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Chapter 6
Chapter 6

... • When DNA is part of the host chromosomal DNA, it is relatively stable and consequently can be maintained for many generations in the absence of selective agents. • The chromosomal integration site of a cloned gene must not be within an essential coding gene. • The input DNA sequence must be target ...
2.24 MB - KFUPM Resources v3
2.24 MB - KFUPM Resources v3

...  Heat, changes in pH, salts, and detergents can disrupt the hydrogen bonds that maintain a protein’s shape  When a protein loses its shape and no longer functions, it is denatured;  a breakfast egg with the “white” set around the yolk is a familiar example of denatured protein ...
6.unknown-genes
6.unknown-genes

... measure of significance. And treat everything with a degree of caution. Main specialised sites for this type of analysis are SMART and Pfam. Which have considerable overlapping functionality. Also InterProScan which attempts to integrate all the available tools… ...
Modeling Protein Structure Activity
Modeling Protein Structure Activity

... by _________ bonds. It is this primary structure – the order of the amino acids – that will determine the protein’s ultimate form and its ________________. 2. Next, find one place to add a beta pleat (an accordion fold), and another place to do an alpha helix (spiral twist). The polypeptide is now i ...
SOLUTE TRANSPORT
SOLUTE TRANSPORT

... typically involve periplasmic binding proteins examples: ...
Membrane Transport Powerpoint
Membrane Transport Powerpoint

... Cell Transport Mechanisms and Homeostasis OSMOSIS: The reality of molecular Transport. Everything is Aqueous!! Most Molecules CANNOT pass through the Cell Membrane directly. However, Water is a small molecule and can “leak” through the various Transport Proteins and CANNOT be completely Stopped! Wa ...
1. Describe the function of the plasma membrane
1. Describe the function of the plasma membrane

... • Ligand  a molecule that binds to a specific receptor site of another • This is how cholesterol enters the cell - it enables cells to acquire bulk quantities of specific substances even if in low concentrations in the extracellular fluid  ...
Virus to the rescue
Virus to the rescue

... pathogenic, biofilm-forming bacterium. Chem. Biol. 14, 387–398 (2007). ...
binding to negatively curved membranes
binding to negatively curved membranes

... Does curvature really not play a role? ...
Protein Unit Study Guide/Review Sheets
Protein Unit Study Guide/Review Sheets

... If you have questions, make sure to ask them. Come after school for extra help. Review: these topics are not completely inclusive of test questions. You must be able to synthesize responses using this information and also to apply this information in different ways or contexts. GENERAL PROTEIN STRUC ...
Document
Document

... – N-linked glycosylation = attachment of 14 sugar residues as a group to an asparagine amino acid within the protein – the sugar is actually built and then transferred as one unit to the nearby translating protein by a transferase protein – needs to be trimmed down in order to allow protein folding ...
function finders
function finders

The Internal Repeats in the Na /Ca2+ Exchanger
The Internal Repeats in the Na /Ca2+ Exchanger

... transmembrane segments, except for the Synechocystis homologue (slr0681), which has an extra predicted C-terminal transmembrane segment not present in the other proteins, and all have the same enrichment of positively charged residues in their predicted cytoplasmic loops as seen for YrbG (data not s ...
Cell Membranes: Chapt. 6 - College Heights Secondary
Cell Membranes: Chapt. 6 - College Heights Secondary

... I. Passive Transport • Diffusion- simple movement from regions of high concentration to low concentration • Osmosis- diffusion of water across a semi-permeable membrane • Facilitated diffusion- protein transporters which assist in ...
Peptides - Alfred State College
Peptides - Alfred State College

... Protection, e.g. toxins ...
Assembly and function of cell surface structures of the
Assembly and function of cell surface structures of the

... et al., 2007). The basE gene encodes a cytosolic ATPase while the basF gene specifies a membrane protein. The purification of tagged BasF lead to the co-isolation of BasE demonstrating that these are interacting proteins (Chapter 3). Extraction of BasEF from the cytoplasmic membrane and solubilisati ...
Document
Document

... 27 residues are the same for all forms. Other variations indicate evolutionary changes. ...
The Plasma Membrane and Membrane Potential
The Plasma Membrane and Membrane Potential

... • Diffusion (simple diffusion) – Net movement from an area of higher concentration to an area of lower concentration – Does not require energy, passive process ...
Translation
Translation

... leads to inhibition of transcription ...
Plant Molecular Biology
Plant Molecular Biology

... Since the cloning and characterization of ADL1 (Dombrowski and Raikhel, 1995) and phragmoplastin in plants (Gu and Verma, 1996), there has been significant progress in research on this group of large GTPases which share sequence homology with the animal dynamins (Hinshaw, 2000). As compared to small ...
Mitochondria Biogenesis
Mitochondria Biogenesis

... Scale in the biological world ...
Full size lecture slides (PDF file, 660 kB)
Full size lecture slides (PDF file, 660 kB)

... •There are 21 amino acids and each can be located at any position along the protein chain •This means that there can be a huge potential number of different proteins with widely different biochemical properties •The amino acid sequence of a protein determines the 3D shape of the protein •The shape o ...
nucleic acids
nucleic acids

... As the protein is being made, the first couple amino acids act as a tag to determine where the protein will end up. When the protein is released from the ribosome if needed, it will be taken to the ER and/or golgi for folding, processing, tagging and packaging ...
Review on Biochemistry: Protein Chemistry
Review on Biochemistry: Protein Chemistry

...  -carboxyglutamate: found in prothrombin and certain Ca2+-binding protein.  Desmosine (a derivative of four Lys residues): found in the fibrous protein elastin.  Selenocysteine: Selenium replaces sulfur in cysteine during amino acid synthesis (derived from serine).  Amino acids not as constitue ...
MATERIALS AND METHODS Materials All chemicals used in the
MATERIALS AND METHODS Materials All chemicals used in the

... calibrated with standard molecular weight markers. Circular Dichroism (CD) measurements- CD measurements were made on JASCO J810 spectropolarimeter calibrated with ammonium (+)-10-camphorsulfonate with 6 µM protein in 10 mM CGH buffer of desired pH with a 2 mm path length cell at 25ºC. The values ob ...
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Magnesium transporter

This page links directly from the magnesium in biological systems page.Magnesium transporters are proteins that transport magnesium across the cell membrane. All forms of life require magnesium, yet the molecular mechanisms of Mg2+ uptake from the environment and the distribution of this vital element within the organism are only slowly being elucidated.In bacteria, Mg2+ is probably mainly supplied by the CorA protein and, where the CorA protein is absent, by the MgtE protein. In yeast the initial uptake is via the Alr1p and Alr2p proteins, but at this stage the only internal Mg2+ distributing protein identified is Mrs2p. Within the protozoa only one Mg2+ transporter (XntAp) has been identified. In metazoa, Mrs2p and MgtE homologues have been identified, along with two novel Mg2+ transport systems TRPM6/TRPM7 and PCLN-1. Finally, in plants, a family of Mrs2p homologues has been identified along with another novel protein, AtMHX.
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