PDF - Oxford Academic - Oxford University Press
... The published sequence of the MAOA promoter (GenBank no. M89636) contains four exact repeats of a 30 bp sequence located at positions k1262 to k1143 (the A of the ATG initiation codon is defined as j1). They are followed by a half repeat consisting of the first 15 bp of the repeated motif. Recently ...
... The published sequence of the MAOA promoter (GenBank no. M89636) contains four exact repeats of a 30 bp sequence located at positions k1262 to k1143 (the A of the ATG initiation codon is defined as j1). They are followed by a half repeat consisting of the first 15 bp of the repeated motif. Recently ...
5-Aminoimidazole-4-Carboxamide Riboside Mimics the
... (Fig. 4A). The major subunit isoforms of AMPK found in DIABETES, VOL. 49, JUNE 2000 ...
... (Fig. 4A). The major subunit isoforms of AMPK found in DIABETES, VOL. 49, JUNE 2000 ...
Duration of antibiotic therapy in hospitalised patients with community-acquired pneumonia
... admission and time to clinical stability (TCS). Among the 2,003 patients enrolled, mean duration of total antibiotic therapy was 11 days. Neither the pneumonia severity index (r250.005) nor the CRB-65 (r250.004) scores were related to total duration of therapy. Duration of intravenous antibiotic the ...
... admission and time to clinical stability (TCS). Among the 2,003 patients enrolled, mean duration of total antibiotic therapy was 11 days. Neither the pneumonia severity index (r250.005) nor the CRB-65 (r250.004) scores were related to total duration of therapy. Duration of intravenous antibiotic the ...
Geographic Distribution And Adaptive Significance
... efforts of the 1000 Genomes Project Consortium, several complementary computational and experimental approaches were integrated to identify and analyze different types of SVs (Mills et al. 2011; 1000 Genomes Project Consortium 2012). Therefore, we argue that the time is ripe for studying SVs in an a ...
... efforts of the 1000 Genomes Project Consortium, several complementary computational and experimental approaches were integrated to identify and analyze different types of SVs (Mills et al. 2011; 1000 Genomes Project Consortium 2012). Therefore, we argue that the time is ripe for studying SVs in an a ...
Disruption of Individual Members of Arabidopsis Syntaxin Gene
... et al., 1999), although SYP22 also has been reported to localize to the vacuole in some cell types (Sato et al., 1997). The members of the SYP2 family are most similar to the yeast prevacuolar syntaxin Pep12p (Becherer et al., 1996) and to mammalian syntaxins 7 and 13 (which reside on various endoso ...
... et al., 1999), although SYP22 also has been reported to localize to the vacuole in some cell types (Sato et al., 1997). The members of the SYP2 family are most similar to the yeast prevacuolar syntaxin Pep12p (Becherer et al., 1996) and to mammalian syntaxins 7 and 13 (which reside on various endoso ...
A systemic gene silencing method suitable for high throughput
... [17-20], indicating that they share a common and evolutionarily conserved mechanism that is likely to be present in all plants, including ferns. One striking feature of gene silencing is that the silencing effects are non-cell autonomous and spread to neighboring cells. For this reason, transient ex ...
... [17-20], indicating that they share a common and evolutionarily conserved mechanism that is likely to be present in all plants, including ferns. One striking feature of gene silencing is that the silencing effects are non-cell autonomous and spread to neighboring cells. For this reason, transient ex ...
Knee pain relief, with no drugs and no surgery
... The safety and effectiveness of SUPARTZ Joint Fluid Therapy were studied in five clinical trials. Patients received injections of SUPARTZ Joint Fluid Therapy or saltwater (619 and 537 patients, respectively). The results of these five studies show that injections of SUPARTZ Joint Fluid Therapy safel ...
... The safety and effectiveness of SUPARTZ Joint Fluid Therapy were studied in five clinical trials. Patients received injections of SUPARTZ Joint Fluid Therapy or saltwater (619 and 537 patients, respectively). The results of these five studies show that injections of SUPARTZ Joint Fluid Therapy safel ...
PPT - LymeRICK
... Some tend to forget that although these are good scientific tools, we should not think more of them. Once again beware: ...
... Some tend to forget that although these are good scientific tools, we should not think more of them. Once again beware: ...
Quorum sensing by peptide pheromones and two-component
... Quorum sensing in Gram-positive bacteria 897 protein kinases. Likewise, the N-terminal domain of Agrlike response regulators share common sequences with other response regulators. Recently, a modified octapeptide that was isolated from culture supernatants was shown to activate transcription from t ...
... Quorum sensing in Gram-positive bacteria 897 protein kinases. Likewise, the N-terminal domain of Agrlike response regulators share common sequences with other response regulators. Recently, a modified octapeptide that was isolated from culture supernatants was shown to activate transcription from t ...
serious asthma should focus on the possible confounding role
... non-protein-coding RNAs and through the formation of double stranded short RNAs. FAULKNER and CARNINCI [3] demonstrated that transcription initiation from promoters present in TEs is a general phenomenon, even when they are corrupted and not easily recognised as genuine transposons. In addition, TE ...
... non-protein-coding RNAs and through the formation of double stranded short RNAs. FAULKNER and CARNINCI [3] demonstrated that transcription initiation from promoters present in TEs is a general phenomenon, even when they are corrupted and not easily recognised as genuine transposons. In addition, TE ...
Polymorphism of Insulin-Like Growth Factor I Gene among Chicken
... with four bands. As mentioned in several studies (Bodenes et al., 1996; Tokue et al., 1995), it is sometimes possible to detect multiple bands for some fragments under electrophoretic conditions. Theoretically, in a SSCP gel, a maximum of four single strands for heterozygous samples could be detecte ...
... with four bands. As mentioned in several studies (Bodenes et al., 1996; Tokue et al., 1995), it is sometimes possible to detect multiple bands for some fragments under electrophoretic conditions. Theoretically, in a SSCP gel, a maximum of four single strands for heterozygous samples could be detecte ...
Cloning and Expression of Endoglucanase genes from Trichoderma
... accumulation of toxic compounds potentially hazardous to human and environment [8 ] and also in the buildup of resistance of the pathogens [1 4 ]. In order to tackle these national and global problems, effective alternatives to chemical control are being investigated and the use of antagonistic micr ...
... accumulation of toxic compounds potentially hazardous to human and environment [8 ] and also in the buildup of resistance of the pathogens [1 4 ]. In order to tackle these national and global problems, effective alternatives to chemical control are being investigated and the use of antagonistic micr ...
Gene Duplication, Gene Conversion and the Evolution of
... Nonrecombining chromosomes, such as the Y, are expected to degenerate over time due to reduced efficacy of natural selection compared to chromosomes that recombine. However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially counteract forces of evolutionary deca ...
... Nonrecombining chromosomes, such as the Y, are expected to degenerate over time due to reduced efficacy of natural selection compared to chromosomes that recombine. However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially counteract forces of evolutionary deca ...
Hodgkin Lymphoma 2013 Zach
... infected with human T-cell lymphocytotropic virus (HTLV) or human immunodeficiency virus (HIV) also have increased probability of developing HL. ...
... infected with human T-cell lymphocytotropic virus (HTLV) or human immunodeficiency virus (HIV) also have increased probability of developing HL. ...
Methylation of an upstream Alu sequence on the Imprinted H19
... Alu sequences are repetitive 300 base pair, site specific elements interspersed in primate genomes. They contain numerous CpG islands that are sometimes methylated. Alu methylation differs between somatic and germ cell DNA, suggesting a possible role for Alu sequences in genomic imprinting. The obje ...
... Alu sequences are repetitive 300 base pair, site specific elements interspersed in primate genomes. They contain numerous CpG islands that are sometimes methylated. Alu methylation differs between somatic and germ cell DNA, suggesting a possible role for Alu sequences in genomic imprinting. The obje ...
russell-silver syndrome
... expressed (turned on) in both the paternally and maternally inherited gene copies. Imprinted genes are different in that they are expressed (turned on) in a parent of origin specific manner. H19 works to suppress or hold back growth. Usually, the maternal copy of H19 is expressed (on) and the patern ...
... expressed (turned on) in both the paternally and maternally inherited gene copies. Imprinted genes are different in that they are expressed (turned on) in a parent of origin specific manner. H19 works to suppress or hold back growth. Usually, the maternal copy of H19 is expressed (on) and the patern ...
Warren, ST and Nelson, DL: Trinucleotide repeat expansions in neurological disease. Current Opinion in Neurobiology 3:752-759 (1993).
... genetic disease have emerged where little or no precedent had been established in other genetically studied organisms. One such mechanism is trinucleotide repeat expansions [ l*,2,3*]. Since early 1991, when the mutation responsible for the fragile X syndrome was uncovered as an astounding expansion ...
... genetic disease have emerged where little or no precedent had been established in other genetically studied organisms. One such mechanism is trinucleotide repeat expansions [ l*,2,3*]. Since early 1991, when the mutation responsible for the fragile X syndrome was uncovered as an astounding expansion ...
Regulation of bolting and identification of the α
... classified into 27 types were found in the 1.5-kb upstream region of the BrTUA genes by Plant CARE. Five BrTUAs, which had the molecular function and the auto-regulation binding site for β-tubulin showed greater differentiation; their promoters had cis-regulatory elements that were involved in circa ...
... classified into 27 types were found in the 1.5-kb upstream region of the BrTUA genes by Plant CARE. Five BrTUAs, which had the molecular function and the auto-regulation binding site for β-tubulin showed greater differentiation; their promoters had cis-regulatory elements that were involved in circa ...
Hypothesis for the evolutionary origin of the chloroplast ribosomal
... Gray 1989), the slightly lower divergence observed between S12 of E. coli and Marchantia may be due to stochastic variation in rate; indeed, many comparisons involving Marchantia cpDNA-encoded r-proteins show lower values of divergence than their counterparts from other species (Christopher and Hall ...
... Gray 1989), the slightly lower divergence observed between S12 of E. coli and Marchantia may be due to stochastic variation in rate; indeed, many comparisons involving Marchantia cpDNA-encoded r-proteins show lower values of divergence than their counterparts from other species (Christopher and Hall ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.