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Distribution of DRB1 and DQB1 HLA class II alleles in
Distribution of DRB1 and DQB1 HLA class II alleles in

... association of asthma with DQB1*0503 and a negative association with DQB1*0501 allele reported by BIGNON et al. [16]. DQB1*0503 and DQB1*0501 differ by a single amino acid residue 57 (aspartic acid in DQB1*0503 and valine in DQB1*0501), and the group postulated that the susceptibility to, or protect ...
Antiviral medications for influenza:Information for health care providers
Antiviral medications for influenza:Information for health care providers

...  almost 17 hours in adults and 29 hours in children based on a meta-analysis of randomized trials by Jefferson et al.; 3 and  25 hours based on a meta-analysis by Dobson et al. of influenza-infected individuals using patient-level data from randomized trials where oseltamivir was given within 36 h ...
Mahmoud Mohamed Mahmoud Badr_final malaria-25
Mahmoud Mohamed Mahmoud Badr_final malaria-25

... Group I (A) _Severe malaria_ (complicated) : They were 30 patients , their age ranged between 2 to 39 years ( 19.6±6.1 ) , they were 19 males and 11 females. The inclusion criteria were established microscopically by the presence of the P. falciparum parasite , that was confirmed with P. falciparum ...
Hypersensitivity reactions to non beta
Hypersensitivity reactions to non beta

... or desensitization protocols are available for these reactions, but patch testing may be helpful. In the acute phase of an anaphylactic reaction, the elevated level of serum tryptase (1-4 hours after anaphylaxis) supports the diagnosis of drug hypersensitivity, IgE- or non IgE-mediated. The two grou ...
Target proteins in human autoimmunity: Cytochromes
Target proteins in human autoimmunity: Cytochromes

... however, LKM-1 autoantibodies almost never overlap with antinuclear autoantibodies, smooth muscle autoantibodies (SMA) or autobodies to soluble liver antigens. AIH-2 is a more severe form of autoimmune hepatitis, with disease onset at younger age, 50% fulminant hepatitis at disease onset and a stron ...
home - MS Trust
home - MS Trust

... contributor to the decision to stop working, and may result in social isolation and admission to residential care. Minimising the impact on the individual and their family is important. The NICE guidance on management of MS6 specifically identifies bowel problems as significant and commonly encounte ...
Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice
Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice

Treatment of Congestive Heart Failure
Treatment of Congestive Heart Failure

... may develop as a complication of many local and systemic disease processes.’ In many cases the clinical and roentgenographic manifestations ...
ACC/AHA Expert Consensus Document
ACC/AHA Expert Consensus Document

Use of sildenafil (Viagra) in patients with cardiovascular
Use of sildenafil (Viagra) in patients with cardiovascular

... and diastolic blood pressures). However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Most at risk are individuals who are concurrently taking organic nitrates. Organic nitrate preparations are commonly ...
What is Hereditary Angioedema?
What is Hereditary Angioedema?

... Anabolic steroids (also known as androgens) such as danazol, oxandrolone and stanozolol have, historically, been the most commonly prescribed preventive HAE therapies. While anabolic steroids have been shown to be useful, they are not well-tolerated by many women, directly linked to liver toxicity a ...
Physician`s guide on when to order CT or MRI for body imaging
Physician`s guide on when to order CT or MRI for body imaging

Physician`s guide on when to order CT or MRI for body imaging
Physician`s guide on when to order CT or MRI for body imaging

CHEST IMAGING GUIDELINES © 2007 MedSolutions
CHEST IMAGING GUIDELINES © 2007 MedSolutions

... patients undergoing active treatment for tuberculosis who had abnormalities seen only on chest CT. o The frequency of the follow-up chest CT scans should be at the discretion of the pulmonary specialist following the patient, as there are no published guidelines or evidence-based data addressing thi ...
Chapter 11 INTERLEUKIN-2 IN THE TREATMENT OF` RENAL CELL
Chapter 11 INTERLEUKIN-2 IN THE TREATMENT OF` RENAL CELL

Contents - Kingston CCG
Contents - Kingston CCG

... Appendix J – Lymphoedema Staging and Referral Criteria  Appendix K – NHS England Policies  Appendix L – Governance 2014/2015  ...
Parallels between Pathogens and Gluten Peptides in Celiac Sprue
Parallels between Pathogens and Gluten Peptides in Celiac Sprue

... the pathogen. Whether this exposure results in disease depends both on the virulence of the pathogen and on the susceptibility of the host [4]. Highly virulent infectious agents, such as human immunodeficiency virus (HIV), cause disease in virtually all exposed individuals, such that the primary dete ...
Antibiotic Prophylaxis Clinical Practice Guideline
Antibiotic Prophylaxis Clinical Practice Guideline

Diagnosis and Management of Osteonecrosis of the Jaw: A
Diagnosis and Management of Osteonecrosis of the Jaw: A

... careful exclusion. Radiographic findings of altered bone morphology, increased bone density, sequestration, or periosteal bone formation in a patient with odontalgia may be early radiographic features suggestive of a prodromal phase of ONJ and such patients require close follow-up and monitoring by t ...
Medicines Adverse Reactions Committee
Medicines Adverse Reactions Committee

... and grading of lesions were done at the initial visit and over three follow-up visits scheduled at weekly intervals. Clinical response was given an overall score for each patient which was further delineated by weighting. Overall evaluations of efficacy revealed good responses in 86%. The conditions ...
(95% CI) OR
(95% CI) OR

... Represents first “targeted therapy” for AD Initial benefit demonstrated in asthma with ...
␤ -Adrenergic Receptor Polymorphisms Affect Response to Treatment in Children With Severe Asthma
␤ -Adrenergic Receptor Polymorphisms Affect Response to Treatment in Children With Severe Asthma

... history between these two patient groups (Table 1). No differences were found in admission MPIS among the study groups; however, despite similar illness severity on hospital admission, children with the Gly/Gly genotype had significantly shorter hospital ICU length of stay, duration of continuously ...
Lupus and Infection - Lupus Research Alliance
Lupus and Infection - Lupus Research Alliance

... immune system and the kidney damage seen frequently in patients with lupus nephritis, a dangerous complication of lupus. Dr. Tsokos will also work to develop a targeted delivery of drugs to block the action of a single enzyme specifically to kidney cells. In earlier studies, Dr. Tsokos has shown tha ...
Can nicotine use alleviate symptoms of psoriasis?
Can nicotine use alleviate symptoms of psoriasis?

... same types of immune cells—Th17 cells in particular—and their mediators, found in the damaged colon in ulcerative colitis, are also found in the skin lesions of plaque psoriasis. 7 The presence of these cells and the pro-inflammatory cytokines they secrete, such as interleukin-17, provide a link bet ...
Low Dose Medicine - The new Paradigm - Dermatology
Low Dose Medicine - The new Paradigm - Dermatology

... Low Dose Medicine (LDM) highlights the importance of the role played by inflammation and, in particular, by low grade chronic inflammation, in the etio-pathogenesis of a wide spectrum of diseases. Some of the more serious and complex dermatological chronic inflammatory autoimmune diseases can today ...
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Multiple sclerosis research

Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
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