMT cases. The defect is in the axon itself. CMT 3 - also known as Dejerine-Sottas disease. This is ...
... CMT 1 - the genes involved in myelin sheath production are faulty. The myelin sheath gradually wastes away. Approximately one third of all CMT cases are of this type. CMT 2 - approximately 17% of all CMT cases. The defect is in the axon itself. CMT 3 - also known as Dejerine-Sottas disease. This is ...
Next-Generation Sequencing Panel
... harbor TP53 mutations, only a fraction carry TP53 mutations without del(17p13) (3-5%).[2] More than 90% of mutations in CLL are in the DNA-binding domain of TP53, with most being missense mutations.[3] CLL patients with TP53 abnormalities have an aggressive clinical course, require earlier intervent ...
... harbor TP53 mutations, only a fraction carry TP53 mutations without del(17p13) (3-5%).[2] More than 90% of mutations in CLL are in the DNA-binding domain of TP53, with most being missense mutations.[3] CLL patients with TP53 abnormalities have an aggressive clinical course, require earlier intervent ...
Document
... Each of the 20,000 genes in the human genome has a unique map position in the genome. Each gene is found at the same position in all members of our species. You can find that position by genetic mapping. ...
... Each of the 20,000 genes in the human genome has a unique map position in the genome. Each gene is found at the same position in all members of our species. You can find that position by genetic mapping. ...
Retrospective Evaluation of Patients Diagnosed with Osteogenesis
... in this type. Type 4 has normal sclera with clinical severity between type 1, 3. Types 5, 6, 7, 8, 9 have also been identified (2). OI treatment involves physiotherapy, rehabilitation and orthopedic surgery. However, strengthening the bones should be our first priority. This is why calcitonin, bisph ...
... in this type. Type 4 has normal sclera with clinical severity between type 1, 3. Types 5, 6, 7, 8, 9 have also been identified (2). OI treatment involves physiotherapy, rehabilitation and orthopedic surgery. However, strengthening the bones should be our first priority. This is why calcitonin, bisph ...
Accepted Manuscript
... investigation including performance of a complete autopsy and review of the circumstances of death and the clinical history” [14]. Our case is in concordance with this definition. The genetic analysis in our index case identified 7 genetic variations in 6 different genes that could explain his death ...
... investigation including performance of a complete autopsy and review of the circumstances of death and the clinical history” [14]. Our case is in concordance with this definition. The genetic analysis in our index case identified 7 genetic variations in 6 different genes that could explain his death ...
Xenotransplantation - How Bad Science and Big Business Put the
... Transgenic pigs, rather than our close relatives primates, were considered as organ donors because there are greater ethical objections to using primates, many of which are endangered protected species [6]. As pigs are already farmed for food, it was thought that there would be less ethical concern, ...
... Transgenic pigs, rather than our close relatives primates, were considered as organ donors because there are greater ethical objections to using primates, many of which are endangered protected species [6]. As pigs are already farmed for food, it was thought that there would be less ethical concern, ...
Gene Section SSX2 (Synovial Sarcoma, X breakpoint 2) in Oncology and Haematology
... prognostic parameter influencing disease progression is still controversial due to contradictory data from later studies. The molecular function of SYT-SSX is key to cancer development. The fusion of SSX to SYT results in the disruption of SYT and its associated chromatinremodeling/coactivator compl ...
... prognostic parameter influencing disease progression is still controversial due to contradictory data from later studies. The molecular function of SYT-SSX is key to cancer development. The fusion of SSX to SYT results in the disruption of SYT and its associated chromatinremodeling/coactivator compl ...
The development of restriction analysis and PCR
... methods, using agarose gel electrophoresis to approximate DNA fragment lengths. Standard curves were constructed to allow approximation of fragment lengths (and thus plasmid identity) using the proposed methods. The efficacy of the restriction analysis and PCR-based techniques was confirmed, with th ...
... methods, using agarose gel electrophoresis to approximate DNA fragment lengths. Standard curves were constructed to allow approximation of fragment lengths (and thus plasmid identity) using the proposed methods. The efficacy of the restriction analysis and PCR-based techniques was confirmed, with th ...
The GOSim package
... The Gene Ontology (GO) has become one of the most widespread systems for systematically annotating gene products within the bioinformatics community and is developed by the Gene Ontology Consortium ?. It is specifically intended for describing gene products with a controlled and structured vocabular ...
... The Gene Ontology (GO) has become one of the most widespread systems for systematically annotating gene products within the bioinformatics community and is developed by the Gene Ontology Consortium ?. It is specifically intended for describing gene products with a controlled and structured vocabular ...
Male-Specific Diseases
... both male and female characteristics can sometimes be found in one individual, and it is possible to have XY women and XX men. Analysis of such individuals has revealed some of the molecules involved in sex determination, including one called SRY, which is important for testis formation. SRY (which ...
... both male and female characteristics can sometimes be found in one individual, and it is possible to have XY women and XX men. Analysis of such individuals has revealed some of the molecules involved in sex determination, including one called SRY, which is important for testis formation. SRY (which ...
Praktikum der Microarray-Datenanalyse
... • if H0 is true, no more than a fraction α of the replications will yield a p-value ≤ α • subject-sampling p-value: replications involve taking a new sample of subjects and measure same genes → a significant p-values gives confidence to find the same associations within a new sample of subjects • ge ...
... • if H0 is true, no more than a fraction α of the replications will yield a p-value ≤ α • subject-sampling p-value: replications involve taking a new sample of subjects and measure same genes → a significant p-values gives confidence to find the same associations within a new sample of subjects • ge ...
Inferring Ancestral Chloroplast Genomes with Inverted
... region (LSC, SSC and IR) independent, which greatly simplify the computation. For two genomes G1 and G2 , the genomic distance between these two can be defined as d(G1 , G2 ) = d(SSC1, SSC2 ) + d(LSC1, LSC2 ) +d(IR1, IR2 ), i.e., the overall distance is the summation of all regional distances. If no ...
... region (LSC, SSC and IR) independent, which greatly simplify the computation. For two genomes G1 and G2 , the genomic distance between these two can be defined as d(G1 , G2 ) = d(SSC1, SSC2 ) + d(LSC1, LSC2 ) +d(IR1, IR2 ), i.e., the overall distance is the summation of all regional distances. If no ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.