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Highlights of the American Academy of Dermatology 61st Annual
Highlights of the American Academy of Dermatology 61st Annual

... documented when there is photographic proof that they were not present at birth. Further, the satellite nevi that are common in patients with giant congenital nevi can develop years after birth. Dr. Marghoob has suggested that perhaps the definition should be changed to "clinically and histologicall ...
Rethinking Meibomian Gland Dysfunction: How to Spot It, Stage It
Rethinking Meibomian Gland Dysfunction: How to Spot It, Stage It

... most common form, characterized by a reduction in meibum, resulting from either hyposecretion or obstruction; and 2) high delivery states, characterized by hypersecretion. In this new classification system, the relationship between MGD and ocular surface diseases such as dry eye is based on changes ...
Head First Presentation
Head First Presentation

... Some signs of a serious head injury are obvious with the athlete requiring urgent medical assessment – examples include an athlete who is knocked out, an athlete lying motionless, having seizures or losing their balance and falling over. However, on most occasions the signs of concussion are more su ...
Age-related macular degeneration: diagnosis and management
Age-related macular degeneration: diagnosis and management

... extrafoveal CNV secondary to AMD.19 This randomized, controlled trial (RCT) terminated recruitment to the extrafoveal arm at 18 months as 60% of untreated eyes but only 25% of treated eyes had severe visual loss.19 A 5-year follow-up data showed that 64% of untreated eyes developed severe visual los ...
Approach To A Patient With Hyponatremia
Approach To A Patient With Hyponatremia

... The estimated total body water (in liters) is calculated as a fraction of body weight. The fraction is 0.6 in children; 0.6 and 0.5 in nonelderly men and women, respectively; and 0.5 and 0.45 in elderly men and women, respectively. Normally extracellular and intracellular fluids account for 40 and 6 ...
Dr. Jack`s MedQuik Guide
Dr. Jack`s MedQuik Guide

... o If switching from immediate-release guanfacine, discontinue that treatment, and titrate with Guanfacine Extended Release (Intuniv) according to this schedule. o Begin at a dose of 1 mg qd and adjust in increments of no more than 1 mg/week. o Maintain the dose at 1-4 mg once daily, depending on cli ...
VOLUME 149 - No. 3 - JUNE 2014 OFFICIAL
VOLUME 149 - No. 3 - JUNE 2014 OFFICIAL

... Submission of the manuscript means that the paper is original and has not yet been totally or partially published and, if accepted, will not be published elsewhere either wholly or in part. All illustrations should be original. Illustrations taken from other publications must be accompanied by the p ...
Design and Conduct of Clinical Trials
Design and Conduct of Clinical Trials

... substitution. Ideally, the efficacy and safety results from all populations will be in general agreement. However, differences may occur, for example, when subjects drop out due to efficacy failure or safety issues. Treatment cross-over, poor compliance, and loss to follow-up are key threats to the ...
Abdominal Pain - University of South Alabama :: Family Medicine
Abdominal Pain - University of South Alabama :: Family Medicine

... June 30, 2008 ...
therapeutics of schizophrenia
therapeutics of schizophrenia

... significantly increases the risk of EPS (15). Thus, a threshold between 65% and 80% D2 occupancy appears to represent the optimal therapeutic range to minimize the risk of EPS for typical antipsychotic drugs (18–20). It should be noted, however, that despite adequate D2 occupancy, many patients do n ...
Metoprolol ratiopharm prolonged
Metoprolol ratiopharm prolonged

... Epinephrine: A dozen reports exist in respect of severe hypertension and bradycardia in patients treated with non-selective beta-receptor blockers (including pindolol and propanalol), who were administered epinephrine (adrenaline). These clinical observations have been confirmed in studies on health ...
spc-doc_PL 36390-0191 - Medicines and Healthcare products
spc-doc_PL 36390-0191 - Medicines and Healthcare products

... ototoxicity are more likely seen in patients treated with other platinum treatments and other ototoxic agents. Although peripheral neurologic toxicity is generally common and mild, limited to paresthesia and decreases in osteotendinous reflexes, its frequency is increased in patients older than 65 y ...
Informed Prescribing
Informed Prescribing

common clinical conditions and minor ailments
common clinical conditions and minor ailments

... A comment from a general practitioner (GP) is also included for many of the conditions. Communication with our GP colleagues is vital in relation to the community pharmacy contract and established protocols should always be in place. When you see this icon in the text, you are being asked to complet ...
Update on Syphilis - San Francisco City Clinic
Update on Syphilis - San Francisco City Clinic

... * Treatment failure may be caused by untreated neurosyphilis. † Reinfection may be consistent with a 4-fold serologic titer decline followed by a 4-fold serologic titer increase and re-exposure. Treat with penicillin G benzathine (Bicillin® L-A) 2.4 MU IM once. ...
poster presentations - Psikofarmakoloji Bülteni
poster presentations - Psikofarmakoloji Bülteni

... One major characteristic of cabergoline is its long duration of effect. It is highly effective in suppressing prolactin levels up to 21 days after a single 1 mg oral dose. The prolonged elimination half-life offers an advantage of once daily dosing but it might be a handicap in terms of wash-out of ...
polish annals of medicine - Warmińsko
polish annals of medicine - Warmińsko

... and degree of expressiveness are hardly studied in depth. The issues referring to the presence of mental frustrations and their features observed in the given category of patients are insufficiently examined. There are no accurate data about emotional disturbances, mental frustrations, and indicator ...
Community-acquired pneumonia
Community-acquired pneumonia

... increased mortality of patients with CAP include extremes of age, comorbid illnesses such as malignant disease, congestive heart failure, coronary artery disease, alcoholism, abnormality of vital signs, and several laboratory and radiographic findings.16 The admission decision relies on a clinician’ ...
Scabies - Boston Health Care for the Homeless Program
Scabies - Boston Health Care for the Homeless Program

... and toenails. The medicine should be left on for 8-10 hours and then washed off. The patient should then put on clean clothes. The treatment may be repeated in 1 week if necessary. Permethrin is safe for children over 2 months of age. Though less desirable for the reasons already discussed, lindane ...
Review Cytomegalovirus infection in patients with systemic lupus
Review Cytomegalovirus infection in patients with systemic lupus

... the onset of SLE has been proposed over the last few decades. SLE patients show an increased risk of viral infection and this is a leading cause of morbidity and mortality (1-3). Recent evidence has suggested an important role of retroviruses, especially human endogenous retroviruses (HERV), as a ca ...
BIOTERRORISM AGENTS - Health Services Agency
BIOTERRORISM AGENTS - Health Services Agency

... Biphasic illness, with initial phase characterized by nonspecific flu-like illness followed by acute phase characterized by acute respiratory distress and toxemia (sepsis) Chest x-ray findings: Mediastinal widening in a previously healthy patient in the absence of trauma is pathognomonic for anthrax ...
Management of Major Depressive Disorder
Management of Major Depressive Disorder

... Antidepressant medication should be offered. A A SSRI should be considered as first line antidepressants. Patients should preferably be seen again within 2 weeks, unless the clinical situation (e.g. suicide risk) makes an earlier appointment necessary. The frequency of C subsequent appointments will ...
The syndrome of inappropriate antidiuretic hormone: current and future management options
The syndrome of inappropriate antidiuretic hormone: current and future management options

... treated with i.v. normal (0.9%) saline, particularly if urine osmolality is !530 mosmol/kg (28). However, treatment with normal saline is generally reserved for patients in whom the differentiation between hypovolaemia and euvolaemia is difficult; in this situation, i.v. saline is a safer first–line ...
A Comparative Study of Diane-35 plus Spironolactone and Diane
A Comparative Study of Diane-35 plus Spironolactone and Diane

... could have better controlled hirsutism and probably have curtailed rebound recurrence. Another combination Diane-35 plus finasteride reduced the hirsutism score from 11.1 ± 2.4 to 4.5 ±2.1 (i.e. total reduction 59.4%±17.5) at 1 year. Sahin Y et al compared treatments of Diane-35 and Diane-35 plus fi ...
Antabuse (disulfiram) 200mg Tablets – Data Sheet
Antabuse (disulfiram) 200mg Tablets – Data Sheet

... weakness in hands or feet (peripheral neuritis, polyneuritis). Patients who are maintained on disulfiram 500 mg daily tend to develop peripheral neuropathy. This neuropathy improves when disulfiram is discontinued. Eye pain or tenderness and changes in vision (optic neuritis), mood and mental change ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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