Using Gene Ontology Annotations to Interpret DNA Array Data
... Stefan Pierrou PhD, AstraZeneca Spotfire Users Conference 2001-05-03 ...
... Stefan Pierrou PhD, AstraZeneca Spotfire Users Conference 2001-05-03 ...
Document
... The LMNA gene produces a polypeptide that requires post-translational processing to produce the mature lamin A protein, which functions as a nuclear protein scaffold significant to the integrity of the nuclear structure. In a study conducted by De SandreGiovannoli et al.2 on classical HGPS, a revers ...
... The LMNA gene produces a polypeptide that requires post-translational processing to produce the mature lamin A protein, which functions as a nuclear protein scaffold significant to the integrity of the nuclear structure. In a study conducted by De SandreGiovannoli et al.2 on classical HGPS, a revers ...
Poster - University of British Columbia
... hydroxyprostaglandin dehyrogenase 15-(NAD) (HPGD), TU3A protein (TU3A) and the down-regulated genes are: toll-like receptor 3 (TLR3), TIR domain ...
... hydroxyprostaglandin dehyrogenase 15-(NAD) (HPGD), TU3A protein (TU3A) and the down-regulated genes are: toll-like receptor 3 (TLR3), TIR domain ...
Zemaira - CSL Behring
... Zemaira is an alpha1-proteinase inhibitor (A1-PI) indicated for chronic augmentation and maintenance therapy in adults with A1-PI deficiency and clinical evidence of emphysema. Zemaira increases antigenic and functional (anti-neutrophil elastase capacity [ANEC]) serum levels and lung epithelial lini ...
... Zemaira is an alpha1-proteinase inhibitor (A1-PI) indicated for chronic augmentation and maintenance therapy in adults with A1-PI deficiency and clinical evidence of emphysema. Zemaira increases antigenic and functional (anti-neutrophil elastase capacity [ANEC]) serum levels and lung epithelial lini ...
Validating therapeutic targets through human genetics
... possible to assess its effect on a biological phenotype (y axis) such as cellular signalling or receptor levels. The red points on the graph indicate a dose-dependent relationship between target function and biological phenotype, as loss of function of a target leads to reduced (low) biological acti ...
... possible to assess its effect on a biological phenotype (y axis) such as cellular signalling or receptor levels. The red points on the graph indicate a dose-dependent relationship between target function and biological phenotype, as loss of function of a target leads to reduced (low) biological acti ...
IJBT 10(2) 235-237
... cattle12 and goat13. The kappa casein protein variants in goats were established and confirmed at the protein14,15 and DNA15-19 level. A total of 14 DNA variants have been identified in the domestic goats19,20 and showed that the number of alleles identified in the domesticated goat has increased to ...
... cattle12 and goat13. The kappa casein protein variants in goats were established and confirmed at the protein14,15 and DNA15-19 level. A total of 14 DNA variants have been identified in the domestic goats19,20 and showed that the number of alleles identified in the domesticated goat has increased to ...
GUEST COMMENTARY
... one was found that fused lacY to purE. In this strain synthesis of Lac permease is repressed by the addition of excess adenine. Maxime Schwartz (30) might best sum up the reaction of the bacterial genetics community to the purE-lacY⫹ fusion. At the time this fusion was isolated, he was a graduate st ...
... one was found that fused lacY to purE. In this strain synthesis of Lac permease is repressed by the addition of excess adenine. Maxime Schwartz (30) might best sum up the reaction of the bacterial genetics community to the purE-lacY⫹ fusion. At the time this fusion was isolated, he was a graduate st ...
FEBS Letters
... Similarity (48.7%) of the deduced ORF3 amino acid sequence was found to a hypothetical protein slr1679 of Synechocystis sp. PCC 6803 [24]. However, in Synechocystis, the corresponding gene is located far away from the dxs-like gene and also far away from the above mentioned locus of sll1998, which i ...
... Similarity (48.7%) of the deduced ORF3 amino acid sequence was found to a hypothetical protein slr1679 of Synechocystis sp. PCC 6803 [24]. However, in Synechocystis, the corresponding gene is located far away from the dxs-like gene and also far away from the above mentioned locus of sll1998, which i ...
Chapter 6 Genetic analysis of two loci
... Figure 6.1 Coat color in animals is an example of a trait that affected by more than one locus. ...
... Figure 6.1 Coat color in animals is an example of a trait that affected by more than one locus. ...
CETT CDG handout for clinicians AKT 4-30-10 17-39-08
... by a small letter code (Ia, Ib, Ic, etc.). Type I CDGs are caused by defects in genes coding for enzymes that create the sugar chain precursors or that attach them to proteins and lipids. Type II CDGs are caused by defects in genes coding for enzymes that modify the sugar chains after they are added ...
... by a small letter code (Ia, Ib, Ic, etc.). Type I CDGs are caused by defects in genes coding for enzymes that create the sugar chain precursors or that attach them to proteins and lipids. Type II CDGs are caused by defects in genes coding for enzymes that modify the sugar chains after they are added ...
Lipid-Lowering Therapy - St. Joseph Mercy Ann Arbor
... much larger cohort of patients with both ST- and non–STelevation MI hospitalized in hundreds of medical centers worldwide. In contrast to a study from the National Registry of Myocardial Infarction,13 we did not observe a significant decrease in in-hospital clinical events in patients on lipidloweri ...
... much larger cohort of patients with both ST- and non–STelevation MI hospitalized in hundreds of medical centers worldwide. In contrast to a study from the National Registry of Myocardial Infarction,13 we did not observe a significant decrease in in-hospital clinical events in patients on lipidloweri ...
gyrA AND SEQUENCING METHOD
... acid had a single mutation in gyrA. However, efflux pump activity could be less important in decreasing ciprofloxacin susceptibility levels, atleast the low level of resistance observed in these isolates. It seems likely that over expression of the AcrABTolC efflux pump is responsible for this effec ...
... acid had a single mutation in gyrA. However, efflux pump activity could be less important in decreasing ciprofloxacin susceptibility levels, atleast the low level of resistance observed in these isolates. It seems likely that over expression of the AcrABTolC efflux pump is responsible for this effec ...
Gene Section CDX2 (caudal-related homeobox 2) Atlas of Genetics and Cytogenetics
... Fusion of ETV6 exon 2 to CDX2 exon 2. The predicted protein contains the N-terminal region of ETV6 38 fused to the entire homeobox of CDX2. The single case described that harbours this fusion also expressed normal CDX2, which is not normally expressed in haemopoietic cells. ...
... Fusion of ETV6 exon 2 to CDX2 exon 2. The predicted protein contains the N-terminal region of ETV6 38 fused to the entire homeobox of CDX2. The single case described that harbours this fusion also expressed normal CDX2, which is not normally expressed in haemopoietic cells. ...
Investigation 1: Identify the Transcriptional Unit
... 1. Open a new web browser window and go to the UCSC Genome Browser Mirror site at http://gander.wustl.edu/. Follow the instructions given in module 1 to navigate to the contig1 project in the D. melanogaster "July 2014 (Gene)" assembly. 2. To navigate to the genomic region surrounding the tra gene, ...
... 1. Open a new web browser window and go to the UCSC Genome Browser Mirror site at http://gander.wustl.edu/. Follow the instructions given in module 1 to navigate to the contig1 project in the D. melanogaster "July 2014 (Gene)" assembly. 2. To navigate to the genomic region surrounding the tra gene, ...
Dosage Growth Defect Overexpression of one gene in the presence
... Dosage Growth Defect Dosage Lethality Dosage Rescue Phenotypic Enhancement Phenotypic Suppression Synthetic Growth Defect Synthetic Rescue Synthetic Lethality Negative Genetic Positive Genetic ...
... Dosage Growth Defect Dosage Lethality Dosage Rescue Phenotypic Enhancement Phenotypic Suppression Synthetic Growth Defect Synthetic Rescue Synthetic Lethality Negative Genetic Positive Genetic ...
Conservation of gene function in behaviour
... is conservation of a specific gene’s function in behaviour, we would conclude that this is true for some genes and not others. For example, one could ask when and why the function of the timeless gene has changed over the course of vertebrate evolution. Or how genomic evolution has allowed for the p ...
... is conservation of a specific gene’s function in behaviour, we would conclude that this is true for some genes and not others. For example, one could ask when and why the function of the timeless gene has changed over the course of vertebrate evolution. Or how genomic evolution has allowed for the p ...
- Biological Psychiatry
... experiment with many subjects and conditions. Although these commercial products also offer access to the substantial experience base of the vendors, the costs remain largely beyond the reach of most academic research laboratories. However, the costs for developing the homegrown variety can in some ...
... experiment with many subjects and conditions. Although these commercial products also offer access to the substantial experience base of the vendors, the costs remain largely beyond the reach of most academic research laboratories. However, the costs for developing the homegrown variety can in some ...
Genetic Profiling of Changes Underlying Different Sized Human
... gender matched normal controls. Approval for the study was obtained from our institutional review board. RNA was extracted from the small biopsy specimens. To ensure high quality RNA, only specimens with an RNA integrity number of greater than 6.8 were used. Gene expression analysis was conducted us ...
... gender matched normal controls. Approval for the study was obtained from our institutional review board. RNA was extracted from the small biopsy specimens. To ensure high quality RNA, only specimens with an RNA integrity number of greater than 6.8 were used. Gene expression analysis was conducted us ...
Hematology…Literally and Seriously
... This report carries with it all the caveats in interpretation inherent in retrospective data. While the authors carefully adjusted for clinical factors that could affect outcomes to limit bias, there may still be confounding factors that are important to discuss. That said, while perhaps not practic ...
... This report carries with it all the caveats in interpretation inherent in retrospective data. While the authors carefully adjusted for clinical factors that could affect outcomes to limit bias, there may still be confounding factors that are important to discuss. That said, while perhaps not practic ...
NAME: ________________ DATE: ____________ BLOCK: _____
... TAS2R38, was identified in 2003. Sequencing identified three nucleotide positions that vary within the human population—each variable position is termed a single nucleotide polymorphism (SNP). One specific combination of the three SNPs, termed a haplotype, correlates most strongly with tasting abili ...
... TAS2R38, was identified in 2003. Sequencing identified three nucleotide positions that vary within the human population—each variable position is termed a single nucleotide polymorphism (SNP). One specific combination of the three SNPs, termed a haplotype, correlates most strongly with tasting abili ...
GENETICS REVIEW
... contributes to the color of skin, eyes and hair. Some people have the hereditary condition, albinism; they are not able to produce melanin and have little or no pigment in their skin and hair. Two different versions of the same gene are called alleles. One allele of this gene codes for melanin produ ...
... contributes to the color of skin, eyes and hair. Some people have the hereditary condition, albinism; they are not able to produce melanin and have little or no pigment in their skin and hair. Two different versions of the same gene are called alleles. One allele of this gene codes for melanin produ ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.