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Medication-Related Osteonecrosis of the Jaws From Once Per Year
Medication-Related Osteonecrosis of the Jaws From Once Per Year

... a commonly reported side effect with patients prescribed oral antiresorptive medications (formerly known as bisphosphonates) to treat osteoporosis and osteopenia.1,2 Oral antiresorptive agents are considered as the standard of care for the prevention and treatment of women with postmenopausal osteop ...
Omni Bio Pharmaceutical, Inc.  Creating Breakthrough Therapies Company Overview
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... of plasma-derived alpha-1 antitrypsin (p-AAT) —  Now developing “Enbrel-like” recombinant Fc fusion ...
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... aminotransferase) greater than 3 x ULN and bilirubin greater than 2 x ULN: one patient with Cushing’s disease and three healthy volunteers [see Adverse Reactions (6)]. In these cases, total bilirubin elevations were seen either concomitantly or preceding the transaminase elevation. Monitoring of liv ...
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Management of Adverse Drug Reactions in Treatment of MDR-TB

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... treatment (HAART) developed Cushings Syndrome and adrenal suppression after intraarticular triamcinolone acetate administration. The mechanism is due to increased systemic concentrations of triamcinolone (over 10 x normal levels) due to inhibition of the cytochrome p450 3A4 metabolism. The symptoms ...
Altered Mental Status in the Geriatric Patient
Altered Mental Status in the Geriatric Patient

... • Diabetic ketoacidosis – buildup of ketone bodies in advanced stages of diabetes mellitus. • Lactic acidosis – buildup of lactic acid in the blood due to poor perfusion and oxygenation of vital organs. • Metabolic acidosis – a decrease of pH in the body due to the retention of acids or a lack of bi ...
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The Burden of Refractory Epilepsy
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... antiepileptic medications. In the European Union, VNS Therapy is approved for use as an adjunctive therapy in reducing the frequency of seizures in patients whose epileptic disorder is dominated by partial seizures (with or without secondary generalization) or generalized seizures that are refractor ...
The Medial Longitudinal Fasciculus in Multiple Sclerosis
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... The lifetime costs of treating RA can exceed those for treating coronary artery disease and stroke (Allaire 1994).Annual direct medical expenditures for RA patients without comorbidities are about $9,300, and indirect ...
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... are generally safe, their effectiveness requires instructors skilled in conveying appropriate technique and regular practice by the patient. These helpful complementary modalities can be used as part of a multidisciplinary approach to patient care. Major research studies are underway to elucidate th ...
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... • ~20 to 1 ratio in patients with recurrent UTI • Not as well defined as UTI • Typical presentation: • Cystitis + flank pain and fevers • Septic shock is uncommon → important to consider an obstructive etiology • E. coli in 90% • Unique virulence characteristics ...
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... For as long as scientists have studied rheumatic disease, bacterial infections have been believed to trigger certain types of arthritis. The strongest support for this theory is seen in ReA and IBD arthritis. In ReA, bacterial infections of the intestines, genitals, and upper respiratory tract typic ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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