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Glial Cell Line-derived Neurotrophic Factor (GDNF) Therapy for
Glial Cell Line-derived Neurotrophic Factor (GDNF) Therapy for

... using GDNF to a halt, but not the pre-clinical and basic research [46, 47]. The main reasons for this decision were the negative results of the recent randomized controlled trial and the neutralizing antiGDNF antibody found in 3 of 34 patients [48]. The latter was a factor even though these three pa ...
2013/14 South West London Effective Commissioning Initiative
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Module I Trach Care ALS
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(TNF) in sarcoidosis - Sarcoidosis, Vasculitis and Diffuse Lung
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Recurrent Herpes Simplex Labialis: Selected Therapeutic Options P
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Clinical Care Options Hepatitis Annual Update 2009
Clinical Care Options Hepatitis Annual Update 2009

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... were receiving heparin or warfarin at the time of cardioversion, whereas in the study by Stoddard and colleagues (3), only 24% of patients were receiving anticoagulation therapy before transesophageal echocardiography was done. Furthermore, in the patients studied by Stoddard and colleagues, thrombi ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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