Nicole Gurtler - Genomics and Multiple Sclerosis
... The Complexity of Multiple Sclerosis “There is no single gene that causes the autoimmune condition multiple sclerosis (MS). Dozens of genetic variations act in concert with environmental factors to cause the debilitating neurological disease.” (http://www.nature.com/news/genome-studyhighlights-risk- ...
... The Complexity of Multiple Sclerosis “There is no single gene that causes the autoimmune condition multiple sclerosis (MS). Dozens of genetic variations act in concert with environmental factors to cause the debilitating neurological disease.” (http://www.nature.com/news/genome-studyhighlights-risk- ...
Detection of mutation status of IgVH genes and minimal residual
... aberration have been associated with the failure of treatment with alkylating agents, purine analogs and rituximab[33, 34]. An interphase FISH study also showed that patients whose leukemic cells showed a 17p- deletion had significantly shorter survival times than patients without this aberration, a ...
... aberration have been associated with the failure of treatment with alkylating agents, purine analogs and rituximab[33, 34]. An interphase FISH study also showed that patients whose leukemic cells showed a 17p- deletion had significantly shorter survival times than patients without this aberration, a ...
Zofran Subcutaneous Pump in the Treatment of Hyperemesis
... effectiveness cannot be substantiated with the available data. CONCLUSION: Randomized, controlled trials of sufficient power are necessary before long-term continuous subcutaneous metoclopramide or ondansetron can be used on a widespread basis to treat nausea and vomiting during pregnancy. Cost appr ...
... effectiveness cannot be substantiated with the available data. CONCLUSION: Randomized, controlled trials of sufficient power are necessary before long-term continuous subcutaneous metoclopramide or ondansetron can be used on a widespread basis to treat nausea and vomiting during pregnancy. Cost appr ...
A Rapid Chromosome Mapping Method for Cloned Fragments of Yeast DNA.
... containing virtually any yeast gene in which mutants can be found [see BOTSTEIN and DAVIS (1982) for review]. Recombinant DNA methods have, in addition, allowed the identification of interesting DNA segments corresponding to no mapped yeast gene. T h e classical mapping methods referred to can be ap ...
... containing virtually any yeast gene in which mutants can be found [see BOTSTEIN and DAVIS (1982) for review]. Recombinant DNA methods have, in addition, allowed the identification of interesting DNA segments corresponding to no mapped yeast gene. T h e classical mapping methods referred to can be ap ...
article in press - MRC
... Recently, a novel method for the detection of gene deletions and duplications has been devised: multiplex ligationdependent probe amplification (MLPA) [8]. The method depends on the hybridisation of two short specific oligonucleotide probes to abutting regions of an exon in genomic DNA from a patien ...
... Recently, a novel method for the detection of gene deletions and duplications has been devised: multiplex ligationdependent probe amplification (MLPA) [8]. The method depends on the hybridisation of two short specific oligonucleotide probes to abutting regions of an exon in genomic DNA from a patien ...
Current Therapeutic Strategy for Multiple Myeloma
... Received September 26, 2012; accepted November 23, 2012 ...
... Received September 26, 2012; accepted November 23, 2012 ...
A Superfamily of S Locus-Related Sequences in
... Arabidopsis ARK genes and the Brassica SRK6 and SflK2 genes as well (data not shown). Thus, in all these receptorlike genes, the first exon encodes the entire S domain, the second exon encodes the transmembrane domain, and exons 3 to 7 encode the kinase domain. The ARK2 gene, from the predicted tran ...
... Arabidopsis ARK genes and the Brassica SRK6 and SflK2 genes as well (data not shown). Thus, in all these receptorlike genes, the first exon encodes the entire S domain, the second exon encodes the transmembrane domain, and exons 3 to 7 encode the kinase domain. The ARK2 gene, from the predicted tran ...
Genetics of ankylosing spondylitis
... first-born children and in the children of younger mothers has been reported (11). The increased risk of AS with low birth-order was not replicated in a study of multicase-spondyloarthropathy families (12), or British AS families (13), and no association between maternal age and risk of AS in childr ...
... first-born children and in the children of younger mothers has been reported (11). The increased risk of AS with low birth-order was not replicated in a study of multicase-spondyloarthropathy families (12), or British AS families (13), and no association between maternal age and risk of AS in childr ...
Familial Adenomatous Polyposis (FAP) and Other Polyposis
... Searching for the APC Gene and its Function The first advance in the understanding of the molecular nature of FAP occurred after the discovery by Herrera et al. [27] of a mentally retarded male who presented with Gardner’s syndrome. Cytogenetic analysis revealed that the patient had an interstitial ...
... Searching for the APC Gene and its Function The first advance in the understanding of the molecular nature of FAP occurred after the discovery by Herrera et al. [27] of a mentally retarded male who presented with Gardner’s syndrome. Cytogenetic analysis revealed that the patient had an interstitial ...
achondroplasia
... As noted above, scientists have identified the gene, and the exact mutation (change) in the gene, that causes achondroplasia. The gene is one of a family of genes that makes proteins called fibroblast growth factor receptors. Scientists have recently linked these genes with several skeletal disorder ...
... As noted above, scientists have identified the gene, and the exact mutation (change) in the gene, that causes achondroplasia. The gene is one of a family of genes that makes proteins called fibroblast growth factor receptors. Scientists have recently linked these genes with several skeletal disorder ...
Sepsis review St Luc Hospital, September 2003 By Antonios Liolios
... undertaken to replenish the missing factors: Various other agents have been used, including recombinant soluble human thrombomodulin (ART-123), platelet activating factor acetylhydrolase, recombinant form of tissue factor pathway inhibitor (Tifacogin), monoclonal antibodies to the platelet GPIIb/III ...
... undertaken to replenish the missing factors: Various other agents have been used, including recombinant soluble human thrombomodulin (ART-123), platelet activating factor acetylhydrolase, recombinant form of tissue factor pathway inhibitor (Tifacogin), monoclonal antibodies to the platelet GPIIb/III ...
Types of NLRDs - Office of the Gene Technology Regulator
... (ii) does not involve any of the following: (A) a genetically modified laboratory guinea pig; (B) a genetically modified laboratory mouse; (C) a genetically modified laboratory rabbit; (D) a genetically modified laboratory rat; (E) a genetically modified Caenorhabditis elegans; (aa) a dealing involv ...
... (ii) does not involve any of the following: (A) a genetically modified laboratory guinea pig; (B) a genetically modified laboratory mouse; (C) a genetically modified laboratory rabbit; (D) a genetically modified laboratory rat; (E) a genetically modified Caenorhabditis elegans; (aa) a dealing involv ...
Functional SNPs in the SCGB3A2 promoter are
... autoimmune diseases with recent data estimating frequencies of up to 1.3% (0.5% clinical and 0.7% subclinical) in the USA (1) and 0.25– 1.09% in China (2). The hallmark of GD is the production of thyroid-stimulating hormone receptor (TSHR)-stimulating antibodies, leading to hyperthyroidism. GD is a ...
... autoimmune diseases with recent data estimating frequencies of up to 1.3% (0.5% clinical and 0.7% subclinical) in the USA (1) and 0.25– 1.09% in China (2). The hallmark of GD is the production of thyroid-stimulating hormone receptor (TSHR)-stimulating antibodies, leading to hyperthyroidism. GD is a ...
Chapter 55. Cancer Chemotherapy
... causes AIDS (HIV-1) is closely related. Cellular genes are known that are homologous to the transforming genes of the retroviruses, a family of RNA viruses, and induce oncogenic transformation. These mammalian cellular genes, known as oncogenes, have been shown to code for specific growth factors an ...
... causes AIDS (HIV-1) is closely related. Cellular genes are known that are homologous to the transforming genes of the retroviruses, a family of RNA viruses, and induce oncogenic transformation. These mammalian cellular genes, known as oncogenes, have been shown to code for specific growth factors an ...
Phenotype and gene ontology enrichment as guides for
... Rheumatoid arthritis is an auto-immune disease that is characterized by swollen and painful joints that progressively deteriorate [37]. Unlike lupus, rheumatoid arthritis is not life-threatening, and comorbidity between rheumatoid arthritis and lupus has not been described in past comorbidity studie ...
... Rheumatoid arthritis is an auto-immune disease that is characterized by swollen and painful joints that progressively deteriorate [37]. Unlike lupus, rheumatoid arthritis is not life-threatening, and comorbidity between rheumatoid arthritis and lupus has not been described in past comorbidity studie ...
Full Paper - Biotechniques.org
... when this sample was taken, in aquatic systems at similar latitudes to that of Peters Kill (McMillan and Verduin 1953, Graham et al. 1985). Although both aliquots had the same genotype richness and dominant genotype, the community compositions of the two aliquots were significantly different. This d ...
... when this sample was taken, in aquatic systems at similar latitudes to that of Peters Kill (McMillan and Verduin 1953, Graham et al. 1985). Although both aliquots had the same genotype richness and dominant genotype, the community compositions of the two aliquots were significantly different. This d ...
See a Sample
... © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
... © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
The energy-less red blood cell is lost: erythrocyte
... deficiency also affects nonerythroid tissues, causing neurologic symptoms and granulocyte dysfunction.33 Normally, GPI is very stable, but a striking feature of nearly all GPI mutants is their thermolability, whereas kinetic properties are more or less unaffected. Twenty-nine mutations have been det ...
... deficiency also affects nonerythroid tissues, causing neurologic symptoms and granulocyte dysfunction.33 Normally, GPI is very stable, but a striking feature of nearly all GPI mutants is their thermolability, whereas kinetic properties are more or less unaffected. Twenty-nine mutations have been det ...
Messenger RNA reprogramming by spliceosome-mediated
... PTMs include a binding domain responsible for specific targeting of the PTM and a coding domain that includes the new or modified genetic information that will reprogram the target (Figure 6). A more extensive discussion of PTM structure by Garcia-Blanco et al. can be reviewed in ref. 4. It must be ...
... PTMs include a binding domain responsible for specific targeting of the PTM and a coding domain that includes the new or modified genetic information that will reprogram the target (Figure 6). A more extensive discussion of PTM structure by Garcia-Blanco et al. can be reviewed in ref. 4. It must be ...
Theoretical and Applied Genetics
... Development of blackleg resistant canola cultivars is an effective method to control this disease in canola production. In particular, blackleg resistance is considered as one of the most important traits in the canola breeding programs of all seed companies in Canada, Europe and Australia. Mapping ...
... Development of blackleg resistant canola cultivars is an effective method to control this disease in canola production. In particular, blackleg resistance is considered as one of the most important traits in the canola breeding programs of all seed companies in Canada, Europe and Australia. Mapping ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.