REVIEWS - Ken Wolfe`s
... Nevertheless, citations of Susumu Ohno’s book Evolution by Gene Duplication 3 have tripled between the years 1990 and 2000. In this book, written when only a few protein sequences were known, Ohno proposed that it is much easier to make new genes by duplicating old ones than to create them de novo, ...
... Nevertheless, citations of Susumu Ohno’s book Evolution by Gene Duplication 3 have tripled between the years 1990 and 2000. In this book, written when only a few protein sequences were known, Ohno proposed that it is much easier to make new genes by duplicating old ones than to create them de novo, ...
CUC proforma for assessment of genetic testing
... This clinical utility card (CUC) proforma is modelled on the clinical utility gene card format used by EuroGentest. When completed, a CUC provides relevant information regarding the clinical utility of genetic testing of relevant heritable mutations in particular circumstances grouped by disease are ...
... This clinical utility card (CUC) proforma is modelled on the clinical utility gene card format used by EuroGentest. When completed, a CUC provides relevant information regarding the clinical utility of genetic testing of relevant heritable mutations in particular circumstances grouped by disease are ...
A Predictive Based Regression Algorithm for Gene Network
... According to our understanding of the problem (i.e. single model based on likelihood methods): YES! However: Focusing on a single model suggests a level of confidence in our final result that is not justified by the data as other models generally exist with similar good fit (Whittingham et al., 2006 ...
... According to our understanding of the problem (i.e. single model based on likelihood methods): YES! However: Focusing on a single model suggests a level of confidence in our final result that is not justified by the data as other models generally exist with similar good fit (Whittingham et al., 2006 ...
Absence of unidentified CAG repeat expansion in
... repeat expansions. However, the performance of this method does not allow detection of small expansions (such as those found in SCA6) as the threshold is about 40 repeats. ERDA-1 and CTG18.1 loci represent polymorphic and unstable sequences which may explain RED scores of 40 repeats or more. Therefo ...
... repeat expansions. However, the performance of this method does not allow detection of small expansions (such as those found in SCA6) as the threshold is about 40 repeats. ERDA-1 and CTG18.1 loci represent polymorphic and unstable sequences which may explain RED scores of 40 repeats or more. Therefo ...
Fine Mapping of Two Wheat Powdery Mildew Resistance Genes
... To obtain more markers for Mlm2033 and Mlm80, wheat ESTs homologous to the predicted B. distachyon CDS of the Bradi1 g30190-Bradi1 g29320 interval were used for identification of additional markers. Three markers, including MAG5827, MAG5240, and MAG5825, corresponding to Bradi1 g29590, Bradi1 g29658 ...
... To obtain more markers for Mlm2033 and Mlm80, wheat ESTs homologous to the predicted B. distachyon CDS of the Bradi1 g30190-Bradi1 g29320 interval were used for identification of additional markers. Three markers, including MAG5827, MAG5240, and MAG5825, corresponding to Bradi1 g29590, Bradi1 g29658 ...
REVIEW Mouse models of human disease. Part I: Techniques and
... Manipulation of the mouse genome: transgenic mice In the early 1980s, methods were developed that allowed foreign DNA to be introduced into the germ line of mice by pronuclear injection (see Hogan et al. 1994). It then became possible to create transgenic mice carrying various forms of genes associa ...
... Manipulation of the mouse genome: transgenic mice In the early 1980s, methods were developed that allowed foreign DNA to be introduced into the germ line of mice by pronuclear injection (see Hogan et al. 1994). It then became possible to create transgenic mice carrying various forms of genes associa ...
Fine Mapping of Two Wheat Powdery Mildew Resistance Genes
... To obtain more markers for Mlm2033 and Mlm80, wheat ESTs homologous to the predicted B. distachyon CDS of the Bradi1 g30190-Bradi1 g29320 interval were used for identification of additional markers. Three markers, including MAG5827, MAG5240, and MAG5825, corresponding to Bradi1 g29590, Bradi1 g29658 ...
... To obtain more markers for Mlm2033 and Mlm80, wheat ESTs homologous to the predicted B. distachyon CDS of the Bradi1 g30190-Bradi1 g29320 interval were used for identification of additional markers. Three markers, including MAG5827, MAG5240, and MAG5825, corresponding to Bradi1 g29590, Bradi1 g29658 ...
Slide 1
... – Gene Exchange only occurs between sexually compatible species – Most of the genetic variation is created through recombination (crossing) – Selection is conducted by measuring plant characteristics (yield, grain moisture, etc) – Genes under selection are unknown ...
... – Gene Exchange only occurs between sexually compatible species – Most of the genetic variation is created through recombination (crossing) – Selection is conducted by measuring plant characteristics (yield, grain moisture, etc) – Genes under selection are unknown ...
Comparison of genes among cereals
... (2700 Mb), and wheat (16 000 Mb) [19] and the evolutionary divergence time of 60 million years for these species [17,20]. The initial work on the colinearity of genetic markers was reinforced when it was discovered that quantitative loci for agronomic traits such as dwarfing were also colinear betwe ...
... (2700 Mb), and wheat (16 000 Mb) [19] and the evolutionary divergence time of 60 million years for these species [17,20]. The initial work on the colinearity of genetic markers was reinforced when it was discovered that quantitative loci for agronomic traits such as dwarfing were also colinear betwe ...
Advances in Environmental Biology IL-11 play important role in scoliosis patients
... were also evaluated. Those receiving any form of treatment for scoliosis were excluded. Girls with a history of congenital deformities, neuromuscular disease, endocrine disease, skeletal dysplasia, connective tissue abnormalities, mental retardation, inflammatory diseases and use of medication known ...
... were also evaluated. Those receiving any form of treatment for scoliosis were excluded. Girls with a history of congenital deformities, neuromuscular disease, endocrine disease, skeletal dysplasia, connective tissue abnormalities, mental retardation, inflammatory diseases and use of medication known ...
Discussion section: Gymnasts File
... performance and the ACTN3 (R allele), PPARGC1A (482Ser allele), Β3-AR (Arg allele) and possibly the ACE (D allele). Current evidence is limited and therefore these conclusions can only be deemed as preliminary. For confirmation, future studies should employ large samples of well-defined cohorts of g ...
... performance and the ACTN3 (R allele), PPARGC1A (482Ser allele), Β3-AR (Arg allele) and possibly the ACE (D allele). Current evidence is limited and therefore these conclusions can only be deemed as preliminary. For confirmation, future studies should employ large samples of well-defined cohorts of g ...
AHA Medical/Scientific Statement
... for HCM and in the process have provided insights into the considerable clinical heterogeneity characteristic of this disorder.3–5,8,14,15 The consequences of these different gene defects for patients appear to differ greatly and are not yet completely understood. HCM can be caused by a mutation in ...
... for HCM and in the process have provided insights into the considerable clinical heterogeneity characteristic of this disorder.3–5,8,14,15 The consequences of these different gene defects for patients appear to differ greatly and are not yet completely understood. HCM can be caused by a mutation in ...
Randomized controlled trials of autologous hematopoietic stem cell
... used in the HSCT conditioning regimen for cancer that are not myeloablative when given at lower doses, including numerous chemotherapeutic drugs such as busulfan, etoposide, mitoxantrone, cytarabine, and the like. Myeloablative regimens utilize total body irradiation (TBI) and/or employ potentially ...
... used in the HSCT conditioning regimen for cancer that are not myeloablative when given at lower doses, including numerous chemotherapeutic drugs such as busulfan, etoposide, mitoxantrone, cytarabine, and the like. Myeloablative regimens utilize total body irradiation (TBI) and/or employ potentially ...
Antibiotic Resistance and Genetically Engineered Plants
... The process of inserting a gene of interest into a plant is crude, haphazard, and random. Scientists cannot easily determine where a gene will land, or even if a gene has been successfully incorporated into a plant cell. There are two common methods of gene insertion. The first involves a “gene gun ...
... The process of inserting a gene of interest into a plant is crude, haphazard, and random. Scientists cannot easily determine where a gene will land, or even if a gene has been successfully incorporated into a plant cell. There are two common methods of gene insertion. The first involves a “gene gun ...
The Association of DRD2 Gene TaqI Polymorphism with Attention
... ADHD following a detailed psychiatric assessment. At the end 89 ADHD patients were recruited. Oral and written informed consents were obtained from at one parent of all participants, and the research protocol was approved by the Ethics Committee of Tabriz University of Medical Sciences (ID number: 6 ...
... ADHD following a detailed psychiatric assessment. At the end 89 ADHD patients were recruited. Oral and written informed consents were obtained from at one parent of all participants, and the research protocol was approved by the Ethics Committee of Tabriz University of Medical Sciences (ID number: 6 ...
Analysis of a Rhizobium leguminosarum gene
... There have been relatively few studies on GSTs in prokaryotes, although a recent survey showed that a wide range of Gram-negative soil bacteria have GST activity, albeit at a low level in most cases (Zablotowicz et al., 1995). Allocati et al. (1994) reported that in Proteus mirabilis, a GST-like pro ...
... There have been relatively few studies on GSTs in prokaryotes, although a recent survey showed that a wide range of Gram-negative soil bacteria have GST activity, albeit at a low level in most cases (Zablotowicz et al., 1995). Allocati et al. (1994) reported that in Proteus mirabilis, a GST-like pro ...
Journal of Biotechnology 84:
... Received 2 December 1999; received in revised form 11 August 2000; accepted 16 August 2000 ...
... Received 2 December 1999; received in revised form 11 August 2000; accepted 16 August 2000 ...
The 39th David A. Karnofsky Lecture: Bench-to-Bedside
... the lineage and stage of differentiation of B-cell malignancies as well as comparison of the neoplastic B cell with its normal cellular counterpart. A panel of B-cell MoAbs was useful to complement histopathologic diagnosis and identify non–T-cell acute lymphoblastic leukemia, chronic lymphocytic le ...
... the lineage and stage of differentiation of B-cell malignancies as well as comparison of the neoplastic B cell with its normal cellular counterpart. A panel of B-cell MoAbs was useful to complement histopathologic diagnosis and identify non–T-cell acute lymphoblastic leukemia, chronic lymphocytic le ...
Fc RIIIB Gene Duplication: Evidence for Presence and Expression of
... NA(11,21)SH(2) controls showed a single band at position 266 (Fig 2D to E). Additionally, NA2-FcgRIIIB–specific PCR products were digested with SfaNI, which recognizes a 58-GATGC-38 sequence present only in the SH-FcgRIIIB–derived fragment.10 Figure 3 shows the results of this digestion. Lane 1 show ...
... NA(11,21)SH(2) controls showed a single band at position 266 (Fig 2D to E). Additionally, NA2-FcgRIIIB–specific PCR products were digested with SfaNI, which recognizes a 58-GATGC-38 sequence present only in the SH-FcgRIIIB–derived fragment.10 Figure 3 shows the results of this digestion. Lane 1 show ...
Critical Thinking Diagram Worksheet 9-1
... 1. Explain why one of the female children in the Punnett square will be a carrier for hemophilia, the other will have hemophilia. ...
... 1. Explain why one of the female children in the Punnett square will be a carrier for hemophilia, the other will have hemophilia. ...
Chapter 5: Heredity
... all looked like one of the two parents. He called these new plants hybrids (HI brudz) because they received different genetic information, or different alleles, for a trait from each parent. The results of these studies made Mendel even more curious about how traits are inherited. Garden peas are ea ...
... all looked like one of the two parents. He called these new plants hybrids (HI brudz) because they received different genetic information, or different alleles, for a trait from each parent. The results of these studies made Mendel even more curious about how traits are inherited. Garden peas are ea ...
Integrated genomic DNA/RNA profiling of
... (NHLs),11 which impact clinical outcome and can guide therapeutic decisions.12 More recent studies have identified recurrent mutations and amplifications/deletions in a spectrum of hematologic malignancies, including AML,13 ALL, multiple myeloma (MM), and lymphoma, creating a pressing need to develop ...
... (NHLs),11 which impact clinical outcome and can guide therapeutic decisions.12 More recent studies have identified recurrent mutations and amplifications/deletions in a spectrum of hematologic malignancies, including AML,13 ALL, multiple myeloma (MM), and lymphoma, creating a pressing need to develop ...
Genetics 2
... Mendel’s cross between tall pea plants yielded all tall pea plants. His cross between small pea plants yielded all small pea plants. X ...
... Mendel’s cross between tall pea plants yielded all tall pea plants. His cross between small pea plants yielded all small pea plants. X ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.