HCLSIG$$Meetings$$2009-02
... expertise, can utilize the expertise of the person who designed the Class. Easily share your expertise with others Easily utilize the expertise of others ...all based on the premise that we define the world by its properties, rather than its classes ...
... expertise, can utilize the expertise of the person who designed the Class. Easily share your expertise with others Easily utilize the expertise of others ...all based on the premise that we define the world by its properties, rather than its classes ...
milova_032405 - Microarray Facility
... Gene Ontology annotation for all GO IDs is kept in three different information fields: biological processes, molecular function and cellular compartment. For each of the fields all available annotation was prefiltered with redundancy check and concatenated. Kate Milova ...
... Gene Ontology annotation for all GO IDs is kept in three different information fields: biological processes, molecular function and cellular compartment. For each of the fields all available annotation was prefiltered with redundancy check and concatenated. Kate Milova ...
Full Text PDF - Journal of Integrative Plant Biology
... 2.1 The morphology and anatomical structure of the mutant florets No difference in phenotype was observed between the mutant and the wild type plant before heading time. After head ing, th e different ap pearan ce in florets between the mutant and wild type was intuitive. In contrast to the wild typ ...
... 2.1 The morphology and anatomical structure of the mutant florets No difference in phenotype was observed between the mutant and the wild type plant before heading time. After head ing, th e different ap pearan ce in florets between the mutant and wild type was intuitive. In contrast to the wild typ ...
Fertility, Reproduction, and Genetic Disease
... the origin of germ cells throughout the male's reproductive life, and their permanence provides the only germ-cell stage wherein genetic damage can accumulate through time and thereby pose an increasing risk of genetic damage to the progeny. Further, gene mutations are less likely than chromosomal d ...
... the origin of germ cells throughout the male's reproductive life, and their permanence provides the only germ-cell stage wherein genetic damage can accumulate through time and thereby pose an increasing risk of genetic damage to the progeny. Further, gene mutations are less likely than chromosomal d ...
Extent of Gene Duplication in the Genomes of
... above questions in these genomes. However, the presence of same genes with different names and the existence of alternative splicing forms in the database make it difficult to study the extent of gene duplication in a genome. Moreover, retrotranscriptase (RT) and protein parts derived from repetitiv ...
... above questions in these genomes. However, the presence of same genes with different names and the existence of alternative splicing forms in the database make it difficult to study the extent of gene duplication in a genome. Moreover, retrotranscriptase (RT) and protein parts derived from repetitiv ...
file - ORCA - Cardiff University
... Generating molecular diversity lies at the heart of directed evolution (1-4). With an everexpanding directed evolution toolbox, different mutational approaches are required. These will access sequence space beyond that sampled by simple gene point mutations that ultimately restrict sequence, structu ...
... Generating molecular diversity lies at the heart of directed evolution (1-4). With an everexpanding directed evolution toolbox, different mutational approaches are required. These will access sequence space beyond that sampled by simple gene point mutations that ultimately restrict sequence, structu ...
Molecular biology of brain aging and neurodegenerative disorders
... predicted to have 554 amino acids. At the primary structure level STM2 and S182 are 67% identical over all, while in the hydrophobic transmembrane regions they are 84% identical (Levy-Lahad et al. 1995). A single mutation at codon 141 (N14 11) has been found in the Volga kindred in the STM2 gene (Le ...
... predicted to have 554 amino acids. At the primary structure level STM2 and S182 are 67% identical over all, while in the hydrophobic transmembrane regions they are 84% identical (Levy-Lahad et al. 1995). A single mutation at codon 141 (N14 11) has been found in the Volga kindred in the STM2 gene (Le ...
Full Text - Harvard University
... devoted to identifying sets of genes associated with biologically relevant phenotypes and which distinguish these from others (Golub, T. R., et. al., (1999), Van't Veer, L. J., et. al., (2002) and Wang, Y., et. al., (2005)). The standard approach is to first identify a "significant gene list" and th ...
... devoted to identifying sets of genes associated with biologically relevant phenotypes and which distinguish these from others (Golub, T. R., et. al., (1999), Van't Veer, L. J., et. al., (2002) and Wang, Y., et. al., (2005)). The standard approach is to first identify a "significant gene list" and th ...
Both parents affected
... For some conditions, being homozygous for the dominant disorder causes the individual to be more severely affected (as in achondroplasia) or for the disorder to have an earlier age of onset (eg familial hypercholesterolaemia). In other disorders, for instance Huntington disease, homozygotes appear t ...
... For some conditions, being homozygous for the dominant disorder causes the individual to be more severely affected (as in achondroplasia) or for the disorder to have an earlier age of onset (eg familial hypercholesterolaemia). In other disorders, for instance Huntington disease, homozygotes appear t ...
Chronic Lymphocytic Leukemia (CLL) - URMC
... The course of CLL varies a lot. Most patients do not need treatment at diagnosis, but they need to be monitored carefully for progression of their disease. A small number of patients have advanced disease at diagnosis and require treatment right away, but most will not need treatment until a later t ...
... The course of CLL varies a lot. Most patients do not need treatment at diagnosis, but they need to be monitored carefully for progression of their disease. A small number of patients have advanced disease at diagnosis and require treatment right away, but most will not need treatment until a later t ...
The amdR product and a CCAAT-binding factor
... unlabelled pUC18 plasmid DNA containing either no insert, 280 bp of the intergenic promoter region of the divergently transcribed lamA and lamB genes (plam28) or 1 kb of the 5' region of the gatA gene (pIR12). Both DNA inserts contain presumed binding sites for the amdR gene product based on in vivo ...
... unlabelled pUC18 plasmid DNA containing either no insert, 280 bp of the intergenic promoter region of the divergently transcribed lamA and lamB genes (plam28) or 1 kb of the 5' region of the gatA gene (pIR12). Both DNA inserts contain presumed binding sites for the amdR gene product based on in vivo ...
Conclusions Synapsin IIa is expressed in the brain of adult zebrafish
... Figure 1: RT-PCR analysis of Synapsin IIa from zebrafish embryos. The SynIIa gene was amplified from zebrafish brain, 24 hpf, and 72 hpf. The primers used encompassed the predicted ATG start codon and stop codon to produce an amplicon of 1420 base pairs ...
... Figure 1: RT-PCR analysis of Synapsin IIa from zebrafish embryos. The SynIIa gene was amplified from zebrafish brain, 24 hpf, and 72 hpf. The primers used encompassed the predicted ATG start codon and stop codon to produce an amplicon of 1420 base pairs ...
Methods S1: Vector constructions and transformation of yeast and
... were digested by XbaI and ligated into XbaI digested pBIN-eGFP or pBIN. The constructs, termed pBIN-A47noPS-eGFP and pBIN-A47noPS were cloned in E. coli, reextracted and sequenced. Finally, the constructs were introduced into A. tumefaciens strain C58 by electroporation at 1.5 kV, 200 ohms and 25 µF ...
... were digested by XbaI and ligated into XbaI digested pBIN-eGFP or pBIN. The constructs, termed pBIN-A47noPS-eGFP and pBIN-A47noPS were cloned in E. coli, reextracted and sequenced. Finally, the constructs were introduced into A. tumefaciens strain C58 by electroporation at 1.5 kV, 200 ohms and 25 µF ...
ppt - University of Illinois at Urbana
... Blocks represent conserved genes. In the course of evolution or in a clinical context, blocks 1,…,10 could be misread as 1, 2, 3, -8, -7, -6, -5, -4, 9, 10. Reversals occurred one-two times every million years on the evolutionary path between human and mouse. ...
... Blocks represent conserved genes. In the course of evolution or in a clinical context, blocks 1,…,10 could be misread as 1, 2, 3, -8, -7, -6, -5, -4, 9, 10. Reversals occurred one-two times every million years on the evolutionary path between human and mouse. ...
Genetica per Scienze Naturali aa 03
... the molecular basis of the thalassemias were uncovered. The initial patients with Cooley’s disease are now recognized to have been afflicted with b-thalassemia. In the following few years, different types of thalassemia involving polypeptide chains other than beta chains were recognized and describe ...
... the molecular basis of the thalassemias were uncovered. The initial patients with Cooley’s disease are now recognized to have been afflicted with b-thalassemia. In the following few years, different types of thalassemia involving polypeptide chains other than beta chains were recognized and describe ...
Annotating your D - GEP Community Server
... the first time that this sequence has ever been looked at by anyone. The goal is to come to the most reasonable interpretation of the data and be able to articulate the reasoning behind your hypothesis. While we are interested in all features of genome organization, especially as they relate to euch ...
... the first time that this sequence has ever been looked at by anyone. The goal is to come to the most reasonable interpretation of the data and be able to articulate the reasoning behind your hypothesis. While we are interested in all features of genome organization, especially as they relate to euch ...
عرض تقديمي من PowerPoint
... Lymphoproliferative disorders (CLL, Large granular lymphocytic leukemia, and lymphoma), infection with HIV and hepatitis c virus, and therapy with drugs such as heparin and quinidine. ...
... Lymphoproliferative disorders (CLL, Large granular lymphocytic leukemia, and lymphoma), infection with HIV and hepatitis c virus, and therapy with drugs such as heparin and quinidine. ...
Functional Consequences of a SDHB Gene Mutation in an
... Arg46, cationic residue, could thus be important for the physical organization of the iron-sulfur clusters of the protein. Interestingly, this residue has been found as mutated in glycine in two patients with pheochromocytoma (8) and in glutamine in our patient. Whether it might represent a hotspot ...
... Arg46, cationic residue, could thus be important for the physical organization of the iron-sulfur clusters of the protein. Interestingly, this residue has been found as mutated in glycine in two patients with pheochromocytoma (8) and in glutamine in our patient. Whether it might represent a hotspot ...
M leprae
... carbol-fuchsin appear as solid rods with rounded ends, while those is irregular stain are dead. ...
... carbol-fuchsin appear as solid rods with rounded ends, while those is irregular stain are dead. ...
12864_2008_1659_MOESM3_ESM
... sequence similarity, we assume that YWHAB spawned the retrogene YWHAH. The latter covers all of the exons (no corresponding introns) of the parent gene and has been preserved from fish to mammals. After the retroposition event, YWHAG probably was derived from YWHAH, or vice versa, by segmental dupli ...
... sequence similarity, we assume that YWHAB spawned the retrogene YWHAH. The latter covers all of the exons (no corresponding introns) of the parent gene and has been preserved from fish to mammals. After the retroposition event, YWHAG probably was derived from YWHAH, or vice versa, by segmental dupli ...
Protective effect against type 2 diabetes mellitus ACDC African diabetic cohort
... al [8] was probably caused by a defect in the aforementioned pathway. Any alteration on a genetic level that affects the production of this protein, thus leading to impaired insulin action, may consequently result in T2D. ...
... al [8] was probably caused by a defect in the aforementioned pathway. Any alteration on a genetic level that affects the production of this protein, thus leading to impaired insulin action, may consequently result in T2D. ...
Quantitative genetics and breeding theory
... Some properties of status number • NS can never be higher than the census number (N); q NS can never be lower than 0.5 (NS of a gamete); q NS considers relatedness and inbreeding; q NS may be derived for any hypothetical population (with known relatedness patterns to a known source population). It ...
... Some properties of status number • NS can never be higher than the census number (N); q NS can never be lower than 0.5 (NS of a gamete); q NS considers relatedness and inbreeding; q NS may be derived for any hypothetical population (with known relatedness patterns to a known source population). It ...
Genetic disorders of pigmentation - Zielinski Fam
... melanosomes called bmacromelanosomes.Q These macromelanosomes are present in skin, iris, and retina. Ultrastructural analysis of the retinal pigment epithelium cells suggested that the giant melanosomes may form by abnormal growth of single melanosomes rather than by the fusion of several organelles ...
... melanosomes called bmacromelanosomes.Q These macromelanosomes are present in skin, iris, and retina. Ultrastructural analysis of the retinal pigment epithelium cells suggested that the giant melanosomes may form by abnormal growth of single melanosomes rather than by the fusion of several organelles ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.